다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기
Blood, v.96 no.13, 2000년, pp.4103 - 4110
Sirven, Aude (From the Institut National de la Santé) , Pflumio, Françoise (et de la Recherche Mé) , Zennou, Véronique (dicale (INSERM) U362, Institut Gustave Roussy, Villejuif, France, and the Unité) , Titeux, Monique (d'Oncologie Virale, Institut Pasteur, Paris, France.) , Vainchenker, William (From the Institut National de la Santé) , Coulombel, Laure (et de la Recherche Mé) , Dubart-Kupperschmitt, Anne (dicale (INSERM) U362, Institut Gustave Roussy, Villejuif, France, and the Unité) , Charneau, Pierre (d'Oncologie Virale, Institut Pasteur, Paris, France.)
AI-Helper
Gene transfer in human hematopoietic stem cells (HSCs) has great potential for both gene therapy and the understanding of hematopoiesis. As HSCs have extensive proliferative capacities, stable gene transfer should include genomic integration of the transgene. Lentiviral vectors are now preferred to ...
Cell. Zennou 101 1 2000 10.1016/S0092-8674(00)80828-4 HIV-1 genome nuclear import is mediated by a central DNA flap.
J Exp Med. Weinberg 174 1477 1991 10.1084/jem.174.6.1477 Productive human immunodeficiency virus type 1 (HIV-1) infection of nonproliferating human monocytes.
Proc Natl Acad Sci U S A. Bukrinsky 89 6580 1992 10.1073/pnas.89.14.6580 Active nuclear import of human immunodeficiency virus type 1 preintegration complexes.
Nature. Bukrinsky 365 666 1993 10.1038/365666a0 A nuclear localization signal within HIV-1 matrix protein that governs infection of non-dividing cells [see comments].
Nature. Emerman 369 108 1994 10.1038/369108a0 HIV-1 infection of non-dividing cells: reply to Freed ED and Martin MA.
EMBO J. Popov 17 909 1998 10.1093/emboj/17.4.909 Viral protein R regulates nuclear import of the HIV-1 pre-integration complex.
Proc Natl Acad Sci U S A. von Schwedler 91 6992 1994 10.1073/pnas.91.15.6992 The nuclear localization signal of the matrix protein of human immunodeficiency virus type 1 allows the establishment of infection in macrophages and quiescent T lymphocytes.
Proc Natl Acad Sci U S A. Gallay 94 9825 1997 10.1073/pnas.94.18.9825 HIV-1 infection of nondividing cells through the recognition of integrase by the importin/karyopherin pathway.
EMBO J. Fouchier 16 4531 1997 10.1093/emboj/16.15.4531 HIV-1 infection of non-dividing cells: evidence that the amino-terminal basic region of the viral matrix protein is important for Gag processing but not for post-entry nuclear import.
Nature. Freed 369 107 1994 10.1038/369107b0 HIV-1 infection of non-dividing cells [letter; see comment].
J Virol. Freed 69 3949 1995 10.1128/JVI.69.6.3949-3954.1995 Role of the basic domain of human immunodeficiency virus type 1 matrix in macrophage infection.
Cell. Freed 88 171 1997 10.1016/S0092-8674(00)81836-X Phosphorylation of residue 131 of HIV-1 matrix is not required for macrophage infection.
J Virol. Charneau 65 2415 1991 10.1128/JVI.65.5.2415-2421.1991 A single-stranded gap in human immunodeficiency virus unintegrated linear DNA defined by a central copy of the polypurine tract.
J Virol. Charneau 66 2814 1992 10.1128/JVI.66.5.2814-2820.1992 A second origin of DNA plus-strand synthesis is required for optimal human immunodeficiency virus replication.
J Mol Biol. Charneau 241 651 1994 10.1006/jmbi.1994.1542 HIV-1 reverse transcription: a termination step at the center of the genome.
J Mol Biol. Lavigne 266 507 1997 10.1006/jmbi.1996.0805 DNA curvature controls termination of plus strand DNA synthesis at the centre of HIV-1 genome.
Retroviruses. Miller 437 1997 Development and application of retroviral vectors.
Science. Naldini 272 263 1996 10.1126/science.272.5259.263 In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector [see comments].
J Exp Med. Robin 189 1601 1999 10.1084/jem.189.10.1601 Identification of lymphomyeloid primitive progenitor cells in fresh human cord blood and in the marrow of nonobese diabetic-severe combined immunodeficient (NOD-SCID) mice transplanted with human CD34(+) cord blood cells.
Nat Biotechnol. Zufferey 15 871 1997 10.1038/nbt0997-871 Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo.
J Virol. Zufferey 72 9873 1998 10.1128/JVI.72.12.9873-9880.1998 Self-inactivating lentivirus vector for safe and efficient in vivo gene delivery.
Proc Natl Acad Sci U S A. Yee 91 9564 1994 10.1073/pnas.91.20.9564 A general method for the generation of high-titer, pantropic retroviral vectors: highly efficient infection of primary hepatocytes.
Blood. Debili 86 2516 1995 10.1182/blood.V86.7.2516.bloodjournal8672516 The Mpl-ligand or thrombopoietin or megakaryocyte growth and differentiative factor has both direct proliferative and differentiative activities on human megakaryocyte progenitors.
Blood. Croisille 84 4116 1994 10.1182/blood.V84.12.4116.bloodjournal84124116 Hydrocortisone differentially affects the ability of murine stromal cells and human marrow-derived adherent cells to promote the differentiation of CD34++/CD38？ long-term culture-initiating cells.
Blood. Issaad 81 2916 1993 10.1182/blood.V81.11.2916.2916 A murine stromal cell line allows the proliferation of very primitive human CD34++/CD38[minud] progenitor cells in long-term cultures and semisolid assays.
Hum Gene Ther. Marandin 9 1497 1998 10.1089/hum.1998.9.10-1497 Retrovirus-mediated gene transfer into human CD34+38low primitive cells capable of reconstituting long-term cultures in vitro and nonobese diabetic-severe combined immunodeficiency mice in vivo.
Proc Natl Acad Sci U S A. Case 96 2988 1999 10.1073/pnas.96.6.2988 Stable transduction of quiescent CD34(+)CD38(？) human hematopoietic cells by HIV-1-based lentiviral vectors.
AIDS Res Hum Retroviruses. Barbosa 10 53 1994 10.1089/aid.1994.10.53 Kinetic analysis of HIV-1 early replicative steps in a coculture system.
Blood. Huang 83 1515 1994 10.1182/blood.V83.6.1515.1515 Lymphoid and myeloid differentiation of single human CD34+, HLA-DR+, CD38？ hematopoietic stem cells.
Blood. Hao 86 3745 1995 10.1182/blood.V86.10.3745.bloodjournal86103745 A functional comparison of CD34 + CD38？ cells in cord blood and bone marrow.
J Virol. Sutton 73 3649 1999 10.1128/JVI.73.5.3649-3660.1999 Transduction of human progenitor hematopoietic stem cells by human immunodeficiency virus type 1-based vectors is cell cycle dependent.
Blood. Gothot 92 2641 1998 10.1182/blood.V92.8.2641.420k36_2641_2649 Cell cycle-related changes in repopulating capacity of human mobilized peripheral blood CD34(+) cells in non-obese diabetic/severe combined immune-deficient mice.
Stem Cells. Dick 15 199 1997 10.1002/stem.5530150826 Assay of human stem cells by repopulation of NOD/SCID mice.
J Virol. Sutton 72 5781 1998 10.1128/JVI.72.7.5781-5788.1998 Human immunodeficiency virus type 1 vectors efficiently transduce human hematopoietic stem cells.
J Virol. Korin 72 3161 1998 10.1128/JVI.72.4.3161-3168.1998 Progression to the G1b phase of the cell cycle is required for completion of human immunodeficiency virus type 1 reverse transcription in T cells.
Cell. Zack 61 213 1990 10.1016/0092-8674(90)90802-L HIV-1 entry into quiescent primary lymphocytes: molecular analysis reveals a labile, latent viral structure.
J Virol. Tang 69 5659 1995 10.1128/JVI.69.9.5659-5665.1995 Highly purified quiescent human peripheral blood CD4+ T cells are infectible by human immunodeficiency virus but do not release virus after activation.
EMBO J. Stevenson 9 1551 1990 10.1002/j.1460-2075.1990.tb08274.x HIV-1 replication is controlled at the level of T cell activation and proviral integration.
Proc Natl Acad Sci U S A. Reiser 93 15266 1996 10.1073/pnas.93.26.15266 Transduction of nondividing cells using pseudotyped defective high-titer HIV type 1 particles.
Proc Natl Acad Sci U S A. Uchida 95 11939 1998 10.1073/pnas.95.20.11939 HIV, but not murine leukemia virus, vectors mediate high efficiency gene transfer into freshly isolated G0/G1 human hematopoietic stem cells.
Science. Miyoshi 283 682 1999 10.1126/science.283.5402.682 Transduction of human CD34+ cells that mediate long-term engraftment of NOD/SCID mice by HIV vectors.
Science. Berardi 267 104 1995 10.1126/science.7528940 Functional isolation and characterization of human hematopoietic stem cells.
Copyright KISTI. All Rights Reserved.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.