[논문]Intrahepatic mast cell population correlates with clinical outcome in biliary atresia

doi:10.1053/jpsu.2000.19245

[해외논문] Intrahepatic mast cell population correlates with clinical outcome in biliary atresia

Journal of pediatric surgery, v.35 no.12, 2000년, pp.1762 - 1765

Uddin Ahmed, Abul Faiz Kabir (Departments of Pediatric Surgery and Pathology, Tohoku University School of Medicine, Aoba-ku, Sendai, Japan) , Ohtani, Haruo (Departments of Pediatric Surgery and Pathology, Tohoku University School of Medicine, Aoba-ku, Sendai, Japan) , Nio, Masaki (Departments of Pediatric Surgery and Pathology, Tohoku University School of Medicine, Aoba-ku, Sendai, Japan) , Funaki, Nobuo (Departments of Pediatric Surgery and Pathology, Tohoku University School of Medicine, Aoba-ku, Sendai, Japan) , Sasaki, Hideyuki (Departments of Pediatric Surgery and Pathology, Tohoku University School of Medicine, Aoba-ku, Sendai, Japan) , Nagura, Hiroshi (Departments of Pediatric Surgery and Pathology, Tohoku University School of Medicine, Aoba-ku, Sendai, Japan) , Ohi, Ryoji (Departments of Pediatric Surgery and Pathology, Tohoku University School of Medicine, Aoba-ku, Sendai, Japan)

Abstract ▼ AI-Helper

AbstractPurpose: To determine if mast cells influence the clinical outcome in biliary atresia (BA), the authors examined the intrahepatic mast cell population in BA. Methods: Mast cells were identified histochemically using Toludin Blue and immunohistochemically using antimast cell tryptase antibody in formalin-fixed paraffin-embedded sections from 21 cases of BA. Patients were divided into 3 groups; group I (n = 8) with good liver function, group II (n = 8) with moderate liver dysfunction, and group III (n = 5) with severe liver dysfunction. Liver biopsies from patients with choledochal cysts (CDC, n = 5), and normal liver (NL, n = 4) served as controls. The results were compared among the groups. Results: Both histochemical and immunohistochemical methods showed similar data. Mast cells were seen mostly in the portal tracts. Mast cell numbers per medium power field (20× magnification) were higher in BA than in the controls (15.03 ± 2.25 v 3.85 ±.65, [mean ± SEM], P <.05, BA v CDC; 15.03 ± 2.25 v 1.73 ±.06, [mean ± SEM], P <.05, BA v NL, immunohistochemical data). Clinical correlation showed an association between higher mast cell number and liver dysfunction (32.62 ±.80 v 8.52 ±.87 [mean ± SEM], group III v group I; P <.05, immunohistochemical data). Conclusion: Increased mast cell population in BA adversely affects liver function and raises the possibility that type I allergic reaction may play role in the pathology of BA. J Pediatr Surg 35:1762-1765. Copyright © 2000 by W.B. Saunders Company.

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DOI : 10.1053/jpsu.2000.19245
WB Saunders : 저널
Elsevier : 저널 > 논문

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