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NTIS 바로가기Journal of applied physiology, v.89 no.6, 2000년, pp.2382 - 2390
Winters, Bradford (Departments of Anesthesiology and Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287) , Mo, Zhiping (Departments of Anesthesiology and Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287) , Brooks-Asplund, Esther (Departments of Anesthesiology and Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287) , Kim, Soonyul (Departments of Anesthesiology and Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287) , Shoukas, Artin (Departments of Anesthesiology and Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287) , Li, Dechun (Departments of Anesthesiology and Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287) , Nyhan, Daniel (Departments of Anesthesiology and Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287) , Berkowitz, Dan E. (Departments of Anesthesiology and Biomedical Engineering, Johns Hopkins University)
Obesity is a major health care problem and is associated with significant cardiovascular morbidity. Leptin, a neuroendocrine hormone released by adipose tissue, is important in modulating obesity by signaling satiety and increasing metabolism. Moreover, leptin receptors are expressed on vascular en...
Bouloumié, Anne, Drexler, Hannes C. A., Lafontan, Max, Busse, Rudi. Leptin, the Product of Ob Gene, Promotes Angiogenesis. Circulation research : a journal of the American Heart Association, vol.83, no.10, 1059-1066.
Brayden, JE, Nelson, MT. Regulation of arterial tone by activation of calcium-dependent potassium channels. Science, vol.256, no.5056, 532-535.
Breslow, Michael J., Min-Lee, Kyoung, Brown, Daniel R., Chacko, V. P., Palmer, David, Berkowitz, Dan E.. Effect of leptin deficiency on metabolic rate inob/obmice. American journal of physiology, Endocrinology and metabolism, vol.276, no.3, E443-E449.
Campfield, L. A., Smith, F. J., Burn, P.. The OB Protein (Leptin) Pathway - A Link Between Adipose Tissue Mass and Central Neural Networks. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme, vol.28, no.12, 619-632.
Caprio, S., Tamborlane, W. V., Silver, D., Robinson, C., Leibel, R., McCarthy, S., Grozman, A., Belous, A., Maggs, D., Sherwin, R. S.. Hyperleptinemia: an early sign of juvenile obesity. Relations to body fat depots and insulin concentrations. American journal of physiology, Endocrinology and metabolism, vol.271, no.3, E626-E630.
Caro, José F, Kolaczynski, Jerzy W, Nyce, Mark R, Ohannesian, Joanna P, Opentanova, Irina, Goldman, Warren H, Lynn, Richard B, Zhang, Pei-Li, Sinha, Madhur K, Considine, Robert V. Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance. The Lancet, vol.348, no.9021, 159-161.
Considine, Robert V., Sinha, Madhur K., Heiman, Mark L., Kriauciunas, Aidas, Stephens, Thomas W., Nyce, Mark R., Ohannesian, Joanna P., Marco, Cheryl C., McKee, Linda J., Bauer, Thomas L., Caro, José F.. Serum Immunoreactive-Leptin Concentrations in Normal-Weight and Obese Humans. The New England journal of medicine, vol.334, no.5, 292-295.
Dart, A.M., Chin-Dusting, J.P.F.. Lipids and the endothelium. Cardiovascular research, vol.43, no.2, 308-322.
Ernsberger, Paul, Koletsky, Richard J., Collins, Laura A., Bedol, David. Sympathetic nervous system in salt-sensitive and obese hypertension: Amelioration of multiple abnormalities by a central sympatholytic agent. Cardiovascular drugs and therapy, vol.10, no.suppl1, 275-282.
Faraci, Frank M., Sigmund, Curt D., Shesely, Edward G., Maeda, Nobuyo, Heistad, Donald D.. Responses of carotid artery in mice deficient in expression of the gene for endothelial NO synthase. American journal of physiology, Heart and circulatory physiology, vol.274, no.2, H564-H570.
Frühbeck, G. Pivotal role of nitric oxide in the control of blood pressure after leptin administration.. Diabetes, vol.48, no.4, 903-908.
Garland, Christopher J., Plane, Frances. Endothelium-dependent hyperpolarization: a role in the control of vascular tone. Trends in pharmacological sciences, vol.16, no.1, 23-30.
Ghilardi, N, Ziegler, S, Wiestner, A, Stoffel, R, Heim, M H, Skoda, R C. Defective STAT signaling by the leptin receptor in diabetic mice.. Proceedings of the National Academy of Sciences of the United States of America, vol.93, no.13, 6231-6235.
Giugliano, Dario, Ceriello, Anthonio, Paolisso, Giuseppe. Oxidative Stress and Diabetic Vascular Complications. Diabetes care, vol.19, no.3, 257-267.
Haffner, SM, Miettinen, H, Mykkänen, L, Karhapää, P, Rainwater, DL, Laakso, M. Leptin concentrations and insulin sensitivity in normoglycemic men. International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, vol.21, no.5, 393-399.
Halaas, Jeffrey L., Boozer, Carol, Blair-West, John, Fidahusein, Naseem, Denton, Derek A., Friedman, Jeffrey M.. Physiological response to long-term peripheral and central leptin infusion in lean and obese mice. Proceedings of the National Academy of Sciences of the United States of America, vol.94, no.16, 8878-8883.
Harris, Ruth B. S., Zhou, Jun, Redmann Jr., Stephen M., Smagin, Gennady N., Smith, Steven R., Rodgers, Erin, Zachwieja, Jeffrey J.. A Leptin Dose-Response Study in Obese (ob/ob) and Lean (+/?) Mice. Endocrinology, vol.139, no.1, 8-19.
Haynes, W G, Morgan, D A, Walsh, S A, Mark, A L, Sivitz, W I. Receptor-mediated regional sympathetic nerve activation by leptin.. The Journal of clinical investigation, vol.100, no.2, 270-278.
Haynes, William G., Morgan, Donald A., Walsh, Susan A., Sivitz, William I., Mark, Allyn L.. CARDIOVASCULAR CONSEQUENCES OF OBESITY: ROLE OF LEPTIN. Clinical and experimental pharmacology & physiology, vol.25, no.1, 65-69.
Haynes, William G., Sivitz, William I., Morgan, Donald A., Walsh, Susan A., Mark, Allyn L.. Sympathetic and Cardiorenal Actions of Leptin. Hypertension, vol.30, no.3, 619-623.
Huang, Paul L., Huang, Zhihong, Mashimo, Hiroshi, Bloch, Kenneth D., Moskowitz, Michael A., Bevan, John A., Fishman, Mark C.. Hypertension in mice lacking the gene for endothelial nitric oxide synthase. Nature, vol.377, no.6546, 239-242.
Jiang, Zhen Y., Lin, You-Wei, Clemont, Allen, Feener, Edward P., Hein, Katherine D., Igarashi, Masahiko, Yamauchi, Teruaki, White, Morris F., King, George L.. Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats. The Journal of clinical investigation, vol.104, no.4, 447-457.
Johns, R A, Peach, M J, Linden, J, Tichotsky, A. NG-monomethyl L-arginine inhibits endothelium-derived relaxing factor-stimulated cyclic GMP accumulation in cocultures of endothelial and vascular smooth muscle cells by an action specific to the endothelial cell.. Circulation research : a journal of the American Heart Association, vol.67, no.4, 979-985.
Kessler, R, Chaouat, A, Weitzenblum, E, Oswald, M, Ehrhart, M, Apprill, M, Krieger, J. Pulmonary hypertension in the obstructive sleep apnoea syndrome: prevalence, causes and therapeutic consequences. The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology, vol.9, no.4, 787-794.
Kleinert, Hartmut, Wallerath, Thomas, Fritz, Gerhard, Ihrig‐Biedert, Irmgard, Rodriguez‐Pascual, Fernando, Geller, David A, Forstermann, Ulrich. Cytokine induction of NO synthase II in human DLD‐1 cells: roles of the JAK‐STAT, AP‐1 and NF‐κB‐signaling pathways. British journal of pharmacology : BJP, vol.125, no.1, 193-201.
Lee, Gwo-Hwa, Proenca, R., Montez, J. M., Carroll, K. M., Darvishzadeh, J. G., Lee, J. I., Friedman, J. M.. Abnormal splicing of the leptin receptor in diabetic mice. Nature, vol.379, no.6566, 632-635.
Lollmann, B., Gruninger, S., Stricker-Krongrad, A., Chiesi, M.. Detection and Quantification of the Leptin Receptor Splice Variants Ob-Ra, b, and, e in Different Mouse Tissues. Biochemical and biophysical research communications, vol.238, no.2, 648-652.
Mark, Allyn L., Correia, Marcelo, Morgan, Donald A., Shaffer, Richard A., Haynes, William G.. Obesity-Induced Hypertension : New Concepts From the Emerging Biology of Obesity. Hypertension, vol.33, no.1, 537-541.
Marrero, M.B., Venema, V.J., He, H., Caldwell, R.B., Venema, R.C.. Inhibition by the JAK/STAT Pathway of IFNγ- and LPS-Stimulated Nitric Oxide Synthase Induction in Vascular Smooth Muscle Cells. Biochemical and biophysical research communications, vol.252, no.2, 508-512.
Mikhail, Nasser, Golub, Michael S., Tuck, Michael L.. Obesity and hypertension. Progress in cardiovascular diseases, vol.42, no.1, 39-58.
Montague, Carl T., Farooqi, I. Sadaf, Whitehead, Jonathan P., Soos, Maria A., Rau, Harald, Wareham, Nicholas J., Sewter, Ciaran P., Digby, Janet E., Mohammed, Shehla N., Hurst, Jane A., Cheetham#, Christopher H., Earley#, Alison R., Barnett, Anthony H., Prins, Johannes B., O'Rahilly, Stephen. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature, vol.387, no.6636, 903-908.
Müller, Günter, Ertl, Johann, Gerl, Martin, Preibisch, Gerald. Leptin Impairs Metabolic Actions of Insulin in Isolated Rat Adipocytes. The Journal of biological chemistry, vol.272, no.16, 10585-10593.
Must, A, Spadano, J, Coakley, E H, Field, A E, Colditz, G, Dietz, W H. The disease burden associated with overweight and obesity.. JAMA : the journal of the American Medical Association, vol.282, no.16, 1523-1529.
Pelleymounter, MA, Cullen, MJ, Baker, MB, Hecht, R, Winters, D, Boone, T, Collins, F. Effects of the obese gene product on body weight regulation in ob/ob mice. Science, vol.269, no.5223, 540-543.
Scherrer, U, Randin, D, Vollenweider, P, Vollenweider, L, Nicod, P. Nitric oxide release accounts for insulin's vascular effects in humans.. The Journal of clinical investigation, vol.94, no.6, 2511-2515.
Schwartz, Michael W., Woods, Stephen C., Porte Jr, Daniel, Seeley, Randy J., Baskin, Denis G.. Central nervous system control of food intake. Nature, vol.404, no.6778, 661-671.
Nature Sierra-Honigmann MR 1683 281 1998
Sivitz, W. I., Walsh, S. A., Morgan, D. A., Thomas, M. J., Haynes, W. G.. Effects of Leptin on Insulin Sensitivity in Normal Rats*. Endocrinology, vol.138, no.8, 3395-3401.
Steinberg, H O, Brechtel, G, Johnson, A, Fineberg, N, Baron, A D. Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release.. The Journal of clinical investigation, vol.94, no.3, 1172-1179.
Surks, Howard K., Mochizuki, Naoki, Kasai, Yasuyo, Georgescu, Serban P., Tang, K. Mary, Ito, Masaaki, Lincoln, Thomas M., Mendelsohn, Michael E.. Regulation of Myosin Phosphatase by a Specific Interaction with cGMP- Dependent Protein Kinase Iα. Science, vol.286, no.5444, 1583-1587.
Tartaglia, Louis A., Dembski, Marlene, Weng, Xun, Deng, Nanhua, Culpepper, Janice, Devos, Rene, Richards, Grayson J., Campfield, L.Arthur, Clark, Frederick T., Deeds, Jim, Muir, Craig, Sanker, Sean, Moriarty, Ann, Moore, Karen J., Smutko, John S., Mays, Gail G., Wool, Elizabeth A., Monroe, Cheryl A., Tepper, Robert I.. Identification and expression cloning of a leptin receptor, OB-R. Cell, vol.83, no.7, 1263-1271.
Turpeinen, A K, Haffner, S M, Louheranta, A M, Niskanen, L K, Miettinen, H, Uusitupa, M I J. Serum leptin in subjects with impaired glucose tolerance in relation to insulin sensitivity and first-phase insulin response. International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, vol.21, no.4, 284-287.
Wu-Peng, X Sharon, C Chua Jr, Streamson, Okada, Norichika, Liu, Shun-Mei, Nicolson, Margery, Leibel, Rudolph L. Phenotype of the Obese Koletsky (f) Rat Due to Tyr763Stop Mutation in the Extracellular Domain of the Leptin Receptor (Lepr): Evidence for Deficient Plasma-to-CSF Transport of Leptin in Both the Zucker and Koletsky Obese Rat. Diabetes, vol.46, no.3, 513-518.
Zeng, G, Quon, M J. Insulin-stimulated production of nitric oxide is inhibited by wortmannin. Direct measurement in vascular endothelial cells.. The Journal of clinical investigation, vol.98, no.4, 894-898.
Zhang, Yiying, Proenca, Ricardo, Maffei, Margherita, Barone, Marisa, Leopold, Lori, Friedman, Jeffrey M.. Positional cloning of the mouse obese gene and its human homologue. Nature, vol.372, no.6505, 425-432.
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