[논문]Novel activation of non‐selective cationic channels by dinitrosyl iron‐thiosulfate in PC12 cells

Giannone, Gré; gory; Takeda, Kenneth; Kleschyov, Andrei L.

doi:10.1111/j.1469-7793.2000.00735.x

[해외논문] Novel activation of non‐selective cationic channels by dinitrosyl iron‐thiosulfate in PC12 cells 원문보기

The Journal of physiology, v.529 no.3, 2000년, pp.735 - 745

Giannone, Grégory , Takeda, Kenneth , Kleschyov, Andrei L.

Abstract ▼ AI-Helper

Low molecular mass dinitrosyl iron complexes (DNICs) are nitrosating agents and it is known that the dinitrosyl iron moiety can be transferred to proteins. The aim of the present study was to determine if the formation of protein-bound dinitrosyl iron can modulate ionic channel activity. In PC12 cells, dinitrosyl iron-thiosulfate (50 microM) caused irreversible activation of a depolarizing inward current (IDNIC). IDNIC was partially inhibited by the metal chelator diethyldithiocarbamate (DETC, 1 mM), but not by the reducing/denitrosylating agent dithiothreitol (DTT, 5 mM). The activation of IDNIC was not reproduced by application of nitric oxide (NO., 100 microM), S-nitrocysteine (200 microM) or ferrous iron-thiosulfate (50 microM), and was not prevented by the irreversible guanylyl cyclase inhibitor 1H-[1,2,4]oxadiazolo-[4, 3-a]quinoxalin-1-one (ODQ, 1 microM). Similarly, intracellular perfusion of dinitrosyl iron-thiosulfate (100 microM) did not result in activation of IDNIC. Ion replacement experiments show that the DETC-sensitive component of IDNIC is a non-selective cationic current. In accordance, IDNIC was blocked by antagonists of receptor-operated calcium entry, gadolinium (25 microM) and SK&F 96365 (25 microM). Single-channel measurements from outside-out patches reveal that the DETC-sensitive component of IDNIC is an inward current carried by a cationic channel having a conductance of 50 pS. The present observations suggest that the formation of ion channel-bound dinitrosyl iron represents another mechanism of regulation of ion channel activity by NO.-related species, which may be particularly important in pathophysiological processes where NO. is overproduced.

참고문헌 (46)

Arnelle, Derrick R., Day, Brian J., Stamler, Jonathan S.. Diethyl Dithiocarbamate-Induced Decomposition ofS-Nitrosothiols. Nitric oxide : biology and chemistry, vol.1, no.1, 56-64.

상세보기
Boese, Matthias, Keese, Michael A., Becker, Katja, Busse, Rudi, Mülsch, Alexander. Inhibition of Glutathione Reductase by Dinitrosyl-Iron-Dithiolate Complex. The Journal of biological chemistry, vol.272, no.35, 21767-21773.

상세보기
Boese, Matthias, Mordvintcev, Peter I., Vanin, Anatoly F., Busse, Rudi, Mülsch, Alexander. S-Nitrosation of Serum Albumin by Dinitrosyl-Iron Complex. The Journal of biological chemistry, vol.270, no.49, 29244-29249.

상세보기
Bolotina, Victoria M., Najibi, Soheil, Palacino, James J., Pagano, Patrick J., Cohen, Richard A.. Nitric oxide directly activates calcium-dependent potassium channels in vascular smooth muscle. Nature, vol.368, no.6474, 850-853.

상세보기
Broillet, M.-C., Firestein, S.. β Subunits of the Olfactory Cyclic Nucleotide-Gated Channel Form a Nitric Oxide Activated Ca²⁺ Channel. Neuron, vol.18, no.6, 951-958.

상세보기
Campbell, D L, Stamler, J S, Strauss, H C. Redox modulation of L-type calcium channels in ferret ventricular myocytes. Dual mechanism regulation by nitric oxide and S-nitrosothiols. The Journal of general physiology, vol.108, no.4, 277-293.

상세보기
Clementi, Emilio. The cross-talk between nitric oxide and Ca²⁺: a story with a complex past and a promising future. Trends in pharmacological sciences, vol.18, no.4, 266-269.

상세보기
Clementi, Emilio, Riccio, Maria, Sciorati, Clara, Nisticò, Giuseppe, Meldolesi, Jacopo. The Type 2 Ryanodine Receptor of Neurosecretory PC12 Cells Is Activated by Cyclic ADP-ribose. The Journal of biological chemistry, vol.271, no.30, 17739-17745.

상세보기
Dawson, VL, Kizushi, VM, Huang, PL, Snyder, SH, Dawson, TM. Resistance to neurotoxicity in cortical cultures from neuronal nitric oxide synthase-deficient mice. The Journal of neuroscience : the official journal of the Society for Neuroscience, vol.16, no.8, 2479-2487.

상세보기
Journal of Biological Chemistry Fasolato C. 20351 265 1990 10.1016/S0021-9258(17)30510-0 Receptor‐mediated calcium influx in PC12 cells. ATP and bradykinin activate two independent pathways

상세보기
Feelisch, Martin, te Poel, Marc, Zamora, Rubén, Deussen, Andreas, Moncada, Salvador. Understanding the controversy over the identity of EDRF. Nature, vol.368, no.6466, 62-65.

상세보기
Good, Paul F., Perl, Daniel P., Bierer, Linda M., Schmeidler, James. Selective accumulation of aluminum and iron in the neurofibrillary tangles of Alzheimer's disease: A laser microprobe (LAMMA) study. Annals of neurology, vol.31, no.3, 286-292.

상세보기
Gordon, S E, Zagotta, W N. Subunit interactions in coordination of Ni2+ in cyclic nucleotide-gated channels.. Proceedings of the National Academy of Sciences of the United States of America, vol.92, no.22, 10222-10226.

상세보기
Gow, Andrew J., Stamler, Jonathan S.. Reactions between nitric oxide and haemoglobin under physiological conditions. Nature, vol.391, no.6663, 169-173.

상세보기
Hantraye, Philippe, Brouillet, Emmanuel, Ferrante, Robert, Palfi, Stéphane, Dolan, Robert, Matthews, Russell T., Beal, M. Flint. Inhibition of neuronal nitric oxide synthase prevents MPTP-induced parkinsonism in baboons. Nature medicine, vol.2, no.9, 1017-1021.

상세보기
Henry, Yann, Lepoivre, Michel, Drapier, Jean‐Claude, Ducrocq, Claire, Boucher, Jean‐Luc, Guissani, Annie. EPR characterization of molecular targets for NO in mammalian cells and organelles. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, vol.7, no.12, 1124-1134.

상세보기
Ignarro, L J. Biosynthesis and Metabolism of Endothelium-Derived Nitric Oxide. Annual review of pharmacology and toxicology, vol.30, 535-560.

상세보기
Kennedy, M. Claire, Antholine, William E., Beinert, Helmut. An EPR Investigation of the Products of the Reaction of Cytosolic and Mitochondrial Aconitases with Nitric Oxide. The Journal of biological chemistry, vol.272, no.33, 20340-20347.

상세보기
Kluge, Ina, Gutteck‐Amsler, Ursula, Zollinger, Markus, Do, Kim Quang. S‐Nitrosoglutathione in Rat Cerebellum: Identification and Quantification by Liquid Chromatography‐Mass Spectrometry. Journal of neurochemistry, vol.69, no.6, 2599-2607.

상세보기
Koh, S D, Campbell, J D, Carl, A, Sanders, K M. Nitric oxide activates multiple potassium channels in canine colonic smooth muscle.. The Journal of physiology, vol.489, no.3, 735-743.

상세보기
Koivisto, A, Nedergaard, J. Modulation of calcium‐activated non‐selective cation channel activity by nitric oxide in rat brown adipose tissue.. The Journal of physiology, vol.486, no.1, 59-65.

상세보기
Koppenol, W. H., Moreno, J. J., Pryor, William A., Ischiropoulos, H., Beckman, J. S.. Peroxynitrite, a cloaked oxidant formed by nitric oxide and superoxide. Chemical research in toxicology, vol.5, no.6, 834-842.

상세보기
Lancaster Jr, J R, Hibbs Jr, J B. EPR demonstration of iron-nitrosyl complex formation by cytotoxic activated macrophages.. Proceedings of the National Academy of Sciences of the United States of America, vol.87, no.3, 1223-1227.

상세보기
Lander, Harry M., Hajjar, David P., Hempstead, Barbara L., Mirza, Urooj A., Chait, Brian T., Campbell, Sharon, Quilliam, Lawrence A.. A Molecular Redox Switch on p21. The Journal of biological chemistry, vol.272, no.7, 4323-4326.

상세보기
Lei, S.Z., Pan, Z.-H., Aggarwal, S.K., Chen, H.-S.V., Hartman, J., Sucher, N.J., Lipton, S.A.. Effect of nitric oxide production on the redox modulatory site of the NMDA receptor-channel complex. Neuron, vol.8, no.6, 1087-1099.

상세보기
Li, Z., Chapleau, M.W., Bates, J.N., Bielefeldt, K., Lee, H.-C., Abboud, F.M.. Nitric Oxide as an Autocrine Regulator of Sodium Currents in Baroreceptor Neurons. Neuron, vol.20, no.5, 1039-1049.

상세보기
Lipton, Stuart A., Choi, Yun-Beom, Pan, Zhuo-Hua, Lei, Sizheng Z., Chen, Huei-Sheng Vincent, Sucher, Nikolaus J., Loscalzo, Joseph, Singel, David J., Stamler, Jonathan S.. A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds. Nature, vol.364, no.6438, 626-632.

상세보기
Meda, Lucia, Cassatella, Marco A., Szendrei, Gyorgyi I., Otvos Jr, Laszlo, Baron, Pierluigi, Villalba, Martin, Ferrari, Davide, Rossi, Filippo. Activation of microglial cells by β-amyloid protein and interferon-γ. Nature, vol.374, no.6523, 647-650.

상세보기
Merritt, J E, Armstrong, W P, Benham, C D, Hallam, T J, Jacob, R, Jaxa-Chamiec, A, Leigh, B K, McCarthy, S A, Moores, K E, Rink, T J. SK&F 96365, a novel inhibitor of receptor-mediated calcium entry. The Biochemical journal, vol.271, no.2, 515-522.

상세보기
Minowa, Tetsuya, Miwa, Soichi, Kobayashi, Shigeo, Enoki, Taijiro, Zhang, Xiao‐Feug, Komuro, Taro, Iwamuro, Yasushi, Masaki, Tomoh. Inhibitory effect of nitrovasodilators and cyclic GMP on ET‐1‐activated Ca²⁺‐permeable nonselective cation channel in rat aortic smooth muscle cells. British journal of pharmacology : BJP, vol.120, no.8, 1536-1544.

상세보기
Pharmacological Reviews Moncada S. 109 43 1991 Nitric oxide: physiology, pathophysiology, and pharmacology

상세보기
Muller, Bernard, Kleschyov, Andrei L., Stoclet, Jean‐Claude. Evidence for N‐acetylcysteine‐sensitive nitric oxide storage as dinitrosyl‐iron complexes in lipopolysaccharide‐treated rat aorta. British journal of pharmacology : BJP, vol.119, no.6, 1281-1285.

상세보기
Mulsch, A., Mordvintcev, P., Vanin, A.F., Busse, R.. The potent vasodilating and guanylyl cyclase activating dinitrosyl-iron(II) complex is stored in a protein-bound form in vascular tissue and is released by thiols. FEBS letters, vol.294, no.3, 252-256.

상세보기
Mulsch, A., Mordvintcev, P.I., Vanin, A.F., Busse, R.. Formation and Release of Dinitrosyl Iron Complexes by Endothelial Cells. Biochemical and biophysical research communications, vol.196, no.3, 1303-1308.

상세보기
Richardson, Des R, Ponka, Prem. The molecular mechanisms of the metabolism and transport of iron in normal and neoplastic cells. Biochimica et biophysica acta, Reviews on biomembranes, vol.1331, no.1, 1-40.

상세보기
Richter, C.. Biophysical consequences of lipid peroxidation in membranes. Chemistry and physics of lipids, vol.44, no.2, 175-189.

상세보기
Snyder, SH. Nitric oxide: first in a new class of neurotransmitters. Science, vol.257, no.5069, 494-496.

상세보기
Stamler, J S, Simon, D I, Osborne, J A, Mullins, M E, Jaraki, O, Michel, T, Singel, D J, Loscalzo, J. S-nitrosylation of proteins with nitric oxide: synthesis and characterization of biologically active compounds.. Proceedings of the National Academy of Sciences of the United States of America, vol.89, no.1, 444-448.

상세보기
Stamler, JS, Singel, DJ, Loscalzo, J. Biochemistry of nitric oxide and its redox-activated forms. Science, vol.258, no.5090, 1898-1902.

상세보기
Stamler, J.S., Toone, E.J., Lipton, S.A., Sucher, N.J.. (S)NO Signals: Translocation, Regulation, and a Consensus Motif. Neuron, vol.18, no.5, 691-696.

상세보기
Biokhimia Vanin A. F. 228 32 1967 Identification of divalent iron complexes with cysteine in biological systems by EPR method
Vanin, Anatoly F., Malenkova, Irina V., Serezhenkov, Vladimir A.. Iron Catalyzes both Decomposition and Synthesis ofS-Nitrosothiols: Optical and Electron Paramagnetic Resonance Studies. Nitric oxide : biology and chemistry, vol.1, no.3, 191-203.

상세보기
VITHAYATHIL, ANTONY J., TERNBERG, JESSIE L., COMMONER, BARRY. Changes in Electron Spin Resonance Signals of Rat Liver During Chemical Carcinogenesis. Nature, vol.207, no.5003, 1246-1249.

상세보기
Xu, Le, Eu, Jerry P., Meissner, Gerhard, Stamler, Jonathan S.. Activation of the Cardiac Calcium Release Channel (Ryanodine Receptor) by Poly-S-Nitrosylation. Science, vol.279, no.5348, 234-237.

상세보기
Yu, Shan Ping, Yeh, Chen-Hsiung, Sensi, Stefano L., Gwag, Byoung J., Canzoniero, Lorella M. T., Farhangrazi, Z. Shadi, Ying, Howard S., Tian, Min, Dugan, Laura L., Choi, Dennis W.. Mediation of Neuronal Apoptosis by Enhancement of Outward Potassium Current. Science, vol.278, no.5335, 114-117.

상세보기
Yun, Hye-Young, Gonzalez-Zulueta, Mirella, Dawson, Valina L., Dawson, Ted M.. Nitric oxide mediatesN-methyl-D-aspartate receptor-induced activation of p21^ras. Proceedings of the National Academy of Sciences of the United States of America, vol.95, no.10, 5773-5778.

상세보기

활용도 분석정보

상세보기

다운로드

내보내기

활용도 Top5 논문

해당 논문의 주제분야에서 활용도가 높은 상위 5개 콘텐츠를 보여줍니다.
더보기 버튼을 클릭하시면 더 많은 관련자료를 살펴볼 수 있습니다.

표제어: PCR

동의어: Packet Collision Rate

용어 설명 출처 목록 (6)

용어 설명: PCR은 세균 특이성이 있는 primer를 이용하여 적은 수의 세균이 있을지라도 쉽게 검출할 수 있는 유용한 방법이며, 이를 이용하여 구강 내 치면세균막이나 타액에서 직접 세균을 검출할 수 있게 되었다[8].

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관 관리번호, 논문명, 대등논문명, 저자 , 저널/프로시딩명, 발행기관, 발행년, 발행언어, 권, 호, 시작페이지, 끝페이지, ISBN, ISSN, 주제분야, 키워드, 초록(한글), 초록(영문), 저자(소속기관)
저장형식	Text(ASCII format) Excel format RefWorks Direct Export RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증