[논문]Protective Effect of Tetrahydroquinolines from the Edible Insect Allomyrina dichotoma on LPS-Induced Vascular Inflammatory Responses

Park, InWha; Lee, Wonhwa; Yoo, Youngbum; Shin, Hyosoo; Oh, Joonseok; Kim, Hyelim; Kim, Mi-Ae; Hwang, Jae Sam; Bae, Jong-Sup; Na, MinKyun

doi:10.3390/ijms21103406

[해외논문] Protective Effect of Tetrahydroquinolines from the Edible Insect Allomyrina dichotoma on LPS-Induced Vascular Inflammatory Responses 원문보기

International journal of molecular sciences, v.21 no.10, 2020년, pp.3406 -

Park, InWha (College of Pharmacy, Chungnam National University, Daejeon 34134, Korea) , Lee, Wonhwa (inwha129@naver.com (I.P.)) , Yoo, Youngbum (rimeeyo@gmail.com (H.K.)) , Shin, Hyosoo (Aging Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Korea) , Oh, Joonseok (wonhwalee@kribb.re.kr (W.L.)) , Kim, Hyelim (ddq3416@gmail.com (Y.Y.)) , Kim, Mi-Ae (hysooo0914@gmail.com (H.S.)) , Hwang, Jae Sam (Aging Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Korea) , Bae, Jong-Sup (wonhwalee@kribb.re.kr (W.L.)) , Na, MinKyun (ddq3416@gmail.com (Y.Y.))

Abstract ▼ AI-Helper

The larva of Allomyrina dichotoma (family Scarabaeidae) is an edible insect that is registered in the Korean Food Standards Codex as a food resource. The chemical study on the larvae of A. dichotoma resulted in the isolation of three new tetrahydroquinolines, allomyrinaines A–C (1–3), one new dopamine derivative, allomyrinamide A (4), and four known compounds (5–8). The structures were elucidated on the basis of 1D and 2D nuclear magnetic resonance (NMR) and MS spectroscopic data analysis. Allomyrinaines A–C (1–3) possessed three stereogenic centers at C-2, C-3, and C-4, whose relative configurations were determined by analyses of the coupling constants and the nuclear Overhauser enhancement spectroscopy (NOESY) data, as well as DP4+ calculation. The anti-inflammatory effects of compounds 1–4 were evaluated in human endothelial cells. Allomyrinaines A–C (1–3) could stabilize vascular barrier integrity on lipopolysaccharide (LPS)-induced vascular inflammation via inhibition of the nuclear factor-κB (NF-κB) pathway. The physiologically relevant concentration was confirmed by Q-TOF-MS-based quantitative analysis on allomyrinaines A–C in crude extract. This study suggests that allomyrinaines A–C (1–3) are bioactive constituents of A. dichotoma to treat vascular inflammatory disorder.

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참고문헌 (27)

1. Huis A.V. Itterbeeck J.V. Klunder H. Mertens E. Halloran A. Muir G. Vantomme P. Edible Insects. Future Prospects for Food and Feed Security Food and Agriculture Organization of the United Nations Rome, Italy 2013 Volume 171
2. Song M.C. Yang H.J. Bang M.H. Kim Y.C. Kim S.Y. Rho Y.D. Chung S.H. Baek N.I. Isolation and quantitative analysis of inosine as an index component from larva of Allomirina dichotoma J. Korean Soc. Appl. Biol. Chem. 2006 49 334 338
3. Youn K. Kim J.Y. Yeo H. Yun E.Y. Hwang J.S. Jun M. Fatty acid and volatile oil compositions of Allomyrina dichotoma larvae Prev. Nutr. Food Sci. 2012 17 310 314 10.3746/pnf.2012.17.4.310 24471102

원문보기 상세보기
4. Lee J.E. Jo D.E. Lee A.J. Park H.K. Youn K. Yun E.Y. Hwang J.S. Jun M. Kang B.H. Hepatoprotective and anticancer activities of Allomyrina dichotoma larvae J. Life Sci. 2015 25 307 316 10.5352/JLS.2015.25.3.307

원문보기 상세보기
5. Kim M. Youn K. Yun E.-Y. Hwang J.S. Ahn M.R. Jeong W.S. Jun M. Effects of solvent fractions of Allomyrina dichotoma larvae through the inhibition of in vitro？BACE1 and β-amyloid(25-35)-induced toxicity in rat pheochromocytoma PC12 cells Entomol. Res. 2014 44 23 30 10.1111/1748-5967.12046

상세보기
6. Kim J. Yun E.Y. Park S.W. Goo T.-W. Seo M. Allomyrina dichotoma larvae regulate food intake and body weight in high fat diet-induced obese mice through mTOR and Mapk signaling pathways Nutrients 2016 8 100 10.3390/nu8020100 26901224

상세보기
7. Suh H.J. Kim S.R. Lee K.S. Park S. Kang S.C. Antioxidant activity of various solvent extracts from Allomyrina dichotoma (Arthropoda: Insecta) larvae J. Photochem. Photobiol. B 2010 99 67 73 10.1016/j.jphotobiol.2010.02.005 20236833

상세보기
8. Goldblum S.E. Brann T.W. Ding X. Pugin J. Tobias P.S. Lipopolysaccharide (LPS)-binding protein and soluble CD14 function as accessory molecules for LPS-induced changes in endothelial barrier function, in vitro J. Clin. Investig. 1994 93 692 702 10.1172/JCI117022 7509346

상세보기
9. Varani J. Ward P.A. Mechanisms of endothelial cell injury in acute inflammation Shock 1994 2 311 319 10.1097/00024382-199411000-00001 7743355

상세보기
10. Aird W.C. Endothelium as a therapeutic target in sepsis Curr. Drug Targets 2007 8 501 507 10.2174/138945007780362782 17430120

상세보기
11. Czermak B.J. Breckwoldt M. Ravage Z.B. Huber-Lang M. Schmal H. Bless N.M. Friedl H.P. Ward P.A. Mechanisms of enhanced lung injury during sepsis Am. J. Pathol. 1999 154 1057 1065 10.1016/S0002-9440(10)65358-8 10233844

상세보기
12. Lu X. Pu Y. Kong W. Tang X. Zhou J. Gou H. Song X. Zhou H. Gao N. Shen J. Antidesmone, a unique tetrahydroquinoline alkaloid, prevents acute lung injury via regulating MAPK and NF-κB activities Int. Immunopharmacol. 2017 45 34 42 10.1016/j.intimp.2017.01.026 28157559

상세보기
13. Tuan N.Q. Oh J. Park H.B. Ferreira D. Choe S. Lee J. Na M. A grayanotox-9(11)-ene derivative from Rhododendron brachycarpum and its structural assignment via a protocol combining NMR and DP4 plus application Phytochemistry 2017 133 45 50 10.1016/j.phytochem.2016.10.010 27816176

상세보기
14. Lee W. Lee H. Kim M.A. Choi J. Kim K.M. Hwang J.S. Na M. Bae J.S. Evaluation of novel factor Xa inhibitors from Oxya chinensis sinuosa with anti-platelet aggregation activity Sci. Rep. 2017 7 7934 7946 10.1038/s41598-017-08330-1 28801633

상세보기
15. Erenler R. Sen O. Aksit H. Demirtas I. Yaglioglu A.S. Elmastas M. Telci I. Isolation and identification of chemical constituents from Origanum majorana and investigation of antiproliferative and antioxidant activities J. Sci. Food Agric. 2016 96 822 836 10.1002/jsfa.7155 25721137

상세보기
16. Lee W. Kim M.A. Park I. Hwang J.S. Na M. Bae J.S. Novel direct factor Xa inhibitory compounds from Tenebrio molitor with anti-platelet aggregation activity Food Chem. Toxicol. 2017 109 19 27 10.1016/j.fct.2017.08.026 28844963

상세보기
17. Lee J. Hwang I.H. Kim J.H. Kim M.A. Hwang J.S. Kim Y.H. Na M. Quinoxaline-, dopamine-, and amino acid-derived metabolites from the edible insect Protaetia brevitarsis seulensis Arch. Pharm. Res. 2017 40 1064 1070 10.1007/s12272-017-0942-x 28780757

상세보기
18. Riedemann N.C. Guo R.-F. Ward P.A. Novel strategies for the treatment of sepsis Nat. Med. 2003 9 517 524 10.1038/nm0503-517 12724763

상세보기
19. Jonathan C. The immunopathogenesis of sepsis Nature 2002 420 885 891 12490963

상세보기
20. Bierhaus A. Chen J. Liliensiek B. Nawroth P.P. LPS and cytokine-activated endothelium Semin. Thromb. Hemost. 2000 26 571 587 10.1055/s-2000-13214 11129414

상세보기
21. Lee W. Park S.Y. Yoo Y. Kim S.Y. Kim J.E. Kim S.W. Seo Y.K. Park E.K. Kim I.S. Bae J.S. Macrophagic stabilin-1 restored disruption of vascular integrity caused by sepsis Thromb. Haemost. 2018 118 1776 1789 10.1055/s-0038-1669477 30235477

상세보기
22. Bae J.S. Role of high mobility group box 1 in inflammatory disease: Focus on sepsis Arch. Pharm. Res. 2012 35 1511 1523 10.1007/s12272-012-0901-5 23054707

원문보기 상세보기
23. Tuan N.Q. Lee W. Oh J. Kwak S. Lee H.G. Ferreira D. Bae J.S. Na M. Quinic acid derivatives from Salicornia herbacea alleviate HMGB1-mediated endothelial dysfunction J. Funct. Foods 2015 15 326 338 10.1016/j.jff.2015.03.044

상세보기
24. Walton K.L. Holt L. Sartor R.B. Lipopolysaccharide activates innate immune responses in murine intestinal myofibroblasts through multiple signaling pathways Am. J. Physiol. Gastrointest. Liver Physiol. 2009 296 G601 G611 10.1152/ajpgi.00022.2008 19136385

상세보기
25. Astiz M.E. Rackow E.C. Septic shock Lancet 1998 351 1501 1505 10.1016/S0140-6736(98)01134-9 9605819

상세보기
26. Grimblat N. Zanardi M.M. Sarotti A.M. Beyond DP4: An improved probability for the stereochemical assignment of isomeric compounds using quantum chemical calculations of NMR shifts J. Org. Chem. 2015 80 12526 12534 10.1021/acs.joc.5b02396 26580165

상세보기
27. Bui B.P. Oh Y. Lee H. Cho J. Inhibition of inflammatory mediators and cell migration by 1,2,3,4-tetrahydroquinoline derivatives in LPS-stimulated BV2 microglial cells via suppression of NF-κB and JNK pathway Int. Immunopharmacol. 2020 80 106231 106241 10.1016/j.intimp.2020.106231 32007708

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