[논문]Suppression of DNCB-Induced Atopic Skin Lesions in Mice by Wikstroemia indica Extract

Lee, So-Yeon; Park, No-June; Jegal, Jonghwan; Jo, Beom-Geun; Choi, Sangho; Lee, Sang Woo; Uddin, Md. Salah; Kim, Su-Nam; Yang, Min Hye

doi:10.3390/nu12010173

[해외논문] Suppression of DNCB-Induced Atopic Skin Lesions in Mice by Wikstroemia indica Extract 원문보기

Nutrients, v.12 no.1, 2020년, pp.173 -

Lee, So-Yeon (College of Pharmacy, Pusan National University, Busan 46241, Korea) , Park, No-June (s7315@naver.com (S.-Y.L.)) , Jegal, Jonghwan (jhjegal@pusan.ac.kr (J.J.)) , Jo, Beom-Geun (dtc98103@pusan.ac.kr (B.-G.J.)) , Choi, Sangho (Natural Products Research Institute, Korea Institute of Science and Technology, Gangneung 25451, Korea) , Lee, Sang Woo (115519@kist.re.kr) , Uddin, Md. Salah (College of Pharmacy, Pusan National University, Busan 46241, Korea) , Kim, Su-Nam (s7315@naver.com (S.-Y.L.)) , Yang, Min Hye (jhjegal@pusan.ac.kr (J.J.))

Abstract ▼ AI-Helper

Wikstroemia indica (L.) C.A. Mey. is used in traditional Chinese medicine to treat inflammatory diseases such as arthritis and bronchitis. In this study, we aimed to investigate the effects of an ethanolic extract of W. indica on cutaneous inflammation in mice with 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD). Dermal administration of W. indica ethanolic extract to DNCB-sensitized hairless mice with dermatitis, for two weeks, reduced erythema, scaling, and edema. Skin hydration was improved and transepidermal water loss was reduced at a W. indica concentration of 1%. Furthermore, W. indica also significantly reduced serum IgE and IL-4 concentrations in our mouse model. These results suggest that W. indica has potential as a topical treatment for AD and as an adjunctive agent to control AD.

Keyword

참고문헌 (37)

1. Lee J.H. Han K.D. Park Y.G. Lee J.Y. Park Y.M. Prevalence of atopic dermatitis in Korean children based on data from the 2008-2011 Korean National Health and Nutrition Examination Survey Allergy Asthma Immunol. Res. 2016 8 79 83 10.4168/aair.2016.8.1.79 26540505

상세보기
2. Pyun B.Y. Natural history and risk factors of atopic dermatitis in children Allergy Asthma Immunol. Res. 2015 7 101 105 10.4168/aair.2015.7.2.101 25729616

상세보기
3. Megna M. Patruno C. Villani A. Balato A. Monfrecola G. Ayala F. Balato N. Systemic treatment of adult atopic dermatitis: A review Dermatol. Ther. 2017 7 1 23 10.1007/s13555-016-0170-1

상세보기
4. Bin L. Leung D.Y. Genetic and epigenetic studies of atopic dermatitis Allergy Asthma Clin. Immunol. 2016 12 1 14 10.1186/s13223-016-0158-5 26734065

상세보기
5. Leung D.Y. Boguniewicz M. Howell M.D. Nomura I. Hamid Q.A. New insights into atopic dermatitis J. Clin. Invest. 2004 113 651 657 10.1172/JCI21060 14991059

상세보기
6. Tang M. Kemp A. Varigos G. IL-4 and interferon-gamma production in children with atopic disease Clin. Exp. Immunol. 1993 92 120 124 10.1111/j.1365-2249.1993.tb05957.x 8467557

상세보기
7. Jensen J.M. Pfeiffer S. Witt M. Brautigam M. Neumann C. Weichenthal M. Schwarz T. Folster-Holst R. Proksch E. Different effects of pimecrolimus and betamethasone on the skin barrier in patients with atopic dermatitis J. Allergy Clin. Immunol. 2009 123 1124 1133 10.1016/j.jaci.2009.03.032 19410693

상세보기
8. Rawlings A.V. Harding C.R. Moisturization and skin barrier function Dermatol. Ther. 2004 17 43 48 10.1111/j.1396-0296.2004.04S1005.x 14728698

상세보기
9. Mori T. Ishida K. Mukumoto S. Yamada Y. Imokawa G. Kabashima K. Kobayashi M. Bito T. Nakamura M. Ogasawara K. Comparison of skin barrier function and sensory nerve electric current perception threshold between IgE-high extrinsic and IgE-normal intrinsic types of atopic dermatitis Br. J. Dermatol. 2010 162 83 90 10.1111/j.1365-2133.2009.09440.x 19785593

상세보기
10. Atherton D.J. Topical corticosteroids in atopic dermatitis BMJ 2003 327 942 943 10.1136/bmj.327.7421.942 14576221

상세보기
11. Ashcroft D.M. Dimmock P. Garside R. Stein K. Williams H.C. Efficacy and tolerability of topical pimecrolimus and tacrolimus in the treatment of atopic dermatitis: Meta-analysis of randomized controlled trials BMJ 2005 330 1 9 10.1136/bmj.38376.439653.D3 15626781

상세보기
12. Elias P.M. Schmuth M. Abnormal skin barrier in the etiopathogenesis of atopic dermatitis Curr. Allergy Asthma Rep. 2009 9 265 272 10.1007/s11882-009-0037-y 19656472

상세보기
13. Simpson E.L. Chalmers J.R. Hanifin J.M. Thomas K.S. Cork M.J. McLean W.H. Brown S.J. Chen Z. Chen Y. Williams H.C. Emollient enhancement of the skin barrier from birth offers effective atopic dermatitis prevention J. Allergy Clin. Immunol. 2014 134 818 823 10.1016/j.jaci.2014.08.005 25282563

상세보기
14. Simpson E.L. Berry T.M. Brown P.A. Hanifin J.M. A pilot study of emollient therapy for the primary prevention of atopic dermatitis J. Am. Acad. Dermatol. 2010 63 587 593 10.1016/j.jaad.2009.11.011 20692725

상세보기
15. Ho W.S. Xue J.Y. Sun S.S. Ooi V.E. Li Y.L. Antiviral activity of daphnoretin isolated from Wikstroemia indica Phytother. Res. 2010 24 657 661 19610034
16. Wang L.Y. Unehara N. Kitanaka S. Lignans from the roots of Wikstroemia indica and their DPPH radical scavenging and nitric oxide inhibitory activities Chem. Pharm. Bull. 2005 53 1348 1351 10.1248/cpb.53.1348 16205001

상세보기
17. Li Y.M. Zhu L. Jiang J.G. Yang L. Wang D.Y. Bioactive components and pharmacological action of Wikstroemia indica (L.) CA Mey and its clinical application Curr. Pharm. Biotechnol. 2009 10 743 752 10.2174/138920109789978748 19939213

상세보기
18. Lee K.H. Tagahara K. Suzuki H. Wu R.Y. Haruna M. Hall I.H. Huang H.C. Ito K. Iida T. Lai J.S. Antitumor agents. 49. Tricin, kaempferol-3-0-β-D-Glucopyranoside and (+)-nortrachelogenin, antileukemic principles from Wikstroemia indica J. Nat. Prod. 1981 44 530 535 10.1021/np50017a003 7320737

상세보기
19. Nunome S. Ishiyama A. Kobayashi M. Otoguro K. Kiyohara H. Yamada H. Omura S. In vitro antimalarial activity of biflavonoids from Wikstroemia indica Planta Med. 2004 70 76 78 14765300

상세보기
20. Wang L.Y. Unehara T. Kitanaka S. Anti-inflammatory activity of new guaiane type sesquiterpene from Wikstroemia indica Chem. Pharm. Bull. 2005 53 137 139 10.1248/cpb.53.137 15635251

상세보기
21. Hu K. Kobayashi H. Dong A. Iwasaki S. Yao X. Antifungal, antimitotic and anti-HIV-1 agents from the roots of Wikstroemia indica Planta Med. 2000 66 564 567 10.1055/s-2000-8601 10985087

상세보기
22. Kitamura A. Takata R. Aizawa S. Watanabe H. Wada T. A murine model of atopic dermatitis can be generated by painting the dorsal skin with hapten twice 14 days apart Sci. Rep. 2018 8 1 9 10.1038/s41598-018-24363-6 29311619

상세보기
23. Lee K.S. Jeong E.S. Heo S.H. Seo J.H. Jeong D.G. Choi Y.K. A novel model for human atopic dermatitis: Application of repeated DNCB patch in BALB/c mice, in comparison with NC/Nga mice Lab. Anim. Res. 2010 26 95 102 10.5625/lar.2010.26.1.95

상세보기
24. Huang W. Zhang X. Wang Y. Ye W. Ooi V.E.C. Chung H.Y. Li Y. Antiviral biflavonoids from Radix wikstroemiae (Liaogewanggen) Chin. Med. 2010 5 1 6 10.1186/1749-8546-5-23 20145733

상세보기
25. Nirmala M.J. Samundeeswari A. Sankar P.D. Natural plant resources in anti-cancer therapy―A review Res. Plant Biol. 2011 1 1 14
26. Rastogi R.P. Dhawan B.N. Anticancer and antiviral activities in Indian medicinal plants: A review Drug Dev. Res. 1990 19 1 12 10.1002/ddr.430190102

상세보기
27. Kim T.Y. Park N.J. Jegal J. Choi S. Lee S.W. Hang J. Kim S.N. Yang M.H. Chamaejasmine isolated from Wikstroemia dolichantha Diels suppresses 2, 4-dinitrofluoro-benzene-induced atopic dermatitis in SKH-1 hairless mice Biomolecules 2019 9 697 10.3390/biom9110697 31694198

상세보기
28. Simpson E.L. Atopic dermatitis: A review of topical treatment options Curr. Med. Res. Opin. 2010 26 633 640 10.1185/03007990903512156 20070141

상세보기
29. Gelmetti C. Wollenberg A. Atopic dermatitis？all you can do from the outside Br. J. Dermatol. 2014 170 19 24 10.1111/bjd.12957 24720530

상세보기
30. Jujo K. Renz H. Abe J. Gelfand E.W. Leung D.Y. Decreased interferon gamma and increased interleukin-4 production in atopic dermatitis promotes IgE synthesis J. Allergy Clin. Immunol. 1992 90 323 331 10.1016/S0091-6749(05)80010-7 1527316

상세보기
31. Kashiwada M. Levy D.M. McKeag L. Murray K. Schroder A.J. Canfield S.M. Traver G. Rothman P.B. IL-4-induced transcription factor NFIL3/E4BP4 controls IgE class switching Proc. Natl. Acad. Sci. USA 2010 107 821 826 10.1073/pnas.0909235107 20080759

상세보기
32. Jabara H.H. Ahern D.J. Vercelli D. Geha R.S. Hydrocortisone and IL-4 induce IgE isotype switching in human B cells J. Immunol. 1991 147 1557 1560 1715363

상세보기
33. Ovsiy I. Riabov V. Manousaridis I. Michel J. Moganti K. Yin S. Liu T. Sticht C. Kremmer E. Harmsen M.C. IL-4 driven transcription factor FoxQ1 is expressed by monocytes in atopic dermatitis and stimulates monocyte migration Sci. Rep. 2017 7 1 9 10.1038/s41598-017-17307-z 28127051

상세보기
34. Kaburagi Y. Shimada Y. Nagaoka T. Hasegawa M. Takehara K. Sato S. Enhanced production of CC-chemokines (RANTES, MCP-1, MIP-1α, MIP-1β, and eotaxin) in patients with atopic dermatitis Arch. Dermatol. Res. 2001 293 350 355 10.1007/s004030100230 11550808

상세보기
35. Kagami S. Kakinuma T. Saeki H. Tsunemi Y. Fujita H. Nakamura K. Takekoshi T. Kishimoto M. Mitsui H. Torii H. Significant elevation of serum levels of eotaxin-3/CCL26, but not of eotaxin-2/CCL24, in patients with atopic dermatitis: Serum eotaxin-3/CCL26 levels reflect the disease activity of atopic dermatitis Clin. Exp. Immunol. 2003 134 309 313 10.1046/j.1365-2249.2003.02273.x 14616792

상세보기
36. Kim B.E. Leung D.Y. Boguniewicz M. Howell M.D. Loricrin and involucrin expression is down-regulated by Th2 cytokines through STAT-6 Clin. Immunol. 2008 126 332 337 10.1016/j.clim.2007.11.006 18166499

상세보기
37. Howell M.D. Kim B.E. Gao P. Grant A.V. Boguniewicz M. DeBenedetto A. Schneider L. Cytokine modulation of atopic dermatitis filaggrin skin expression J. Allergy Clin. Immunol. 2009 124 R7 R12 10.1016/j.jaci.2009.07.012 19720210

상세보기

LOADING...

활용도 분석정보

상세보기

다운로드

내보내기

활용도 Top5 논문

해당 논문의 주제분야에서 활용도가 높은 상위 5개 콘텐츠를 보여줍니다.
더보기 버튼을 클릭하시면 더 많은 관련자료를 살펴볼 수 있습니다.

원문 보기

AccessON 원문보기

원문 URL 링크

DOI : 10.3390/nu12010173 [무료]
PubMed Central : 저널 > 논문 [무료]
Molecular Diversity Preservation International : 저널
AccessON : 저널

*원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다.

오픈액세스(OA) 유형

GOLD

오픈액세스 학술지에 출판된 논문

저작권 관리 안내

내보내기 메뉴

내보내기 구분

파일저장
인쇄
메일전송

구성항목

기본정보
상세정보

관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관

저장형식

Text(ASCII format)
Excel format
RefWorks Direct Export
RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley

메일정보

받는사람 (필수): @
보내는사람 (선택): @
제목
내용: KISTI 검색결과 이메일 서비스

안내

총 건의 자료가 검색되었습니다.

다운받으실 자료의 인덱스를 입력하세요. (1-10,000)

검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다.

데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요)

다운로드 파일은 UTF-8 형태로 저장됩니다.
파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오.

Text(ASCII format)
Excel format

표제어: PCR

동의어: Packet Collision Rate

용어 설명 출처 목록 (6)

용어 설명: PCR은 세균 특이성이 있는 primer를 이용하여 적은 수의 세균이 있을지라도 쉽게 검출할 수 있는 유용한 방법이며, 이를 이용하여 구강 내 치면세균막이나 타액에서 직접 세균을 검출할 수 있게 되었다[8].

AI-Helper ※ AI-Helper는 을 사용합니다.

AI-Helper

안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

연합인증