[논문]Banhasasim-Tang Attenuates Lipopolysaccharide-Induced Cognitive Impairment by Suppressing Neuroinflammation in Mice

Oh, You-Chang; Jeong, Yun Hee; Pak, Malk Eun; Go, Younghoon

doi:10.3390/nu12072019

[해외논문] Banhasasim-Tang Attenuates Lipopolysaccharide-Induced Cognitive Impairment by Suppressing Neuroinflammation in Mice 원문보기

Nutrients, v.12 no.7, 2020년, pp.2019 -

Oh, You-Chang , Jeong, Yun Hee , Pak, Malk Eun , Go, Younghoon

Abstract ▼ AI-Helper

Banhasasim-tang (BHS) is an herbal medicine that has been widely used in East Asia to treat various symptoms associated with upper abdomen swelling. BHS has not been studied previously for neuroinflammation or cognitive disorder. Here, we use a lipopolysaccharide (LPS) model to investigate the effects and mechanisms of BHS in neuroinflammation and cognitive impairment of mice. We used a mouse model of LPS-induced cognitive impairment and neuroinflammation and examined whether administration of BHS prevents these deficits via Morris water maze test, passive avoidance test, histopathological analysis, Western blotting, and real-time reverse transcription polymerase chain reaction (RT-qPCR). We found via behavioral tests that BHS treatment effectively prevented LPS-induced memory loss and neuronal damage in mice. Histopathological analysis of mouse brains revealed that BHS inhibited LPS-induced expression of microglial and astrocyte activation markers. Furthermore, BHS inhibits the production of markers related to neurodegeneration, amyloidogenesis, and inflammation, and mRNA expression of inflammatory mediators in mouse brain tissue. Additionally, BHS pretreatment effectively inhibited generation of inflammatory factors and pathways in BV2 microglial cells stimulated by LPS. These observations indicate that BHS is effective in preventing cognitive impairment caused by neuroinflammation and has strong potential as a candidate treatment for neuronal inflammatory diseases.

Keyword

참고문헌 (36)

1. Allison D.J. Ditor D.S. The common inflammatory etiology of depression and cognitive impairment: A therapeutic target J. Neuroinflammation 2014 11 151 10.1186/s12974-014-0151-1 25178630

상세보기
2. Galimberti D. Scarpini E. Inflammation and oxidative damage in Alzheimer’s disease: Friend or foe? Front. Biosci. (Schol Ed). 2011 3 252 266 10.2741/s149 21196374

상세보기
3. Ransohoff R.M. Cardona A.E. The myeloid cells of the central nervous system parenchyma Nature 2010 468 253 262 10.1038/nature09615 21068834

상세보기
4. Jucker M. Walker L.C. Self-propagation of pathogenic protein aggregates in neurodegenerative diseases Nature 2013 501 45 51 10.1038/nature12481 24005412

상세보기
5. Soares J.B. Pimentel-Nunes P. Roncon-Albuquerque R. Leite-Moreira A. The role of lipopolysaccharide/toll-like receptor 4 signaling in chronic liver diseases Hepatol. Int. 2010 4 659 672 10.1007/s12072-010-9219-x 21286336

상세보기
6. Yao L. Kan E.M. Lu J. Hao A. Dheen S.T. Kaur C. Ling E.A. Toll-like receptor 4 mediates microglial activation and production of inflammatory mediators in neonatal rat brain following hypoxia: Role of TLR4 in hypoxic microglia J. Neuroinflammation 2013 10 23 10.1186/1742-2094-10-23 23388509

상세보기
7. Fiebich B.L. Batista C.R.A. Saliba S.W. Yousif N.M. de Oliveira A.C.P. Role of Microglia TLRs in Neurodegeneration Front. Cell. Neurosci. 2018 12 329 10.3389/fncel.2018.00329 30333729

상세보기
8. Choi D.Y. Lee J.W. Lin G. Lee Y.K. Lee Y.H. Choi I.S. Han S.B. Jung J.K. Kim Y.H. Kim K.H. Obovatol attenuates LPS-induced memory impairments in mice via inhibition of NF-κB signaling pathway Neurochem. Int. 2012 60 68 77 10.1016/j.neuint.2011.11.005 22107706

상세보기
9. Choi J.Y. Jang J.S. Son D.J. Im H.S. Kim J.Y. Park J.E. Choi W.R. Han S.B. Hong J.T. Antarctic Krill Oil Diet Protects against Lipopolysaccharide-Induced Oxidative Stress, Neuroinflammation and Cognitive Impairment Int. J. Mol. Sci. 2017 18 2554 10.3390/ijms18122554

상세보기
10. Oh Y.C. Jeong Y.H. Li W. Go Y. Angelicae Gigantis Radix Regulates LPS-Induced Neuroinflammation in BV2 Microglia by Inhibiting NF-κB and MAPK Activity and Inducing Nrf-2 Activity Molecules 2019 24 3755 10.3390/molecules24203755

상세보기
11. Rasooli A. Fatemi F. Hajihosseini R. Vaziri A. Akbarzadeh K. Mohammadi Malayeri M.R. Dini S. Foroutanrad M. Synergistic effects of deuterium depleted water and Mentha longifolia L. essential oils on sepsis-induced liver injuries through regulation of cyclooxygenase-2 Pharm. Biol. 2019 57 125 132 10.1080/13880209.2018.1563622 30961427

상세보기
12. Yoo S.R. Jeong S.J. Lee M.Y. Shin H.K. Seo C.S. Ha H. Single Oral Acute Toxicity of Banhasasim-Tang and Its Antiobesity Effect on Diet-Induced Obese Mice and 3T3-L1 Adipocytes Evid. Based Complement. Alternat. Med. 2018 2018 3865434 10.1155/2018/3865434 30228826

상세보기
13. Shin M.R. An H.J. Seo B.I. Roh S.S. Anti-apoptotic effect of banhasasim-tang on chronic acid reflux esophagitis World J. Gastroenterol. 2017 23 4644 4653 10.3748/wjg.v23.i25.4644 28740353

상세보기
14. Morris R. Developments of a water-maze procedure for studying spatial learning in the rat J. Neurosci. Methods 1984 11 47 60 10.1016/0165-0270(84)90007-4 6471907

상세보기
15. Liu M. Chen F. Sha L. Wang S. Tao L. Yao L. He M. Yao Z. Liu H. Zhu Z. (-)-Epigallocatechin-3-gallate ameliorates learning and memory deficits by adjusting the balance of TrkA/p75NTR signaling in APP/PS1 transgenic mice Mol. Neurobiol. 2014 49 1350 1363 10.1007/s12035-013-8608-2 24356899

상세보기
16. Chen M. Chang Y.Y. Huang S. Xiao L.H. Zhou W. Zhang L.Y. Li C. Zhou R.P. Tang J. Lin L. Aromatic-Turmerone Attenuates LPS-Induced Neuroinflammation and Consequent Memory Impairment by Targeting TLR4-Dependent Signaling Pathway Mol. Nutr. Food Res. 2018 62 2
17. Hartlage-Rubsamen M. Zeitschel U. Apelt J. Gartner U. Franke H. Stahl T. Gunther A. Schliebs R. Penkowa M. Bigl V. Astrocytic expression of the Alzheimer’s disease beta-secretase (BACE1) is stimulus-dependent Glia 2003 41 169 179 10.1002/glia.10178 12509807

상세보기
18. Jeong Y.H. Oh Y.C. Cho W.K. Yang H.J. Ma J.Y. Maydis Stigma Elicits Analgesia and Blocks Edema in Mice and Inhibits Inflammation in Macrophages Am. J. Chin. Med. 2017 45 1477 1496 10.1142/S0192415X1750080X 28950712

상세보기
19. Olajide O.A. Aderogba M.A. Okorji U.P. Fiebich B.L. Bridelia ferruginea Produces Antineuroinflammatory Activity through Inhibition of Nuclear Factor-kappa B and p38 MAPK Signalling Evid. Based Complement. Alternat. Med. 2012 2012 546873 10.1155/2012/546873 23320030

상세보기
20. Cohen P. The search for physiological substrates of MAP and SAP kinases in mammalian cells Trends Cell Biol. 1997 7 353 361 10.1016/S0962-8924(97)01105-7 17708980

상세보기
21. Tak P.P. Firestein G.S. NF-κB: A key role in inflammatory diseases J. Clin. Investig. 2001 107 7 11 10.1172/JCI11830 11134171

상세보기
22. Xuan A. Long D. Li J. Ji W. Zhang M. Hong L. Liu J. Hydrogen sulfide attenuates spatial memory impairment and hippocampal neuroinflammation in beta-amyloid rat model of Alzheimer’s disease J. Neuroinflammation 2012 9 202 10.1186/1742-2094-9-202 22898621

상세보기
23. Semmler A. Hermann S. Mormann F. Weberpals M. Paxian S.A. Okulla T. Schafers M. Kummer M.P. Klockgether T. Heneka M.T. Sepsis causes neuroinflammation and concomitant decrease of cerebral metabolism J. Neuroinflammation 2008 5 38 10.1186/1742-2094-5-38 18793399

상세보기
24. Sparkman N.L. Martin L.A. Calvert W.S. Boehm G.W. Effects of intraperitoneal lipopolysaccharide on Morris maze performance in year-old and 2-month-old female C57BL/6J mice Behav. Brain Res. 2005 159 145 151 10.1016/j.bbr.2004.10.011 15795008

상세보기
25. Eichenbaum H. A cortical-hippocampal system for declarative memory Nat. Rev. Neurosci. 2000 1 41 50 10.1038/35036213 11252767

상세보기
26. Eichenbaum H. Hippocampus: Cognitive processes and neural representations that underlie declarative memory Neuron 2004 44 109 120 10.1016/j.neuron.2004.08.028 15450164

상세보기
27. Fan L. Wang T. Chang L. Song Y. Wu Y. Ma D. Systemic inflammation induces a profound long term brain cell injury in rats Acta Neurobiol. Exp. 2014 74 298 306

상세보기
28. Grudzien A. Shaw P. Weintraub S. Bigio E. Mash D.C. Mesulam M.M. Locus coeruleus neurofibrillary degeneration in aging, mild cognitive impairment and early Alzheimer’s disease Neurobiol. Aging 2007 28 327 335 10.1016/j.neurobiolaging.2006.02.007 16574280

상세보기
29. Lee J.W. Lee Y.K. Yuk D.Y. Choi D.Y. Ban S.B. Oh K.W. Hong J.T. Neuro-inflammation induced by lipopolysaccharide causes cognitive impairment through enhancement of β-amyloid generation J. Neuroinflamm. 2008 5 37 10.1186/1742-2094-5-37

상세보기
30. Glass C.K. Saijo K. Winner B. Marchetto M.C. Gage F.H. Mechanisms underlying inflammation in neurodegeneration Cell 2010 140 918 934 10.1016/j.cell.2010.02.016 20303880

상세보기
31. Tripathi P. Tripathi P. Kashyap L. Singh V. The role of nitric oxide in inflammatory reactions FEMS Immunol. Med. Microbiol. 2007 51 443 452 10.1111/j.1574-695X.2007.00329.x 17903207

상세보기
32. Ashino T. Yamanaka R. Yamamoto M. Shimokawa H. Sekikawa K. Iwakura Y. Shioda S. Numazawa S. Yoshida T. Negative feedback regulation of lipopolysaccharide-induced inducible nitric oxide synthase gene expression by heme oxygenase-1 induction in macrophages Mol. Immunol. 2008 45 2106 2115 10.1016/j.molimm.2007.10.011 18022235

상세보기
33. Chapman N.R. Perkins N.D. Inhibition of the RelA(p65) NF-kappaB subunit by Egr-1 J. Biol. Chem. 2000 275 4719 4725 10.1074/jbc.275.7.4719 10671503

상세보기
34. Kim B.W. Koppula S. Hong S.S. Jeon S.B. Kwon J.H. Hwang B.Y. Park E.J. Choi D.K. Regulation of microglia activity by glaucocalyxin-A: Attenuation of lipopolysaccharide-stimulated neuroinflammation through NF-κB and p38 MAPK signaling pathways PLoS ONE 2013 8 e55792 10.1371/journal.pone.0055792 23393601

상세보기
35. Lattanzi S. Vernieri F. Silvestrini M. Blood pressure variability and neurocognitive functioning J. Clin. Hypertens. 2018 20 645 647 10.1111/jch.13232 29466608

상세보기
36. Tini G. Scagliola R. Monacelli F. La Malfa G. Porto I. Brunelli C. Rosa G.M. Alzheimer’s Disease and Cardiovascular Disease: A Particular Association Cardiol. Res. Pract. 2020 2020 2617970 10.1155/2020/2617970 32454996

상세보기

LOADING...

활용도 분석정보

상세보기

다운로드

내보내기

활용도 Top5 논문

해당 논문의 주제분야에서 활용도가 높은 상위 5개 콘텐츠를 보여줍니다.
더보기 버튼을 클릭하시면 더 많은 관련자료를 살펴볼 수 있습니다.

원문 보기

AccessON 원문보기

원문 URL 링크

DOI : 10.3390/nu12072019 [무료]
PubMed Central : 저널 > 논문 [무료]
Molecular Diversity Preservation International : 저널
AccessON : 저널

*원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다.

오픈액세스(OA) 유형

GOLD

오픈액세스 학술지에 출판된 논문

저작권 관리 안내

내보내기 메뉴

내보내기 구분

파일저장
인쇄
메일전송

구성항목

기본정보
상세정보

관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관

저장형식

Text(ASCII format)
Excel format
RefWorks Direct Export
RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley

메일정보

받는사람 (필수): @
보내는사람 (선택): @
제목
내용: KISTI 검색결과 이메일 서비스

안내

총 건의 자료가 검색되었습니다.

다운받으실 자료의 인덱스를 입력하세요. (1-10,000)

검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다.

데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요)

다운로드 파일은 UTF-8 형태로 저장됩니다.
파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오.

Text(ASCII format)
Excel format

표제어: PCR

동의어: Packet Collision Rate

용어 설명 출처 목록 (6)

용어 설명: PCR은 세균 특이성이 있는 primer를 이용하여 적은 수의 세균이 있을지라도 쉽게 검출할 수 있는 유용한 방법이며, 이를 이용하여 구강 내 치면세균막이나 타액에서 직접 세균을 검출할 수 있게 되었다[8].

AI-Helper ※ AI-Helper는 을 사용합니다.

AI-Helper

안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

연합인증