[논문]PyrPeg, a Blood-Brain-Barrier-Penetrating Two-Photon Imaging Probe, Selectively Detects Neuritic Plaques, Not Tau Aggregates

Choi, Ji-Woo; Ju, Yeon Ha; Choi, Yunsook; Hyeon, Seung Jae; Gadhe, Changdev G.; Park, Jong-Hyun; Kim, Mun Seok; Baek, Seungyeop; Kim, YoungSoo; Park, Ki Duk; Pae, Ae Nim; Ryu, Hoon; Lee, C. Justin; Cho, Bong Rae

doi:10.1021/acschemneuro.0c00211

[해외논문] PyrPeg, a Blood-Brain-Barrier-Penetrating Two-Photon Imaging Probe, Selectively Detects Neuritic Plaques, Not Tau Aggregates

ACS chemical neuroscience, v.11 no.12, 2020년, pp.1801 - 1810

Choi, Ji-Woo (KU-KIST Graduate School of Converging Science and Technology , Korea University , 145 Anam-ro, Seongbuk-gu , Seoul 02841 , Republic of Korea) , Ju, Yeon Ha (Center for Cognition and Sociality , Institute for Basic Science (IBS) , 55 Expo-ro, Yuseong-gu , Daejeon 34126 , Republic of Korea) , Choi, Yunsook (Center for Functional Connectomics , Korea Institute of Science and Technology (KIST) , 5 Hwarangro 14-gil, Seongbuk-gu , Seoul 02792 , Republic of Korea) , Hyeon, Seung Jae (Centers for Neuromedicine and Neuroscience , Brain Science Institute , KIST, 5 Hwarangro 14-gil, Seongbuk-gu , Seoul 02792 , Republic of Korea) , Gadhe, Changdev G. (Convergence Research Center for Diagnosis, Treatment and Care System of Dementia , KIST , 5 Hwarangro 14-gil, Seongbuk-gu , Seoul 02792 , Republic of Korea) , Park, Jong-Hyun (Convergence Research Center for Diagnosis, Treatment and Care System of De) , Kim, Mun Seok , Baek, Seungyeop , Kim, YoungSoo , Park, Ki Duk , Pae, Ae Nim , Ryu, Hoon , Lee, C. Justin , Cho, Bong Rae

Abstract ▼ AI-Helper

Amyloid-β (Aβ) tracers have made a significant contribution to the treatment of Alzheimer’s disease (AD) by allowing a definitive diagnosis in living patients. Unfortunately, they also detect tau and other protein aggregates that compromise test accuracy. In AD research, there has been a growing need for in vivo Aβ imaging by two-photon microscopy, which enables deep-brain-fluorescence imaging. There is no suitable neuritic Aβ probe for two-photon microscopy. Here we report PyrPeg, a novel two-photon fluorescent probe that can selectively target insoluble Aβ rather than tau and α-synuclein aggregates in the AD model brain and postmortem brain. When injected intravenously, PyrPeg detects the neuritic plaques in the brain and olfactory bulb of the AD model. PyrPeg may serve as a useful blood-brain-barrier-penetrating diagnostic tool for optical and functional monitoring of insoluble forms of Aβ aggregates in the living AD brain.[FIG OMISSION]

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