[논문]The novel bZIP transcription factor Fpo1 negatively regulates perithecial development by modulating carbon metabolism in the ascomycete fungus Fusarium graminearum

Shin, Jiyoung; Bui, Duc‐; Cuong; Kim, Sieun; Jung, So Yun; Nam, Hye Jin; Lim, Jae Yun; Choi, Gyung Ja; Lee, Yin‐; Won; Kim, Jung‐; Eun; Son, Hokyoung

doi:10.1111/1462-2920.14960

[해외논문] The novel bZIP transcription factor Fpo1 negatively regulates perithecial development by modulating carbon metabolism in the ascomycete fungus Fusarium graminearum

Environmental microbiology, v.22 no.7, 2020년, pp.2596 - 2612

Shin, Jiyoung (Department of Agricultural Biotechnology, Seoul National University, Seoul, 08826, Republic of Korea) , Bui, Duc‐Cuong (Department of Agricultural Biotechnology, Seoul National University, Seoul, 08826, Republic of Korea) , Kim, Sieun (Department of Agricultural Biotechnology, Seoul National University, Seoul, 08826, Republic of Korea) , Jung, So Yun (Department of Agricultural Biotechnology, Seoul National University, Seoul, 08826, Republic of Korea) , Nam, Hye Jin (Department of Agricultural Biotechnology, Seoul National University, Seoul, 08826, Republic of Korea) , Lim, Jae Yun (Department of Agricultural Biotechnology, Seoul National University, Seoul, 08826, Republic of Korea) , Choi, Gyung Ja (Therapeutic & Biotechnology Division, Center for Eco‐) , Lee, Yin‐Won (friendly New Materials, Korea Research Institute of Chemical Technology, Daejeon, 34114, Repub) , Kim, Jung‐Eun , Son, Hokyoung

Abstract ▼ AI-Helper

SummaryFungal sexual reproduction requires complex cellular differentiation processes of hyphal cells. The plant pathogenic fungus Fusarium graminearum produces fruiting bodies called perithecia via sexual reproduction, and perithecia forcibly discharge ascospores into the air for disease initiation and propagation. Lipid metabolism and accumulation are closely related to perithecium formation, yet the molecular mechanisms that regulate these processes are largely unknown. Here, we report that a novel fungal specific bZIP transcription factor, F. graminearum perithecium overproducing 1 (Fpo1), plays a role as a global transcriptional repressor during perithecium production and maturation in F. graminearum. Deletion of FPO1 resulted in reduced vegetative growth, asexual sporulation and virulence and overproduced perithecium, which reached maturity earlier, compared with the wild type. Intriguingly, the hyphae of the fpo1 mutant accumulated excess lipids during perithecium production. Using a combination of molecular biological, transcriptomic and biochemical approaches, we demonstrate that repression of FPO1 after sexual induction leads to reprogramming of carbon metabolism, particularly fatty acid production, which affects sexual reproduction of this fungus. This is the first report of a perithecium‐overproducing F. graminearum mutant, and the findings provide comprehensive insight into the role of modulation of carbon metabolism in the sexual reproduction of fungi.

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