다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기
Theranostics, v.10 no.3, 2020년, pp.1262 - 1280
Li, Senlin (Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, People's Republic of China) , Li, Huiru , Xu, Xiaoding (Department of Hepatobiliary Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, People's Republic of China.) , Saw, Phei Er (Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, People's Republic of China) , Zhang, Lei
AI-Helper
Liver is the principal detoxifying organ and metabolizes various compounds that produce free radicals (FR) constantly. To maintain the oxidative/antioxidative balance in the liver, antioxidants would scavenge FR by preventing tissue damage through FR formation, scavenging, or by enhancing their deco...
1 Halliwell B Oxygen and nitrogen are pro-carcinogens. Damage to DNA by reactive oxygen, chlorine and nitrogen species: measurement, mechanism and the effects of nutrition Mutat Res 1999 443 37 52 10415430
2 Brand MD The sites and topology of mitochondrial superoxide production Exp Gerontol 2010 45 466 72 20064600
3 Kumar S Rhim WK Lim DK Nam JM Glutathione dimerization-based plasmonic nanoswitch for biodetection of reactive oxygen and nitrogen species ACS Nano 2013 7 2221 30 23448129
4 Tabner BJ Turnbull S El-Agnaf O Allsop D Production of reactive oxygen species from aggregating proteins implicated in Alzheimer's disease, Parkinson's disease and other neurodegenerative diseases Curr Top Med Chem 2001 1 507 17 11895127
5 Bayir H Reactive oxygen species Crit Care Med 2005 33 S498 501 16340433
6 Kohen R Nyska A Oxidation of biological systems: oxidative stress phenomena, antioxidants, redox reactions, and methods for their quantification Toxicol Pathol 2002 30 620 50 12512863
7 Genestra M Oxyl radicals, redox-sensitive signalling cascades and antioxidants Cell Signal 2007 19 1807 19 17570640
8 Halliwell B Clement MV Long LH Hydrogen peroxide in the human body Febs Letters 2000 486 10 3 11108833
9 Cheeseman KH Slater TF An introduction to free radical biochemistry Br Med Bull 1993 49 481 93 8221017
10 Nordberg J Arner ES Reactive oxygen species, antioxidants, and the mammalian thioredoxin system Free Radic Biol Med 2001 31 1287 312 11728801
11 Marnett LJ Oxyradicals and DNA damage Carcinogenesis 2000 21 361 70 10688856
12 Stadtman ER Levine RL Protein oxidation Ann N Y Acad Sci 2000 899 191 208 10863540
13 Yla-Herttuala S Oxidized LDL and atherogenesis Ann N Y Acad Sci 1999 874 134 7 10415527
14 Schieber M Chandel NS ROS function in redox signaling and oxidative stress Curr Biol 2014 24 R453 62 24845678
15 Klein JA Ackerman SL Oxidative stress, cell cycle, and neurodegeneration J Clin Invest 2003 111 785 93 12639981
16 Zhang J Wang X Vikash V Ye Q Wu D Liu Y ROS and ROS-Mediated Cellular Signaling Oxid Med Cell Longev 2016 2016 4350965 26998193
17 Georgakilas AG Mosley WG Georgakila S Ziech D Panayiotidis MI Viral-induced human carcinogenesis: an oxidative stress perspective Mol Biosyst 2010 6 1162 72 20436967
18 Hagen TM Huang S Curnutte J Fowler P Martinez V Wehr CM Extensive oxidative DNA damage in hepatocytes of transgenic mice with chronic active hepatitis destined to develop hepatocellular carcinoma Proc Natl Acad Sci U S A 1994 91 12808 12 7809125
19 Murakami T Kim T Nakamura H Hepatitis, cirrhosis, and hepatoma J Magn Reson Imaging 1998 8 346 58 9562061
20 Hosel M Quasdorff M Wiegmann K Webb D Zedler U Broxtermann M Not interferon, but interleukin-6 controls early gene expression in hepatitis B virus infection Hepatology 2009 50 1773 82 19937696
21 Wang Q Zhang T Ye L Wang W Zhang X Analysis of hepatitis B virus X gene (HBx) mutants in tissues of patients suffered from hepatocellular carcinoma in China Cancer Epidemiol 2012 36 369 74 22178505
22 Ha HL Yu DY HBx-induced reactive oxygen species activates hepatocellular carcinogenesis via dysregulation of PTEN/Akt pathway World J Gastroenterol 2010 16 4932 7 20954279
23 Pandey MK Sung B Ahn KS Kunnumakkara AB Chaturvedi MM Aggarwal BB Gambogic acid, a novel ligand for transferrin receptor, potentiates TNF-induced apoptosis through modulation of the nuclear factor-kappaB signaling pathway. Blood. 2007;110(10):3517-3525 Blood 2013 121 3778
24 Boltjes A Movita D Boonstra A Woltman AM The role of Kupffer cells in hepatitis B and hepatitis C virus infections J Hepatol 2014 61 660 71 24798624
25 Arzumanyan A Reis HM Feitelson MA Pathogenic mechanisms in HBV- and HCV-associated hepatocellular carcinoma Nat Rev Cancer 2013 13 123 35 23344543
26 Nishimura M Takaki A Tamaki N Maruyama T Onishi H Kobayashi S Serum oxidative-anti-oxidative stress balance is dysregulated in patients with hepatitis C virus-related hepatocellular carcinoma Hepatol Res 2013 43 1078 92 23363268
27 Brandao DF Ramalho LN Ramalho FS Zucoloto S Martinelli Ade L Silva Ode C Liver cirrhosis and hepatic stellate cells Acta Cir Bras 2006 21 Suppl 1 54 7 17013515
28 Dixon LJ Barnes M Tang H Pritchard MT Nagy LE Kupffer cells in the liver Compr Physiol 2013 3 785 97 23720329
29 Bosch J Abraldes JG Fernandez M Garcia-Pagan JC Hepatic endothelial dysfunction and abnormal angiogenesis: new targets in the treatment of portal hypertension J Hepatol 2010 53 558 67 20561700
30 Lin W Tsai WL Shao RX Wu G Peng LF Barlow LL Hepatitis C virus regulates transforming growth factor beta1 production through the generation of reactive oxygen species in a nuclear factor kappaB-dependent manner Gastroenterology 2010 138 2509 18 20230822
31 Kolios G Valatas V Kouroumalis E Role of Kupffer cells in the pathogenesis of liver disease World J Gastroenterol 2006 12 7413 20 17167827
32 Poulsen HE Prieme H Loft S Role of oxidative DNA damage in cancer initiation and promotion Eur J Cancer Prev 1998 7 9 16 9511847
33 Hollstein M Sidransky D Vogelstein B Harris CC p53 mutations in human cancers Science 1991 253 49 53 1905840
34 Dreher D Junod AF Role of oxygen free radicals in cancer development Eur J Cancer 1996 32A 30 8 8695238
35 Valko M Izakovic M Mazur M Rhodes CJ Telser J Role of oxygen radicals in DNA damage and cancer incidence Mol Cell Biochem 2004 266 37 56 15646026
36 Acuna UM Wittwer J Ayers S Pearce CJ Oberlies NH EJ DEB Effects of (5Z)-7-oxozeaenol on the oxidative pathway of cancer cells Anticancer Res 2012 32 2665 71 22753724
37 Cairns RA Harris I McCracken S Mak TW Cancer cell metabolism Cold Spring Harb Symp Quant Biol 2011 76 299 311 22156302
38 Valko M Leibfritz D Moncol J Cronin MT Mazur M Telser J Free radicals and antioxidants in normal physiological functions and human disease Int J Biochem Cell Biol 2007 39 44 84 16978905
39 Chaiswing L Oberley TD Extracellular/microenvironmental redox state Antioxid Redox Signal 2010 13 449 65 20017602
40 Kupiec-Weglinski JW Busuttil RW Ischemia and reperfusion injury in liver transplantation Transplant Proc 2005 37 1653 6 15919422
41 Selzner N Rudiger H Graf R Clavien PA Protective strategies against ischemic injury of the liver Gastroenterology 2003 125 917 36 12949736
42 Clavien PA Harvey PR Strasberg SM Preservation and reperfusion injuries in liver allografts. An overview and synthesis of current studies Transplantation 1992 53 957 78 1585489
43 Jaeschke H Lemasters JJ Apoptosis versus oncotic necrosis in hepatic ischemia/reperfusion injury Gastroenterology 2003 125 1246 57 14517806
44 Sindram D Porte RJ Hoffman MR Bentley RC Clavien PA Platelets induce sinusoidal endothelial cell apoptosis upon reperfusion of the cold ischemic rat liver Gastroenterology 2000 118 183 91 10611167
45 Gow AJ Thom SR Ischiropoulos H Nitric oxide and peroxynitrite-mediated pulmonary cell death Am J Physiol 1998 274 L112 8 9458808
46 Caldwell-Kenkel JC Currin RT Tanaka Y Thurman RG Lemasters JJ Kupffer cell activation and endothelial cell damage after storage of rat livers: effects of reperfusion Hepatology 1991 13 83 95 1988348
47 Rudiger HA Clavien PA Tumor necrosis factor alpha, but not Fas, mediates hepatocellular apoptosis in the murine ischemic liver Gastroenterology 2002 122 202 10 11781294
48 He SQ Zhang YH Venugopal SK Dicus CW Perez RV Ramsamooj R Delivery of antioxidative enzyme genes protects against ischemia/reperfusion-induced liver injury in mice Liver Transpl 2006 12 1869 79 17133584
49 Glantzounis GK Salacinski HJ Yang W Davidson BR Seifalian AM The contemporary role of antioxidant therapy in attenuating liver ischemia-reperfusion injury: a review Liver Transpl 2005 11 1031 47 16123965
50 Teoh NC Farrell GC Hepatic ischemia reperfusion injury: pathogenic mechanisms and basis for hepatoprotection J Gastroenterol Hepatol 2003 18 891 902 12859717
51 Muller MJ Vollmar B Friedl HP Menger MD Xanthine oxidase and superoxide radicals in portal triad crossclamping-induced microvascular reperfusion injury of the liver Free Radic Biol Med 1996 21 189 97 8818634
52 Engerson TD McKelvey TG Rhyne DB Boggio EB Snyder SJ Jones HP Conversion of xanthine dehydrogenase to oxidase in ischemic rat tissues J Clin Invest 1987 79 1564 70 3294898
53 Arai M Thurman RG Lemasters JJ Contribution of adenosine A(2) receptors and cyclic adenosine monophosphate to protective ischemic preconditioning of sinusoidal endothelial cells against Storage/Reperfusion injury in rat livers Hepatology 2000 32 297 302 10915736
54 Yin DP Sankary HN Chong AS Ma LL Shen J Foster P Protective effect of ischemic preconditioning on liver preservation-reperfusion injury in rats Transplantation 1998 66 152 7 9701256
55 Gustot T Durand F Lebrec D Vincent JL Moreau R Severe sepsis in cirrhosis Hepatology 2009 50 2022 33 19885876
56 Abraham E Singer M Mechanisms of sepsis-induced organ dysfunction Crit Care Med 2007 35 2408 16 17948334
57 Gorrini C Harris IS Mak TW Modulation of oxidative stress as an anticancer strategy Nat Rev Drug Discov 2013 12 931 47 24287781
58 Cabello CM Bair WB 3rd Wondrak GT Experimental therapeutics: targeting the redox Achilles heel of cancer Curr Opin Investig Drugs 2007 8 1022 37
59 Lambeth JD Kawahara T Diebold B Regulation of Nox and Duox enzymatic activity and expression Free Radic Biol Med 2007 43 319 31 17602947
60 Reinehr R Becker S Keitel V Eberle A Grether-Beck S Haussinger D Bile salt-induced apoptosis involves NADPH oxidase isoform activation Gastroenterology 2005 129 2009 31 16344068
61 de Mochel NS Seronello S Wang SH Ito C Zheng JX Liang TJ Hepatocyte NAD(P)H oxidases as an endogenous source of reactive oxygen species during hepatitis C virus infection Hepatology 2010 52 47 59 20578128
62 Okuda M Li K Beard MR Showalter LA Scholle F Lemon SM Mitochondrial injury, oxidative stress, and antioxidant gene expression are induced by hepatitis C virus core protein Gastroenterology 2002 122 366 75 11832451
63 Jia D Duan F Peng P Sun L Ruan Y Gu J Pyrroloquinoline-quinone suppresses liver fibrogenesis in mice PLoS One 2015 10 e0121939 25822822
64 Serviddio G Bellanti F Stanca E Lunetti P Blonda M Tamborra R Silybin exerts antioxidant effects and induces mitochondrial biogenesis in liver of rat with secondary biliary cirrhosis Free Radic Biol Med 2014 73 117 26 24819445
65 von Montfort C Matias N Fernandez A Fucho R Conde de la Rosa L Martinez-Chantar ML Mitochondrial GSH determines the toxic or therapeutic potential of superoxide scavenging in steatohepatitis J Hepatol 2012 57 852 9 22687340
66 Ak T Gulcin I Antioxidant and radical scavenging properties of curcumin Chem Biol Interact 2008 174 27 37 18547552
67 Sharma RA Gescher AJ Steward WP Curcumin: the story so far Eur J Cancer 2005 41 1955 68 16081279
68 Reyes-Gordillo K Segovia J Shibayama M Tsutsumi V Vergara P Moreno MG Curcumin prevents and reverses cirrhosis induced by bile duct obstruction or CCl4 in rats: role of TGF-beta modulation and oxidative stress Fundam Clin Pharmacol 2008 22 417 27 18705752
69 Celik I Temur A Isik I Hepatoprotective role and antioxidant capacity of pomegranate (Punica granatum) flowers infusion against trichloroacetic acid-exposed in rats Food Chem Toxicol 2009 47 145 9 19022327
70 Bishayee A Bhatia D Thoppil RJ Darvesh AS Nevo E Lansky EP Pomegranate-mediated chemoprevention of experimental hepatocarcinogenesis involves Nrf2-regulated antioxidant mechanisms Carcinogenesis 2011 32 888 96 21389260
71 Sersen F Vencel T Annus J Silymarin and its components scavenge phenylglyoxylic ketyl radicals Fitoterapia 2006 77 525 9 16956731
72 Saller R Meier R Brignoli R The use of silymarin in the treatment of liver diseases Drugs 2001 61 2035 63 11735632
73 Gazak R Walterova D Kren V Silybin and silymarin-new and emerging applications in medicine Curr Med Chem 2007 14 315 38 17305535
74 Bhatia N Zhao J Wolf DM Agarwal R Inhibition of human carcinoma cell growth and DNA synthesis by silibinin, an active constituent of milk thistle: comparison with silymarin Cancer Lett 1999 147 77 84 10660092
75 Fernandez L Heredia N Grande L Gomez G Rimola A Marco A Preconditioning protects liver and lung damage in rat liver transplantation: role of xanthine/xanthine oxidase Hepatology 2002 36 562 72 12198648
76 Green CJ Healing G Simpkin S Gower J Fuller BJ Allopurinol inhibits lipid peroxidation in warm ischaemic and reperfused rabbit kidneys Free Radic Res Commun 1989 6 329 37 2792846
77 Wheeler MD Katuna M Smutney OM Froh M Dikalova A Mason RP Comparison of the effect of adenoviral delivery of three superoxide dismutase genes against hepatic ischemia-reperfusion injury Hum Gene Ther 2001 12 2167 77 11779401
78 Yan M Xu W Lu L Sun L Liu X Zheng Z Induction of ref-1 ensures AP-1 activation in intracellular oxidative environment of IL-2-stimulated BA/F3beta cells Biochem Biophys Res Commun 2000 278 462 9 11097859
79 Ozaki M Suzuki S Irani K Redox factor-1/APE suppresses oxidative stress by inhibiting the rac1 GTPase FASEB J 2002 16 889 90 12039869
80 Burr M Appleby P Key T Thorogood M Plasma ascorbic acid and risk of heart disease and cancer Lancet 2001 357 2135 6
81 Poljsak B Milisav I The Role of Antioxidants in Cancer, Friends or Foes? Curr Pharm Des 2018 24 5234 44 30674247
82 Cialdella-Kam L Nieman DC Sha W Meaney MP Knab AM Shanely RA Dose-response to 3 months of quercetin-containing supplements on metabolite and quercetin conjugate profile in adults Br J Nutr 2013 109 1923 33 23151341
83 Szende B Tyihak E Kiraly-Veghely Z Dose-dependent effect of resveratrol on proliferation and apoptosis in endothelial and tumor cell cultures Exp Mol Med 2000 32 88 92 10926121
84 Gogvadze V Orrenius S Zhivotovsky B Mitochondria in cancer cells: what is so special about them? Trends Cell Biol 2008 18 165 73 18296052
85 Fulda S Galluzzi L Kroemer G Targeting mitochondria for cancer therapy Nat Rev Drug Discov 2010 9 447 64 20467424
86 Block KI Antioxidants and cancer therapy: furthering the debate Integr Cancer Ther 2004 3 342 8 15523105
87 Zhang Q Zhang F Li S Liu R Jin T Dou Y A Multifunctional Nanotherapy for Targeted Treatment of Colon Cancer by Simultaneously Regulating Tumor Microenvironment Theranostics 2019 9 3732 53 31281510
88 Galati G Lin A Sultan AM O'Brien PJ Cellular and in vivo hepatotoxicity caused by green tea phenolic acids and catechins Free Radic Biol Med 2006 40 570 80 16458187
89 Lipinski B Rationale for the treatment of cancer with sodium selenite Med Hypotheses 2005 64 806 10 15694701
90 Trachootham D Zhou Y Zhang H Demizu Y Chen Z Pelicano H Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate Cancer Cell 2006 10 241 52 16959615
91 Raj L Ide T Gurkar AU Foley M Schenone M Li X Selective killing of cancer cells by a small molecule targeting the stress response to ROS Nature 2011 475 231 4 21753854
92 Ishikawa T Abe S Watanabe T Nozawa Y Sano T Iwanaga A Improved survival with double platinum therapy transcatheter arterial infusion using cisplatin and transcatheter arterial chemoembolization using miriplatin for BCLC-B hepatocellular carcinoma Mol Clin Oncol 2016 5 511 6 27882236
93 Amisaki M Honjo S Morimoto M Hanaki T Arai Y Tokuyasu N The Negative Effect of Preoperative Transcatheter Arterial Chemoembolization on Long-Term Outcomes for Resectable Hepatocellular Carcinoma: A Propensity Score Matching Analysis Yonago Acta Med 2016 59 270 8 28070164
94 Cabrera R Nelson DR Review article: the management of hepatocellular carcinoma Aliment Pharmacol Ther 2010 31 461 76 19925500
95 Ortega Lopez N PET/Computed Tomography in Evaluation of Transarterial Chemoembolization PET Clin 2015 10 507 17 26384597
96 Albert M Kiefer MV Sun W Haller D Fraker DL Tuite CM Chemoembolization of colorectal liver metastases with cisplatin, doxorubicin, mitomycin C, ethiodol, and polyvinyl alcohol Cancer 2011 117 343 52 20830766
97 Zhou Z Song J Tian R Yang Z Yu G Lin L Activatable Singlet Oxygen Generation from Lipid Hydroperoxide Nanoparticles for Cancer Therapy Angew Chem Int Ed Engl 2017 56 6492 6 28470979
98 Lawenda BD Kelly KM Ladas EJ Sagar SM Vickers A Blumberg JB Should supplemental antioxidant administration be avoided during chemotherapy and radiation therapy? J Natl Cancer Inst 2008 100 773 83 18505970
99 Cheng T Liu J Ren J Huang F Ou H Ding Y Green Tea Catechin-Based Complex Micelles Combined with Doxorubicin to Overcome Cardiotoxicity and Multidrug Resistance Theranostics 2016 6 1277 92 27375779
100 Taper HS Jamison JM Gilloteaux J Summers JL Calderon PB Inhibition of the development of metastases by dietary vitamin C:K3 combination Life Sci 2004 75 955 67 15193956
101 Habu D Shiomi S Tamori A Takeda T Tanaka T Kubo S Role of vitamin K2 in the development of hepatocellular carcinoma in women with viral cirrhosis of the liver JAMA 2004 292 358 61 15265851
102 Klement RJ Abbasi-Senger N Adebahr S Alheid H Allgaeuer M Becker G The impact of local control on overall survival after stereotactic body radiotherapy for liver and lung metastases from colorectal cancer: a combined analysis of 388 patients with 500 metastases BMC Cancer 2019 19 173 30808323
103 Carrier F Liao Y Mendenhall N Guerrieri P Todor D Ahmad A Three Discipline Collaborative Radiation Therapy (3DCRT) Special Debate: I would treat prostate cancer with proton therapy J Appl Clin Med Phys 2019 20 7 14
104 Hilgard P Muller S Hamami M Sauerwein WS Haberkorn U Gerken G [Selective internal radiotherapy (radioembolization) and radiation therapy for HCC-current status and perspectives] Z Gastroenterol 2009 47 37 54 19156591
105 Tsai CL Hsu FM Cheng JC How to Improve Therapeutic Ratio in Radiotherapy of HCC Liver Cancer 2016 5 210 20 27493896
106 Wang H Jiang H Van De Gucht M De Ridder M Hypoxic Radioresistance: Can ROS Be the Key to Overcome It? Cancers (Basel) 2019 11
107 Jayakumar S Kunwar A Sandur SK Pandey BN Chaubey RC Differential response of DU145 and PC3 prostate cancer cells to ionizing radiation: role of reactive oxygen species, GSH and Nrf2 in radiosensitivity Biochim Biophys Acta 2014 1840 485 94 24121106
108 Borek C Antioxidants and radiation therapy J Nutr 2004 134 3207S 9S 15514309
109 Pathak AK Bhutani M Guleria R Bal S Mohan A Mohanti BK Chemotherapy alone vs. chemotherapy plus high dose multiple antioxidants in patients with advanced non small cell lung cancer J Am Coll Nutr 2005 24 16 21 15670980
110 Biesalski HK Frank J Antioxidants in cancer therapy: is there a rationale to recommend antioxidants during cancer therapy? Biofactors 2003 17 229 40 12897444
111 Ren KW Li YH Wu G Ren JZ Lu HB Li ZM Quercetin nanoparticles display antitumor activity via proliferation inhibition and apoptosis induction in liver cancer cells Int J Oncol 2017 50 1299 311 28259895
112 Tang B Tang F Wang Z Qi G Liang X Li B Upregulation of Akt/NF-kappaB-regulated inflammation and Akt/Bad-related apoptosis signaling pathway involved in hepatic carcinoma process: suppression by carnosic acid nanoparticle Int J Nanomedicine 2016 11 6401 20 27942213
113 Paulo CS Pires das Neves R Ferreira LS Nanoparticles for intracellular-targeted drug delivery Nanotechnology 2011 22 494002 22101232
114 Lamprecht A Benoit JP Etoposide nanocarriers suppress glioma cell growth by intracellular drug delivery and simultaneous P-glycoprotein inhibition J Control Release 2006 112 208 13 16574265
115 Zhang C Ling CL Pang L Wang Q Liu JX Wang BS Direct Macromolecular Drug Delivery to Cerebral Ischemia Area using Neutrophil-Mediated Nanoparticles Theranostics 2017 7 3260 75 28900508
116 Sharma A Liaw K Sharma R Zhang Z Kannan S Kannan RM Targeting Mitochondrial Dysfunction and Oxidative Stress in Activated Microglia using Dendrimer-Based Therapeutics Theranostics 2018 8 5529 47 30555562
117 Kim GW Kang C Oh YB Ko MH Seo JH Lee D Ultrasonographic Imaging and Anti-inflammatory Therapy of Muscle and Tendon Injuries Using Polymer Nanoparticles Theranostics 2017 7 2463 76 28744328
118 Chrastina A Massey KA Schnitzer JE Overcoming in vivo barriers to targeted nanodelivery Wiley Interdiscip Rev Nanomed Nanobiotechnol 2011 3 421 37 21538941
119 Davis ME Chen ZG Shin DM Nanoparticle therapeutics: an emerging treatment modality for cancer Nat Rev Drug Discov 2008 7 771 82 18758474
120 Chang HI Yeh MK Clinical development of liposome-based drugs: formulation, characterization, and therapeutic efficacy Int J Nanomedicine 2012 7 49 60 22275822
121 Barenholz Y Doxil(R)-the first FDA-approved nano-drug: lessons learned J Control Release 2012 160 117 34 22484195
122 Baig B Halim SA Farrukh A Greish Y Amin A Current status of nanomaterial-based treatment for hepatocellular carcinoma Biomed Pharmacother 2019 116 108852 30999152
123 Dai Y Yang Z Cheng S Wang Z Zhang R Zhu G Toxic Reactive Oxygen Species Enhanced Synergistic Combination Therapy by Self-Assembled Metal-Phenolic Network Nanoparticles Adv Mater 2018 30
124 Varshosaz J Farzan M Nanoparticles for targeted delivery of therapeutics and small interfering RNAs in hepatocellular carcinoma World J Gastroenterol 2015 21 12022 41 26576089
125 Chen F Zhang J Wang L Wang Y Chen M Tumor pH(e)-triggered charge-reversal and redox-responsive nanoparticles for docetaxel delivery in hepatocellular carcinoma treatment Nanoscale 2015 7 15763 79 26355843
126 Chen Y Liu X Yuan H Yang Z von Roemeling CA Qie Y Therapeutic Remodeling of the Tumor Microenvironment Enhances Nanoparticle Delivery Adv Sci (Weinh) 2019 6 1802070 30886813
127 Huang WC Chen SH Chiang WH Huang CW Lo CL Chern CS Tumor Microenvironment-Responsive Nanoparticle Delivery of Chemotherapy for Enhanced Selective Cellular Uptake and Transportation within Tumor Biomacromolecules 2016 17 3883 92 27936723
128 Hu J Liu J Yang D Lu M Yin J Physiological roles of asialoglycoprotein receptors (ASGPRs) variants and recent advances in hepatic-targeted delivery of therapeutic molecules via ASGPRs Protein Pept Lett 2014 21 1025 30 24975671
129 Chen L Liu Y Wang W Liu K Effect of integrin receptor-targeted liposomal paclitaxel for hepatocellular carcinoma targeting and therapy Oncol Lett 2015 10 77 84 26170980
130 Martin DN Uprichard SL Identification of transferrin receptor 1 as a hepatitis C virus entry factor Proc Natl Acad Sci U S A 2013 110 10777 82 23754414
131 Liu Y Wu X Gao Y Zhang J Zhang D Gu S Aptamer-functionalized peptide H3CR5C as a novel nanovehicle for codelivery of fasudil and miRNA-195 targeting hepatocellular carcinoma Int J Nanomedicine 2016 11 3891 905 27574422
132 Liu MC Liu L Wang XR Shuai WP Hu Y Han M Folate receptor-targeted liposomes loaded with a diacid metabolite of norcantharidin enhance antitumor potency for H22 hepatocellular carcinoma both in vitro and in vivo Int J Nanomedicine 2016 11 1395 412 27110110
133 Cai Y Xu Y Chan HF Fang X He C Chen M Glycyrrhetinic Acid Mediated Drug Delivery Carriers for Hepatocellular Carcinoma Therapy Mol Pharm 2016 13 699 709 26808002
134 Wen X Reynolds L Mulik RS Kim SY Van Treuren T Nguyen LH Hepatic Arterial Infusion of Low-Density Lipoprotein Docosahexaenoic Acid Nanoparticles Selectively Disrupts Redox Balance in Hepatoma Cells and Reduces Growth of Orthotopic Liver Tumors in Rats Gastroenterology 2016 150 488 98 26484708
135 Zhao C Cao W Zheng H Xiao Z Hu J Yang L Acid-responsive nanoparticles as a novel oxidative stress-inducing anticancer therapeutic agent for colon cancer Int J Nanomedicine 2019 14 1597 618 30880968
136 de Carvalho TG Garcia VB de Araujo AA da Silva Gasparotto LH Silva H Guerra GCB Spherical neutral gold nanoparticles improve anti-inflammatory response, oxidative stress and fibrosis in alcohol-methamphetamine-induced liver injury in rats Int J Pharm 2018 548 1 14 29886101
137 Chen G Deng H Song X Lu M Zhao L Xia S Reactive oxygen species-responsive polymeric nanoparticles for alleviating sepsis-induced acute liver injury in mice Biomaterials 2017 144 30 41 28820966
138 Bertrand N Wu J Xu X Kamaly N Farokhzad OC Cancer nanotechnology: the impact of passive and active targeting in the era of modern cancer biology Adv Drug Deliv Rev 2014 66 2 25 24270007
139 Maeda H Nakamura H Fang J The EPR effect for macromolecular drug delivery to solid tumors: Improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivo Adv Drug Deliv Rev 2013 65 71 9 23088862
140 Kamaly N Xiao Z Valencia PM Radovic-Moreno AF Farokhzad OC Targeted polymeric therapeutic nanoparticles: design, development and clinical translation Chem Soc Rev 2012 41 2971 3010 22388185
141 Liu D Bimbo LM Makila E Villanova F Kaasalainen M Herranz-Blanco B Co-delivery of a hydrophobic small molecule and a hydrophilic peptide by porous silicon nanoparticles J Control Release 2013 170 268 78 23756152
142 Moghimi SM Hunter AC Capture of stealth nanoparticles by the body's defences Crit Rev Ther Drug Carrier Syst 2001 18 527 50 11789674
143 Chen ZG Small-molecule delivery by nanoparticles for anticancer therapy Trends Mol Med 2010 16 594 602 20846905
144 Harris JM Chess RB Effect of pegylation on pharmaceuticals Nat Rev Drug Discov 2003 2 214 21 12612647
145 Gabizon A Martin F Polyethylene glycol-coated (pegylated) liposomal doxorubicin. Rationale for use in solid tumours Drugs 1997 54 Suppl 4 15 21
146 Perry JL Reuter KG Kai MP Herlihy KP Jones SW Luft JC PEGylated PRINT nanoparticles: the impact of PEG density on protein binding, macrophage association, biodistribution, and pharmacokinetics Nano Lett 2012 12 5304 10 22920324
147 Seymour LW Ferry DR Anderson D Hesslewood S Julyan PJ Poyner R Hepatic drug targeting: phase I evaluation of polymer-bound doxorubicin J Clin Oncol 2002 20 1668 76 11896118
148 Bartlett DW Su H Hildebrandt IJ Weber WA Davis ME Impact of tumor-specific targeting on the biodistribution and efficacy of siRNA nanoparticles measured by multimodality in vivo imaging Proc Natl Acad Sci U S A 2007 104 15549 54 17875985
149 Totsuka M Watanabe Y Asai C Takahashi S Ishikawa H Takamura N Case of severe bullous erythema including intertrigo-like eruptions with angioedema induced by pegylated liposomal doxorubicin J Dermatol 2019 46 535 9 31021010
150 Ashfaq UA Riaz M Yasmeen E Yousaf MZ Recent Advances in Nanoparticle-Based Targeted Drug-Delivery Systems Against Cancer and Role of Tumor Microenvironment Crit Rev Ther Drug Carrier Syst 2017 34 317 53 29199588
151 Lim WT Tan EH Toh CK Hee SW Leong SS Ang PC Phase I pharmacokinetic study of a weekly liposomal paclitaxel formulation (Genexol-PM) in patients with solid tumors Ann Oncol 2010 21 382 8 19633055
152 Chen B Dai W He B Zhang H Wang X Wang Y Current Multistage Drug Delivery Systems Based on the Tumor Microenvironment Theranostics 2017 7 538 58 28255348
153 Xu X Wu J Liu Y Saw PE Tao W Yu M Multifunctional Envelope-Type siRNA Delivery Nanoparticle Platform for Prostate Cancer Therapy ACS Nano 2017 11 2618 27 28240870
154 Kim JY Lee DY Kang S Miao W Kim H Lee Y Bilirubin nanoparticle preconditioning protects against hepatic ischemia-reperfusion injury Biomaterials 2017 133 1 10 28414974
155 Fukumura D Jain RK Tumor microvasculature and microenvironment: targets for anti-angiogenesis and normalization Microvasc Res 2007 74 72 84 17560615
156 Wang S Yu G Wang Z Jacobson O Lin LS Yang W Enhanced Antitumor Efficacy by a Cascade of Reactive Oxygen Species Generation and Drug Release Angew Chem Int Ed Engl 2019 58 14758 63 31429173
157 Stylianopoulos T Poh MZ Insin N Bawendi MG Fukumura D Munn LL Diffusion of particles in the extracellular matrix: the effect of repulsive electrostatic interactions Biophys J 2010 99 1342 9 20816045
158 Uthaman S Huh KM Park IK Tumor microenvironment-responsive nanoparticles for cancer theragnostic applications Biomater Res 2018 22 22 30155269
159 Yang Z Dai Y Yin C Fan Q Zhang W Song J Activatable Semiconducting Theranostics: Simultaneous Generation and Ratiometric Photoacoustic Imaging of Reactive Oxygen Species In vivo Adv Mater 2018 30 e1707509 29707841
160 Johnson RP Uthaman S John JV Lee HR Lee SJ Park H Poly(PEGA)-b-poly(L-lysine)-b-poly(L-histidine) Hybrid Vesicles for Tumoral pH-Triggered Intracellular Delivery of Doxorubicin Hydrochloride ACS Appl Mater Interfaces 2015 7 21770 9 26375278
161 Zheng D Li B Xu L Zhang QL Fan JX Li CX Normalizing Tumor Microenvironment Based on Photosynthetic Abiotic/Biotic Nanoparticles ACS Nano 2018 12 6218 27 29791792
162 Wang S Wang Z Yu G Zhou Z Jacobson O Liu Y Tumor-Specific Drug Release and Reactive Oxygen Species Generation for Cancer Chemo/Chemodynamic Combination Therapy Adv Sci (Weinh) 2019 6 1801986 30886808
163 Liang H Zhou Z Luo R Sang M Liu B Sun M Tumor-specific activated photodynamic therapy with an oxidation-regulated strategy for enhancing anti-tumor efficacy Theranostics 2018 8 5059 71 30429886
164 Watal G Watal A Rai PK Rai DK Sharma G Sharma B Biomedical applications of nano-antioxidant Methods Mol Biol 2013 1028 147 51 23740118
165 Sharma A Madhunapantula SV Robertson GP Toxicological considerations when creating nanoparticle-based drugs and drug delivery systems Expert Opin Drug Metab Toxicol 2012 8 47 69 22097965
166 Saab AM Tundis R Loizzo MR Lampronti I Borgatti M Gambari R Antioxidant and antiproliferative activity of Laurus nobilis L. (Lauraceae) leaves and seeds essential oils against K562 human chronic myelogenous leukaemia cells Nat Prod Res 2012 26 1741 5 22017546
167 Aggarwal BB Bhardwaj A Aggarwal RS Seeram NP Shishodia S Takada Y Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies Anticancer Res 2004 24 2783 840 15517885
168 Lacatusu I Badea N Badea G Oprea O Mihaila MA Kaya DA Lipid nanocarriers based on natural oils with high activity against oxygen free radicals and tumor cell proliferation Materials Science and Engineering: C 2015 56 88 94 26249569
169 Mata R Nakkala JR Sadras SR Biogenic silver nanoparticles from Abutilon indicum: their antioxidant, antibacterial and cytotoxic effects in vitro Colloids Surf B Biointerfaces 2015 128 276 86 25701118
170 Shahriary M Veisi H Hekmati M Hemmati S In situ green synthesis of Ag nanoparticles on herbal tea extract (Stachys lavandulifolia)-modified magnetic iron oxide nanoparticles as antibacterial agent and their 4-nitrophenol catalytic reduction activity Mater Sci Eng C Mater Biol Appl 2018 90 57 66 29853127
171 Shi T Sun X He Q Cytotoxicity of Silver Nanoparticles Against Bacteria and Tumor Cells Current protein & peptide science 2018 19 525 36 27829349
172 Ovais M Khalil AT Raza A Khan MA Ahmad I Islam NU Green synthesis of silver nanoparticles via plant extracts: beginning a new era in cancer theranostics Nanomedicine (Lond) 2016 11 3157 77 27809668
173 Onitsuka S Hamada T Okamura H Preparation of antimicrobial gold and silver nanoparticles from tea leaf extracts Colloids Surf B Biointerfaces 2019 173 242 8 30300830
174 Boomi P Ganesan RM Poorani G Gurumallesh Prabu H Ravikumar S Jeyakanthan J Biological synergy of greener gold nanoparticles by using Coleus aromaticus leaf extract Mater Sci Eng C Mater Biol Appl 2019 99 202 10 30889692
175 Bayda S Hadla M Palazzolo S Riello P Corona G Toffoli G Inorganic Nanoparticles for Cancer Therapy: A Transition from Lab to Clinic Curr Med Chem 2018 25 4269 303 29284391
176 Ajiboye TO Komolafe YO Bukoye Oloyede HO Yakubu MT Adeoye MD Abdulsalami IO Diethylnitrosamine-induced redox imbalance in rat microsomes: protective role of polyphenolic-rich extract from Sorghum bicolor grains J Basic Clin Physiol Pharmacol 2013 24 41 9 23183745
177 Noeman SA Hamooda HE Baalash AA Biochemical study of oxidative stress markers in the liver, kidney and heart of high fat diet induced obesity in rats Diabetol Metab Syndr 2011 3 17 21812977
178 Mohammed M Abdel-Gawad E Awwad S Kandil E El-Agamy B Therapeutic role of a synthesized calcium phosphate nanocomposite material on hepatocarcinogenesis in rats Biochem Cell Biol 2016 94 279 88 27276232
179 Liu Y Li P Lu J Xiong W Oger J Tetzlaff W Bilirubin possesses powerful immunomodulatory activity and suppresses experimental autoimmune encephalomyelitis J Immunol 2008 181 1887 97 18641326
180 Lee Y Kim H Kang S Lee J Park J Jon S Bilirubin Nanoparticles as a Nanomedicine for Anti-inflammation Therapy Angew Chem Int Ed Engl 2016 55 7460 3 27144463
181 Peralta C Jimenez-Castro MB Gracia-Sancho J Hepatic ischemia and reperfusion injury: effects on the liver sinusoidal milieu J Hepatol 2013 59 1094 106 23811302
182 Zhai Y Petrowsky H Hong JC Busuttil RW Kupiec-Weglinski JW Ischaemia-reperfusion injury in liver transplantation-from bench to bedside Nat Rev Gastroenterol Hepatol 2013 10 79 89 23229329
183 Li S Tan HY Wang N Zhang ZJ Lao L Wong CW The Role of Oxidative Stress and Antioxidants in Liver Diseases Int J Mol Sci 2015 16 26087 124 26540040
184 Matough FA Budin SB Hamid ZA Alwahaibi N Mohamed J The role of oxidative stress and antioxidants in diabetic complications Sultan Qaboos Univ Med J 2012 12 5 18 22375253
185 Zhu X Lei X Wang J Dong W Protective effects of resveratrol on hyperoxia-induced lung injury in neonatal rats by alleviating apoptosis and ROS production J Matern Fetal Neonatal Med 2019 1 9
186 Yan B Cheng L Jiang Z Chen K Zhou C Sun L Resveratrol Inhibits ROS-Promoted Activation and Glycolysis of Pancreatic Stellate Cells via Suppression of miR-21 Oxid Med Cell Longev 2018 2018 1346958 29854071
187 Subedi L Lee TH Wahedi HM Baek SH Kim SY Resveratrol-Enriched Rice Attenuates UVB-ROS-Induced Skin Aging via Downregulation of Inflammatory Cascades Oxid Med Cell Longev 2017 2017 8379539 28900534
188 Yuan Y Xue X Guo RB Sun XL Hu G Resveratrol enhances the antitumor effects of temozolomide in glioblastoma via ROS-dependent AMPK-TSC-mTOR signaling pathway CNS Neurosci Ther 2012 18 536 46 22530672
189 Mahgoub E Kumaraswamy SM Kader KH Venkataraman B Ojha S Adeghate E Genipin attenuates cisplatin-induced nephrotoxicity by counteracting oxidative stress, inflammation, and apoptosis Biomed Pharmacother 2017 93 1083 97 28738532
190 Yao ML Gu J Zhang YC Wang N Zhu ZH Yang QT [Inhibitory effect of Genipin on uncoupling protein-2 and energy metabolism of androgen-independent prostate cancer cells] Zhonghua Nan Ke Xue 2015 21 973 6 26738321
191 Liu YG Dai QL Wang SB Deng QJ Wu WG Chen AZ Preparation and in vitro antitumor effects of cytosine arabinoside-loaded genipin-poly-l-glutamic acid-modified bacterial magnetosomes Int J Nanomedicine 2015 10 1387 97 25733831
192 Deep G Singh RP Agarwal C Kroll DJ Agarwal R Silymarin and silibinin cause G1 and G2-M cell cycle arrest via distinct circuitries in human prostate cancer PC3 cells: a comparison of flavanone silibinin with flavanolignan mixture silymarin Oncogene 2006 25 1053 69 16205633
193 Wang Y Zhang L Wang Q Zhang D Recent advances in the nanotechnology-based drug delivery of Silybin J Biomed Nanotechnol 2014 10 543 58 24734507
194 Chidambara Murthy KN Jayaprakasha GK Singh RP Studies on antioxidant activity of pomegranate (Punica granatum) peel extract using in vivo models J Agric Food Chem 2002 50 4791 5 12166961
195 Kaur G Jabbar Z Athar M Alam MS Punica granatum (pomegranate) flower extract possesses potent antioxidant activity and abrogates Fe-NTA induced hepatotoxicity in mice Food Chem Toxicol 2006 44 984 93 16426722
*원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다.
오픈액세스 학술지에 출판된 논문
Copyright KISTI. All Rights Reserved.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.