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Population Admixture: Detection by Hardy-Weinberg Test and Its Quantitative Effects on Linkage-Disequilibrium Methods for Localizing Genes Underlying Complex Traits 원문보기

Genetics, v.157 no.2, 2001년, pp.885 - 897  

Deng, Hong-Wen (Osteoporosis Research Center, Creighton University, Omaha, Nebraska 68131) ,  Chen, Wei-Min (Osteoporosis Research Center, Creighton University, Omaha, Nebraska 68131) ,  Recker, Robert R (Osteoporosis Research Center, Creighton University, Omaha, Nebraska 68131)

Abstract AI-Helper 아이콘AI-Helper

AbstractIn association studies searching for genes underlying complex traits, the results are often inconsistent, and population admixture has been recognized qualitatively as one major potential cause. Hardy-Weinberg equilibrium (HWE) is often employed to test for population admixture; however, its...

참고문헌 (51)

  1. Am. J. Hum. Genet. Allison 60 676 1997 Transmission-disequilibrium tests for quantitative traits 

  2. J. Am. Med. Assoc. Blum 263 2055 1990 10.1001/jama.1990.03440150063027 Allelic association of human dopamine D2 receptor gene in alcoholism 

  3. Alcohol Blum 8 409 1991 10.1016/0741-8329(91)90693-Q Association of the A1 allele of the D2 Dopamine receptor gene with severe alcoholism 

  4. Ann. Hum. Genet. Boerwinkle 50 181 1986 10.1111/j.1469-1809.1986.tb01037.x The use of measured genotype information in the analysis of quantitative phenotypes in man 

  5. Am. J. Med. Genet. Boerwinkle 27 567 1987 10.1002/ajmg.1320270310 The use of measured genotype information in the analysis of quantitative phenotypes in man. II. The role of the apolipoprotein E polymorphisms in determining levels, variability, and covariability of cholesterol, betalipoprotein, and triglycerides in a sample of unrelated individuals 

  6. J. Hered. Briscoe 85 59 1994 Linkage disequilibrium in admixed populations: applications in gene mapping 

  7. Obes. Res. Chagnon 5 76 1998 10.1002/j.1550-8528.1998.tb00318.x The human obesity gene map: the 1997 update 

  8. Proc. Natl. Acad. Sci. USA Chakraborty 85 3071 1988 10.1073/pnas.85.9.3071 Recombination in haplotypes leads to biased estimates of admixture proportions in human populations 

  9. Basic Concepts in Population, Quantitative, and Evolutionary Genetics Crow 1983 

  10. An Introduction to Population Genetics Theory Crow 1970 

  11. Am. J. Epidemiol. Deng 151 335 2000 10.1093/oxfordjournals.aje.a010210 Re: “biased tests of association: comparison of allele frequencies when departing from Hardy-Weinberg proportions.” 

  12. Genetics Deng 143 203 1996 10.1093/genetics/143.1.203 Change of genetic architecture in response to sex 

  13. Osteoporos. Int. Deng 9 499 1999 10.1007/s001980050177 Association of VDR and estrogen receptor genotypes with bone mass in postmenopausal caucasian women: different conclusions with different analyses and the implications 

  14. Am. J. Hum. Genet. Deng 66 1027 2000 10.1086/302804 QTL fine mapping in extreme samples from populations 

  15. Biometrics Devlin 55 997 1999 10.1111/j.0006-341X.1999.00997.x Genomic control for association studies 

  16. Biometrics Eguchi 46 415 1990 10.2307/2531446 Testing the Hardy-Weinberg equilibrium in the HLA system 

  17. J. Bone Miner. Res. Eisman 10 1289 1995 10.1002/jbmr.5650100903 Vitamin D receptor gene alleles and osteoporosis: an affirmative view 

  18. Nat. Genet. Feder 13 399 1996 10.1038/ng0896-399 A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis 

  19. J. Am. Med. Assoc. Gelernter 269 1673 1993 10.1001/jama.1993.03500130087038 The A1 allele at the D2 dopamine receptor gene and alcoholism 

  20. Osteoporos. Int. Gong 9 55 1999 10.1007/s001980050116 On the association of bone mass density and Vitamin-D genotype polymorphisms 

  21. Biometrics Guo 48 361 1992 10.2307/2532296 Performing the exact test of Hardy-Weinberg proportion for multiple alleles 

  22. Principles of Population Genetics. Hartl 1989 

  23. Mem. Ist. Ital. Idrobiol. Hebert 45 439 1987 Genetics of Daphnia 

  24. Biometrics Hernandez 45 53 1989 10.2307/2532034 A disequilibrium coefficient approach to Hardy-Weinberg testing 

  25. Science Holden 264 1696 1994 10.1126/science.8209249 A cautionary genetic tale: the sobering story of D2 

  26. Continuous Univariate Distributions I. Johnson 1994 

  27. Continuous Univariate Distributions II Johnson 1995 

  28. Science Lander 265 2037 1994 10.1126/science.8091226 Genetic dissection of complex traits 

  29. Biometrics Louis 43 805 1987 10.2307/2531534 An exact test for Hardy-Weinberg and multiple alleles 

  30. J. Am. Stat. Assoc. Ling 73 274 1978 A study of the accuracy of some approximations for t, χ2, and F tail probabilities 

  31. Ecological Genetics Lynch 109 1994 Evolutionary genetics of Daphnia 

  32. Nature Morrison 367 284 1994 10.1038/367284a0 Prediction of bone density from vitamin D receptor alleles 

  33. Ann. Hum. Genet. Nam 61 163 1997 10.1017/S0003480097006052 Testing a genetic equilibrium across strata 

  34. Molecular Population Genetics and Evolution Nei 1975 

  35. Am. J. Hum. Genet. Nielsen 63 1531 1999 10.1086/302114 Detecting marker-disease association by testing for Hardy-Weinberg disequilibrium at a marker locus 

  36. Analysis of Human Genetic Linkage Ott 1991 

  37. Am. J. Hum. Genet. Page 64 1194 1999 10.1086/302331 Comparison of linkage-disequilibrium methods for localization of genes influencing quantitative traits in humans 

  38. Am. J. Med. Genet. Pato 48 78 1993 10.1002/ajmg.1320480204 Review of the putative association of dopamine D2 receptor and alcoholism: a meta-analysis 

  39. J. Bone Miner. Res. Peacock 10 1294 1995 10.1002/jbmr.5650100904 Vitamin D receptor gene alleles and osteoporosis: a contrasting view 

  40. Biometrika Pearson 46 364 1959 10.2307/2333533 Note on an approximation to the distribution of noncentral χ2 

  41. Am. J. Hum. Genet. Pritchard 65 220 1999 10.1086/302449 Use of unlinked genetics markers to detect population stratification in association studies 

  42. Genetics Pritchard 155 945 2000 10.1093/genetics/155.2.945 Inference of population admixture using multilocus genotype data 

  43. Am. J. Hum. Genet. Pritchard 67 170 2000 10.1086/302959 Association mapping in structured populations 

  44. Genome Res. Risch 8 1273 1998 10.1101/gr.8.12.1273 The relative power of family-based and case-control designs for linkage disequilibrium studies of complex human diseases. I. DNA polling 

  45. Am. J. Epidemiol. Schaid 149 706 1999 10.1093/oxfordjournals.aje.a009878 Biased tests of association: comparisons of allele frequencies when departing from Hardy-Weinberg proportions 

  46. Genetics Shoemaker 149 2079 1998 10.1093/genetics/149.4.2079 A Bayesian characterization of Hardy-Weinberg disequilibrium 

  47. Am. J. Hum. Genet. Spielman 52 506 1993 Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM) 

  48. Circulation Tiret 92 3364 1995 Letter: Departure from Hardy-Weinberg equilibrium should be systematically tested in studies of association between genetic markers and disease 

  49. Genetic Data Analysis II Weir 1996 

  50. Proc. Natl. Acad. Sci. USA Wilson 17 684 1931 10.1073/pnas.17.12.684 The distribution of chisquare 

  51. Ann. Hum. Genet. Xiong 62 431 1998 10.1046/j.1469-1809.1998.6250431.x TDT statistics for mapping quantitative trait loci 

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