다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기
Radiochimica acta, v.89 no.1, 2001년, pp.43 - 50
Gupta, A. , Seifert, S. , Syhre, R. , Scheunemann, M. , Brust, P. , Johannsen, B.
The stability and reactivity of mixed-ligand99mTc complexes of the general formula [99mTcOL1L2], where L1H2is either an N-substituted bis-(2-mercaptoethyl)amine [SNMeS] or 3-thiapentane-1,5-dithiol [SSS] and L2H is a monodentate thiol [RS], were investigated. The complexes undergo transchelation reactions with glutathione and other SH-group containing blood constituents. The reactions are reversible and can be inhibited by addition of diethylmaleate. Challenge experiments were performed with a broad set of99mTc mixed-ligand complexes to investigate the influence of both the tridentate ligand and the monodentate ligand on the stability of this type of complex. The occurrence of ligand exchange reactions with glutathione depends on the donor set of the tridentate ligands as well as the structure of the monodentate ligands. Especially the stability of complexes containing a monodentate ligand with an amine nitrogen in the side chain can be increased by lengthening the carbon chain between the sulfhydryl group and the nitrogen. Thus, it might be possible to improve their in-vivo performance.
Johannsen, B., Scheunemann, M., Spies, H., Brust, P., Wober, J., Syhre, R., Pietzsch, H.-J.. Technetium(v) and rhenium(v) complexes for 5-HT2A serotonin receptor binding: Structure-affinity considerations. Nuclear medicine and biology, vol.23, no.4, 429-438.
Pietzsch, H.-J, Scheunemann, M, Kretzschmar, M, Elz, S, Pertz, H.H, Seifert, S, Brust, P, Spies, H, Syhre, R, Johannsen, B. Synthesis and autoradiographic evaluation of a novel high-affinity Tc-99m ligand for the 5-HT2A receptor. Nuclear medicine and biology, vol.26, no.8, 865-875.
U. Mazzi SGEDITORIALI Padova Seifert S. 687 5 1999
Syhre, R., Seifert, S., Spies, H., Gupta, A., Johannsen, B.. Stability versus reactivity of ”3+1" mixed-ligand technetium-99m complexes in vitro and in vivo. European journal of nuclear medicine, vol.25, no.7, 793-796.
Nock, B. A., Maina, T., Yannoukakos, D., Pirmettis, I. C., Papadopoulos, M. S., Chiotellis, E.. Glutathione-Mediated Metabolism of Technetium-99m SNS/S Mixed Ligand Complexes: A Proposed Mechanism of Brain Retention. Journal of medicinal chemistry, vol.42, no.6, 1066-1075.
Pelecanou, M., Pirmettis, I.C., Nock, B.A., Papadopoulos, M., Chiotellis, E., Stassinopoulou, C.I.. Interaction of [ReO(SNS) (S)] and [99mTcO(SNS) (S)] mixed ligand complexes with glutathione: isolation and characterization of the product. Inorganica chimica acta, vol.281, no.2, 148-152.
Biol. Chem. Cooper A. J. L. 793 378 1997
Ecobichon, D. J.. Glutathione Depletion and Resynthesis in Laboratory Animals. Drug and chemical toxicology, vol.7, no.4, 345-355.
10.1016/S0076-6879(85)13073-9
Biochem. J. Owens C. W. I. 705 94 1965 10.1042/bj0940705
Tietze, Frank. Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissues. Analytical biochemistry, vol.27, no.3, 502-522.
Griffith, Owen W.. Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. Analytical biochemistry, vol.106, no.1, 207-212.
해당 논문의 주제분야에서 활용도가 높은 상위 5개 콘텐츠를 보여줍니다.
더보기 버튼을 클릭하시면 더 많은 관련자료를 살펴볼 수 있습니다.
*원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다.
Copyright KISTI. All Rights Reserved.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.