[논문]Sex Differences in the Effects of Alcohol on Brain Structure

Pfefferbaum, Adolf; Rosenbloom, Margaret; Deshmukh, Anjali; Sullivan, Edith V.

doi:10.1176/appi.ajp.158.2.188

Sex Differences in the Effects of Alcohol on Brain Structure

The American journal of psychiatry, v.158 no.2, 2001년, pp.188 - 197

Pfefferbaum, Adolf , Rosenbloom, Margaret , Deshmukh, Anjali , Sullivan, Edith V.

Abstract ▼ AI-Helper

OBJECTIVE: This study investigated whether alcoholic women manifest deficits in cortical gray and white matter volumes and ventricular enlargement similar to those seen in alcoholic men. METHOD: Volumetric measures of intracranium, cortical gray matter, white matter and sulci, and lateral and third ventricles were obtained from magnetic resonance images of 42 women and 44 men with DSM-III-R alcoholism and age-matched healthy comparison groups (37 women and 48 men). Groups of alcoholic men and women were matched on age and length of sobriety, but men had a 2.5 times higher lifetime alcohol consumption than women. RESULTS: Women, regardless of diagnosis, had less cortical gray and white matter and smaller third ventricles than men, consistent with sex-related differences in intracranial volume. Alcoholics had larger volumes of cortical sulci and lateral and third ventricles than comparison subjects. Diagnosis-by-sex interactions for cortical white matter and sulcal volumes were due to abnormalities in alcoholic men but not alcoholic women, relative to same-sex comparison subjects. This interaction persisted for cortical sulci after covarying for lifetime alcohol consumption. Slopes relating cortical gray matter and sulcal volumes to age were steeper in alcoholic than in comparison men. Slopes relating lateral ventricle volume to age were steeper in alcoholic than in comparison women. In alcoholic women, longer sobriety was associated with larger white matter volumes. CONCLUSIONS: Alcoholic men and women show different brain morphological deficits, relative to same-sex comparison subjects. However, age and alcoholism interact in both sexes, which puts all older alcoholics at particular risk for the negative sequelae of alcoholism.

참고문헌 (36)

10.15288/jsa.1994.55.743 York JL, Welte JW: Gender comparisons of alcohol consumption in alcoholic and nonalcoholic populations. J Stud Alcohol 1994; 55:743-750

상세보기
10.1001/archpsyc.1994.03950010008002 Kessler RC, McGonagle KA, Zhao S, Nelson CB, Hughes M, Eshleman S, Wittchen H-U, Kendler KS: Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States: results from the National Comorbidity Survey. Arch Gen Psychiatry 1994; 51:8-19
10.1001/archinte.137.7.883 Ashley MJ, Olin JS, le Riche WH: Morbidity in alcoholics: evidence for accelerated development of physical disease in women. Arch Intern Med 1977; 137:883-887
10.1111/j.1530-0277.1992.tb00702.x Pfefferbaum A, Lim KO, Zipursky RB, Mathalon DH, Lane B, Ha CN, Rosenbloom MJ, Sullivan EV: Brain gray and white matter volume loss accelerates with aging in chronic alcoholics: a quantitative MRI study. Alcohol Clin Exp Res 1992; 16:1078-1089

상세보기
10.1111/j.1530-0277.1991.tb00540.x Jernigan TL, Butters N, DiTraglia G, Schafer K, Smith T, Irwin M, Grant I, Schuckit M, Cermak L: Reduced cerebral grey matter observed in alcoholics using magnetic resonance imaging. Alcohol Clin Exp Res 1991; 15:418-427

상세보기
10.1016/0925-4927(93)90004-2 Pfefferbaum A, Sullivan EV, Rosenbloom MJ, Shear PK, Mathalon DH, Lim KO: Increase in brain cerebrospinal fluid volume is greater in older than in younger alcoholic patients: a replication study and CT/MRI comparison. Psychiatry Res Neuroimaging 1993; 50:257-274

상세보기
10.1111/j.1530-0277.1997.tb03798.x Pfefferbaum A, Sullivan EV, Mathalon DH, Lim KO: Frontal lobe volume loss observed with magnetic resonance imaging in older chronic alcoholics. Alcohol Clin Exp Res 1997; 21:521-529

상세보기
10.1111/j.1530-0277.1995.tb01598.x Pfefferbaum A, Sullivan EV, Mathalon DH, Shear PK, Rosenbloom MJ, Lim KO: Longitudinal changes in magnetic resonance imaging brain volumes in abstinent and relapsed alcoholics. Alcohol Clin Exp Res 1995; 19:1177-1191

상세보기
10.1001/archpsyc.55.10.905 Pfefferbaum A, Sullivan E, Rosenbloom MJ, Mathalon DH, Lim KO: A controlled study of cortical gray matter and ventricular changes in alcoholic men over a five year interval. Arch Gen Psychiatry 1998; 55:905-912
10.1111/j.1530-0277.1989.tb00298.x Muuronen A, Bergman H, Hindmarsh T, Telakivi T: Influence of improved drinking habits on brain atrophy and cognitive performance in alcoholic patients: a 5-year follow-up study. Alcohol Clin Exp Res 1989; 13:137-141

상세보기
10.1017/S003329170001031X Jacobson R: The contributions of sex and drinking history to the CT brain scan changes in alcoholics. Psychol Med 1986; 16:547-549

상세보기
10.1111/j.1530-0277.1992.tb00698.x Mann K, Batra A, Gunthner A, Schroth G: Do women develop alcoholic brain damage more readily than men? Alcohol Clin Exp Res 1992; 16:1052-1056

상세보기
10.1016/0741-8329(91)91200-L Kroft CL, Gescuk B, Woods BT, Mello NK, Weiss RD, Mendelson JH: Brain ventricular size in female alcoholics: an MRI study. Alcohol 1991; 8:31-34

상세보기
10.1001/archneur.1996.00550040099019 Hommer D, Momenan R, Rawlings R, Ragan P, Williams W, Rio D, Eckardt M: Decreased corpus callosum size among alcoholic women. Arch Neurol 1996; 53:359-363

상세보기
10.1001/archpsyc.56.4.356 Agartz I, Momenan R, Rawlings RR, Kerich MJ, Hommer DW: Hippocampal volume in patients with alcohol dependence. Arch Gen Psychiatry 1999; 56:356-363
10.1111/j.1530-0277.1996.tb01682.x Pfefferbaum A, Lim KO, Desmond J, Sullivan EV: Thinning of the corpus callosum in older alcoholic men: a magnetic resonance imaging study. Alcohol Clin Exp Res 1996; 20:752-757

상세보기
10.1001/archneur.1994.00540210046012 Pfefferbaum A, Mathalon DH, Sullivan EV, Rawles JM, Zipursky RB, Lim KO: A quantitative magnetic resonance imaging study of changes in brain morphology from infancy to late adulthood. Arch Neurol 1994; 51:874-887

상세보기
10.1093/cercor/8.2.117 Sullivan E, Lim K, Mathalon D, Marsh L, Beal D, Harris D, Hoff A, Faustman W, Pfefferbaum A: A profile of cortical gray matter volume deficits characteristic of schizophrenia. Cereb Cortex 1998; 8:117-124

상세보기
10.1001/archneur.1997.00550180039010 Fama R, Sullivan EV, Shear PK, Marsh L, Yesavage JA, Tinklenberg JR, Lim KO, Pfefferbaum A: Selective cortical and hippocampal volume correlates of Mattis Dementia Rating Scale in Alzheimer disease. Arch Neurol 1997; 54:719-728

상세보기
10.15288/jsa.1982.43.1157 Skinner HA, Sheu WJ: Reliability of alcohol use indices: the lifetime drinking history and the MAST. J Stud Alcohol 1982; 43:1157-1170

상세보기
10.1016/0925-4927(93)90016-B Mathalon DH, Sullivan EV, Rawles JM, Pfefferbaum A: Correction for head size in brain-imaging measurements. Psychiatry Res Neuroimaging 1993; 50:121-139

상세보기
10.1097/00004728-198907000-00006 Lim KO, Pfefferbaum A: Segmentation of MR brain images into cerebrospinal fluid spaces, white and gray matter. J Comput Assist Tomogr 1989; 13:588-593

상세보기
10.1016/S0006-3223(97)00264-3 Sullivan E, Mathalon DH, Lim KO, Marsh L, Pfefferbaum A: Patterns of regional cortical dysmorphology distinguishing schizophrenia and chronic alcoholism. Biol Psychiatry 1998; 43:118-131

상세보기
10.1002/mrm.1910390107 Wang Y, Li S-J: Differentiation of metabolic concentrations between gray matter and white matter of human brain by in vivo 1H magnetic resonance spectroscopy. Magn Reson Med 1998; 39:28-33

상세보기
10.1016/0006-3223(90)90059-B De Lacoste MC, Adesanya T, Woodward DJ: Measures of gender differences in the human brain and their relationship to brain weight. Biol Psychiatry 1990; 28:931-942

상세보기
10.1523/JNEUROSCI.12-11-04133.1992 Breedlove SM: Sexual dimorphism in the vertebrate nervous system. J Neurosci 1992; 12:4133-4142

상세보기
10.1002/cne.902800205 Clarke S, Kraftsik R, van der loos H, Innocenti GM: Forms and measures of adult and developing human corpus callosum: is there sexual dimorphism? J Comp Neurol 1989; 280:213-230

상세보기
10.1523/JNEUROSCI.11-04-00933.1991 Allen LS, Richey MF, Chai YM, Gorski RA: Sex differences in the corpus callosum of the living human being. J Neurosci 1991; 11:933-942

상세보기
Blatter DD, Bigler ED, Gale SD, Johnson SC, Anderson C, Burnett BM, Parker N, Kurth S, Horn S: Quantitative volumetric analysis of brain MRI: normative database spanning five decades of life. Am J Neuroradiol 1995; 16:241-245
10.1073/pnas.88.7.2845 Gur RC, Mozley PD, Resnick SM, Gottlieb GL, Kohn M, Zimmerman R, Herman G, Atlas S, Grossman R, Berretta D, Erwin R, Gur RE: Gender differences in age effect on brain atrophy measured by magnetic resonance imaging. Proc Natl Acad Sci USA 1991; 88:2845-2849

상세보기
10.1111/j.1530-0277.1994.tb00899.x Shear PK, Jernigan TL, Butters N: Volumetric magnetic resonance imaging quantification of longitudinal brain changes in abstinent alcoholics. Alcohol Clin Exp Res 1994; 18:172-176

상세보기
10.1093/alcalc/34.6.894 Ely M, Hardy R, Longford N, Wadsworth M: Gender differences in the relationship between alcohol consumption and drink problems are largely accounted for by body water. Alcohol Alcohol 1999; 34:894-902

상세보기
10.1056/NEJM199001113220205 Frezza M, di Padova C, Pozzato G, Terpin M, Baraona E, Lieber CS: High blood alcohol levels in women. N Engl J Med 1990; 322:95-99

상세보기
10.1006/hbeh.1998.1476 Resnick SM, Maki PM, Golski S, Kraut MA, Zonderman AB: Effects of estrogen replacement therapy on PET cerebral blood flow and neuropsychological performance. Hormones and Behavior 1998; 34:171-182

상세보기
10.1615/CritRevNeurobiol.v13.i1.10 Woolley CS: Electrophysiological and cellular effects of estrogen on neuronal function. Crit Rev Neurobiol 1999; 13:1-20

상세보기
10.1016/S0193-953X(05)70074-5 Brady KT, Randall CL: Gender differences in substance use disorders. Psychiatr Clin North Am 1999; 22:241-252

상세보기

표제어: PCR

동의어: Packet Collision Rate

용어 설명 출처 목록 (6)

용어 설명: PCR은 세균 특이성이 있는 primer를 이용하여 적은 수의 세균이 있을지라도 쉽게 검출할 수 있는 유용한 방법이며, 이를 이용하여 구강 내 치면세균막이나 타액에서 직접 세균을 검출할 수 있게 되었다[8].

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관 관리번호, 논문명, 대등논문명, 저자 , 저널/프로시딩명, 발행기관, 발행년, 발행언어, 권, 호, 시작페이지, 끝페이지, ISBN, ISSN, 주제분야, 키워드, 초록(한글), 초록(영문), 저자(소속기관)
저장형식	Text(ASCII format) Excel format RefWorks Direct Export RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증

Sex Differences in the Effects of Alcohol on Brain Structure

Abstract ▼ AI-Helper

참고문헌 (36)

이 논문을 인용한 문헌

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트