[논문]Pharmacokinetics and adverse effects of butorphanol administered by single intravenous injection or continuous intravenous infusion in horses

Sellon, Debra C.; Monroe, Veronica L.; Roberts, Malcolm C.; Papich, Mark G.

doi:10.2460/ajvr.2001.62.183

Pharmacokinetics and adverse effects of butorphanol administered by single intravenous injection or continuous intravenous infusion in horses

American journal of veterinary research, v.62 no.2, 2001년, pp.183 - 189

Sellon, Debra C. , Monroe, Veronica L. , Roberts, Malcolm C. , Papich, Mark G.

Abstract ▼ AI-Helper

AbstractObjective-To determine an infusion rate of butorphanol tartrate in horses that would maintain therapeutic plasma drug concentrations while minimizing development of adverse behavioral and gastrointestinal tract effects.Animals-10 healthy adult horses.Procedure-Plasma butorphanol concentrations were determined by use of high-performance liquid chromatography following administration of butorphanol by single IV injection (0.1 to 0.13 mg/kg of body weight) or continuous IV infusion (loading dose, 17.8 µg/kg; infusion dosage, 23.7 µg/kg/h for 24 hours). Pharmacokinetic variables were calculated, and changes in physical examination data, gastrointestinal tract transit time, and behavior were determined over time.Results-A single IV injection of butorphanol was associated with adverse behavioral and gastrointestinal tract effects including ataxia, decreased borborygmi, and decreased defecation. Elimination half-life of butorphanol was brief (44.37 minutes). Adverse gastrointestinal tract effects were less apparent during continuous 24-hour infusion of butorphanol at a dosage that resulted in a mean plasma concentration of 29 ng/ml, compared with effects after a single IV injection. No adverse behavioral effects were observed during or after continuous infusion.Conclusions and Clinical Relevance-Continuous IV infusion of butorphanol for 24 hours maintained plasma butorphanol concentrations within a range associated with analgesia. Adverse behavioral and gastrointestinal tract effects were minimized during infusion, compared with a single injection of butorphanol. Continuous infusion of butorphanol may be a useful treatment to induce analgesia in horses. (Am J Vet Res 2001;62:183-189)

참고문헌 (26)

Philadelphia: Lea & Febiger Benedetti C 1640 1990
Fifth World Congress on Pain Kehlet H 35 1991
KEHLET, H.. SURGICAL STRESS: THE ROLE OF PAIN AND ANALGESIA. British journal of anaesthesia : BJA, vol.63, no.2, 189-195.

상세보기
Am J Vet Res Kalpravidh M 211 45 1984

상세보기
Am J Vet Res Muir WW 2081 46 1985

상세보기
Johnson, C., Taylor, P., Young, S., Brearley, J.. Postoperative analgesia using phenylbutazone, flunixin or carprofen in horses. The Veterinary record : journal of the British Veterinary Association, vol.133, no.14, 336-338.

상세보기
LEES, P., HIGGINS, A. J.. Clinical pharmacology and therapeutic uses of non‐steroidal anti‐inflammatory drugs in the horse. Equine veterinary journal, vol.17, no.2, 83-96.

상세보기
Ohio: McGraw-Hill Book Co Reisine T 521 1996
NOLAN, A. M., BESLEY, W., REID, J., GRAY, G.. The effects of butorphanol on locomotor activity in ponies: a preliminary study. Journal of veterinary pharmacology and therapeutics, vol.17, no.4, 323-326.

상세보기
Am J Vet Res Sojka JE 527 49 1988

상세보기
Am J Vet Res Adams SB 795 45 1984

상세보기
ROBERTS, M. C., ARGENZIO, A.. Effects of amitraz, several opiate derivatives and anticholinergic agents on intestinal transit in ponies. Equine veterinary journal, vol.18, no.4, 256-260.

상세보기
Ann Roy Coll Surg Engl Rascher LA 204 71 1989
R�d, U., Fischer, M. V., Mewes, R., Paravicini, D.. Postoperative Analgesie mit Tramadol. Der Anaesthesist, vol.43, no.5, 316-321.

상세보기
Br Med J Church JJ 977 1 1979 10.1136/bmj.1.6169.977

상세보기
Kungl Lantbrukshogskolans Annaler Hyden S 139 22 1955
Am J Vet Res Kalpravidh M 217 45 1984

상세보기
Am J Vet Res Roger T 31 46 1985

상세보기
Comp Cont Ed Pract Vet Orsini JA 849 10 1988
KAMERLING, S., WECKMAN, T., DONAHOE, J., TOBIN, T.. Dose related effects of the kappa agonist U‐50, 488H on behaviour, nociception and autonomic response in the horse. Equine veterinary journal, vol.20, no.2, 114-118.

상세보기
Drug Metab Dispos Gaver RC 230 8 1980

상세보기
Am J Vet Res Robertson JT 41 42 1981

상세보기
Fifth World Congress on Pain Ready LB 53 1991
Ninth Annu Meet Vet Med Forum Hansen BD 161 1981
Br Vet J Liles JH 515 149 1993 10.1016/S0007-1935(05)80036-3

상세보기
Tverskoy, Mark, Cozacov, Carlos, Ayache, Mikhal, Bradley Jr, Edwin L., Kissin, Igor. Postoperative Pain After Inguinal Herniorrhaphy with Different Types of Anesthesia :. Anesthesia and analgesia, vol.70, no.1, 29???35-.

상세보기

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Pharmacokinetics and adverse effects of butorphanol administered by single intravenous injection or continuous intravenous infusion in horses

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참고문헌 (26)

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