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[해외논문] Human Immunodeficiency Virus Type 1 Nef-Induced CD4 Cell Surface Downregulation Is Inhibited by Ikarugamycin 원문보기

Journal of virology, v.75 no.5, 2001년, pp.2488 - 2492  

Luo, Tianci (<) ,  Fredericksen, Brenda L. (!--label omitted: 1-->) ,  Hasumi, Keiji (Genetic Therapy Inc., Gaithersburg, Maryland 208791) ,  Endo, Akira ,  Garcia, J. Victor (<)

Abstract AI-Helper 아이콘AI-Helper

ABSTRACTOne well-characterized in vitro function of Nef is its ability to remove CD4, the human immunodeficiency virus (HIV) receptor, from the cell surface. Nef accomplishes this by accelerating the internalization and degradation of CD4. Current models propose that Nef promotes CD4 internalization...

참고문헌 (48)

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