[논문]p53-dependent radiation-induced crypt intestinal epithelial cells apoptosis is mediated in part through TNF-TNFR1 system

Inagaki-Ohara, Kyoko; Yada, Shinichiro; Takamura, Noriaki; Reaves, Miriam; Yu, Xiaohong; Liu, Erdong; Rooney, Isabelle; Nicholas, Shelby; Castro, Arturo; Ware, Carl F; Green, Douglas R; Lin, Tesu

doi:10.1038/sj/onc/1204172

p53-dependent radiation-induced crypt intestinal epithelial cells apoptosis is mediated in part through TNF-TNFR1 system

Oncogene, v.20 no.7, 2001년, pp.812 - 818

Inagaki-Ohara, Kyoko (Section of Gastroenterology, Department of Medicine, Northwestern University Medical School, Chicago, Illinois, IL 60611, USA) , Yada, Shinichiro (Section of Gastroenterology, Department of Medicine, Northwestern University Medical School, Chicago, Illinois, IL 60611, USA) , Takamura, Noriaki (Section of Gastroenterology, Department of Medicine, Northwestern University Medical School, Chicago, Illinois, IL 60611, USA) , Reaves, Miriam (Division of Cellular Immunology, La Jolla Institute of Allergy and Immunology, San Diego California, CA 92121, USA) , Yu, Xiaohong (Section of Gastroenterology, Department of Medicine, Northwestern University Medical School, Chicago, Illinois, IL 60611, USA) , Liu, Erdong (Section of Gastroenterology, Department of Medicine, Northwestern University Medical School, Chicago, Illinois, IL 60611, USA) , Rooney, Isabelle (Division of Molecular Immunology, La Jolla Institute of Allergy and Immunology, San Diego, California, CA 92121, USA) , Nicholas, Shelby (Division of Cellular Immunology, La Jolla Institute of Allergy and Immunology, San Diego California, CA 92121, USA) , Castro, Arturo (Divisio) , Ware, Carl F , Green, Douglas R , Lin, Tesu

Abstract ▼ AI-Helper

Radiation induces apoptosis of crypt intestinal epithelial cells (IEC) through a pathway that is largely dependent on p53. However, exactly how p53 mediates IEC apoptosis is unclear. Studies in vitro suggest that one mechanism by which p53 mediates apoptosis is through its ability to transactivate members of the TNF receptor family of ‘Death Receptors’. Here, we examined the role of one of its member, TNF receptor type 1 (TNFR1), in an in vivo model of p53-dependent radiation-induced IEC apoptosis. We demonstrate that mice genetically engineered to be deficient in TNF receptor type 1 (TNFR1−/−) and mice injected with TNFR1-fusion chimeric protein (TNFR1-Fc; a competitive inhibitor of TNFR1) were partially protected (30–40%) from p53-dependent radiation-induced IEC apoptosis. However, we found no evidence to support the possibility p53 transcriptionally regulates the expression of TNFR1 nor increases the susceptibility of IEC to TNF-mediated apoptosis. Interestingly, we found that injection of TNF readily induced IEC apoptosis and that radiation induced a p53-dependent increase in the intestinal level of TNF. Furthermore, injection of a neutralizing anti-TNF mAb reduced p53-dependent radiation-induced IEC apoptosis by approximately 60%. Overall, these results suggest that p53-dependent radiation-induced IEC apoptosis is mediated in part through ability of p53 to regulate TNF, which subsequently induces IEC apoptosis through TNFR1.

참고문헌 (38)

10.1126/science.274.5288.782 Beg AA and Baltimore D. . 1996 Science 274: 782-784.

상세보기
10.1126/science.282.5387.290 Bennett M, Macdonald K, Chan SW, Luzio JP, Simari R and Weissberg P. . 1998 Science 282: 290-293.

상세보기
10.1038/362849a0 Clarke AR, Purdie CA, Harrison DJ, Morris RG, Bird CC, Hooper ML and Wyllie AH. . 1993 Nature 362: 849-852.

상세보기
Clarke AR, Gledhill S, Hooper ML, Bird CC and Wyllie AH. . 1994 Oncogene 9: 1767-1773.
10.1016/0022-1759(94)90212-7 Crowe PD, VanArsdale TL, Walter BN, Dahms KM and Ware CF. . 1994 J. Immunol. Methods 168: 79-89.

상세보기
10.4049/jimmunol.160.1.134 Faris M, Kokot N, Latinis K, Kasibhatla S, Green DR, Koretzky GA and Nel A. . 1998a J. Immunol. 160: 134-144.

상세보기
10.1128/MCB.18.9.5414 Faris M, Latinis KM, Kempiak SJ, Koretzky GA and Nel A. . 1998b Mol. Cell. Biol. 18: 5414-5424.

상세보기
10.1002/bjs.1800740833 Galland RB and Spencer J. . 1987 Br. J. Surg. 74: 742-747.

상세보기
10.1084/jem.180.2.525 Haimovitz-Friedman A, Kan CC, Ehleiter D, Persaud RS, McLoughlin M, Fuks Z and Kolesnick RN. . 1994 J. Exp. Med. 180: 525-535.

상세보기
10.1073/pnas.86.24.10104 Hallahan DE, Spriggs DR, Beckett MA, Kufe DW and Weichselbaum RR. . 1989 Proc. Natl. Acad. Sci. USA 86: 10104-10107.

상세보기
10.4049/jimmunol.162.1.486 Higgins LM, McDonald SA, Whittle N, Crockett N, Shields JG and MacDonald TT. . 1999 J. Immunol. 162: 486-493.

상세보기
10.1182/blood.V90.8.3204 Hill GR, Crawford JM, Cooke KR, Brinson YS, Pan L and Ferrara JL. . 1997 Blood 90: 3204-3213.

상세보기
10.1128/mcb.13.10.6231-6240.1993 Hiscott J, Marois J, Garoufalis J, D'Addario M, Roulston A, Kwan I, Pepin N, Lacoste J, Nguyen H, Bensi G and Fenton M. . 1993 Mol. Cell. Biol. 13: 6231-6240.

상세보기
10.1002/eji.1830271121 Inagaki-Ohara K, Nishimura H, Mitani A and Yoshikai Y. . 1997 Eur. J. Immunol. 27: 2885-2891.

상세보기
10.2307/3578739 Iwamoto KS and McBride WH. . 1994 Radiat. Res. 139: 103-108.

상세보기
Kastan MB, Onyekwere O, Sidransky D, Vogelstein B and Craig RW. . 1991 Cancer Res. 51: 6304-6311.
10.1038/sj.onc.1203717 Komarova EA, Christov K, Faerman AI and Gudkov AV. . 2000 Oncogene 19: 3791-3798.

상세보기
10.1172/JCI896 Lin T, Brunner T, Tietz B, Madsen J, Bonfoco E, Reaves M, Huflejt M and Green DR. . 1998 J. Clin. Invest. 101: 570-577.

상세보기
10.1038/362847a0 Lowe SW, Schmitt EM, Smith SW, Osborne BA and Jacks T. . 1993 Nature 362: 847-849.

상세보기
10.1128/mcb.4.9.1689-1694.1984 Maltzman W and Czyzyk L. . 1984 Mol. Cell. Biol. 4: 1689-1694.

상세보기
10.1074/jbc.271.16.9778 Medvedev AE, Espevik T, Ranges G and Sundan A. . 1996 J. Biol. Chem. 271: 9778-9784.

상세보기
Merritt AJ, Potten CS, Kemp CJ, Hickman JA, Balmain A, Lane DP and Hall PA. . 1994 Cancer Res. 54: 614-617.
10.1038/sj.onc.1201126 Merritt AJ, Allen TD, Potten CS and Hickman JA. . 1997 Oncogene 14: 2759-2766.

상세보기
10.1016/0092-8674(95)90412-3 Miyashita T and Reed JC. . 1995 Cell 80: 293-299.

상세보기
10.1097/00004836-197903000-00003 Novak JM, Collins JT, Donowitz M, Farman J, Sheahan DG and Spiro HM. . 1979 J. Clin. Gastroenterol. 1: 9-39.

상세보기
10.1084/jem.166.5.1280 Piguet PF, Grau GE, Allet B and Vassalli P. . 1987 J. Exp. Med. 166: 1280-1289.

상세보기
10.1002/(SICI)1521-4141(199811)28:11<3499::AID-IMMU3499>3.0.CO;2-Q Piguet PF, Vesin C, Guo J, Donati Y and Barazzone C. . 1998 Eur. J. Immunol. 28: 3499-3505.

상세보기
10.1080/09553009414550101 Potten CS, Merritt A, Hickman J, Hall P and Faranda A. . 1994 Int. J. Radiat. Biol. 65: 71-78.

상세보기
10.1038/sj.onc.1203150 Pritchard DM, Potten CS, Korsmeyer SJ, Roberts S and Hickman JA. . 1999 Oncogene 18: 7287-7293.

상세보기
10.1038/sj.onc.1201316 Reinke V and Lozano G. . 1997 Oncogene 15: 1527-1534.

상세보기
10.1038/35009130 Ryan KM, Ernst MK, Rice NR and Vousden KH. . 2000 Nature 404: 892-897.

상세보기
Sheikh MS, Burns TF, Huang Y, Wu GS, Amundson S, Brooks KS, Fornace Jr AJ and El-Deiry WS. . 1998 Cancer Res. 58: 1593-1598.
10.1074/jbc.275.10.7337 Schuler M, Bossy-Wetzel E, Goldstein JC, Fitzgerald P and Green DR. . 2000 J. Biol. Chem. 275: 7337-7342.

상세보기
10.1007/s002689900422 Shiraishi M, Hiroyasu S, Ishimine T, Shimabuku M, Kusano T, Higashi M and Muto Y. . 1998 World J. Surg. 22: 491-493.

상세보기
10.1126/science.274.5288.787 Van Antwerp DJ, Martin SJ, Kafri T, Green DR and Verma IM. . 1996 Science 274: 787-789.

상세보기
10.1073/pnas.91.7.2762 Williams RO, Mason LJ, Feldmann M and Maini RN. . 1994 Proc. Natl. Acad. Sci. USA 91: 2762-2766.

상세보기
10.1038/ng1097-141 Wu GS, Burns TF, McDonald ER 3rd, Jiang W, Meng R, Krantz ID, Kao G, Gan DD, Zhou JY, Muschel R, Hamilton SR, Spinner NB, Markowitz S, Wu G and El-Deiry WS. . 1997 Nat. Genet. 17: 141-143.

상세보기
10.4049/jimmunol.151.12.6986 Ziegler-Heitbrock HW, Sternsdorf T, Liese J, Belohradsky B, Weber C, Wedel A, Schreck R, Bauerle P and Strobel M. . 1993 J. Immunol. 151: 6986-6993.

상세보기

표제어: PCR

동의어: Packet Collision Rate

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p53-dependent radiation-induced crypt intestinal epithelial cells apoptosis is mediated in part through TNF-TNFR1 system

Abstract ▼ AI-Helper

참고문헌 (38)

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