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p53-dependent radiation-induced crypt intestinal epithelial cells apoptosis is mediated in part through TNF-TNFR1 system

Oncogene, v.20 no.7, 2001년, pp.812 - 818  

Inagaki-Ohara, Kyoko (Section of Gastroenterology, Department of Medicine, Northwestern University Medical School, Chicago, Illinois, IL 60611, USA) ,  Yada, Shinichiro (Section of Gastroenterology, Department of Medicine, Northwestern University Medical School, Chicago, Illinois, IL 60611, USA) ,  Takamura, Noriaki (Section of Gastroenterology, Department of Medicine, Northwestern University Medical School, Chicago, Illinois, IL 60611, USA) ,  Reaves, Miriam (Division of Cellular Immunology, La Jolla Institute of Allergy and Immunology, San Diego California, CA 92121, USA) ,  Yu, Xiaohong (Section of Gastroenterology, Department of Medicine, Northwestern University Medical School, Chicago, Illinois, IL 60611, USA) ,  Liu, Erdong (Section of Gastroenterology, Department of Medicine, Northwestern University Medical School, Chicago, Illinois, IL 60611, USA) ,  Rooney, Isabelle (Division of Molecular Immunology, La Jolla Institute of Allergy and Immunology, San Diego, California, CA 92121, USA) ,  Nicholas, Shelby (Division of Cellular Immunology, La Jolla Institute of Allergy and Immunology, San Diego California, CA 92121, USA) ,  Castro, Arturo (Divisio) ,  Ware, Carl F ,  Green, Douglas R ,  Lin, Tesu

Abstract AI-Helper 아이콘AI-Helper

Radiation induces apoptosis of crypt intestinal epithelial cells (IEC) through a pathway that is largely dependent on p53. However, exactly how p53 mediates IEC apoptosis is unclear. Studies in vitro suggest that one mechanism by which p53 mediates apoptosis is through its ability to transactivate m...

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