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Impaired cutaneous wound healing in interleukin‐6‐deficient and immunosuppressed mice
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, v.14 no.15, 2000년, pp.2525 - 2531
Gallucci, Randle M. (Toxicology and Molecular Biology Branch, Health Effects Laboratory DivisionNational Institute for Occupational Safety and HealthMorgantownWest VirginiaUSA) , Simeonova, Petia P. (Toxicology and Molecular Biology Branch, Health Effects Laboratory DivisionNational Institute for Occupational Safety and HealthMorgantownWest VirginiaUSA) , Matheson, Joanna M. (Toxicology and Molecular Biology Branch, Health Effects Laboratory DivisionNational Institute for Occupational Safety and HealthMorgantownWest VirginiaUSA) , Kommineni, Choudari (Toxicology and Molecular Biology Branch, Health Effects Laboratory DivisionNational Institute for Occupational Safety and HealthMorgantownWest VirginiaUSA) , Guriel, Jennifer L. (Toxicology and Molecular Biology Branch, Health Effects Laboratory DivisionNational Institute for Occupational Safety and HealthMorgantownWest VirginiaUSA) , Sugawara, Tadaki (Drug Safety Research LaboratoryDaiichi Pharmaceutical CompanyTokyoJapan) , Luster, Michael I. (Toxicology and Molecular Biology Branch, Health Effects Laboratory DivisionNational Institute for Occupational Safety and HealthMorgantownWes)
Abstract
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It has been postulated that an inflammatory response after cutaneous wounding is a prerequisite for healing, and inflammatory cytokines, such as interleukin-6 (IL-6), might be intimately involved in this process. IL-6-deficient transgenic mice (IL-6 KO) displayed significantly delayed cutaneous woun...
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