[논문]Increased susceptibility to ischemia‐induced brain damage in transgenic mice overexpressing a dominant negative form of SHP2

Aoki, Yoko; Huang, Zhihong; Thomas, Sunu S.; Bhide, Pradeep G.; Huang, Ivana; Moskowltz, Michael A.; Reeves, Steven A.

doi:10.1096/fj.00-0105com

Increased susceptibility to ischemia‐induced brain damage in transgenic mice overexpressing a dominant negative form of SHP2

The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, v.14 no.13, 2000년, pp.1965 - 1973

Aoki, Yoko (Department of Medical GeneticsTohoku University School of Medicine1-1 Seiryo-Machi Sendai Miyagi 980-8574 Japan) , Huang, Zhihong (Stroke and Neurovascular RegulationMassachusetts General HospitalHarvard Medical SchoolCharlestown Massachusetts 02129 USA) , Thomas, Sunu S. (Stroke and Neurovascular RegulationMassachusetts General HospitalHarvard Medical SchoolCharlestown Massachusetts 02129 USA) , Bhide, Pradeep G. (Developmental NeurobiologyMassachusetts General HospitalHarvard Medical SchoolCharlestown Massachusetts 02129 USA) , Huang, Ivana (CNS Signaling LaboratoryMolecular Neuro-OncologyMassachusetts General HospitalHarvard Medical SchoolCharlestown Massachusetts 02129 USA) , Moskowltz, Michael A. (Stroke and Neurovascular RegulationMassachusetts General HospitalHarvard Medical SchoolCharlestown Massachusetts 02129 USA) , Reeves, Steven A. (CNS Signaling LaboratoryMolecular Neuro-OncologyMassachusetts General HospitalHarvard Medical SchoolCharlestown Massachusetts 02129 USA)

Abstract ▼ AI-Helper

Cell culture studies have established SH2 domain-containing protein tyrosine phosphatase-2 (SHP2) as an important factor in growth factor and cytokine-activated signaling pathways. However, the significance of SHP2 in the mammalian central nervous system (CNS) is not known since early embryonic lethality occurs in shp2 null mice. To bypass this embryonic lethality, transgenic animals containing a catalytically inactive mutant of SHP2 (SHP2-CS) under the control of a nestin intron II/thymidine kinase minimal promoter were generated. In the developing CNS of these animals, although high-level transgene expression was detected in the neuroepithelium, there was no obvious abnormality in progenitor cell proliferation or migration. In the adult brain, high-level transgene expression was detected in the subventricular zone, rostral migratory stream, dentate gyrus of hippocampus, and cerebellum. Because SHP2 function is likely important in cell survival pathways, we used a focal cerebral ischemia model to examined whether SHP2 is important during CNS injury. Ischemia-induced damage and neuronal death was found to be significantly greater in nestin-SHP2-CS mice than in wild-type littermates. These findings indicate that SHP2 is a required factor in signaling pathway(s) important for neuronal survival.

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Increased susceptibility to ischemia‐induced brain damage in transgenic mice overexpressing a dominant negative form of SHP2

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