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GD3 ganglioside directly targets mitochondria in a bcl‐2‐controlled fashion
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, v.14 no.13, 2000년, pp.2047 - 2054
Rippo, Maria Rita (Laboratory of Signal TransductionDepartment of Experimental Medicine and Biochemical SciencesUniversity of RomeTor Vergata 00133 Rome) , Malisan, Florence (Laboratory of Signal TransductionDepartment of Experimental Medicine and Biochemical SciencesUniversity of RomeTor Vergata 00133 Rome) , Rayagnan, Luigi (Centre National de la Recherche ScientifiqueUMR 1599Institut Gustave RoussyF94805 Villejuif France) , Tomassini, Barbara (Laboratory of Signal TransductionDepartment of Experimental Medicine and Biochemical SciencesUniversity of RomeTor Vergata 00133 Rome) , Condo, Ivano (Laboratory of Signal TransductionDepartment of Experimental Medicine and Biochemical SciencesUniversity of RomeTor Vergata 00133 Rome) , Costantini, Paola (Laboratory of Signal TransductionDepartment of Experimental Medicine and Biochemical SciencesUniversity of RomeTor Vergata 00133 Rome) , Susin, Santos A. (Centre National de la Recherche ScientifiqueUMR 1599Institut Gustave RoussyF94805 Villejuif France) , Rufini, Alessandra (Centre National de la Recherche ScientifiqueUMR 1599Institut Gustave RoussyF94805 Villejuif France) , Todaro, Matilde (Laboratory of Sig) , Kroemer, Guido , Testi, Roberto
Abstract
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Lipid and glycolipid diffusible mediators are involved in the intracellular progression and amplification of apoptotic signals. GD3 ganglioside is rapidly synthesized from accumulated ceramide after the clustering of death-inducing receptors and triggers apoptosis. Here we show that GD3 induces diss...
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