[논문]Comparison of Nebulized Particle Size Distribution with Malvern Laser Diffraction Analyzer Versus Andersen Cascade Impactor and Low-Flow Marple Personal Cascade Impactor

KWONG, W.T. JENNY; HO, SHARON L.; COATES, ALLAN L.

doi:10.1089/jam.2000.13.303

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Particle size of nebulized aerosols can be measured directly using laser diffraction or by evaluating aerodynamic properties by cascade impaction. As of today, there are no generally accepted standards for measuring particle size distribution from nebulizers. Laser diffraction has been questioned be...

Particle size of nebulized aerosols can be measured directly using laser diffraction or by evaluating aerodynamic properties by cascade impaction. As of today, there are no generally accepted standards for measuring particle size distribution from nebulizers. Laser diffraction has been questioned because of potential evaporative losses of the small particles at the edge of the plume, causing an apparent shift in the particle size distribution and thus a larger mass median diameter (MMD). When particle-sizing wet aerosols, cascade impaction may give rise to an apparent shift in the distribution, resulting in a smaller mass median aerodynamic diameter (MMAD) due to evaporative losses of aerosol droplets as they enter the impactor at ambient temperature. The modified low-flow Marple 296 Personal Cascade Impactor (MPCI) is currently being proposed as the European standard for wet aerosol analysis to minimize evaporative losses during sampling. The present study compared the particle size distribution of salbutamol and sodium cromoglycate aerosols nebulized by the Pari LC Star, using laser diffraction (Malvern Mastersizer X; MMX) and cascade impaction (Andersen Cascade Impactor [ACI] and the commercially available MPCI), which was either at ambient temperature or cooled to the nebulized aerosol temperature (10 degrees C). MMDs obtained with the MMX were virtually identical to the MMADs measured with both impactors when cooled with no significant differences in geometric standard deviation (sigma(g)). When the impactors were operated at ambient temperature, MMADs were smaller (18 to 30%) with a significantly larger sigma(g) (p < 0.05) compared to the MMX. These findings suggest that droplet distribution data for wet aerosol where evaporation process has not been minimized must be viewed with caution. There was no evidence suggesting a significant evaporative loss of small droplets from the edge of the plume during laser particle sizing. The MPCI does not minimize evaporative losses of aerosol particles during sampling.

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Singapore Hinds W.C. 315 1982
DOLOVICH, M.. Measurement of Particle Size Characteristics of Metered Dose Inhaler (MDI) Aerosols. Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine, vol.4, no.3, 251-263.

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PHIPPS, PAUL R., GONDA, IGOR. Evaporation of Aqueous Aerosols Produced by Jet Nebulizers: Effects on Particle Size and Concentration of Solution in the Droplets. Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine, vol.7, no.3, 239-258.

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Ho, K K L, Kellaway, I W, Tredree, R. Particle Size Analysis of Nebulised Aerosols Using Fraunhofer Laser Diffraction and Inertial Compaction Methods. Journal of pharmacy and pharmacology, vol.38, no.suppl12, 26P-26P.

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Clark, Andrew R.. The use of laser diffraction for the evaluation of the aerosol clouds generated by medical nebulizers. International journal of pharmaceutics, vol.115, no.1, 69-78.

상세보기
Finlay, W.H, Stapleton, K.W. Undersizing of droplets from a vented nebulizer caused by aerosol heating during transit through an anderson impactor. Journal of aerosol science, vol.30, no.1, 105-109.

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DENNIS, J.H.. Standardisation in Drug Nebulisers: BS7711 Part 3. Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine, vol.8, no.3, 313-315.

상세보기
Standardization. Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine, vol.12, no.2, 134-135.

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Phipps, Paul R., Pharm, B., Gonda, Igor. Droplets Produced by Medical Nebulizers. Chest : official publication of the American College of Chest Physicians, vol.97, no.6, 1327-1332.

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[해외논문] Comparison of Nebulized Particle Size Distribution with Malvern Laser Diffraction Analyzer Versus Andersen Cascade Impactor and Low-Flow Marple Personal Cascade Impactor

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[해외논문] Comparison of Nebulized Particle Size Distribution with Malvern Laser Diffraction Analyzer Versus Andersen Cascade Impactor and Low-Flow Marple Personal Cascade Impactor

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