$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

[해외논문] Ordered recombination of immunoglobulin light chain genes occurs at the IGK locus but seems less strict at theIGL locus

Blood, v.97 no.4, 2001년, pp.1001 - 1008  

van der Burg, Mirjam (From the Department of Immunology, Erasmus University Rotterdam) ,  Tümkaya, Talip (From the Department of Immunology, Erasmus University Rotterdam) ,  Boerma, Marjan (From the Department of Immunology, Erasmus University Rotterdam) ,  de Bruin-Versteeg, Sandra (From the Department of Immunology, Erasmus University Rotterdam) ,  Langerak, Anton W. (From the Department of Immunology, Erasmus University Rotterdam) ,  van Dongen, Jacques J. M. (From the Department of Immunology, Erasmus University Rotterdam)

Abstract AI-Helper 아이콘AI-Helper

AbstractRegulation of allelic and isotypic exclusion of human immunoglobulin (Ig) light-chain genes was studied in 113 chronic B-cell leukemias as a “single-cell” model that allowed complete analysis of each light chain allele. Our data show that monospecific Ig light chain expression is...

참고문헌 (40)

  1. Immunol Today. Langman 16 141 1995 10.1016/0167-5699(95)80131-6 The proportion of B-cell subsets expressing kappa and lambda light chains changes following antigenic selection. 

  2. Int Immunol. Ten Boekel 7 1013 1995 10.1093/intimm/7.6.1013 The status of Ig loci rearrangements in single cells from different stages of B cell development. 

  3. Eur J Immunol. Engel 29 2167 1999 10.1002/(SICI)1521-4141(199907)29:07<2167::AID-IMMU2167>3.0.CO;2-H B cells are programmed to activate kappa and lambda for rearrangement at consecutive developmental stages. 

  4. Immunol Today. Takeda 17 200 1996 10.1016/0167-5699(96)80622-0 The kappa:lambda ratio of immature B cells. 

  5. J Immunol. Miller 141 2497 1988 10.4049/jimmunol.141.7.2497 The order and orientation of mouse lambda-genes explain lambda-rearrangement patterns. 

  6. Proc Natl Acad Sci U S A. Sanchez 84 9185 1987 10.1073/pnas.84.24.9185 Structure of a third murine immunoglobulin lambda light chain variable region that is expressed in laboratory mice. 

  7. J Mol Biol. Williams 264 220 1996 10.1006/jmbi.1996.0636 Sequence and evolution of the human germline V lambda repertoire. 

  8. J Exp Med. Vasicek 172 609 1990 10.1084/jem.172.2.609 Structure and expression of the human immunoglobulin lambda genes. 

  9. Proc Natl Acad Sci U S A. Korsmeyer 78 7096 1981 10.1073/pnas.78.11.7096 Developmental hierarchy of immunoglobulin gene rearrangements in human leukemic pre-B-cells. 

  10. EMBO J. Zou 12 811 1993 10.1002/j.1460-2075.1993.tb05721.x Gene targeting in the Ig kappa locus: efficient generation of lambda chain-expressing B cells, independent of gene rearrangements in Ig kappa. 

  11. Immunity. Gorman 5 241 1996 10.1016/S1074-7613(00)80319-2 The Ig(kappa) enhancer influences the ratio of Ig(kappa) versus Ig(lambda) B lymphocytes. 

  12. Adv Immunol. Gorman 69 113 1998 10.1016/S0065-2776(08)60607-0 Regulation of immunoglobulin light chain isotype expression. 

  13. EMBO J. Nadel 9 435 1990 10.1002/j.1460-2075.1990.tb08128.x Murine lambda gene rearrangements: the stochastic model prevails over the ordered model. 

  14. Int Immunol. Arakawa 8 91 1996 10.1093/intimm/8.1.91 Re-evaluation of the probabilities for productive arrangements on the kappa and lambda loci. 

  15. Cell. Alt 21 1 1980 10.1016/0092-8674(80)90109-9 Activity of multiple light chain genes in murine myeloma cells producing a single, functional light chain. 

  16. EMBO J. Alt 3 1209 1984 10.1002/j.1460-2075.1984.tb01955.x Ordered rearrangement of immunoglobulin heavy chain variable segments. 

  17. Genes Dev. Mostoslavsky 12 1801 1998 10.1101/gad.12.12.1801 Kappa chain monoallelic demethylation and the establishment of allelic exclusion. 

  18. Nature. Hieter 290 368 1981 10.1038/290368a0 Human immunoglobulin kappa light chain genes are deleted or rearranged in lambda-producing B cells. 

  19. Eur J Immunol. Asenbauer 29 713 1999 10.1002/(SICI)1521-4141(199902)29:02<713::AID-IMMU713>3.0.CO;2-M The immunoglobulin lambda light chain enhancer consists of three modules which synergize in activation of transcription. 

  20. J Clin Immunol. Hauke 8 407 1988 10.1007/BF00917157 IgD/lambda plasmocytoma with immunoglobulin kappa light chain genes in the germ-line configuration. 

  21. J Exp Med. Pauza 178 139 1993 10.1084/jem.178.1.139 Unusual patterns of immunoglobulin gene rearrangement and expression during human B cell ontogeny: human B cells can simultaneously express cell surface kappa and lambda light chains. 

  22. J Exp Med. Giachino 181 1245 1995 10.1084/jem.181.3.1245 kappa+lambda+ dual receptor B cells are present in the human peripheral repertoire. 

  23. Leukemia. Matsu 10 700 1996 Four subclones with distinct immunoglobulin light chain phenotypes (kappa+lambda+, kappa+, lambda+ and kappa-lambda-) from acute leukemia. 

  24. J Exp Med. Padovan 181 1587 1995 10.1084/jem.181.4.1587 Normal T lymphocytes can express two different T cell receptor beta chains: implications for the mechanism of allelic exclusion. 

  25. Eur J Immunol. Mertsching 27 389 1997 10.1002/eji.1830270208 T cell receptor alpha gene rearrangement and transcription in adult thymic gamma delta cells. 

  26. Leukemia. Nakano 14 278 2000 10.1038/sj.leu.2401667 Spontaneous reduction of leukemic lymphoma cells possibly by anti-tumor antibody-mediated phagocytosis: a kappa-lambda-dual-positive B cell lymphoma. 

  27. Acta Haematol. Kawada 100 54 1998 10.1159/000040864 A novel variant of B-lymphoid leukemia expressing kappa/lambda light chains. 

  28. Leukemia. Van Dongen 83 1996 Immunobiology of leukemia. 

  29. Leukemia. Groeneveld 10 1383 1996 Flow cytometric detection of intracellular antigens for immunophenotyping of normal and malignant leukocytes. 

  30. Clin Chim Acta. van Dongen 198 1 1991 10.1016/0009-8981(91)90246-9 Analysis of immunoglobulin and T cell receptor genes; Part I: basic and technical aspects. 

  31. Leukemia. Beishuizen 8 2228 1994 Detection of immunoglobulin kappa light chain gene rearrangement patterns by Southern blot analysis. 

  32. Leukemia. Langerak 11 2192 1997 10.1038/sj.leu.2400887 Heteroduplex PCR analysis of rearranged T cell receptor genes for the diagnosis of suspected T cell proliferations. 

  33. Nucleic Acids Res. Lefranc 27 209 1999 10.1093/nar/27.1.209 IMGT, the international ImMunoGeneTics database. 

  34. Exp Clin Immunogenet. Pallares 15 8 1998 10.1159/000019054 The human immunoglobulin lambda variable (IGLV) genes and joining (IGLJ) segments. 

  35. J Immunol. Mehr 163 1793 1999 10.4049/jimmunol.163.4.1793 Models for antigen receptor gene rearrangement; I: biased receptor editing in B cells: implications for allelic exclusion. 

  36. Semin Immunol. Bergman 11 319 1999 10.1006/smim.1999.0188 Allelic exclusion in B and T lymphopoiesis. 

  37. Blood. Hamblin 94 1848 1999 10.1182/blood.V94.6.1848 Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. 

  38. Eur J Immunol. Giachino 28 3506 1998 10.1002/(SICI)1521-4141(199811)28:11<3506::AID-IMMU3506>3.0.CO;2-J Re-expression of RAG-1 and RAG-2 genes and evidence for secondary rearrangements in human germinal center B lymphocytes. 

  39. J Mol Biol. de Wildt 285 895 1999 10.1006/jmbi.1998.2396 Analysis of heavy and light chain pairings indicates that receptor editing shapes the human antibody repertoire. 

활용도 분석정보

상세보기
다운로드
내보내기

활용도 Top5 논문

해당 논문의 주제분야에서 활용도가 높은 상위 5개 콘텐츠를 보여줍니다.
더보기 버튼을 클릭하시면 더 많은 관련자료를 살펴볼 수 있습니다.

관련 콘텐츠

저작권 관리 안내
섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트

맨위로