[논문]Comparison of subretinal fluid levels of two 0.3% ciprofloxacin‐containing eye drops

Ç; ekiç; , Osman; Batman, Coş; ar; Yaş; ar, Ü; mit; Totan, Yü; ksel; Baş; ci, Nursabah E; Bozkurt, Atilla; Zilelioglu, Orhan; Kayaalp, S Oguz

doi:10.1046/j.1442-9071.2001.00362.x

[해외논문] Comparison of subretinal fluid levels of two 0.3% ciprofloxacin‐containing eye drops

Clinical & experimental ophthalmology, v.29 no.1, 2001년, pp.30 - 32

Çekiç, Osman , Batman, Coşar , Yaşar, Ümit , Totan, Yüksel , Başci, Nursabah E , Bozkurt, Atilla , Zilelioglu, Orhan , Kayaalp, S Oguz

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ABSTRACTPurpose: Two ophthalmic solutions of 0.3% ciprofloxacin eye drops are available in Turkey: Ciloxan and Siprogut. A previous study by the same authors was the first to report vitreous penetration of ciprofloxacin‐containing eye drops. The aim of the present study was to compare the levels of drug found in the subretinal fluid by the two products following local administration.Methods: Forty‐three patients undergoing conventional retinal detachment surgery received either Ciloxan (22 patients) or Siprogut (21 patients). Beginning 6 h before surgery, two drops of solution were instilled onto the operative eye every 30 min for the first 3 h and then hourly for the next 3 h. Subretinal fluid samples were collected 30 min after administration of the last dose and were assayed for ciprofloxacin levels using a method involving high‐ performance liquid chromatography with fluorometric detection.Results: The minimum and maximum subretinal fluid concentrations measured were 0.11 μg/mL and 0.65 μg/mL, respectively, with Ciloxan, and 0.08 μg/mL and 0.62 μg/mL, respectively, with Siprogut. There was no statistical difference between the subretinal fluid ciprofloxacin levels of the two products. The subretinal fluid drug levels attained by both products were below the minimum inhibitory concentrations of common ocular pathogens.Conclusions: Ciloxan and Siprogut can penetrate subretinal fluid. The ocular bioavailability of ciprofloxacin after local administration is equivalent for both pharmaceutical products.

참고문헌 (16)

Can. J. Ophthalmol. Çekiç O 373 33 1998 Comparison of aqueous humour and vitreous humour levels of two 0.3% ciprofloxacin eyedrops.

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Lesk, Mark R., Ammann, Hélène, Marcil, Gilles, Vinet, Bernard, Lamer, Laurent, Sebag, Mikael. The Penetration of Oral Ciprofloxacin Into the Aqueous Humor, Vitreous, and Subretinal Fluid of Humans. American journal of ophthalmology, vol.115, no.5, 623-628.

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Basci, N.E, Bozkurt, A, Kalayci, D, Kayaalp, S.O. Rapid liquid chromatographic assay of ciprofloxacin in human aqueous humor. Journal of pharmaceutical and biomedical analysis, vol.14, no.3, 353-356.

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Ophthalmic Surg. Lasers Kalayci D 21 27 1996 10.3928/1542-8877-19960101-05 Penetration of topical 0.3% ciprofloxacin into human aqueous humor.

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Akkan, A.G., Mutlu, I., Ozyazgan, S., Gok, A., Yigit, U., Ozuner, Z., Senses, V., Pekel, H.. Penetration of Topically Applied Ciprofloxacin, Norfloxacin and Ofloxacin into the Aqueous Humor of the Uninflamed Human Eye. Journal of chemotherapy, vol.9, no.4, 257-262.

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Arzneimittelforschung Durmaz B 413 47 1997 Aqueous humor penetration of topically applied ciprofloxacin, ofloxacin and tobramycin.
Çelebi, Serdal, Ay, Selma, Aykan, Ümit, Bulut, Vedat, Alagöz, Gürsoy, Çeliker, ÜlküÖ.. Penetration of oral and topical ciprofloxacin into human aqueous humor. Acta ophthalmologica Scandinavica, vol.76, no.6, 683-685.

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Ophthalmic Surg. Lasers Çekiç O 524 30 1999 Penetration of ofloxacin and ciprofloxacin in aqueous humor after topical administration.
Çekiç, Osman, Batman, Cosar, Totan, Yüksel, Yasar, Ümit, Basci, Nursabah E, Bozkurt, Atilla, Kayaalp, S Oguz, Zilelioglu, Orhan. Aqueous humour levels of topically applied ciprofloxacin and ofloxacin in the same subjects. Eye, vol.13, no.5, 656-659.

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Çekiç, Osman, Batman, Coşar, Yasar, Ümit, Başci, Nursabah E., Bozkurt, Atilla, Kayaalp, S Oguz. Human aqueous and vitreous humour levels of ciprofloxacin following oral and topical administration. Eye, vol.13, no.4, 555-558.

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ÖZTÜRK, FARUK, KORTUNAY, SELIM, KURT, EMIN, ILKER, S. SAMI, BASCI, NURSABAH E., BOZKURT, ATILA. PENETRATION OF TOPICAL AND ORAL CIPROFLOXACIN INTO THE AQUEOUS AND VITREOUS HUMOR IN INFLAMED EYES. Retina, vol.19, no.3, 218-218.

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Cekic, O., Batman, C., Yasar, U., Totan, Y., Basci, N. E, Bozkurt, A., Zilelioglu, O., Kayaalp, S O.. Penetration of topical, oral, and combined administered ofloxacin into the subretinal fluid. British journal of ophthalmology, vol.83, no.10, 1183-1185.

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El Baba, Fadi Z., Trousdale, Melvin D., Gauderman, W. James, Wagner, David G., Liggett, Peter E.. Intravitreal Penetration of Oral Ciprofloxacin in Humans. Ophthalmology, vol.99, no.4, 483-486.

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Invest. Ophthalmol. Vis. Sci. Keren G 2388 32 1991 The intravitreal penetration of orally administered ciprofloxacin in humans.
SealDV&BronAJ.Infections in the eye. In: O’Grady F Lambert HP Finch RG Greenwood D (eds).Antibiotics and Chemotherapy 7th edn. Edinburgh: Churchill‐Livingstone 1997; 787-8.
OZTURK, FARUK, KORTUNAY, SELIM, KURT, EMIN, IKER, S. SAMI, INAN, U. UBEYT, BASCI, NURSABAH E., BOZKURT, ATILA, KAYAALP, S. OGUZ. EFFECTS OF TRAUMA AND INFECTION ON CIPROFLOXACIN LEVELS IN THE VITREOUS CAVITY. Retina, vol.19, no.2, 127-130.

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