[논문]Interleukin-11 Receptor Expression in Primary Ovarian Carcinomas

doi:10.1006/gyno.2000.6064

[해외논문] Interleukin-11 Receptor Expression in Primary Ovarian Carcinomas

Gynecologic oncology, v.80 no.2, 2001년, pp.121 - 127

Campbell, Cara L. (Cytokine) , Guardiani, Rachel (Cytokine) , Ollari, Christopher (Department of Gynecologic Oncology, UMASS) , Nelson, Beth E. (Department of Gynecologic Oncology, UMASS) , Quesenberry, Peter J. (Cytokine) , Savarese, Todd M. (Cytokine)

Abstract ▼ AI-Helper

Abstract Objectives. The objectives of this study were to determine (1) the frequency of expression of the interleukin-11 receptor α subunit (IL-11Rα) and its signal transducing subunit, gp130, among primary ovarian carcinomas; (2) the frequency of expression of IL-11 in ovarian carcinomas; and (3) the potential role IL-11 might have in ovarian cancer cell biology. Methods. An immunohistochemical assay was used to determine the expression of IL-11Rα and the gp130 cofactor among primary ovarian carcinomas; the expression of IL-11 in ovarian malignancies was determined using reverse transcription polymerase chain reaction (RT-PCR). The ability of IL-11 to stimulate [3H]thymidine incorporation in IL-11R-expressing ovarian carcinoma cell lines (OVCAR-3 and SKOV-3) and/or abrogate cell death mediated by apoptosis-inducing agents using an ELISA assay that quantitates DNA fragmentation was also studied. Results. IL-11Rα was expressed in the malignant epithelial cells of 45 of 48 (93.8%) primary ovarian carcinoma samples studied. In 45 primary ovarian carcinoma samples where both components of the IL-11 receptor (IL-11Rα and gp130) were examined, coexpression was observed in 42 (93.3%). Expression of the IL-11 receptor components was also found in the stromal layer. Coexpression of IL-11Rα and gp130 was commonly observed in both benign ovarian tumors and in the epithelial layer of normal ovaries. In contrast, IL-11 mRNA was expressed in only 3 of 21 malignant samples studied (14.3%). Recombinant human IL-11 was unable either to stimulate [3H]thymidine incorporation or to block cell death effected by paclitaxel or Fas-activating antibodies in in vitro assays using OVCAR -3 or SKOV-3 cells. Conclusions. The IL-11 receptor system is commonly expressed in both malignant and nonmalignant ovarian tissues, although its function in ovarian epithelial cell biology remains unclear.

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