[논문]Effect of Intra-Arterial Papaverine on Regional Cerebral Blood Flow in Hemodynamically Relevant Cerebral Vasospasm

Vajkoczy, Peter; Horn, Peter; Bauhuf, Christian; Munch, Elke; Hubner, Ulrich; Ing, Dipl; Thome, Claudius; Poeckler-Schoeninger, Christiane; Roth, Harry; Schmiedek, Peter

doi:10.1161/01.str.32.2.498

Effect of Intra-Arterial Papaverine on Regional Cerebral Blood Flow in Hemodynamically Relevant Cerebral Vasospasm 원문보기

Stroke, v.32 no.2, 2001년, pp.498 - 505

Vajkoczy, Peter (From the Departments of Neurosurgery (P.V., P.H., C.B., U.H., P.S.), Anesthesiology (E.M., H.R.), and Radiology (C.P-S.), Klinikum Mannheim, University of Heidelberg, Mannheim, Germany.) , Horn, Peter (From the Departments of Neurosurgery (P.V., P.H., C.B., U.H., P.S.), Anesthesiology (E.M., H.R.), and Radiology (C.P-S.), Klinikum Mannheim, University of Heidelberg, Mannheim, Germany.) , Bauhuf, Christian (From the Departments of Neurosurgery (P.V., P.H., C.B., U.H., P.S.), Anesthesiology (E.M., H.R.), and Radiology (C.P-S.), Klinikum Mannheim, University of Heidelberg, Mannheim, Germany.) , Munch, Elke (From the Departments of Neurosurgery (P.V., P.H., C.B., U.H., P.S.), Anesthesiology (E.M., H.R.), and Radiology (C.P-S.), Klinikum Mannheim, University of Heidelberg, Mannheim, Germany.) , Hubner, Ulrich (From the Departments of Neurosurgery (P.V., P.H., C.B., U.H., P.S.), Anesthesiology (E.M., H.R.), and Radiology (C.P-S.), Klinikum Mannheim, University of Heidelberg, Mannheim, Germany.) , Ing, Dipl (From the Departments of Neurosurgery (P.V., P.H., C.B., U.H.) , Thome, Claudius , Poeckler-Schoeninger, Christiane , Roth, Harry , Schmiedek, Peter

Abstract ▼ AI-Helper

Background and Purpose -It remains controversial whether the intra-arterial administration of papaverine (IAP) is effective in reversing vasospasm-associated cerebral hypoperfusion after aneurysmal subarachnoid hemorrhage. The aim of the present study was to continuously assess regional cerebral blood flow (rCBF) during and after IAP with the use of quantitative, bedside thermal diffusion flowmetry. Methods -Eight patients with cerebral vasospasm after subarachnoid hemorrhage (mean flow velocity >120 cm/s; angiographic vessel constriction >33%; hemispheric cerebral blood flow [CBF] <32 mL/100 g per minute) were prospectively entered into the study. Before IAP, thermal diffusion microprobes were implanted into the white matter of each affected vascular territory (n=10) for rCBF monitoring. During and after IAP (300 mg papaverine/50 mL saline over 1 hour), mean arterial blood pressure, intracranial pressure, cerebral perfusion pressure, thermal diffusion rCBF (TD-rCBF), and cerebrovascular resistance (CVR) were recorded continuously. Results -IAP significantly increased TD-rCBF from 7.3±1.6 to 37.9±6.6 mL/100 g per minute (mean±SEM), indicating reversal of cerebral hypoperfusion. This TD-rCBF response was dependent on the degree of cerebral vasospasm and reduced perfusion within the vascular territory. Long-term analysis of TD-rCBF, however, demonstrated that this beneficial effect of IAP on cerebral hypoperfusion was only transient: within 3 hours after treatment, TD-rCBF and CVR returned to baseline values. Furthermore, a lack of correlation between transcranial Doppler sonography and thermal diffusion flowmetry suggested that transcranial Doppler sonography is not suited for CBF-based neuromonitoring after IAP. Conclusions -IAP is not effective in permanently reversing cerebral hypoperfusion in patients with cerebral vasospasm. The need to validate alternative therapeutic strategies that seek to improve cerebral perfusion in vasospasm warrants continued development of CBF-based neuromonitoring strategies.

참고문헌 (39)

Kassell, Neal F., Torner, James C., Haley, E. Clarke, Jane, John A., Adams, Harold P., Kongable, Gail L., _. The International Cooperative Studyon the Timing of Aneurysm Surgery : Part 1: Overall management results. Journal of neurosurgery, vol.73, no.1, 18-36.

상세보기
Pickard, J. D., Murray, G. D., Illingworth, R., Shaw, M. D., Teasdale, G. M., Foy, P. M., Humphrey, P. R., Lang, D. A., Nelson, R., Richards, P.. Effect of oral nimodipine on cerebral infarction and outcome after subarachnoid haemorrhage: British aneurysm nimodipine trial.. BMJ : British medical journal, vol.298, no.6674, 636-642.

상세보기
Kassell, Neal F., Peerless, Sydney J., Durward, Quentin J., Beck, David W., Drake, Charles G., Adams, Harold P.. Treatment of Ischemic Deficits from Vasospasm with Intravascular Volume Expansion and Induced Arterial Hypertension. Neurosurgery, vol.11, no.3, 337-343.

상세보기
Handa, Yuji, Weir, Bryce K. A., Nosko, Michael, Mosewich, Russ, Tsuji, Tsutomu, Grace, Michael. The effect of timing of clot removal on chronic vasospasm in a primate model. Journal of neurosurgery, vol.67, no.4, 558-564.

상세보기
10.1080/01616412.1994.11740193
Kassell, Neal F., Helm, Gregory, Simmons, Nathan, Phillips, C. Douglas, Cail, Wayne S.. Treatment of cerebral vasospasm with intra-arterial papaverine. Journal of neurosurgery, vol.77, no.6, 848-852.

상세보기
Dion, J. E., Duckwiler, G. R., Vi�uela, F., Martin, N., Bentson, J.. Pre-operative micro-angioplasty of refractory vasospasm secondary to subarachnoid hemorrhage. Neuroradiology, vol.32, no.3, 232-236.

상세보기
Elliott, J. Paul, Newell, David W., Lam, Derek J., Eskridge, Joseph M., Douville, Colleen M., Le Roux, Peter D., Lewis, David H., Mayberg, Marc R., Grady, M. Sean, Winn, H. Richard. Comparison of balloon angioplasty and papaverine infusion for the treatment of vasospasm following aneurysmal subarachnoid hemorrhage. Journal of neurosurgery, vol.88, no.2, 277-284.

상세보기
Newell, David W., Aaslid, Rune, Stooss, Renate, Reulen, Hans J.. The relationship of blood flow velocity fluctuations to intracranial pressure B waves. Journal of neurosurgery, vol.76, no.3, 415-421.

상세보기
Fandino, Javier, Kaku, Yasuhiko, Schuknecht, Bernhard, Valavanis, Anton, Yonekawa, Yasuhiro. Improvement of cerebral oxygenation patterns and metabolic validation of superselective intraarterial infusion of papaverine for the treatment of cerebral vasospasm. Journal of neurosurgery, vol.89, no.1, 93-100.

상세보기
Polin, Richard S., Hansen, Carolyn Apperson, German, Penny, Chadduck, James B., Kassell, Neal F.. Intra-arterially Administered Papaverine for the Treatment of Symptomatic Cerebral Vasospasm. Neurosurgery, vol.42, no.6, 1256-1267.

상세보기
Vajkoczy, Peter, Roth, Harry, Horn, Peter, Lucke, Thomas, Thomé, Claudius, Hubner, Ulrich, Martin, Gregory T., Zappletal, Christina, Klar, Ernst, Schilling, Lothar, Schmiedek, Peter. Continuous monitoring of regional cerebral blood flow: experimental and clinical validation of a novel thermal diffusion microprobe. Journal of neurosurgery, vol.93, no.2, 265-274.

상세보기
Clyde, Brent L., Resnick, Daniel K., Yonas, Howard, Smith, Holly A., Kaufmann, Anthony M.. The Relationship of Blood Velocity As Measured by Transcranial Doppler Ultrasonography to Cerebral Blood Flow Determined by Stable Xenon Computed Tomographic As Studies after Aneurysmal Subarachnoid Hemorrhage. Neurosurgery, vol.38, no.5, 896-905.

상세보기
Acta Neurochir Suppl (Wien) 81 42 1988 Lindegaard KF, Nornes H, Bakke SJ, Sorteberg W, Nakstad P. Cerebral vasospasm after subarachnoid haemorrhage investigated by means of transcranial Doppler ultrasound. Acta Neurochir Suppl (Wien). 1988;42:81-84.
Yonas, Howard, Darby, Joseph M., Marks, Elizabeth C., Durham, Susan R., Maxwell, Cheryl. CBF Measured by Xe-CT: Approach to Analysis and Normal Values. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, vol.11, no.5, 716-725.

상세보기
Damasio, H. A computed tomographic guide to the identification of cerebral vascular territories.. Archives of neurology, vol.40, no.3, 138-142.

상세보기
AJNR Am J Neuroradiol 1319 19 1998 Cross DT III, Moran CJ, Angtuaco EE, Milburn JM, Diringer MN, Dacey RG Jr. Intracranial pressure monitoring during intraarterial papaverine infusion for cerebral vasospasm. AJNR Am J Neuroradiol. 1998;19:1319-1323.
Jennett, B., Bond, M.. ASSESSMENT OF OUTCOME AFTER SEVERE BRAIN DAMAGE - A Practical Scale. The Lancet, vol.305, no.7905, 480-484.

상세보기
Milburn, James M., Moran, Christopher J., Cross, DeWitte T., Diringer, Michael N., Pilgram, Thomas K., Dacey, Ralph G.. Increase in diameters of vasospastic intracranial arteries by intraarterial papaverine administration. Journal of neurosurgery, vol.88, no.1, 38-42.

상세보기
Higashida, Randall T., Halbach, Van V., Cahan, Leslie D., Brant-Zawadzki, Michael, Barnwell, Stanley, Dowd, Christopher, Hieshima, Grant B.. Transluminal angioplasty for treatment of intracranial arterial vasospasm. Journal of neurosurgery, vol.71, no.5, 648-653.

상세보기
Schuknecht, B., Fandino, J., Yüksel, C., Yonekawa, Y., Valavanis, A.. Endovascular treatment of cerebral vasospasm: assessment of treatment effect by cerebral angiography and transcranial colour Doppler sonography. Neuroradiology, vol.41, no.6, 453-462.

상세보기
AJNR Am J Neuroradiol 346 14 1993 Livingston K, Guterman LR, Hopkins LN. Intraarterial papaverine as an adjunct to transluminal angioplasty for vasospasm induced by subarachnoid hemorrhage. AJNR Am J Neuroradiol. 1993;14:346-347.
Newell, David W., Eskridge, Joseph M., Mayberg, Marc R., Grady, M. Sean, Winn, H. Richard. Angioplasty for the treatment of symptomatic vasospasm following subarachnoid hemorrhage. Journal of neurosurgery, vol.71, no.5, 654-660.

상세보기
Bolton, T B. Mechanisms of action of transmitters and other substances on smooth muscle.. Physiological reviews, vol.59, no.3, 606-718.

상세보기
Kaku, Yasuhiko, Yonekawa, Yasuhiro, Tsukahara, Tetsuya, Kazekawa, Kiyoshi. Superselective intra-arterial infusion of papaverine for the treatment of cerebral vasospasm after subarachnoid hemorrhage. Journal of neurosurgery, vol.77, no.6, 842-847.

상세보기
Robertson, Claudia S., Narayan, Raj K., Gokaslan, Ziya L., Pahwa, Rajesh, Grossman, Robert G., Caram, Pedro, Allen, Elizabeth. Cerebral arteriovenous oxygen difference as an estimate of cerebral blood flow in comatose patients. Journal of neurosurgery, vol.70, no.2, 222-230.

상세보기
Acta Neurochir Suppl (Wien) 260 71 1998 Meixensberger J, Jager A, Dings J, Baunach S, Roosen K. Multimodal hemodynamic neuromonitoring: quality and consequences for therapy of severely head injured patients. Acta Neurochir Suppl (Wien). 1998;71:260-262.
AJNR Am J Neuroradiol 27 16 1995 Clouston JE, Numaguchi Y, Zoarski GH, Aldrich EF, Simard JM, Zitnay KM. Intraarterial papaverine infusion for cerebral vasospasm after subarachnoid hemorrhage. AJNR Am J Neuroradiol. 1995;16:27-38.
Firlik, Katrina S, Kaufmann, Anthony M, Firlik, Andrew D, Jungreis, Charles A, Yonas, Howard. Intra-arterial papaverine for the treatment of cerebral vasospasm following aneurysmal subarachnoid hemorrhage. Surgical neurology, vol.51, no.1, 66-74.

상세보기
10.1111/ane.1967.43.s27.17 Hoedt-Rasmussen K. Regional cerebral blood flow: the intra-arterial injection method. Acta Neurol Scand. 1967;43(suppl 27):1-81.

상세보기
10.1161/str.30.1.93
Marchal, G, Benali, K, Iglesias, S, Viader, F, Derlon, J M, Baron, J C. Voxel-based mapping of irreversible ischaemic damage with PET in acute stroke.. Brain : a journal of neurology, vol.122, no.12, 2387-2400.

상세보기
Kassell, N. F., Peerless, S. J., Drake, C. G., Boarini, D. J., Adams, H. P.. Treatment of Ischemic Deficits from Cerebral Vasospasm with High Dose Barbiturate Therapy :. Neurosurgery, vol.7, no.6, 593-597.

상세보기
Fandino, J., Schuknecht, B., Yüksel, C., Wieser, H.-G., Valavanis, A., Yonekawa, Y.. Clinical, Angiographic, and Sonographic Findings After Structured Treatment of Cerebral Vasospasm and Their Relation to Final Outcomes. Acta neurochirurgica, vol.141, no.7, 677-690.

상세보기
Finfer, S. R., Ferch, R., Morgan, M. K.. Barbiturate coma for severe, refractory vasospasm following subarachnoid haemorrhage. Intensive care medicine, vol.25, no.4, 406-409.

상세보기
Polin, Richard S., Coenen, Volker A., Hansen, Carolyn Apperson, Shin, Peter, Baskaya, Mustafa K., Nanda, Anil, Kassell, Neal F.. Efficacy of transluminal angioplasty for the management of symptomatic cerebral vasospasm following aneurysmal subarachnoid hemorrhage. Journal of neurosurgery, vol.92, no.2, 284-290.

상세보기
Shiokawa, Kazuhiko, Kasuya, Hidetoshi, Miyajima, Makoto, Izawa, Masahiro, Takakura, Kintomo. Prophylactic Effect of Papaverine Prolonged-release Pellets on Cerebral Vasospasm in Dogs. Neurosurgery, vol.42, no.1, 109-116.

상세보기
Heffez, Dan S., Leong, Kam W.. Sustained release of papaverine for the treatment of cerebral vasospasm: in vitro evaluation of release kinetics and biological activity. Journal of neurosurgery, vol.77, no.5, 783-787.

상세보기
Brauer, Patrie, Kochs, Eberhard, Werner, Christian, Bloom, Marc, Policare, Raymond, Pentheny, Susan, Yonas, Howard, Kofke, W. Andrew, am Esch, J. Schulte. Correlation of Transcranial Doppler Sonography Mean Flow Velocity with Cerebral Blood Flow in Patients with Intracranial Pathology :. Journal of neurosurgical anesthesiology, vol.10, no.2, 80-85.

상세보기

표제어: PCR

동의어: Packet Collision Rate

용어 설명 출처 목록 (6)

용어 설명: PCR은 세균 특이성이 있는 primer를 이용하여 적은 수의 세균이 있을지라도 쉽게 검출할 수 있는 유용한 방법이며, 이를 이용하여 구강 내 치면세균막이나 타액에서 직접 세균을 검출할 수 있게 되었다[8].

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관 관리번호, 논문명, 대등논문명, 저자 , 저널/프로시딩명, 발행기관, 발행년, 발행언어, 권, 호, 시작페이지, 끝페이지, ISBN, ISSN, 주제분야, 키워드, 초록(한글), 초록(영문), 저자(소속기관)
저장형식	Text(ASCII format) Excel format RefWorks Direct Export RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증

Effect of Intra-Arterial Papaverine on Regional Cerebral Blood Flow in Hemodynamically Relevant Cerebral Vasospasm 원문보기

Abstract ▼ AI-Helper

참고문헌 (39)

이 논문을 인용한 문헌

관련 콘텐츠

원문 보기

원문 URL 링크

오픈액세스(OA) 유형

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트