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Comparison of a T Cell Clone and of T Cells from a TCR Transgenic Mouse: TCR Transgenic T Cells Specific for Self-Antigen Are Atypical 원문보기

The journal of immunology : official journal of the American Association of Immunologists, v.166 no.4, 2001년, pp.2495 - 2504  

Dobbs, Cathleen M. (Department of Immunology and The Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, CO 80262) ,  Haskins, Kathryn (Department of Immunology and The Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, CO 80262)

Abstract AI-Helper 아이콘AI-Helper

AbstractIt has been widely assumed that T cells from TCR-transgenic (Tg) mice better represent the behavior of T cells from normal mice than do in vitro cultures of T cell clones. We have found that autoreactive T cells arising in the presumably more physiological environment of the BDC-2.5 TCR-Tg m...

참고문헌 (62)

  1. 10.1016/S0065-2776(08)60490-3 Kikutani, H., S. Makino. 1992. The murine autoimmune diabetes model: NOD and related strains. Adv. Immunol. 51: 285 

  2. 10.1210/edrv-15-4-516 Bach, J. F.. 1994. Insulin-dependent diabetes mellitus as an autoimmune disease. Endocr. Rev. 15: 516 

  3. 10.3181/00379727-214-44067 Bergman, B., K. Haskins. 1997. Autoreactive T-cell clones from the nonobese diabetic mouse. Proc. Soc. Exp. Biol. Med. 214: 41 

  4. 10.1002/(SICI)1099-0895(199709)13:3<127::AID-DMR192>3.0.CO;2-A Schloot, N. C., B. O. Roep. 1997. Islet antigen-specific T cell clones in autoimmune diabetes: from mice to men. Diabetes Metab. Rev. 13: 127 

  5. 10.2337/diabetes.37.10.1444 Haskins, K., M. Portas, B. Bradley, D. Wegmann, K. Lafferty. 1988. T-lymphocyte clone specific for pancreatic islet antigen. Diabetes 37: 1444 

  6. 10.1073/pnas.86.20.8000 Haskins, K., M. Portas, B. Bergman, K. Lafferty, B. Bradley. 1989. Pancreatic islet-specific T-cell clones from nonobese diabetic mice. Proc. Natl. Acad. Sci. USA 86: 8000 

  7. 10.1073/pnas.88.14.6167 Candeias, S., J. Katz, C. Benoist, D. Mathis, K. Haskins. 1991. Islet-specific T-cell clones from nonobese diabetic mice express heterogeneous T-cell receptors. Proc. Natl. Acad. Sci. USA 88: 6167 

  8. 10.2337/diabetes.43.2.197 Bergman, B., K. Haskins. 1994. Islet-specific T-cell clones from the NOD mouse respond to β-granule antigen. Diabetes 43: 197 

  9. 10.2337/diabetes.45.3.328 Peterson, J. D., K. Haskins. 1996. Transfer of diabetes in the NOD-scid mouse by CD4 T-cell clones. Differential requirement for CD8 T-cells. Diabetes 45: 328 

  10. 10.1126/science.2205920 Haskins, K., M. McDuffie. 1990. Acceleration of diabetes in young NOD mice with a CD4+ islet-specific T cell clone. Science 249: 1433 

  11. Peterson, J. D., B. Pike, A. Dallas-Pedretti, K. Haskins. 1995. Induction of diabetes with islet-specific T-cell clones is age dependent. Immunology 85: 455 

  12. 10.1006/cimm.1998.1377 Peterson, J. D., R. Berg, J. D. Piganelli, M. Poulin, K. Haskins. 1998. Analysis of leukocytes recruited to the pancreas by diabetogenic T cell clones. Cell Immunol. 189: 92 

  13. 10.1146/annurev.iy.08.040190.002531 von Boehmer, H.. 1990. Developmental biology of T cells in T cell-receptor transgenic mice. Annu. Rev. Immunol. 8: 531 

  14. 10.1016/0092-8674(93)90074-Z Goverman, J., A. Woods, L. Larson, L. P. Weiner, L. Hood, D. M. Zaller. 1993. Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity. Cell 72: 551 

  15. 10.1016/0092-8674(93)90730-E Katz, J. D., B. Wang, K. Haskins, C. Benoist, D. Mathis. 1993. Following a diabetogenic T cell from genesis through pathogenesis. Cell 74: 1089 

  16. 10.1016/0092-8674(94)90419-7 Lafaille, J. J., K. Nagashima, M. Katsuki, S. Tonegawa. 1994. High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice. Cell 78: 399 

  17. 10.1084/jem.186.7.1059 Schmidt, D., J. Verdaguer, N. Averill, P. Santamaria. 1997. A mechanism for the major histocompatibility complex-linked resistance to autoimmunity. J. Exp. Med. 186: 1059 

  18. 10.1016/S1074-7613(00)80405-7 Gonzalez, A., J. D. Katz, M.-G. Mattei, H. Kikutani, C. Benoist, D. Mathis. 1997. Genetic control of diabetes progression. Immunity 7: 873 

  19. 10.1073/pnas.94.1.213 Kurrer, M. O., S. V. Pakala, H. L. Hanson, J. D. Katz. 1997. β cell apoptosis in T cell-mediated autoimmune diabetes. Proc. Natl. Acad. Sci. USA 94: 213 

  20. 10.1111/j.1600-065X.1997.tb00959.x Pape, K. A., E. R. Kearney, A. Khoruts, A. Mondino, R. Merica, Z. M. Chen, E. Ingulli, J. White, J. G. Johnson, M. K. Jenkins. 1997. Use of adoptive transfer of T-cell-antigen-receptor-transgenic T cell for the study of T-cell activation in vivo. Immunol. Rev. 156: 67 

  21. 10.4049/jimmunol.138.10.3224 Leiter, E. H., M. Prochazka, L. D. Shultz. 1987. Effect of immunodeficiency on diabetogenesis in genetically diabetic (db/db) mice. J. Immunol. 138: 3224 

  22. 10.1126/science.2125367 Murphy, K. M., A. B. Heimberger, D. Y. Loh. 1990. Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo. Science 250: 1720 

  23. 10.1073/pnas.94.6.2438 Araki, R., A. Fujimori, K. Hamatani, K. Mita, T. Saito, M. Mori, R. Fukumura, M. Morimyo, M. Muto, M. Itoh, et al 1997. Nonsense mutation at Tyr-4046 in the DNA-dependent protein kinase catalytic subunit of severe combined immune deficiency mice. Proc. Natl. Acad. Sci. USA 94: 2438 

  24. 10.1038/268154a0 Gillis, S., K. A. Smith. 1977. Long term culture of tumour-specific cytotoxic T cells. Nature 268: 154 

  25. 10.1172/JCI119762 Arreaza, G. A., M. J. Cameron, A. Jaramillo, B. M. Gill, D. Hardy, K. B. Laupland, M. J. Rapoport, P. Zucker, S. Chakrabarti, S. W. Chensue, et al 1997. Neonatal activation of CD28 signaling overcomes T cell anergy and prevents autoimmune diabetes by an IL-4-dependent mechanism. J. Clin. Invest. 100: 2243 

  26. 10.1002/eji.1830270838 Farber, D. L., O. Acuto, K. Bottomly. 1997. Differential T cell receptor-mediated signaling in naive and memory CD4 T cells. Eur. J. Immunol. 27: 2094 

  27. 10.4049/jimmunol.163.6.3053 Ahmadzadeh, M., S. F. Hussain, D. L. Farber. 1999. Effector CD4 T cells are biochemically distinct from the memory subset: evidence for long-term persistence of effectors in vivo. J. Immunol. 163: 3053 

  28. 10.1016/S0041-1345(99)00012-3 Duke, R. C., E. Newell, M. Schleicher, S. Meech, D. Bellgrau. 1999. Transplantation of cells and tissues expressing Fas ligand. Transplant Proc. 31: 1479 

  29. 10.1038/sj.cdd.4400477 Hedlund, T. E., S. J. Meech, S. Srikanth, A. S. Kraft, G. J. Miller, J. B. Schaack, R. C. Duke. 1999. Adenovirus-mediated expression of Fas ligand induces apoptosis of human prostate cancer cells. Cell Death Differ. 6: 175 

  30. 10.1084/jem.177.1.195 Rouvier, E., M. F. Luciani, P. Golstein. 1993. Fas involvement in Ca2+-independent T cell-mediated cytotoxicity. J. Exp. Med. 177: 195 

  31. 10.1084/jem.186.2.299 Pakala, S. V., M. O. Kurrer, J. D. Katz. 1997. T helper 2 (Th2) T cells induce acute pancreatitis and diabetes in immune-compromised nonobese diabetic (NOD) mice. J. Exp. Med. 186: 299 

  32. 10.1016/0008-8749(91)90020-C Lee, W. T., E. S. Vitetta. 1991. The differential expression of homing and adhesion molecules on virgin and memory T cells in the mouse. Cell Immunol. 132: 215 

  33. 10.1126/science.272.5258.60 Butcher, E. C., L. J. Picker. 1996. Lymphocyte homing and homeostasis. Science 272: 60 

  34. 10.1016/S0049-0172(96)80034-5 McMurray, R. W.. 1996. Adhesion molecules in autoimmune disease. Semin. Arthritis Rheum. 25: 215 

  35. 10.4049/jimmunol.156.9.3111 Abitorabi, M. A., C. R. Mackay, E. H. Jerome, O. Osorio, E. C. Butcher, D. J. Erle. 1996. Differential expression of homing molecules on recirculating lymphocytes from sheep gut, peripheral, and lung lymph. J. Immunol. 156: 3111 

  36. 10.1093/intimm/6.2.263 Strauch, U. G., A. Lifka, U. Gosslar, P. J. Kilshaw, J. Clements, B. Holzmann. 1994. Distinct binding specificities of integrins α4β7 (LPAM-1), α4β1 (VLA-4), and αIELβ7. Int. Immunol. 6: 263 

  37. 10.1083/jcb.114.2.343 Berg, E. L., M. K. Robinson, R. A. Warnock, E. C. Butcher. 1991. The human peripheral lymph node vascular addressin is a ligand for LECAM-1, the peripheral lymph node homing receptor. J. Cell Biol. 114: 343 

  38. 10.4049/jimmunol.153.9.3847 Andrew, D. P., C. Berlin, S. Honda, T. Yoshino, A. Hamann, B. Holzmann, P. J. Kilshaw, E. C. Butcher. 1994. Distinct but overlapping epitopes are involved in α4β7-mediated adhesion to vascular cell adhesion molecule-1, mucosal addressin-1, fibronectin, and lymphocyte aggregation. J. Immunol. 153: 3847 

  39. 10.1038/304030a0 Gallatin, W. M., I. L. Weissman, E. C. Butcher. 1983. A cell-surface molecule involved in organ-specific homing of lymphocytes. Nature 304: 30 

  40. 10.4049/jimmunol.153.6.2787 Miskovsky, E. P., A. Y. Liu, W. Pavlat, R. Viveen, P. E. Stanhope, D. Finzi, W. M. Fox, III, R. H. Hruban, E. R. Podack, R. F. Siliciano. 1994. Studies of the mechanisms of cytolysis by HIV-1-specific CD4+ human CTL clones induced by candidate AIDS vaccines. J. Immunol. 153: 2787 

  41. 10.4049/jimmunol.156.1.153 Williams, N. S., V. H. Engelhard. 1996. Identification of a population of CD4+ CTL that use a perforin- rather than a Fas ligand-dependent cytotoxic mechanism. J. Immunol. 156: 153 

  42. 10.4049/jimmunol.159.5.2091 Williams, N. S., V. H. Engelhard. 1997. Perforin-dependent cytotoxic activity and lymphokine secretion by CD4+ T cells are regulated by CD8+ T cells. J. Immunol. 159: 2091 

  43. 10.1046/j.1365-2249.1999.01037.x Xanthou, G., N. I. Tapinos, M. Polihronis, I. P. Nezis, L. H. Margaritis, H. M. Moutsopoulos. 1999. CD4 cytotoxic and dendritic cells in the immunopathologic lesion of Sjogren’s syndrome. Clin. Exp. Immunol. 118: 154 

  44. 10.4049/jimmunol.162.10.6100 Yasukawa, M., H. Ohminami, Y. Yakushijin, J. Arai, A. Hasegawa, Y. Ishida, S. Fujita. 1999. Fas-independent cytotoxicity mediated by human CD4+ CTL directed against herpes simplex virus-infected cells. J. Immunol. 162: 6100 

  45. Berke, G., D. Rosen. 1987. Are lytic granules and perforin 1 involved in lysis induced by in vivo-primed peritoneal exudate cytolytic T lymphocytes?. Transplant Proc. 19: 412 

  46. 10.1093/oxfordjournals.jbchem.a122045 Ishiura, S., H. Anraku, I. Kamo, H. Koizumi, K. Arahata, H. Sugita. 1987. Isolation of a Ca-dependent erythrolytic protein (perforin) from cytotoxic T-lymphocytes. J. Biochem. 102: 9 

  47. 10.1172/JCI8185 Amrani, A., J. Verdaguer, S. Thiessen, S. Bou, P. Santamaria. 2000. IL-1α, IL-1β, and IFN-γ mark β cells for Fas-dependent destruction by diabetogenic CD4+ T lymphocytes. J. Clin. Invest. 105: 459 

  48. 10.1084/jem.189.7.1053 Pakala, S. V., M. Chivetta, C. B. Kelly, J. D. Katz. 1999. In autoimmune diabetes the transition from benign to pernicious insulitis requires an islet cell response to tumor necrosis factor α. J. Exp. Med. 189: 1053 

  49. 10.1182/blood.V90.3.1124.1124_1124_1132 Delneste, Y., P. Jeannin, L. Potier, P. Romero, J. Y. Bonnefoy. 1997. N-acetyl-l-cysteine exhibits antitumoral activity by increasing tumor necrosis factor α-dependent T-cell cytotoxicity. Blood 90: 1124 

  50. Cohen, I. R.. 1985. T lymphocyte clones and experimental autoimmune diseases. Behring Inst. Mitt. 77: 88 

  51. 10.1073/pnas.89.8.3434 Maki, T., T. Ichikawa, R. Blanco, J. Porter. 1992. Long-term abrogation of autoimmune diabetes in nonobese diabetic mice by immunotherapy with anti-lymphocyte serum. Proc. Natl. Acad. Sci. USA 89: 3434 

  52. 10.4049/jimmunol.140.1.52 Miller, B. J., M. C. Appel, J. J. O’Neil, L. S. Wicker. 1988. Both the Lyt-2+ and L3T4+ T cell subsets are required for the transfer of diabetes in nonobese diabetic mice. J. Immunol. 140: 52 

  53. 10.1002/eji.1830220931 Yagi, H., M. Matsumoto, K. Kunimoto, J. Kawaguchi, S. Makino, M. Harada. 1992. Analysis of the roles of CD4+ and CD8+ T cells in autoimmune diabetes of NOD mice using transfer to NOD athymic nude mice. Eur. J. Immunol. 22: 2387 

  54. 10.2337/diabetes.42.1.44 Christianson, S. W., L. D. Shultz, E. H. Leiter. 1993. Adoptive transfer of diabetes into immunodeficient NOD-scid/scid mice: relative contributions of CD4+ and CD8+ T-cells from diabetic versus prediabetic NOD.NON-Thy-1a donors. Diabetes 42: 44 

  55. 10.2337/diabetes.35.8.855 Wicker, L. S., B. J. Miller, Y. Mullen. 1986. Transfer of autoimmune diabetes mellitus with splenocytes from nonobese diabetic (NOD) mice. Diabetes 35: 855 

  56. 10.1172/JCI117153 Baron, J. L., E. P. Reich, I. Visintin, C. A. Janeway, Jr. 1994. The pathogenesis of adoptive murine autoimmune diabetes requires an interaction between α4-integrins and vascular cell adhesion molecule-1. J. Clin. Invest. 93: 1700 

  57. 10.2337/diabetes.45.9.1173 Hanninen, A., M. Salmi, O. Simell, S. Jalkanen. 1996. Mucosa-associated (β7-integrinhigh) lymphocytes accumulate early in the pancreas of NOD mice and show aberrant recirculation behavior. Diabetes 45: 1173 

  58. 10.1007/978-3-642-71987-5_5 Michie, S. A., H. K. Sytwu, J. O. McDevitt, X. D. Yang. 1998. The roles of α4-integrins in the development of insulin-dependent diabetes mellitus. Curr. Top. Microbiol. Immunol. 231: 65 

  59. 10.1002/eji.1830250605 Lepault, F., M. C. Gagnerault, C. Faveeuw, H. Bazin, C. Boitard. 1995. Lack of L-selectin expression by cells transferring diabetes in NOD mice: insights into the mechanisms involved in diabetes prevention by Mel-14 antibody treatment. Eur. J. Immunol. 25: 1502 

  60. 10.2337/diab.45.1.71 Shimada, A., P. Rohane, C. G. Fathman, B. Charlton. 1996. Pathogenic and protective roles of CD45RBlow CD4+ cells correlate with cytokine profiles in the spontaneously autoimmune diabetic mouse. Diabetes 45: 71 

  61. 10.4049/jimmunol.160.12.6018 Hanninen, A., I. Jaakkola, S. Jalkanen. 1998. Mucosal addressin is required for the development of diabetes in nonobese diabetic mice. J. Immunol. 160: 6018 

  62. 10.1016/S0167-5699(99)01468-1 Brandtzaeg, P., I. N. Farstad, G. Haraldsen. 1999. Regional specialization in the mucosal immune system: primed cells do not always home along the same track. Immunol. Today 20: 267 

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