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Matrix Attachment Region-Dependent Function of the Immunoglobulin μ Enhancer Involves Histone Acetylation at a Distance without Changes in Enhancer Occupancy 원문보기

Molecular and cellular biology, v.21 no.1, 2001년, pp.196 - 208  

Fernández, Luis A. (Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, California 94143) ,  Winkler, Michael (Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, California 94143) ,  Grosschedl, Rudolf (Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, California 94143)

Abstract AI-Helper 아이콘AI-Helper

ABSTRACT Nuclear matrix attachment regions (MARs), which flank the immunoglobulin μ heavy-chain enhancer on either side, are required for the activation of the distal variable-region (V H ) promoter in transgenic mice. Previously, we have shown that the MARs extend a local domain of chromatin acc...

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