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[해외논문] Immunogenetic analysis reveals that epitope shifting occurs during B-cell affinity maturation in primary biliary cirrhosis

Journal of molecular biology, v.306 no.1, 2001년, pp.37 - 46  

Potter, K.N. ,  Thomson, R.K. ,  Hamblin, A. ,  Richards, S.D. ,  Lindsay, J. ,  Stevenson, F.K.

Abstract AI-Helper 아이콘AI-Helper

Primary biliary cirrhosis (PBC) is a liver disease characterized by serum autoantibodies against the pyruvate dehydrogenase complex (PDC) located in the inner mitochondrial membrane. The predominant target in PDC has previously been localized to the inner lipoyl domain (ILD) of the E2 subunit. The e...

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참고문헌 (34)

  1. J. Hepatol. Butler 17 408 1993 10.1016/S0168-8278(05)80225-9 M2 mitochondrial antibodies and urinary rough mutant bacteria in patients with primary biliary cirrhosis and in patients with recurrent bacteriuria 

  2. J. Immunol. Chapman 151 1051 1993 10.4049/jimmunol.151.2.1051 Autoanti-red cell antibodies synthesized by patients with infectious monocuclesis utilize the V4-21 gene segment 

  3. J. Autoimmun. Chen 11 151 1998 10.1006/jaut.1998.0188 Natural and disease associated autoantibodies to the autoantigen, dihydrolipoamide acetyltransferase, recognize different epitopes 

  4. Proc. Natl Acad. Sci. USA Coppel 85 8654 1988 10.1073/pnas.85.19.7317 Primary structure of the human M2 mitochondrial autoantigen of primary biliary cirrhosis 

  5. J. Mol. Biol. Dardel 229 1037 1993 10.1006/jmbi.1993.1103 Three-dimensinal structure of the lipoyl domain from Bacillus stearothermophilus pyruvate dehydrogenase complex 

  6. J. Cell. Biol. Davidson 109 85 1989 10.1083/jcb.109.1.85 Epitope directed processing of specific antigen by B lymphocytes 

  7. J. Immunol. Eulitz 154 3256 1995 10.4049/jimmunol.154.7.3256 Distinctive serologic, chemical, and molecular properties of human λIV light chains 

  8. J. Biol. Chem. Fujiwara 267 20011 1992 10.1016/S0021-9258(19)88657-X Expression of mature bovine H-protein of the glycine cleavage system in Escherichia coli and in vitro lipoylation of the apoform 

  9. Proc. Natl Acad. Sci. USA Fussey 85 8654 1988 10.1073/pnas.85.22.8654 Identification and analysis of the major M2 autoantigens in primary biliary cirrhosis 

  10. FEBS Letters Fussey 246 49 1989 10.1016/0014-5793(89)80251-0 Characterization of the reactivity of autoantibodies in primary biliary cirrhosis 

  11. Gastroenterology Gershwin 100 822 1991 10.1016/0016-5085(91)80033-6 Primary biliary cirrhosis 

  12. J. Immunol. Gershwin 138 3525 1987 10.4049/jimmunol.138.10.3525 Identification and specificity of a cDNA encoding the 70 kd mitochondrial antigen recognized in primary biliary cirrhosis 

  13. J. Biol. Chem. Griffin 265 13174 1990 10.1016/S0021-9258(19)38282-1 Genetic reconstruction and characterisation of the recombinant transketolase (E2b) component of bovine branched-chain α-keto acid dehydrogenase complex 

  14. Gene Ho 77 51 1989 10.1016/0378-1119(89)90358-2 Site-directed mutagenesis by overlap extension using the polymerase chain reaction 

  15. Nucl. Acids Res Hoogenboom 19 4133 1991 10.1093/nar/19.15.4133 Multi-subunit proteins on the surface of filamentous phage 

  16. Gene Horton 77 61 1989 10.1016/0378-1119(89)90359-4 Engineering hybrid genes without the use of restriction enzymes 

  17. Gastroenterology Howard 115 139 1998 10.1016/S0016-5085(98)70375-0 Three-dimensional structure of the major autoantigen in primary biliary cirrhosis 

  18. Clin. Sci. Jones 91 551 1996 10.1042/cs0910551 T-cell autoimmunity in primary biliary cirrhosis 

  19. J. Autoimmun. Leung 5 703 1992 10.1016/0896-8411(92)90187-U Characterization and epitope mapping of human monoclonal antibodies to PDC-E2 the immunodominant autoantigen of primary biliary cirrhosis 

  20. J. Autoimmun. Leung 9 119 1996 10.1006/jaut.1996.0015 Molecular aspects and the pathological basis of primary biliary cirrhosis 

  21. Immunol. Rev. Mamula 164 231 1998 10.1111/j.1600-065X.1998.tb01223.x Epitope spreading 

  22. Hepatology Matsui 18 1069 1993 10.1002/hep.1840180509 Human monoclonal antibodies from a patient with primary biliary cirrhosis that recognize two distinct autoepitopes in the E2 component of the pyruvate dehydrogenase complex 

  23. J. Immunol. Mockridge 157 2449 1996 10.4049/jimmunol.157.6.2449 Use of phage surface expression to analyze regions of a human V4-34 (VH 4-21)-encoded IgG autoantibody required for recognition of DNA. No involvement of the 9G4 idiotope 

  24. J. Immunol. Pascual 152 2577 1994 10.4049/jimmunol.152.5.2577 Nucleotide sequence analysis of natural and combinatorial anti-PDC-E2 antibodies in patients with primary biliary cirrhosis. Recapitulating immune selection with molecular biology 

  25. Int. Rev. Immunol. Potter 14 291 1997 10.3109/08830189709116521 Staphylococcal protein A binding to VH3 encoded immunoglobulins 

  26. Int. Immunol. Rowley 4 1245 1992 10.1093/intimm/4.11.1245 Differing epitope selection of experimentally-induced and natural antibodies to a disease-specific autoantigen, the E2 subunit of pyruvate dehydrogenase complex. (PDC-E2) 

  27. J. Mol. Biol. Sanger 143 161 1980 10.1016/0022-2836(80)90196-5 Cloning in single-stranded bacteriophage as an aid to rapid DNA sequencing 

  28. J. Immunol. Surh 144 3367 1990 10.4049/jimmunol.144.9.3367 Structural requirement for autoreactivity on human pyruvate dehyrodgenase-E2, the major autoantigen of primary biliary cirrhosis 

  29. FEBS Letters Thekkumkara 240 45 1988 10.1016/0014-5793(88)80337-5 Nucleotide sequence of a cDNA for the dihydrolipoamide acetyltransferase component of human pyruvate deydrogenase complex 

  30. J. Hepatol. Thomson 28 582 1998 10.1016/S0168-8278(98)80281-X Immunogenetic analysis of a panel of monoclonal IgG and IgM anti-PDC-E2/X antibodies derived from patients with primary biliary cirrhosis 

  31. Clin. Expt. Immunol. Uibo 80 19 1990 10.1111/j.1365-2249.1990.tb06435.x Inhibition of enzyme function by human autoantibodies to an autoantigen pyruvate dehydrogenase E2 

  32. J. Clin. Invest. Van de Water 91 2653 1993 10.1172/JCI116504 Molecular mimicry in primary biliary cirrhosis. Evidence for biliary epithelial expression of a molecule cross-reactive with pyruvate dehydrogenase complex-E2 

  33. Lancet Yeaman 1 1067 1988 10.1016/S0140-6736(88)91894-6 Primary biliary cirrhosis 

  34. Brit. J. Haematol. Zhu 107 114 1999 10.1046/j.1365-2141.1999.01679.x VH gene sequences from a novel tropical splenic lymphoma reveal a naive B cell as the cell of origin 

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