[논문]Agouti-related protein is a mediator of diabetic hyperphagia

doi:10.1016/S0167-0115(00)00230-5

[해외논문] Agouti-related protein is a mediator of diabetic hyperphagia

Regulatory peptides, v.98 no.1/2, 2001년, pp.69 - 75

Qu, Song-Yi (Corresponding author. Present address: Department of Physiology, Lanzhou Medical College, Gansu Province, People’) , Yang, Ying-Kui (s Republic of China) , Li, Ji-Yao (Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA) , Zeng, Qun (Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA) , Gantz, Ira (Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA)

Abstract ▼ AI-Helper

AbstractTo explore the role of agouti-related protein (AGRP) in diabetic hyperphagia changes in hypothalamic AGRP mRNA levels were examined in diabetic rats. Rats rendered diabetic by streptozotocin displayed marked hyperglycemia (blood glucose 456.0±8.4 mg/dl versus 71.8±1.9 mg/dl) and hyperphagia (36.9±1.0 g/day versus 22.0±0.4 g/day), that was associated with a 286.6±4.4% increase in hypothalamic AGRP mRNA and a 178.9±13.5% increase in hypothalamic NPY mRNA. Insulin treatment of diabetic rats partially corrected blood glucose (147.4±13.1 mg/dl) and ameliorated hyperphagia (26.6±2.0 g/day). Insulin replacement was also associated with a return of hypothalamic AGRP mRNA (111.7±8.3% of controls) and NPY mRNA (125.0±8.9% of controls) from the elevated levels that were observed in untreated diabetic rats. In contrast to insulin treated rats, sodium orthovanadate treated diabetic rats remained significantly hyperglycemic (361.5±12.5 mg/dl). However, despite their persistent hyperglycemia, orthovanadate treated diabetic rats were still observed to have a significant reduction of hypothalamic AGRP mRNA (138.7±11.4%) and NPY mRNA (129.9±9.8%). Simultaneous measurement of serum leptin revealed suppressed levels in both untreated diabetic (0.5±0.1 ng/ml) and sodium orthovanadate treated rats (0.5±0.1 ng/ml) compared to non-diabetic controls (2.1±0.1 ng/ml). These data indicate that AGRP is a mediator of diabetic hyperhpagia and suggest that insulin can directly influence hypothalamic AGRP and NPY mRNA expression.

주제어

참고문헌 (34)

Peptides McKibbin 13 721 1992 10.1016/0196-9781(92)90178-6 Insulin deficiency is a specific stimulus to hypothalamic neuropeptide Y: a comparison of the effects of insulin replacement and food restriction in streptozocin-diabetic rats

상세보기
Diabetologia Marks 36 497 1993 10.1007/BF02743264 Effects of streptozotocin-induced diabetes mellitus and insulin treatment on neuropeptide Y mRNA in the rat hypothalamus

상세보기
Diabetes Sipols 44 147 1995 10.2337/diabetes.44.2.147 Effect of intracerebroventricular insulin infusion on diabetic hyperphagia and hypothalamic neuropeptide gene expression

상세보기
Endocrinology Dumontell 139 4540 1998 10.1210/en.139.11.4540 Insulin, but not glucose lowering corrects the hyperglucagonemia and increased proglucagon messenger ribonucleic acid levels observed in insulinopenic diabetes
Diabetes Sindelar 48 1275 1999 10.2337/diabetes.48.6.1275 Low plasma leptin levels contribute to diabetic hyperphagia in rats

상세보기
Am. J. Physiol. Kim 276 R1320 1999 STZ-induced diabetes decreases and insulin normalizes POMC mRNA in arcuate nucleus and pituitary in rats
Diabetes Havel 49 244 2000 10.2337/diabetes.49.2.244 Effects of streptozotocin-induced diabetes and insulin treatment on the hypothalamic melanocortin system and muscle uncoupling protein 3 expression in rats

상세보기
Nature Schwartz 404 661 2000 10.1038/35007534 Central nervous system control of food intake

상세보기
Am. J. Physiol. Levine R1223 1999 Brain glucose sensing and body energy homeostasis: role in obesity and diabetes
Endocrinology Mizuno 140 4551 1999 10.1210/en.140.10.4551 Fasting regulates hypothalamic neuropeptide Y, agouti-related peptide, and pro-opiomelanocortin in diabetic mice independent of changes in leptin or insulin
Genes Develop. Shutter 11 593 1997 10.1101/gad.11.5.593 Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice

상세보기
Biochem. Biophys. Res. Commun. Fong 237 629 1997 10.1006/bbrc.1997.7200 ART (protein product of agouti-related transcript) as an antagonist of MC-3 and MC-4 receptors

상세보기
Science Ollmann 278 135 1997 10.1126/science.278.5335.135 Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein

상세보기
Biochem. Biophys. Res. Commun. Harold 258 574 1999 10.1006/bbrc.1999.0675 Changes in hypothalamic agouti-related protein (AGRP), but not α-MSH or pro-opiomelanocortin concentrations in dietary-obese and food-restricted rats

상세보기
Diabetes Kim 49 177 2000 10.2337/diabetes.49.2.177 Hypothalamic localization of the feeding effect of agouti-related peptide and α-melanocyte-stimulating hormone

상세보기
Nature Neurosci. Hahn 1 271 1998 10.1038/1082 Coexpression of AGRP and NPY in fasting-activated hypothalamic neurons

상세보기
Mol. Endocrinol. Yang 13 148 1999 10.1210/me.13.1.148 Characterization of agouti-related protein binding to melanocortin receptors

상세보기
J. Neurosci. Grill 18 10128 1998 10.1523/JNEUROSCI.18-23-10128.1998 Brainstem application of melanocortin receptor ligands produces long-lasting effects on feeding and body weight

상세보기
Endocrinology Wilson 140 2387 1999 10.1210/en.140.5.2387 Physiological and anatomical circuitry between agouti-related protein and leptin signaling

상세보기
Endocrinology Mizuno 140 814 1999 10.1210/en.140.2.814 Hypothalamic agouti-related protein messenger ribonucleic acid is inhibited by leptin and stimulated by fasting

상세보기
Diabetes Ebihara 48 2028 1999 10.2337/diabetes.48.10.2028 Involvement of agouti-related protein, an endogenous antagonist of hypothalamic melanocortin receptor in leptin action

상세보기
Endocrinology Li 141 1942 2000 10.1210/en.141.6.1942 Agouti-related protein-like immunoreactivitiy: characterization of release from hypothalamic tissue and presence in serum

상세보기
Endocrinology Marks 127 3234 1990 10.1210/endo-127-6-3234 Localization of insulin receptor mRNA in rat brain by in situ hybridization

상세보기
Prog. Neurobiol. Unger 36 343 1991 10.1016/0301-0082(91)90015-S Insulin receptors in the central nervous system: localization, signalling mechanisms and functional aspects

상세보기
Endocrinology Schwartz 128 2645 1991 10.1210/endo-128-5-2645 Central insulin administration reduces neuropeptide Y mRNA expression in the arcuate nucleus of food-reprived lean (Fa/Fa) but not obese (fa/fa) zucker rats

상세보기
Endocrinology Schwartz 130 3608 1992 10.1210/en.130.6.3608 Inhibition of hypothalamic neuropeptide Y gene expression by insulin

상세보기
Endocrinology Sahu 136 5718 1995 10.1210/en.136.12.5718 Insulin and insulin-like growth factor II suppress neuropeptide Y release from the nerve terminals in the paraventricular nucleus: a putative hypothalamic site for energy homeostasis

상세보기
Endocrinology Sahu 131 2979 1992 10.1210/en.131.6.2979 Neuropeptide Y release from the paraventricular nucleus increases in association with hyperphagia in streptozotocin-induced diabetic rats

상세보기
Brain Res. Sahu 755 339 1997 10.1016/S0006-8993(97)00192-3 Evidence that hypothalamic neuropeptide Y gene expression and NPY levels in the paraventricular nucleus increase before the onset of hyperphagia in experimental diabetes

상세보기
Mol. Cell. Biochem. Goldfine 153 217 1995 10.1007/BF01075941 In vivo and in vitro studies of vanadate in human and rodent diabetes mellitus

상세보기
Diabetes Shechter 39 1 1990 10.2337/diabetes.39.1.1 Insulin-mimetic effects of vanadate, possible implications for future treatment of diabetes

상세보기
Science Elchebly 283 1544 1999 10.1126/science.283.5407.1544 Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene

상세보기
Biochem. Pharm. Kennedy 60 877 2000 10.1016/S0006-2952(00)00305-1 Protein tyrosine phosphatase-1B in diabetes

상세보기
Eur. J. Endocrinol. Wauters 143 293 2000 10.1530/eje.0.1430293 Human leptin: from an adipocyte hormone to an endocrine mediator

상세보기

원문 URL 링크

DOI : 10.1016/S0167-0115(00)00230-5
Elsevier : 저널 > 논문

*원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다.

ScienceON TREND 당뇨병, 당뇨

저작권 관리 안내

내보내기 메뉴

내보내기 구분

파일저장
인쇄
메일전송

구성항목

기본정보
상세정보

관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관

저장형식

Text(ASCII format)
Excel format
RefWorks Direct Export
RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley

메일정보

받는사람 (필수): @
보내는사람 (선택): @
제목
내용: KISTI 검색결과 이메일 서비스

안내

총 건의 자료가 검색되었습니다.

다운받으실 자료의 인덱스를 입력하세요. (1-10,000)

검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다.

데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요)

다운로드 파일은 UTF-8 형태로 저장됩니다.
파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오.

Text(ASCII format)
Excel format

표제어: PCR

동의어: Packet Collision Rate

용어 설명 출처 목록 (6)

용어 설명: PCR은 세균 특이성이 있는 primer를 이용하여 적은 수의 세균이 있을지라도 쉽게 검출할 수 있는 유용한 방법이며, 이를 이용하여 구강 내 치면세균막이나 타액에서 직접 세균을 검출할 수 있게 되었다[8].

AI-Helper ※ AI-Helper는 을 사용합니다.

AI-Helper

안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

연합인증

[해외논문] Agouti-related protein is a mediator of diabetic hyperphagia

Abstract ▼ AI-Helper

주제어

참고문헌 (34)

이 논문을 인용한 문헌

관련 콘텐츠

원문 URL 링크

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관 관리번호, 논문명, 대등논문명, 저자 , 저널/프로시딩명, 발행기관, 발행년, 발행언어, 권, 호, 시작페이지, 끝페이지, ISBN, ISSN, 주제분야, 키워드, 초록(한글), 초록(영문), 저자(소속기관)
저장형식	Text(ASCII format) Excel format RefWorks Direct Export RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format