[논문]Neuroprotective effect of green tea extract in experimental ischemia-reperfusion brain injury

doi:10.1016/S0361-9230(00)00348-8

[해외논문] Neuroprotective effect of green tea extract in experimental ischemia-reperfusion brain injury

Brain research bulletin, v.53 no.6, 2000년, pp.743 - 749

Hong, Jin Tae (National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul, South Korea) , Ryu, Seung Rel (National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul, South Korea) , Kim, Hye Jin (National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul, South Korea) , Lee, Jong Kwon (National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul, South Korea) , Lee, Sun Hee (National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul, South Korea) , Kim, Dai Byung (National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul, South Korea) , Yun, Yeo Pyo (College of Pharmacy, Chungbuk National University, Chungbuk, South Korea) , Ryu, Jong Hoon (College of Pharmacy, Kyung Hee University, Seoul, South Korea) , Lee, Byung Mu (Division of Toxicology, College of Pharmacy, SengKyunKwan University, Kyunggido, South Korea) , Kim, Pu Young (National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul, South Korea)

Abstract ▼ AI-Helper

AbstractEicosanoids accumulation and formation of oxygen free radicals have been implicated in the pathogenesis of ischemia/reperfusion brain injury. In the present study, we examined whether green tea extract protects against ischemia/reperfusion-induced brain injury by minimizing eicosanoid accumulation and oxygen radical-induced oxidative damage in the brain. Green tea extract (0.5%) was orally administered to Wistar rats for 3 weeks before induction of ischemia. Ischemia was induced by the occlusion of middle cerebral arteries for 60 min and reperfusion was achieved for 24 h. Infarction volume in the ipsilateral hemisphere of ischemia/reperfusion animals was 114 ± 16 mm3 in the 0.5% green tea pretreated animals compared to 180 ± 54 mm3 in left hemisphere of nontreated animals. Green tea extract (0.5%) also reduced ischemia/reperfusion-induced eicosanoid concentration: Leukotriene C4 (from 245 ± 51 to186 ± 22), prostoglandin E2 (from 306 ± 71 to 212 ± 43) and thromboxane A2 (327 ± 69 to 251 ± 87 ng/mg protein). Ischemia/reperfusion-induced increases of hydrogen peroxide level (from 688 ± 76 to 501 ± 99 nmole/mg protein), lipid peroxidation products (from 1010 ± 110 to 820 ± 70 nmole/mg protein) and 8-oxodG formation (from 1.3 ± 0.3 to 0.8 ± 0.2 ng/μg DNA, ×10−2) were also reduced. Moreover, 0.5% green tea extract also reduced the apoptotic cell number (from 44 ± 11 to 29 ± 1 in the striatum, and from 72 ± 11 to 42 ± 5 apoptotic cells/high power field in the cortex region). Green tea extract pretreatment also promoted recovery from the ischemia/reperfusion-induced inhibition of active avoidance. The present study shows that the minimizing effect of green tea extract on the eicosanoid accumulation and oxidative damage in addition to the reduction of neuronal cell death could eventually result in protective effect on the ischemia/reperfusion-induced brain injury and behavior deficit.

주제어

참고문헌 (27)

Am. J. Cardiol. Albers 75 6 34B 1995 10.1016/0002-9149(95)80008-G Antithrombotic agents in cerebral ischemia

상세보기
J. Neurosurg. Baskaya 85 112 1996 10.3171/jns.1996.85.1.0112 Protective effect of the 5-lipoxygenase inhibitor AA-861 on cerebral edema after transient ischemia

상세보기
J. Thromb. Thrombolysis Bednar 1 179 1995 10.1007/BF01062576 Neutrophil and platelet activity and quantification following delayed tPA therapy in a rabbit model of thromboembolic stroke

상세보기
Brain Res. Block 694 308 1995 10.1016/0006-8993(95)00821-7 The antioxidant LY 231617 ameliorates functional and morphological sequelae induced by global ischemia in rats

상세보기
Cancer Lett. Cho 74 141 1993 10.1016/0304-3835(93)90235-2 Organotropic formation and disappearance of 8-hydroxydeoxyguanosine in the kidney of Sprague-Dawley rats exposed to adriamycin and KBrO3

상세보기
Neurol. Res. Dempsey 8 53 1986 10.1080/01616412.1986.11739731 Lipoxygenase metabolites of arachidonic acid and the development of ischaemic cerebral oedema
Proc. Natl. Acad. Sci. Haqqi 96 4524 1999 10.1073/pnas.96.8.4524 Prevention of collagen-induced arthritis in mice by a polyphenolic fraction from green tea

상세보기
Neurosci. Lett. Hara 256 53 1998 10.1016/S0304-3940(98)00755-1 Effect of selective inhibition of cyclooxygenase 2 on temporary focal cerebral ischemia in rats

상세보기
J. Cell. Physiol. Hong 169 309 1996 10.1002/(SICI)1097-4652(199611)169:2<309::AID-JCP10>3.0.CO;2-4 Comitogenicity of eicosanoids and the peroxisome proliferator ciprofibrate in cultured rat hepatocytes

상세보기
Thromb. Res. Kang 96 229 1999 10.1016/S0049-3848(99)00104-8 Antithrombotic activities of green tea catechins and (？)-epigallocatechin gallate

상세보기
Neurol. Clin. Kasner 16 355 1998 10.1016/S0733-8619(05)70068-2 Ischemic stroke

상세보기
J. Neurosci. Kruman 17 5089 1997 10.1523/JNEUROSCI.17-13-05089.1997 Evidence that 4-hydroxynonenal mediates oxidative stress-induced neuronal apoptosis

상세보기
J. Neurosurg. Anesthesiol. Lijima 8 237 1996 10.1097/00008506-199607000-00009 Thromboxane synthetase inhibitor ameliorates delayed neuronal death in the CA1 subfield of the hippocampus after transient global ischemia in gerbils

상세보기
Am. J. Physiol. Littleton-Kearney 274 4 Pt. 2 H1293 1998 Incomplete global cerebral ischemia alters platelet biology in neonatal and adult sheep
Brain Res. Matsuo 709 296 1996 10.1016/0006-8993(95)01324-5 Role of platelet-activating factor and thromboxane A2 in radical production during ischemia and reperfusion of the rat brain

상세보기
Acta Neurochir. Namura 60 296 1994 LTC4/LTB4 alterations in rat forebrain ischemia and reperfusion and effects of AA-861, CV-3988
Brain Res. Ohtsuki 736 353 1996 10.1016/0006-8993(96)00948-1 Induction of cyclooxygenase-2 mRNA in gerbil hippocampal neurons after transient forebrain ischemia

상세보기
Brain Res. Patel 614 315 1993 10.1016/0006-8993(93)91050-3 Effect of ibuprofen on regional eicosanoid production and neuronal injury after forebrain ischemia in rats

상세보기
J. Neurochem. Petroni 53 747 1989 10.1111/j.1471-4159.1989.tb11768.x Accumulation of arachidonic acid cyclo- and lipoxygenase products in rat brain during ischemia and reperfusion

상세보기
Neurosci. Lett. Phillis 116 315 1990 10.1016/0304-3940(90)90093-O Protection from cerebral ischemic injury in gerbils with the spin trap agent N-tert-butyl-alpha-phenylnitrone (PBN)

상세보기
Neurochem. Res. Rao 24 1225 1999 10.1023/A:1020916905312 Arachidonic acid and leukotriene C4

상세보기
FEBS Lett. Soriani 439 253 1998 10.1016/S0014-5793(98)01387-8 Modulation of the UVA activation of haem oxygenase, collagenase and cyclooxygenase gene expression by epigallocatechin in human skin cells

상세보기
Clin. Exp. Pharmacol. Physiol. Uchida 22 suppl. 1 S302 1995 10.1111/j.1440-1681.1995.tb02928.x Effects of (？)-epigallocatechin-3-O-gallate (green tea tannin) on the life span of stroke-prone spontaneously hypertensive rats

상세보기
J. Pharmacol. Exp. Ther. Watanabe 268 1597 1994 Protective effects of MCI-186 on cerebral ischemia possible involvement of free radical scavenging and antioxidant actions

상세보기
J. Cereb. Blood Flow Metab. Westerberg 7 189 1987 10.1038/jcbfm.1987.43 Regional differences in arachidonic acid release in rat hippocampal CA1 and CA3 regions during cerebral ischemia

상세보기
Brain Res. Won 836 70 1999 10.1016/S0006-8993(99)01611-X Immunohistochemical detection of oxidative DNA damage induced by ischemia-reperfusion insults in gerbil hippocampus in vivo

상세보기
J. Nutr. Sci. Vitaminol. Yang 45 337 1999 10.3177/jnsv.45.337 Effects of green tea catechin on phospholipase A2 activity and antithrombus in streptozotocin diabetic rats

상세보기

원문 URL 링크

DOI : 10.1016/S0361-9230(00)00348-8
Elsevier : 저널 > 논문

*원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다.

저작권 관리 안내

내보내기 메뉴

내보내기 구분

파일저장
인쇄
메일전송

구성항목

기본정보
상세정보

관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관

저장형식

Text(ASCII format)
Excel format
RefWorks Direct Export
RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley

메일정보

받는사람 (필수): @
보내는사람 (선택): @
제목
내용: KISTI 검색결과 이메일 서비스

안내

총 건의 자료가 검색되었습니다.

다운받으실 자료의 인덱스를 입력하세요. (1-10,000)

검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다.

데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요)

다운로드 파일은 UTF-8 형태로 저장됩니다.
파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오.

Text(ASCII format)
Excel format

표제어: PCR

동의어: Packet Collision Rate

용어 설명 출처 목록 (6)

용어 설명: PCR은 세균 특이성이 있는 primer를 이용하여 적은 수의 세균이 있을지라도 쉽게 검출할 수 있는 유용한 방법이며, 이를 이용하여 구강 내 치면세균막이나 타액에서 직접 세균을 검출할 수 있게 되었다[8].

AI-Helper ※ AI-Helper는 을 사용합니다.

AI-Helper

안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

연합인증

[해외논문] Neuroprotective effect of green tea extract in experimental ischemia-reperfusion brain injury

Abstract ▼ AI-Helper

주제어

참고문헌 (27)

이 논문을 인용한 문헌

관련 콘텐츠

원문 URL 링크

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관 관리번호, 논문명, 대등논문명, 저자 , 저널/프로시딩명, 발행기관, 발행년, 발행언어, 권, 호, 시작페이지, 끝페이지, ISBN, ISSN, 주제분야, 키워드, 초록(한글), 초록(영문), 저자(소속기관)
저장형식	Text(ASCII format) Excel format RefWorks Direct Export RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format