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NTIS 바로가기The journal of immunology : official journal of the American Association of Immunologists, v.166 no.5, 2001년, pp.3423 - 3431
Ropert, Catherine (*René) , Almeida, Igor C. (Rachou Research Center-Fundaç) , Closel, Meire (ao Oswaldo Cruz and Department of Biochemistry and Immunology, Instituto de Ciê) , Travassos, Luiz R. (ncias Bioló) , Ferguson, Michael A. J. (gicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil) , Cohen, Philip , Gazzinelli, Ricardo T. (†Department of Parasitology, Instituto de Ciê)
AbstractIn the present study, we evaluated the ability of GPI-anchored mucin-like glycoproteins purified from Trypanosoma cruzi trypomastigotes (tGPI-mucin) to trigger phosphorylation of different mitogen-activated protein kinases (MAPKs) and related transcription factors in inflammatory macrophages...
10.1126/science.272.5258.50 Fearon, D. T., R. M. Locksley. 1996. The instructive role of innate immunity in the acquired immune response. Science 272: 50
10.1146/annurev.iy.13.040195.002253 Ulevitch, R. J., P. S. Tobias. 1995. Receptor-dependent mechanisms of cell-stimulation by bacterial endotoxin. Annu. Rev. Immunol. 13: 437
10.1146/annurev.iy.13.040195.001343 Trinchieri, G.. 1995. Interleukin 12: a proinflammatory cytokine with regulatory function that bridge innate resistance and adaptive immunity. Annu. Rev. Immunol. 13: 251
10.1073/pnas.93.7.2879 Klinman, D. M., A. K. Yi, S. L. Beaucage, J. Conover, A. M. Krieg. 1996. CpG motifs present in bacteria DNA rapidly induce lymphocytes to sevrete interleukin 6, interleukin 12 and interferon γ. Proc. Natl. Acad. Sci. USA 93: 2879
10.1084/jem.185.11.1951 Muhlradt, P. F., M. Kieβ, H. Meyer, R. Suβmuth, G. Jung. 1997. Isolation, structure and synthesis of a macrophage stimulatory lipopeptide from Mycoplasma fermentans acting at picomolar concentration. J. Exp. Med. 185: 1951
10.4049/jimmunol.163.1.1 Yoshimura, A., E. Lien, R. R. Ingalls, E. Tuomanen, R. Dziarski, D. Golenbock. 1999. Recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll like receptor 2. J. Immunol. 163: 1
10.1126/science.285.5428.732 Brightbill, H. D., H. D. Libraty, S. R. Krutzick, R. B. Yang, J. T. Beliste, J. R. Bleharski, M. Maitland, M. V. Norgard, S. E. Plevy, S. T. Smale, et al 1999. Host defense mechanisms triggered by microbial lipoproteins through Toll-like receptors. Science 285: 732
10.1016/0952-7915(95)80093-X Biron, C. A., R. T. Gazzinelli. 1995. Effects of IL-12 on immune response to microbial infections: a key mediator in regulating disease outcome. Curr. Opin. Immunol. 7: 485
10.1016/S0952-7915(97)80157-4 Sharton-Kersten, T., A. Sher. 1997. Role of natural killer cells in innate resistance to protozoan infection. Curr. Opin. Immunol. 9: 44
10.1073/pnas.90.13.6115 Gazzinelli, R. T., S. Hieny, T. A. Wynn, S. Wolf, A. Sher. 1993. Interleukine-12 is required for the T-lymphocyte-independent induction of interferon-γ by an intracellular parasite and induces resistance in T-cell deficient hosts. Proc. Natl. Acad. Sci. USA 90: 6115
10.4049/jimmunol.158.12.5890 Camargo, M. M., I. C. Almeida, M. E. S. Pereira, M. A. J. Ferguson, L. R. Travassos, R.T. Gazzinelli. 1997. GPI-anchored mucin-like glycoprotein isolated from Trypanosoma cruzi initiate the synthesis of pro-inflammatory cytokines by macrophages. J. Immunol. 158: 5890
10.4049/jimmunol.159.12.6131 Camargo, M. M., A. C. Andrade, I. C. Almeida, L. R. Travassos, R. T. Gazzinelli. 1997. Glyconjugates isolated from Trypanosoma cruzi but not from Leishmania sp. parasite membranes trigger nitric oxide synthesis as well as microbicidal activity by IFN-γ-primed macrophages. J. Immunol. 159: 6131
10.1038/sj.bjp.0702624 Procopio, D. O., M. M. Teixeira, M. M. Camargo, L. R. Travassos, M. A. J. Ferguson, I. C. Almeida, R. T. Gazzinelli. 1999. Differential inhibitory mechanism of cyclic AMP on TNF-α and IL-12 synthesis by macrophages exposed to microbial stimuli. Br. J. Pharmacol. 127: 1195
10.1002/jlb.66.4.593 Ferreira, L. R. P., A. M. Silva, V. Michailowsky, L. F. L. Reis, R. T. Gazzinelli. 1999. Expression of serum amyloid A3 mRNA by inflammatory macrophages exposed to membrane glycoconjugates from Trypanosoma cruzi. J. Leukocyte Biol. 66: 593
10.1016/S1286-4579(00)00388-9 Talvani, A., C. S. Ribeiro, J. C. S. Aliberti, V. Michailowsky, P. V. A. Santos, S. M. F. Murta, A. J. Romanha, I. C. Almeida, J. Farber, J. Lannes-Vieira, J. S. Silva, R. T. Gazzinelli. 2000. Kinetics of cytokine genees expression in experimental chagasic cardiomyopathy: tissue parasitism and endogenous IFN-γ as important determinants of chemokine mRNA expression during infection with Trypanosoma cruzi. Microbes Infect. 2: 851
10.1093/emboj/19.7.1476 Almeida, I. C., M. M. Camargo, D. O. Procopio, L. S. Silva, A. Mehlert, L. R. Travassos, R. T. Gazzinelli, M. A. J. Ferguson. 2000. Highly purified glycosylphosphatidylinositols from Trypanosoma cruzi are potent proinflammatory agents. EMBO J. 19: 1476
10.1084/jem.177.1.145 Schofield, L., F. Hackett. 1993. Signal transduction in host cells by glysosylphosphatidylinositol toxin of malaria parasites. J. Exp. Med. 177: 145
10.1006/bbrc.1994.2763 Tachado, S. D., L. Schofield. 1994. Glycosylphosphatidylinositol toxin of Trypanosoma brucei regulates IL-1-α and TNF-α expression in macrophages by protein tyrosine kinase mediated signal transduction. Biochem. Biophys. Res. Commun. 205: 984
10.1016/S1369-5274(00)00111-9 Ropert, C., R. T. Gazzinelli. 2000. Signaling of immune system cells by glycosylphosphatidylinositol (GPI) anchor and related structures derived from parasitic protozoa. Curr. Opin. Microbiol. 3: 395
10.4049/jimmunol.156.5.1897 Tachado, S. D., P. Gerold, M. J. McConville, T. Baldwin, D. Quilici, R. T. Schwarz, L. Schofield. 1996. Glycophosphatidylinositol toxin of Plasmodium induces nitric oxide synthase expression in macrophages and vascular endothelial cells by a protein tyrosine kinase-dependent and protein kinase C-dependent signaling pathway. J. Immunol. 156: 1897
10.4049/jimmunol.156.5.1886 Schofield, L., S. Novakovic, P. Gerold, R. T. Schwarz, M. J. Mc Conville, S. D. Tachado. 1996. Glycosylphosphatidylinositol toxin of Plasmodium up-regulates intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and E-selectin expression in vascular endothelial cells and increases leukocyte and parasite cytoadherence via tyrosine kinase-dependent signal transduction. J. Immunol. 156: 1886
10.4049/jimmunol.160.4.1949 Magez, S., B. Stijlemans, M. Radwanska, E. Pays, M. A. Ferguson, P. Debestlier. 1998. The glycosyl-inositol-phosphate and dimyristoylglycerol moieties of the glycosylphosphatidylinositol anchor of the Trypanosoma variant-specific surface glycoprotein are distinct macrophage activating factors. J. Immunol. 160: 1949
10.1073/pnas.94.8.4022 Tachado, S. D., P. Gerold, R. Schwarz, S. Novakovic, M. McConville, L. Schofield. 1997. Signal transduction in macrophages by glycosylphosphatidylinositols of Plasmodium, Trypanosoma and Leishmania: activation of protein tyrosine kinases and protein kinase C by inositolglycan and diacylglycerol moieties. Proc. Natl. Acad. Sci. USA 94: 4022
10.1016/S0021-9258(18)42133-3 Weinstein, S. L., J. S. Sanghera, K. Lemke, A. L. DeFranco, S. L. Pelech. 1995. Bacterial lipopolysaccharide induces tyrosine phosphorylation and activation of mitogen-activated protein-kinases in macrophages. J. Biol. Chem. 267: 14955
10.1074/jbc.270.13.7420 Raingeaud, J., S. Gupta, J. S. Rogers, M. Dickens, J. Han, R. J. Ulevitch, R. J. Davis. 1995. Pro-inflammatory cytokines and environmental stress cause p38 mitogen protein kinase activation by dual phosphorylation on tyrosine and threonine. J. Biol. Chem. 270: 7420
10.1073/pnas.93.7.2774 Hambleton, J., S. L. Weinstein, L. Lem, A. L. DeFranco. 1996. Activation of c-Jun N-terminal kinase in bacterial lipopolysaccharide-stimulated macrophages. Proc. Natl. Acad. Sci. USA 93: 2774
10.1523/JNEUROSCI.18-05-01633.1998 Bhat, N. R., O. S. Zhang, J. C. Lee, E. L. Hogan. 1998. Extracellular signal regulated kinase and SAPK-2/p38 subgroups of mitogen-activated protein kinase regulate inducible oxide synthase and tumor necrosis factor α gene expression in endotoxin-stimulated primary glial cultures. J. Neuroscience 18: 1633
10.1074/jbc.271.40.24313 Kiriakis, J. M., J. Avuruch. 1996. Sounding the alarm: protein kinase cascades activated by stress and inflammation. J. Biol. Chem. 271: 24313
10.1096/fasebj.9.9.7601337 Seger, R., E. G. Krebs. 1997. The MAPK signaling cascade. FASEB J. 9: 726
10.1016/S0962-8924(97)01105-7 Cohen, P.. 1997. The search for physiological substrates of MAP and SAP kinases in mammalian cells. Trends Cell Biol. 7: 353
10.1016/S0955-0674(98)80143-9 Ip, Y. T., R. J. Davis. 1998. Signal transduction by the c-jun N-terminal kinase (JNK) from inflammation to development. Curr. Opin. Cell Biol. 10: 205
10.1016/S0304-419X(97)00018-8 Minden, A., M. Karin. 1997. Regulation and function of the JNK subgroup of MAP kinase. Biochim. Biophys. Acta 1333: F85
10.1128/MCB.17.5.2360 Whitmarsh, A. J., S. H. Yang, M. S. S. Su, A. D. Sharrocks, R. J. Davies. 1997. Role of p38 and JNK activated protein kinases in the activation of ternary complex factors. Mol. Cell Biol. 17: 2360
10.1074/jbc.270.46.27489 Alessi, D. R., A. Cuenda, P. Cohen, D. T. Dudley, A. R. Saltiel. 1995. PD 98059 is a specific inhibitor of the activation of mitogen activated protein kinase in vitro and in vivo. J. Biol. Chem. 270: 27289
10.1016/0014-5793(95)00357-F Cuenda, A., J. Rouse, Y. N. Doza, R. Meier, P. Cohen, T. F. Gallagher, P. R. Young, J. C. Lee. 1995. SB 203580 is a specific inhibitor of a MAP kinase homolog which is stimulated by cellular stresses and interleukin-1. FEBS Lett. 364: 229
10.1042/bj3040793 Almeida, I. C., M. A. J. Ferguson, S. Schenkman, L. R. Travassos. 1994. Lytic anti-α-galactosyl antibodies from patients with chronic Chagas’ disease recognize novel O-linked oligosaccharides on mucin-like glycosyl-phosphatidylinositol-anchored glycoproteins of Trypanosoma cruzi. Biochem. J. 304: 793
10.1002/eji.1830181018 Drapier, J. C., J. Wietzerbin, J. B. Hibbs, Jr. 1988. Interferon-γ and tumor necrosis factor induce the l-arginine-dependent cytotoxic effector mechanism in murine macrophages. Eur. J. Immunol. 18: 1587
Miller, M. A.. 1994. Quantification of functional T cells by limiting dilution. Curr. Protocols. Immunol. 1: 3.15.5
10.1016/0092-8674(94)90277-1 Rouse, J., P. Cohen, S. Trigon, M. Morange, A. Alonso Llamazares, D. Zamanillo, T. Hunt, A. R. Nebreda. 1994. A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP-kinase-2. Cell 78: 1027
10.4049/jimmunol.162.1.415 Chan, E. D., B. W. Winston, S. T. Uh, M. W. Wynes, D. M. Rose, D. W. H. Riches. 1999. Evaluation of the role of mitogen-activated protein kinases in the expression of inducible nitric oxide synthase by IFN-γ and TNF-α in mouse macrophages. J. Immunol. 162: 415
10.1016/S0014-5793(98)00578-X Caivano, M.. 1998. Role of MAP kinase cascades in inducing arginine transporters and nitric oxide synthetase in RAW264 macrophages. FEBS Lett. 429: 249
10.4049/jimmunol.163.12.6403 Feng, G.-J., H. S. Goodridge, M. M. Harnett, X.-Q. Wei, A. V. Nikolaev, A. P. Higson, F.-Y. Liew. 1999. Extracellular signal-related kinase (ERK) and p38 mitogen-activated protein (MAP) kinases differentially regulate the lypopolysaccharide-mediated induction of inducible nitric oxide synthase and IL12 in macrophages: Leishmania phosphoglycans subvert macrophage IL-12 production by targeting ERK MAP kinase. J. Immunol. 163: 6403
10.1074/jbc.270.24.14255 Lin, Y. Z., S. Y. Yao, R. A. Veach, T. R. Torgerson, J. Hawiger. 1995. Inhibition of nuclear translocation of transcription factor NF-κB by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence. J. Biol. Chem. 269: 20952
10.4049/jimmunol.164.11.5564 Medvedev, A. E., K. M. Kopydlowski, S. N. Vogel. 2000. Inhibition of lipopolysaccharide-induced signal transduction in endotoxin-tolerized mouse macrophages: dysregulation of cytokine, chemokine and Toll-like receptor 2 and 4 gene expression. J. Immunol. 164: 5564
10.1038/41131 Medzhitov, R., P. Preston-Hurlburt, C. A. Janeway. 1997. A human homologue of the Drosophila Toll protein signals activation of adaptative immunity. Nature 388: 394
10.1016/S1074-7613(00)80119-3 Takeuchi, O., K. Hoshino, T. Kawai, H. Sanjo, H. Takahada, T. Ogawa, K. Takeda, S. Akira. 1999. Differential roles of TLR2 and TLR4 in recognition of Gram-negative and Gram-positive bacterial cell wall components. Immunity 11: 443
10.4049/jimmunol.162.7.3749 Hoshino, K., O. Takeuchi, T. Kawai, H. Sanjo, T. Ogawa, Y. Takeda, K. Takeda, S. Akira. 1999. Toll like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the LPS gene product. J. Immunol. 162: 3749
10.1126/science.282.5396.2085 Poltorak, A., X. He, I. Smirnova, M.-Y. Liu, C. Van Huffel, X. Du, D. Birdwell, E. Alejos, M. Silva, C. Galanos, et al 1998. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in TLR4 gene. Science 282: 2085
10.1007/BF03403535 Geppert, T. D., C. E. Whitehurst, P. Thompson, B. Beutler. 1994. Lipopolysaccharide signals activation of tumor necrosis factor biosynthesis through the Ras/Raf-1/MEK/mapk pathway. Mol. Med. 1: 93
10.1038/372739a0 Lee, J. C., J. T. Laydon, P. C. McDonnell, T. F. Gallagher, S. Kumar, D. Green, D. Mk Nulty, M. J. Blumenthal, J. R. Heys, S. W. Landvatter, et al 1994. A protein kinase involved in the regulation of inflammatory cytokines biosynthesis. Nature 372: 739
10.4049/jimmunol.160.2.920 Foey, A. D., S. L. Perry, M. William, M. Feldmann, B. M. J. Foxwell, F. M. Brennan. 1998. Regulation of monocyte IL-10 synthesis by endogenous IL-1 and TNF-α: role of the p42/44 mitogen-activated protein kinases. J. Immunol. 160: 920
Prichett, W., A. Hand, J. Sheilds, D. Dumington. 1995. Mechanism of cation of bicyclic imidazoles defines a translational regulatory pathway for tumor necrosis factor α. J. Inflamm. 45: 97
10.4049/jimmunol.164.6.3018 Caivano, M., P. Cohen. 2000. Role of mitogen-activated protein kinase cascades in mediating lipopolysaccharide-stimulated induction of cyclooxygenase-2 and IL-β in RAW264 macrophages. J. Immunol. 164: 3025
10.1073/pnas.97.8.3925 Falvo, J. V., B. M. Brinkman, A. V. Tsytsykova, E. Y. Tsai, T. P. Yao, A. L. Kung, A. E. Goldfeld. 2000. A stimulus-specific role for CREB-binding protein (CBP) in T cell receptor-activated tumor necrosis factor α gene expression. Proc. Natl. Acad. Sci. USA 97: 3925
10.1093/emboj/18.7.1845 Lu, H.-T., D. D. Yang, M. Wysk, E. Gatti, I. Mellman, R. J. Davis, R. A. Flavell. 1999. Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (MKK3)-deficient mice. EMBO J. 18: 1845
10.1074/jbc.272.45.28373 Da Silva, J., B. Pierrat, J. L. Mary, W. Lesslauer. 1997. Blockage of p38 mitogen activated protein kinase pathway inhibits inducible nitric oxide synthase expression in mouse astrocytes. J. Biol. Chem. 272: 28373
10.1074/jbc.271.2.1111 Singh, K., J. L. Balligand, T. A. Fisher, T. W. Smith, R. A. Kelly. 1996. Regulation of cytokine inducible nitric oxide synthase in cardiac myocytes and microvascular endothelial cells: role of extracellular signal-regulated kinases 1 and 2 (ERK1/ERK2) and Stat 1α. J. Biol. Chem. 271: 1111
10.1016/S0014-5793(97)00383-9 Nishiya, T., T. Uehara, H. Edamatsu, Y. Kaziro, H. Itoh, Y. Nomura. 1997. Activation of Stat1 and subsequent transcription of inducible nitric oxide synthase gene in C6 glioma cells is independent of interferon-γ-induced MAPK activation that is mediated by p21. FEBS Lett. 408: 33
10.1523/JNEUROSCI.18-05-01633.1998 Bhat, N. R., P. Zhang, J. C. Lee, E. L. Hogan. 1998. Extracellular signal-regulated kinase and SAPK-2/p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-α gene expression in endotoxin-stimulated primary glial cultures. J. Neurosci. 18: 1633
10.4049/jimmunol.164.8.4277 Liu, H., P. Sidiropoulos, G. Song, L. J. Pagliari, M. J. Birrer, B. Stein, J. Anrather, R. M. Pope. 2000. TNF-α gene expression in macrophages: regulation by NF-κB is independent of c-Jun or C/EBPβ. J. Immunol. 164: 4277
10.1128/MCB.15.10.5258 Murphy, T. L., M. G. Cleveland, P. Kuesza, J. Magram, K. M. Murphy. 1995. Regulation of interleukin 12 p40 expression through an NF-κB half-site. Mol. Cell Biol. 15: 5258
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