[논문]Pathology and Pathogenesis of Idiopathic Portal Hypertension with an Emphasis on the Liver

doi:10.1078/0344-0338-5710012

[해외논문] Pathology and Pathogenesis of Idiopathic Portal Hypertension with an Emphasis on the Liver

Pathology, research and practice, v.197 no.2, 2001년, pp.65 - 76

Nakanuma, Yasuni (Department of Pathology (II), Kanazawa University School of Medicine, Kanazawa, Japan) , Tsuneyama, Koichi (Department of Pathology (II), Kanazawa University School of Medicine, Kanazawa, Japan) , Makoto, Ohbu (Department of Pathology, Kitasato University School of Medicine, Sagamihara, Japan) , Katayanagi, Kazuyoshi (Department of Pathology (II), Kanazawa University School of Medicine, Kanazawa, Japan)

Abstract ▼ AI-Helper

Summary Idiopathic portal hypertension (IPH) is characterized by a long-standing presinusoidal portal hypertension of unknown etiology in adults. Some unidentified agent(s) affect(s) the intrahepatic small portal veins or portal tracts. Immunological disturbance, thromboembolism, infectious etiology and\\/or increased fibrogenesis in portal tracts are suspected as being candidates for the primary agent(s). During the long clinical course of IPH, several pathological changes may occur, including subcapsular parenchymal atrophy, atrophy of the liver, portal and parenchymal fibrosis, and portal venous phlebosclerosis and thrombosis. The last-named of these lesions is mostly found in patients with a history of splenectomy. Subcapsular parenchymal and hepatic atrophy may result from a hepatocellular dropout via apoptosis or necrosis because of intrahepatic hemodynamic disturbances, particularly chronic portal venous blood insufficiency. Pericellular fibrosis and thin fibrous septa are also frequently found and associated with activated perisinusoidal cells positive for smooth muscle actin. At the same time, vague nodular hyperplasia of hepatocytes not surrounded by fibrous septa is not infrequently seen. It may resemble nodular regenerative hyperplasia, partial nodular transformation, or focal nodular hyperplasia. However, liver cirrhosis does not occur even at the terminal stage. Taking these findings into consideration, a new staging of IPH with a combination of hepatic parenchymal atrophy and portal venous thrombosis was proposed: non-atrophic liver without subcapsular parenchymal atrophy (stage I), non-atrophic liver with subcapsular parenchymal atrophy (stage II), atrophic liver with subcapsular parenchymal atrophy (stage III), and portal venous occlusive thrombosis (stage IV). IPH livers are likely to progress from stage I to stage III. Stage IV, which occurs relatively late, has a poor prognosis. This staging is applicable to clinical and autopsy cases without any histological data.

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