[논문]Triamcinolone-Gold Nanoparticles Repolarize Synoviocytes and Macrophages in an Inflamed Synovium

Park, Jun-Young; Kwon, Song; Kim, Sang-Hyun; Kang, Youn Joo; Khang, Dongwoo

doi:10.1021/acsami.0c09842

[해외논문] Triamcinolone-Gold Nanoparticles Repolarize Synoviocytes and Macrophages in an Inflamed Synovium

ACS applied materials & interfaces, v.12 no.35, 2020년, pp.38936 - 38949

Park, Jun-Young (Department of Gachon Advanced Institute for Health Science & Technology (GAIHST) , Gachon University , Incheon 21999 , South Korea) , Kwon, Song (Lee Gil Ya Cancer and Diabetes Institute , Gachon University , Incheon 21999 , South Korea) , Kim, Sang-Hyun (Department of Pharmacology, School of Medicine , Kyungpook National University , Daegu 41944 , South Korea) , Kang, Youn Joo , Khang, Dongwoo

Abstract ▼ AI-Helper

Understanding the crosstalk between synoviocytes and macrophages is very important for the development of strategies to regulate inflammatory responses in an inflamed synovium. Simultaneous regulation of the pro- and anti-inflammatory responses of synoviocytes and macrophages (repolarization) is critical for the treatment of arthritis. Thus, the immune regulatory functions of an ideal nanodrug should not only decrease the pro-inflammatory response but also effectively increase the anti-inflammatory response. In this study, crosstalk between synoviocytes and macrophages was found to be significantly involved in the activation and deactivation of inflammatory responses in the synovium. Interestingly, a developed triamcinolone-gold nanoparticle (Triam-AuNP) complex both decreased the pro-inflammatory responses and increased the anti-inflammatory responses of fibroblast-like synoviocytes (FLSs) and macrophages via repolarization of macrophages from the M1 to the M2 phenotype. In contrast, triamcinolone alone only decreased the pro-inflammatory responses of FLSs and macrophages without upregulating their anti-inflammatory responses. In vitro (human), ex vivo (human), and in vivo (mouse) analyses clearly indicated that Triam-AuNPs effectively regulated the expression of both pro- and anti-inflammatory cytokines in FLSs and effectively repolarized activity of macrophages in the inflamed synovium. Furthermore, Triam-AuNPs significantly promoted cartilage regeneration, whereas triamcinolone alone did not induce either FLS anti-inflammatory activity or macrophage repolarization.[FIG OMISSION]

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