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NTIS 바로가기Oncogene, v.20 no.10, 2001년, pp.1229 - 1234
Arevalo, Juan C (Instituto de Microbiologia Bioquimica, Departamento de Microbiologia y Genetica, CSIC Universidad de Salamanca, 37007 Salamanca, Spain) , Conde, Blanca (Departamento de Ciencias Morfologicas, Universidad de Zaragoza, Spain) , Hempstead, Barbara I (Hematology) , Chao, Moses V (Molecular Neurobiology Program, Skirball Institute, Departments of Cell Biology and Physiology and Neuroscience, New York University Medical Center, New York, NY 10016, USA) , Martín-Zanca, Dionisio (Instituto de Microbiologia Bioquimica, Departamento de Microbiologia y Genetica, CSIC Universidad de Salamanca, 37007 Salamanca, Spain) , Pérez, Pilar (Instituto de Microbiologia Bioquimica, Departamento de Microbiologia y Genetica, CSIC Universidad de Salamanca, 37007 Salamanca, Spain)
The TrkA NGF receptor extracellular region contains three leucine repeats flanked by cysteine clusters and two immunoglobulin-like domains that are required for specific ligand binding. Deletion of the immunoglobulin-like domains abolishes NGF binding and causes ligand independent activation of the ...
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