[논문]Disturbance of peristalsis in the guinea‐pig isolated small intestine by indomethacin, but not cyclo‐oxygenase isoform‐selective inhibitors

Shahbazian, Anaid; Schuligoi, Rufina; Heinemann, Akos; Peskar, Bernhard A; Holzer, Peter

doi:10.1038/sj.bjp.0703940

[해외논문] Disturbance of peristalsis in the guinea‐pig isolated small intestine by indomethacin, but not cyclo‐oxygenase isoform‐selective inhibitors 원문보기

British journal of pharmacology : BJP, v.132 no.6, 2001년, pp.1299 - 1309

Shahbazian, Anaid , Schuligoi, Rufina , Heinemann, Akos , Peskar, Bernhard A , Holzer, Peter

Abstract ▼ AI-Helper

Since the cyclo‐oxygenase (COX) isoform‐nonselective inhibitor indomethacin is known to modify intestinal motility, we analysed the effects of COX‐1 and COX‐2 inhibition on intestinal peristalsis.Peristalsis in isolated segments of the guinea‐pig small intestine was triggered by a rise of the intraluminal pressure and recorded via the pressure changes associated with peristalsis.The COX‐1 inhibitor SC‐560, the COX‐2 inhibitor NS‐398 (both at 0.1 - 1 μM) and the isoform‐nonselective inhibitors flurbiprofen (0.01 - 10 μM) and piroxicam (0.1 - 50 μM) were without major influence on peristalsis, whereas indomethacin and etodolac (0.1 - 10 μM) disturbed the regularity of peristalsis by causing nonpropulsive circular muscle contractions.Radioimmunoassay measurements showed that SC‐560, NS‐398, indomethacin and etodolac (each at 1 μM) suppressed the release of 6‐keto‐prostaglandin F1α (6‐keto‐PGF1α) from the intestinal segments.Reverse transcription - polymerase chain reaction tests revealed that, relative to glyceraldehyde‐3 phosphate dehydrogenase ribonucleic acid, the expression of COX‐1 mRNA increased by a factor of 2.0 whereas that of COX‐2 mRNA rose by a factor of 7.9 during the 2 h experimental period.Pharmacological experiments indicated that the action of indomethacin to disturb intestinal peristalsis was unrelated to inhibition of L‐type calcium channels, adenosine triphosphate‐sensitive potassium channels or phosphodiesterase type IV.These results show that selective inhibition of COX‐1 and COX‐2 does not grossly alter peristaltic motor activity in the guinea‐pig isolated small intestine and that the effect of indomethacin to disturb the regular pattern of propulsive motility in this species is unrelated to COX inhibition.British Journal of Pharmacology (2001) 132, 1299-1309; doi:10.1038/sj.bjp.0703940

참고문헌 (46)

Amann, R., Schuligoi, R., Peskar, B. A.. Eicosanoid release in the endotoxin-primed isolated perfused rat lung and its pharmacological modification. Inflammation research : official journal of the European Histamine Research Society ... [et al.], vol.48, no.12, 632-636.

상세보기
Beattyc, C.H., Bocek, R.M., Young, M.K., Novy, M.J.. Effect of indomethacin on cyclic AMP phosphodiesterase activity in myometrium from pregnant rhesus monkeys. Prostaglandins, vol.11, no.4, 713-725.

상세보기
BENNETT, A., ELEY, K.G., STOCKLEY, HELEN L.. INHIBITION OF PERISTALSIS IN GUINEA‐PIG ISOLATED ILEUM AND COLON BY DRUGS THAT BLOCK PROSTAGLANDIN SYNTHESIS. British journal of pharmacology : BJP, vol.57, no.3, 335-340.

상세보기
Bracken, K E, Elger, W, Jantke, I, Nanninga, A, Gellersen, B. Cloning of guinea pig cyclooxygenase-2 and 15-hydroxyprostaglandin dehydrogenase complementary deoxyribonucleic acids: steroid-modulated gene expression correlates to prostaglandin F2 alpha secretion in cultured endometrial cells.. Endocrinology, vol.138, no.1, 237-247.

상세보기
Acta Hepatogastroenterol. BRUCH H.P. 303 25 1978 The role of prostaglandins in peristalsis of the human colon
Buchheit, K.-H., Bertholet, A.. Inhibition of small intestine motility by cromakalim (BRL 34915). European journal of pharmacology, vol.154, no.3, 335-337.

상세보기
J. Pharmacol. Exp. Ther. BURCH R.M. 84 227 1983 Prostaglandin‐independent inhibition of calcium transport by nonsteroidal anti‐inflammatory drugs: differential effects of carboxylic acids and piroxicam

상세보기
Elliott, Graham R., Lauwen, Adrianus P.M., Bonta, Ivan L.. Prostaglandin E₂ inhibits and indomethacin and aspirin enhance, A23187‐stimulated leukotriene B₄ synthesis by rat peritoneal macrophages. British journal of pharmacology : BJP, vol.96, no.2, 265-270.

상세보기
Ferraz, JG, Sharkey, KA, Reuter, BK, Asfaha, S, Tigley, AW, Brown, ML, McKnight, W, Wallace, JL. Induction of cyclooxygenase 1 and 2 in the rat stomach during endotoxemia: Role in resistance to damage. Gastroenterology, vol.113, no.1, 195-204.

상세보기
Flower, R.J., Vane, J.R.. Inhibition of prostaglandin biosynthesis. Biochemical pharmacology, vol.23, no.10, 1439-1450.

상세보기
Arch. Int. Pharmacodyn. Ther. FONTAINE J. 341 226 1977 Effects of prostaglandins on the peristaltic reflex of the guinea‐pig ileum
Franck, H., Kong, I. D., Shuttleworth, C. W. R., Sanders, K. M.. Rebound excitation and alternating slow wave patterns depend upon eicosanoid production in canine proximal colon. The Journal of physiology, vol.520, no.3, 885-895.

상세보기
Futaki, N., Takahashi, S., Yokoyama, M., Arai, I., Higuchi, S., Otomo, S.. NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro. Prostaglandins, vol.47, no.1, 55-59.

상세보기
Heinemann, Ákos, Holzer, Peter. Stimulant action of pituitary adenylate cyclase‐activating peptide on normal and drug‐compromised peristalsis in the guinea‐pig intestine. British journal of pharmacology : BJP, vol.127, no.3, 763-771.

상세보기
Heinemann, Ákos, Shahbazian, Anaid, Barthó, Loránd, Holzer, Peter. Different receptors mediating the inhibitory action of exogenous ATP and endogenously released purines on guinea‐pig intestinal peristalsis. British journal of pharmacology : BJP, vol.128, no.2, 313-320.

상세보기
Hide, Emma J., Ney, Peter, Piper, Julie, Thiemermann, Christoph, Vane, John R.. Reduction by prostaglandin E₁ or prostaglandin E₀ of myocardial infarct size in the rabbit by activation of ATP‐sensitive potassium channels. British journal of pharmacology : BJP, vol.116, no.5, 2435-2440.

상세보기
Holzer, P., Lippe, I.Th., Barthó, L., Saria, A.. Neuropeptide Y inhibits excitatory enteric neurons supplying the circular muscle of the guinea pig small intestine. Gastroenterology, vol.92, no.6, 1944-1950.

상세보기
Holzer, Peter, Lippe, Irmgard Th, Heinemann, Ákos, Barthó, Loránd. Tachykinin NK₁ and NK₂ receptor-mediated control of peristaltic propulsion in the guinea-pig small intestine in vitro. Neuropharmacology, vol.37, no.1, 131-138.

상세보기
J. Pharmacol. Exp. Ther. HOLZER P. 154 280 1997 Dual excitatory and inhibitory effect of nitric oxide on peristalsis in the guinea pig intestine

상세보기
Iseki, Shoichi. Immunocytochemical localization of cyclooxygenase-1 and cyclooxygenase-2 in the rat stomach. The Histochemical journal, vol.27, no.4, 323-328.

상세보기
Izzo, A. A., Mascolo, Nicola, Capasso, Francesco. Effect of selective phosphodiesterase inhibitors on synaptic transmission in the guinea-pig ileum :. Naunyn-Schmiedeberg's archives of pharmacology, vol.357, no.6, 677-681.

상세보기
Johnson, P. J., Bornstein, J. C., Burcher, E.. Roles of neuronal NK₁ and NK₃ receptors in synaptic transmission during motility reflexes in the guinea‐pig ileum. British journal of pharmacology : BJP, vol.124, no.7, 1375-1384.

상세보기
Johnson, P.J., Bornstein, J.C., Yuan, S.Y., Furness, J.B.. Analysis of contributions of acetylcholine and tachykinins to neuro‐neuronal transmission in motility reflexes in the guinea‐pig ileum. British journal of pharmacology : BJP, vol.118, no.4, 973-983.

상세보기
Kargman, S, Charleson, S, Cartwright, M, Frank, J, Riendeau, D, Mancini, J, Evans, J, O'Neill, G. Characterization of Prostaglandin G/H Synthase 1 and 2 in rat, dog, monkey, and human gastrointestinal tracts. Gastroenterology, vol.111, no.2, 445-454.

상세보기
Kuehl, F.A., Dougherty, H.W., Ham, E.A.. Interactions between prostaglandins and leukotrienes. Biochemical pharmacology, vol.33, no.1, 1-5.

상세보기
Maggi, Carlo Alberto, Patacchini, Riccardo, Meini, Stefania, Giuliani, Sandro. Effect of longitudinal muscle‐myenteric plexus removal and indomethacin on the response to tachykinin NK‐2 and NK‐3 receptor agonists in the circular muscle of the guinea‐pig ileum. Journal of autonomic pharmacology, vol.14, no.1, 49-60.

상세보기
Maggi, Carlo Alberto, Santicioli, Paolo, Giuliani, Sandro. Effect of exercise and 2-deoxyglucose on the K⁺ channel opener action of CGRP in the guinea pig ureter. General pharmacology, vol.27, no.1, 95-100.

상세보기
Maricic, Nenad, Ehrlich, Karlheinz, Gretzer, Britta, Schuligoi, Rufina, Respondek, Michael, Peskar, Brigitta M. Selective cyclo‐oxygenase‐2 inhibitors aggravate ischaemia‐reperfusion injury in the rat stomach. British journal of pharmacology : BJP, vol.128, no.8, 1659-1666.

상세보기
Mitchell, Jane A, Warner, Timothy D. Cyclo‐oxygenase‐2: pharmacology, physiology, biochemistry and relevance to NSAID therapy. British journal of pharmacology : BJP, vol.128, no.6, 1121-1132.

상세보기
J. Lipid Mediat. MÜLLER‐PEDDINGHAUS R. 245 6 1993 BAY X 1005, a new selective inhibitor of leukotriene synthesis: pharmacology and pharmacokinetics

상세보기
Nakajima, Takashi, Hamanaka, Kozue, Fukuda, Toshio, Oyama, Tetsunari, Kashiwabara, Kenji, Sano, Takaaki. Why is cyclooxygenase‐2 expressed in neuroendocrine cells of the human alimentary tract?. Pathology international, vol.47, no.12, 889-891.

상세보기
Newcombe, D.S., Thanassi, N.M., Ciosek, C.P.. Cartilage cyclic nucleotide phosphodiesterase: Inhibition by anti-inflammatory agents. Life sciences, vol.14, no.3, 505-519.

상세보기
Northover, B.J.. Indomethacin-A calcium antagonist. General pharmacology, vol.8, no.5, 293-296.

상세보기
J. Pharmacol. Exp. Ther. OGLETREE M.L. 435 234 1985 Pharmacological actions of SQ 29,548, a novel selective thromboxane antagonist

상세보기
Radioimmunoassay of Drugs and Hormones in Cardiovascular Medicine. PESKAR B.A. 239 1979
Ravens, Ursula, Sch�pper, Hans-Peter. Opposite cardiac actions of the enantiomers of Bay K 8644 at different membrane potentials in guinea-pig papillary muscles. Naunyn-Schmiedeberg's archives of pharmacology, vol.341, no.3,

상세보기
Schuligoi, Rufina, Amann, Rainer, Donnerer, Josef, Peskar, B. A.. Release of calcitonin gene-related peptide in cardiac anaphylaxis :. Naunyn-Schmiedeberg's archives of pharmacology, vol.355, no.2, 224-229.

상세보기
Singh, J.. Prostaglandin release from rat stomach following vagal stimulation or administration of acetylcholine. European journal of pharmacology, vol.65, no.1, 39-48.

상세보기
Smith, Christopher J., Zhang, Yan, Koboldt, Carol M., Muhammad, Jerry, Zweifel, Ben S., Shaffer, Alex, Talley, John J., Masferrer, Jaime L., Seibert, Karen, Isakson, Peter C.. Pharmacological analysis of cyclooxygenase-1 in inflammation. Proceedings of the National Academy of Sciences of the United States of America, vol.95, no.22, 13313-13318.

상세보기
Tymkewycz, Paulina M., Jones, R.L., Wilson, N.H., Marr, C.G.. Heterogeneity of thromboxane A₂ (TP‐) receptors: evidence from antagonist but not agonist potency measurements. British journal of pharmacology : BJP, vol.102, no.3, 607-614.

상세보기
Vane, J. R., Bakhle, Y. S., Botting, R. M.. CYCLOOXYGENASES 1 AND 2. Annual review of pharmacology and toxicology, vol.38, 97-120.

상세보기
Wallace, J.L., McKnight, W., Reuter, B.K., Vergnolle, N.. NSAID-induced gastric damage in rats: Requirement for inhibition of both cyclooxygenase 1 and 2. Gastroenterology, vol.119, no.3, 706-714.

상세보기
Warner, Timothy D., Giuliano, Francesco, Vojnovic, Ivana, Bukasa, Antoaneta, Mitchell, Jane A., Vane, John R.. Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: A full in vitro analysis. Proceedings of the National Academy of Sciences of the United States of America, vol.96, no.13, 7563-7568.

상세보기
Waterman, S A, Costa, M. The role of enteric inhibitory motoneurons in peristalsis in the isolated guinea‐pig small intestine.. The Journal of physiology, vol.477, no.3, 459-468.

상세보기
10.1254/jjp.30.853
Zafirov, D.H., Palmer, J.M., Nemeth, P.R., Wood, J.D.. Cyclic 3',5'-adenosine monophosphate mimics slow synaptic excitation in myenteric plexus neurons. Brain research, vol.347, no.2, 368-371.

상세보기

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[해외논문] Disturbance of peristalsis in the guinea‐pig isolated small intestine by indomethacin, but not cyclo‐oxygenase isoform‐selective inhibitors 원문보기

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