$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

[해외논문] The Amino Terminus of Smads Permits Transcriptional Specificity 원문보기

Developmental biology, v.230 no.2, 2001년, pp.110 - 124  

Fortuno, E.S. ,  LeSueur, J.A. ,  Graff, J.M.

Abstract AI-Helper 아이콘AI-Helper

Smad proteins transduce transforming growth factor-β signals from the cell surface to the nucleus, regulating a variety of physiologic processes. In the nucleus, Smads control gene expression by binding to both DNA and transcription factors. Individual Smads regulate distinct subsets of target ...

Keyword

참고문헌 (77)

  1. Genes & Dev. Baker 10 1880 1996 10.1101/gad.10.15.1880 A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway 

  2. Nature Chen 383 691 1996 10.1038/383691a0 A transcriptional partner for MAD proteins in TGFβ signalling 

  3. Nature Chen 389 85 1997 10.1038/38008 Smad4 and FAST-1 in the assembly of activin-responsive factor 

  4. Proc. Natl. Acad. Sci. USA Chen 94 12938 1997 10.1073/pnas.94.24.12938 Smad8 mediates the signaling of the receptor serine kinase 

  5. Genes & Dev. Chen 12 2144 1998 10.1101/gad.12.14.2144 Determinants of specificity in TGF-β signal transduction 

  6. Proc. Natl. Acad. Sci. USA Chien 88 9578 1991 10.1073/pnas.88.21.9578 The two-hybrid system: A method to identify and clone genes for proteins that interact with a protein of interest 

  7. EMBO J. Dennler 17 3091 1998 10.1093/emboj/17.11.3091 Direct binding of Smad3 and Smad4 to critical TGFβ-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene 

  8. Cell Eppert 86 543 1996 10.1016/S0092-8674(00)80128-2 MADR2 maps to 18q21 and encodes a TGFβ-regulated MAD-related protein that is functionally mutated in colorectal carcinoma 

  9. Genes & Dev. Germain 14 435 2000 10.1101/gad.14.4.435 Homeodomain and winged-helix transcription factors recruit activated Smads to distinct promoter elements via a common Smad interaction motif 

  10. Cell Graff 85 479 1996 10.1016/S0092-8674(00)81249-0 Xenopus Mad proteins transduce distinct subsets of signals for the TGFβ superfamily 

  11. Cell Graff 79 169 1994 10.1016/0092-8674(94)90409-X Studies with a Xenopus BMP receptor suggest that ventral mesoderm-inducing signals override dorsal signals in vivo 

  12. Science Hahn 271 350 1996 10.1126/science.271.5247.350 DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1 

  13. Genes & Dev. Hata 12 186 1998 10.1101/gad.12.2.186 Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor 

  14. Nature Hata 388 82 1997 10.1038/40424 Mutations increasing autoinhibition inactivate the tumour suppressors Smad2 and Smad4 

  15. Mol. Med. Today Hata 4 257 1998 10.1016/S1357-4310(98)01247-7 TGF-β signaling and cancer: Structural and functional consequences of mutations in Smads 

  16. Cell Hayashi 89 1165 1997 10.1016/S0092-8674(00)80303-7 The MAD-related protein Smad7 associates with the TGFβ receptor and functions as an antagonist of TGFβ signaling 

  17. Nature Heldin 390 465 1997 10.1038/37284 TGF-β signalling from cell membrane to nucleus through SMAD proteins 

  18. Development Hemmati-Brivanlou 110 325 1990 10.1242/dev.110.2.325 Localization of specific mRNAs in Xenopus embryos by whole-mount in situ hybridization 

  19. Cell Hemmati-Brivanlou 77 273 1994 10.1016/0092-8674(94)90319-0 Inhibition of activin receptor signaling promotes neuralization in Xenopus 

  20. Dev. Genet. Hemmati-Brivanlou 17 78 1995 10.1002/dvg.1020170109 Ventral mesoderal patterning in Xenopus embryos: Expression patterns and activities of BMP2 and BMP4 

  21. Cell Hoodless 85 489 1996 10.1016/S0092-8674(00)81250-7 MADR1, a MAD-related protein that functions in BMP2 signaling pathways 

  22. Gene Horton 77 61 1989 10.1016/0378-1119(89)90359-4 Engineering hybrid genes without the use of restriction enzymes: gene splicing by overlap extension 

  23. Dev. Biol. Howell 214 354 1999 10.1006/dbio.1999.9430 Xenopus Smad4β is the co-Smad component of developmentally regulated transcription factor complexes responsible for induction of early mesodermal genes 

  24. Genes & Dev. Hua 12 3081 1998 10.1101/gad.12.19.3084 Synergistic cooperation of the TFE3 and Smad proteins in the TGF-β-induced transcription of the plasminogen activator inhibitor-1 gene 

  25. Nature Imamura 389 622 1997 10.1038/39355 Smad6 inhibits signalling by the TGFβ superfamily 

  26. Nature Kim 388 304 1997 10.1038/40906 Drosophila Mad binds to DNA and directly mediates activation of vestigal by Decapentaplegic 

  27. Development Kintner 99 311 1987 10.1242/dev.99.3.311 Expression of Xenopus N-CAM RNA in ectoderm is an early response to neural induction 

  28. Genes & Dev. Kretzschmar 11 984 1997 10.1101/gad.11.8.984 The TGFβ family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase 

  29. Methods Enzymol. Krieg 155 397 1987 10.1016/0076-6879(87)55027-3 In vitro RNA synthesis with SP6 RNA polymerase 

  30. Dev. Biol. Krieg 133 93 1989 10.1016/0012-1606(89)90300-X The mRNA encoding elongation factor 1α (EF-1α) is a major transcript at the mid blastula transition in Xenopus 

  31. Mol. Cell Labbe 2 109 1998 10.1016/S1097-2765(00)80119-7 Smad2 and Smad3 positively and negatively regulate TGFβ-dependent transcription through the forkhead DNA-binding protein FAST-2 

  32. Nature Lagna 383 832 1996 10.1038/383832a0 Partnership between DPC4 and SMAD proteins in TGFβ signalling pathways 

  33. Dev. Dyn. Lagna 21 269 1999 10.1002/(SICI)1097-0177(199903)214:3<269::AID-AJA10>3.0.CO;2-# A molecular basis for Smad specificity 

  34. Development LeSueur 126 137 1999 10.1242/dev.126.1.137 Spemann organizer activity of Smad10 

  35. Annu. Rev. Immunol. Letterio 16 137 1998 10.1146/annurev.immunol.16.1.137 Regulation of immune responses by TGF-β 

  36. Proc. Natl. Acad. Sci. USA Liberati 96 4844 1999 10.1073/pnas.96.9.4844 Smads bind directly to the Jun family of AP-1 transcription factors 

  37. Mol. Cell. Biol. Liu 19 424 1999 10.1128/MCB.19.1.424 FAST-2 is a mammalian winged-helix protein which mediates transforming growth factor β signals 

  38. Nature Liu 381 620 1996 10.1038/381620a0 A human Mad protein acting as a BMP-regulated transcriptional activator 

  39. Genes & Dev. Liu 11 3157 1997 10.1101/gad.11.23.3157 Dual roles of Smad4/DPC4 tumor suppressor in TGFβ-inducible transcriptional complexes 

  40. Cell Macias-Silva 87 1215 1996 10.1016/S0092-8674(00)81817-6 MADR2 is a substrate of the TGFβ receptor and its phosphorylation is required for nuclear accumulation and signaling 

  41. J. Biol. Chem. Macias-Silva 273 25628 1998 10.1074/jbc.273.40.25628 Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2 

  42. Annu. Rev. Biochem. Massague 67 753 1998 10.1146/annurev.biochem.67.1.753 TGF-β signal transduction 

  43. Genes & Dev. Massague 14 627 2000 10.1101/gad.14.6.627 Controlling TGF-β signaling 

  44. J. Biol. Chem. Masuyama 274 12163 1999 10.1074/jbc.274.17.12163 Identification of two Smad4 proteins in Xenopus 

  45. Mech. Dev. Meersseman 61 127 1997 10.1016/S0925-4773(96)00629-6 The C-terminal domain of Mad-like signal transducers is sufficient for biological activity in Xenopus embryo and transcriptional activation 

  46. Nature Mohun 311 716 1984 10.1038/311716a0 Cell type specific activation of actin genes in the early amphibian embryo 

  47. Proc. Natl. Acad. Sci. USA Moustakas 95 6733 1998 10.1073/pnas.95.12.6733 Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between SP1 and Smad family members 

  48. Nature Nakao 389 631 1997 10.1038/39369 Identification of Smad7, a TGFβ-inducible antagonist of TGFβ signalling 

  49. EMBO J. Nakao 16 5353 1997 10.1093/emboj/16.17.5353 TGF-β receptor-mediated signaling through Smad2, Smad3 and Smad4 

  50. J. Biol. Chem. Nakao 272 2896 1997 10.1074/jbc.272.5.2896 Identification of Smad2, a human Mad-related protein in the TGFβ signaling pathway 

  51. Nieuwkoop 1967 Normal Table of Xenopus laevis (Daudin) 

  52. Cancer Metastasis Rev. Padgett 18 247 1999 10.1023/A:1006325408261 TGF-β signaling pathways and human diseases 

  53. Trends Genet. Patterson 16 27 1999 10.1016/S0168-9525(99)01916-2 TGFβ-related pathways: roles in Caenorhabditis elegans development 

  54. Genes & Dev. Pawson 14 1027 2000 10.1101/gad.14.9.1027 Protein-protein interactions define specificity in signal transduction 

  55. FASEB J. Piek 13 2105 1999 10.1096/fasebj.13.15.2105 Specificity, diversity and regulation in TGF-β superfamily signaling 

  56. Nature Ptashne 335 683 1988 10.1038/335683a0 How eukaryotic transcriptional activators work 

  57. Science Rosa 239 783 1988 10.1126/science.3422517 Mesoderm induction in amphibians: The role of TGF-β2-like factors 

  58. Cell Shi 94 585 1998 10.1016/S0092-8674(00)81600-1 Crystal structure of a Smad MH1 domain bound to DNA: Insights on DNA binding in TGF-β signaling 

  59. Dev. Biol. Suzuki 184 402 1997 10.1006/dbio.1997.8548 Smad5 induces ventral fates in Xenopus embryo 

  60. Mol. Biol. Cell Tall 10 1873 1999 10.1091/mbc.10.6.1873 The phosphotidylinositol 3-phosphate binding protein Vac1p interacts with a Rab GTPase and a Sec1p homologue to facilitate vesicle-mediated vacuolar protein sorting 

  61. J. Cell. Physiol. Tamaki 177 355 1998 10.1002/(SICI)1097-4652(199811)177:2<355::AID-JCP17>3.0.CO;2-8 Intracellular signaling of osteogenic protein-1 through Smad5 activation 

  62. Trends Biochem. Sci. ten Dijke 25 64 2000 10.1016/S0968-0004(99)01519-4 Signaling inputs converge on nuclear effectors in TGF-β signaling 

  63. Nature Genetics Thomas 12 315 1996 10.1038/ng0396-315 A human chondrodysplasia due to a mutation in a TGF-β superfamily member 

  64. Development Thomsen 122 2359 1996 10.1242/dev.122.8.2359 Xenopus mothers against decapentaplegic is an embryonic ventralizing agent that acts downstream of the BMP-2/4 receptor 

  65. Cell Thomsen 63 485 1990 10.1016/0092-8674(90)90445-K Activins are expressed early in Xenopus embryogenesis and can induce axial mesoderm and anterior structures 

  66. Cell Thomsen 74 433 1993 10.1016/0092-8674(93)80045-G Processed Vg1 protein is an axial mesoderm inducer in Xenopus 

  67. Development Watanabe 126 5621 1999 10.1242/dev.126.24.5621 FAST-1 is a key maternal effector in mesoderm inducers in early Xenopus embryo 

  68. Genes & Dev. Whitman 12 2445 1998 10.1101/gad.12.16.2445 Smads and early developmental signaling by the TGFβ superfamily 

  69. Curr. Biol. Wilson 4 676 1994 10.1016/S0960-9822(00)00152-4 Mesodermal patterning by an inducer gradient depends on secondary cell-cell communication 

  70. Cell Wrana 100 189 2000 10.1016/S0092-8674(00)81556-1 Regulation of Smad activity 

  71. Mol. Cell. Biol. Wu 17 2521 1997 10.1128/MCB.17.5.2521 Heteromeric and homomeric interactions correlate with signaling activity and functional cooperativity of Smad3 and Smad4/DPC4 

  72. Mol. Cell. Biol. Yingling 17 7019 1997 10.1128/MCB.17.12.7019 Tumor suppressor Smad4 is a transforming growth factor β-inducible DNA binding protein 

  73. Mol. Cell Zawel 1 611 1998 10.1016/S1097-2765(00)80061-1 Human Smad3 and Smad4 are sequence-specific transcriptional activators 

  74. Nature Zhang 394 909 1998 10.1038/29814 Smad3 and Smad4 cooperate with the c-Jun/c-Fos to mediate TGF-β-induced transcription 

  75. Nature Zhang 383 168 1996 10.1038/383168a0 Receptor-associated Mad homologues synergize as effectors of the TGFβ response 

  76. Curr. Biol. Zhang 7 270 1997 10.1016/S0960-9822(06)00123-0 The tumor suppressor Smad4/DPC4 as a central mediator of Smad function 

  77. Mol. Cell Zhou 2 121 1998 10.1016/S1097-2765(00)80120-3 Characterization of human FAST-1, a TGF-β and activin signal transducer 

활용도 분석정보

상세보기
다운로드
내보내기

활용도 Top5 논문

해당 논문의 주제분야에서 활용도가 높은 상위 5개 콘텐츠를 보여줍니다.
더보기 버튼을 클릭하시면 더 많은 관련자료를 살펴볼 수 있습니다.

관련 콘텐츠

오픈액세스(OA) 유형

BRONZE

출판사/학술단체 등이 한시적으로 특별한 프로모션 또는 일정기간 경과 후 접근을 허용하여, 출판사/학술단체 등의 사이트에서 이용 가능한 논문

저작권 관리 안내
섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트

맨위로