[논문]Neuropilin-1 expression in osteogenic cells: Down-regulation during differentiation of osteoblasts into osteocytes

Harper, Jay; Gerstenfeld, Louis C.; Klagsbrun, Michael

doi:10.1002/1097-4644(20010401)81:1<82::AID-JCB1025>3.0.CO;2-P

[해외논문] Neuropilin-1 expression in osteogenic cells: Down-regulation during differentiation of osteoblasts into osteocytes

Journal of cellular biochemistry, v.81 no.1, 2001년, pp.82 - 92

Harper, Jay (Department of Surgical Research, Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115) , Gerstenfeld, Louis C. (Department of Orthopedic Surgery, Boston University School of Medicine, Boston, Massachusetts 02118) , Klagsbrun, Michael (Department of Surgical Research, Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115)

Abstract ▼ AI-Helper

The expression of neuropilin-1 (NRP1), a recently described VEGF and semaphorin receptor expressed by endothelial cells (EC) but some non-EC types as well, was analyzed in osteoblasts in vitro and in vivo. Cultured MC3T3-E1 osteoblasts expressed NRP1 mRNA and bound VEGF165 but not VEGF121, characteristic of the VEGF isoform-specific binding of NRP1. These cells did not express VEGFR-1 or VEGFR-2 so that VEGF binding to osteoblasts was strictly NRP1-dependent. In a chick osteocyte differentiation system, NRP1 was expressed by osteoblasts but its expression was absent as the cells matured into osteocytes. Immunohistochemical localization of NRP1 within the developing bones of 36-day-old mice and embryonic Day 17 chicks demonstrated that NRP1 was expressed by osteoblasts migrating alongside invading blood vessels within the metaphysis of the growth plate, as well as by osteoblasts at the developing edge of trabeculae within the marrow cavity. On the other hand, NRP1 was not expressed by osteocytes in either species, consistent with the in vitro results. In addition to osteogenic cells, NRP1 expression by EC was observed throughout the bone. Together these results suggest that NRP1 might have a dual function in bone by mediating osteoblast function directly as well as angiogenesis. J. Cell. Biochem. 81:82–92, 2001. © 2001 Wiley-Liss, Inc.

주제어

참고문헌 (38)

Nature (London) Behar 383 525 1996 10.1038/383525a0

상세보기
Clin Orthop Rel Res Brighton 136 22 1978
Clin Orthop Caplan 261 257 1990 10.1097/00003086-199012000-00031

상세보기
J Cell Sci Carlevaro 113 59 2000 10.1242/jcs.113.1.59

상세보기
J Bone Min Res Damoulis 12 412 1997 10.1359/jbmr.1997.12.3.412

상세보기
Anat Rec Decker 242 310 1995 10.1002/ar.1092420304

상세보기
Endocrinology Deckers 141 1667 2000 10.1210/endo.141.5.7458

상세보기
Heart and Vessels Doi 12 18 1997

상세보기
Development Filvaroff 126 4267 1999 10.1242/dev.126.19.4267

상세보기
Curr Opin Neurobiol Fujisawa 8 587 1998 10.1016/S0959-4388(98)80085-8

상세보기
Nature Med Gerber 5 623 1999 10.1038/9467

상세보기
Endocrinology Gerstenfeld 137 3957 1996 10.1210/endo.137.9.8756572

상세보기
J Biol Chem Gitay-Goren 267 6093 1992 10.1016/S0021-9258(18)42666-X

상세보기
Cell He 90 739 1997 10.1016/S0092-8674(00)80534-6

상세보기
J Anat Horner 194 519 1999 10.1046/j.1469-7580.1999.19440519.x

상세보기
J Neurobiol Kawakami 29 1 1996 10.1002/(SICI)1097-4695(199601)29:1<1::AID-NEU1>3.0.CO;2-F

상세보기
Development Kitsukawa 121 4309 1995 10.1242/dev.121.12.4309

상세보기
Cell Kolodkin 90 753 1997 10.1016/S0092-8674(00)80535-8

상세보기
J Cell Biol Miao 146 233 1999

상세보기
Biochem Biophys Res Commun Midy 199 380 1994 10.1006/bbrc.1994.1240

상세보기
J Biol Chem Natsume 272 11535 1997 10.1074/jbc.272.17.11535

상세보기
FASEB Neufeld 13 9 1999 10.1096/fasebj.13.1.9

상세보기
Eur J Clin Nutri Price 48 s131 1994
Cytokine Reher 11 416 1999 10.1006/cyto.1998.0444

상세보기
Toxicol Pathol Ryan 27 78 1999 10.1177/019262339902700115

상세보기
Am J Physiol Saadeh 277 c628 1999 10.1152/ajpcell.1999.277.4.C628

상세보기
Anat Embryol Skawina 189 457 1994 10.1007/BF00185441

상세보기
J Biol Chem Soker 271 5761 1996 10.1074/jbc.271.10.5761

상세보기
J Biol Chem Soker 272 31582 1997 10.1074/jbc.272.50.31582

상세보기
Cell Soker 92 735 1998 10.1016/S0092-8674(00)81402-6

상세보기
Plast Reconstr Surg Steinbrech 104 738 1999 10.1097/00006534-199909010-00019

상세보기
J Cell Biol Sudo 96 191 1983 10.1083/jcb.96.1.191

상세보기
Neuron Takagi 7 295 1991 10.1016/0896-6273(91)90268-5

상세보기
Develop Biol Takagi 170 207 1995 10.1006/dbio.1995.1208

상세보기
J Bone Joint Surg (Br) Trueta 42 367 1960 10.1302/0301-620X.42B2.367

상세보기
J Biol Chem Waltenberger 269 26988 1994 10.1016/S0021-9258(18)47116-5

상세보기
Endocrinology Wang 138 2953 1997 10.1210/endo.138.7.5275

상세보기
J Biol Chem Xiao 275 4453 2000 10.1074/jbc.275.6.4453

상세보기

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관 관리번호, 논문명, 대등논문명, 저자 , 저널/프로시딩명, 발행기관, 발행년, 발행언어, 권, 호, 시작페이지, 끝페이지, ISBN, ISSN, 주제분야, 키워드, 초록(한글), 초록(영문), 저자(소속기관)
저장형식	Text(ASCII format) Excel format RefWorks Direct Export RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증

[해외논문] Neuropilin-1 expression in osteogenic cells: Down-regulation during differentiation of osteoblasts into osteocytes

Abstract ▼ AI-Helper

주제어

참고문헌 (38)

이 논문을 인용한 문헌

관련 콘텐츠

원문 URL 링크

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트