$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

Moonlighting Proteins

Annual review of genetics, v.54 no.1, 2020년, pp.265 - 285  

Singh, Nadia (Department of Biology, University of Oregon, Eugene, Oregon 97403, USA) ,  Bhalla, Needhi

Abstract AI-Helper 아이콘AI-Helper

The single gene, single protein, single function hypothesis is increasingly becoming obsolete. Numerous studies have demonstrated that individual proteins can moonlight, meaning they can have multiple functions based on their cellular or developmental context. In this review, we discuss moonlightin...

참고문헌 (151)

  1. Agarwal, Vaibhav, Hammerschmidt, Sven, Malm, Sven, Bergmann, Simone, Riesbeck, Kristian, Blom, Anna M.. Enolase ofStreptococcus pneumoniaeBinds Human Complement Inhibitor C4b-Binding Protein and Contributes to Complement Evasion. The journal of immunology : official journal of the American Association of Immunologists, vol.189, no.7, 3575-3584.

  2. Allen, M., Cox, C., Belbin, O., Ma, L., Bisceglio, G.D., Wilcox, S.L., Howell, C.C., Hunter, T.A., Culley, O., Walker, L.P., Carrasquillo, M.M., Dickson, D.W., Petersen, R.C., Graff-Radford, N.R., Younkin, S.G., Ertekin-Taner, N.. Association and heterogeneity at the GAPDH locus in Alzheimer's disease. Neurobiology of aging, vol.33, no.1, 203.e25-203.e33.

  3. Alvarez, René A., Blaylock, Mark W., Baseman, Joel B.. Surface localized glyceraldehyde-3-phosphate dehydrogenase of Mycoplasma genitalium binds mucin. Molecular microbiology, vol.48, no.5, 1417-1425.

  4. Ameisen, J C. On the origin, evolution, and nature of programmed cell death: a timeline of four billion years. Cell death and differentiation, vol.9, no.4, 367-393.

  5. Aravind, L., Koonin, Eugene V.. The HORMA domain: a common structural denominator in mitotic checkpoints, chromosome synapsis and DNA repair. Trends in biochemical sciences, vol.23, no.8, 284-286.

  6. Baba, Takeshi, Kobayashi, Hiroyuki, Kawasaki, Hiroaki, Mineki, Reiko, Naito, Hisashi, Ohmori, Daijiro. Glyceraldehyde-3-phosphate dehydrogenase interacts with phosphorylated Akt resulting from increased blood glucose in rat cardiac muscle. FEBS letters, vol.584, no.13, 2796-2800.

  7. Bassik, Michael C., Kampmann, M., Lebbink, R., Wang, S., Hein, Marco Y., Poser, I., Weibezahn, J., Horlbeck, Max A., Chen, S., Mann, M., Hyman, Anthony A., LeProust, Emily M., McManus, Michael T., Weissman, Jonathan S.. A Systematic Mammalian Genetic Interaction Map Reveals Pathways Underlying Ricin Susceptibility. Cell, vol.152, no.4, 909-922.

  8. Behrends, Christian, Sowa, Mathew E., Gygi, Steven P., Harper, J. Wade. Network organization of the human autophagy system. Nature, vol.466, no.7302, 68-76.

  9. Bergmann, Simone, Rohde, Manfred, Chhatwal, Gursharan S., Hammerschmidt, Sven. &agr;-Enolase of Streptococcus pneumoniae is a plasmin(ogen)-binding protein displayed on the bacterial cell surface. Molecular microbiology, vol.40, no.6, 1273-1287.

  10. Bergmann, Simone, Rohde, Manfred, Hammerschmidt, Sven. Glyceraldehyde-3-Phosphate Dehydrogenase of Streptococcus pneumoniae Is a Surface-Displayed Plasminogen-Binding Protein. Infection and immunity, vol.72, no.4, 2416-2419.

  11. Bhat, Suraj P., Nagineni, Chandrasekharam N.. αB subunit of lens-specific protein α-crystallin is present in other ocular and non-ocular tissues. Biochemical and biophysical research communications, vol.158, no.1, 319-325.

  12. Bird, Adrian. The Selfishness of Law-Abiding Genes. Trends in genetics, vol.36, no.1, 8-13.

  13. Bloemendal, H. The vertebrate eye lens. Science, vol.197, no.4299, 127-138.

  14. Boehning, Darren, Patterson, Randen L., Sedaghat, Leela, Glebova, Natalia O., Kurosaki, Tomohiro, Snyder, Solomon H.. Cytochrome c binds to inositol (1,4,5) trisphosphate receptors, amplifying calcium-dependent apoptosis. Nature cell biology, vol.5, no.12, 1051-1061.

  15. Boleij, Annemarie, Laarakkers, Coby M., Gloerich, Jolein, Swinkels, Dorine W., Tjalsma, Harold, Camilli, A.. Surface-Affinity Profiling To Identify Host-Pathogen Interactions. Infection and immunity, vol.79, no.12, 4777-4783.

  16. Bonafé, Nathalie, Gilmore-Hebert, Maureen, Folk, Nancy L., Azodi, Masoud, Zhou, Yi, Chambers, Setsuko K.. Glyceraldehyde-3-Phosphate Dehydrogenase Binds to the AU-Rich 3′ Untranslated Region of Colony-Stimulating Factor-1 (CSF-1) Messenger RNA in Human Ovarian Cancer Cells: Possible Role in CSF-1 Posttranscriptional Regulation and Tumor Phenotype. Cancer research : the official organ of the American Association for Cancer Research, Inc, vol.65, no.9, 3762-3771.

  17. Booth, Daniel G, Hood, Fiona E, Prior, Ian A, Royle, Stephen J. A TACC3/ch-TOG/clathrin complex stabilises kinetochore fibres by inter-microtubule bridging : TACC3/ch-TOG/clathrin inter-microtubule bridges. The EMBO journal, vol.30, no.5, 906-919.

  18. Bornholdt, Zachary A., Noda, T., Abelson, Dafna M., Halfmann, P., Wood, Malcolm R., Kawaoka, Y., Saphire, E.. Structural Rearrangement of Ebola Virus VP40 Begets Multiple Functions in the Virus Life Cycle. Cell, vol.154, no.4, 763-774.

  19. Brassard, Julie, Gottschalk, Marcelo, Quessy, Sylvain. Cloning and purification of the Streptococcus suis serotype 2 glyceraldehyde-3-phosphate dehydrogenase and its involvement as an adhesin. Veterinary microbiology, vol.102, no.1, 87-94.

  20. Brodehl, Andreas, Gaertner‐Rommel, Anna, Klauke, Bärbel, Grewe, Simon Andre, Schirmer, Ilona, Peterschröder, Andreas, Faber, Lothar, Vorgerd, Matthias, Gummert, Jan, Anselmetti, Dario, Schulz, Uwe, Paluszkiewicz, Lech, Milting, Hendrik. The novel αB‐crystallin (CRYAB) mutation p.D109G causes restrictive cardiomyopathy. Human mutation, vol.38, no.8, 947-952.

  21. Brunet, Stephanie, Sacher, Michael. In Sickness and in Health: The Role of TRAPP and Associated Proteins in Disease. Traffic, vol.15, no.8, 803-818.

  22. Butterfield, D. Allan, Hardas, Sarita S., Lange, Miranda L. Bader. Oxidatively Modified Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) and Alzheimer's Disease: Many Pathways to Neurodegeneration. Journal of Alzheimer's disease, vol.20, no.2, 369-393.

  23. Buttner, Edgar (Ned) A., Gil-Krzewska, Aleksandra J., Rajpurohit, Anandita K., Hunter, Craig P.. Progression from mitotic catastrophe to germ cell death in Caenorhabditis elegans lis-1 mutants requires the spindle checkpoint. Developmental biology, vol.305, no.2, 397-410.

  24. Büttner, Sabrina, Eisenberg, Tobias, Carmona-Gutierrez, Didac, Ruli, Doris, Knauer, Heide, Ruckenstuhl, Christoph, Sigrist, Carola, Wissing, Silke, Kollroser, Manfred, Fröhlich, Kai-Uwe, Sigrist, Stephan, Madeo, Frank. Endonuclease G Regulates Budding Yeast Life and Death. Molecular cell, vol.25, no.2, 233-246.

  25. Chapple, Charles E., Robisson, Benoit, Spinelli, Lionel, Guien, Céline, Becker, Emmanuelle, Brun, Christine. Extreme multifunctional proteins identified from a human protein interaction network. Nature communications, vol.6, 7412-.

  26. Chiche, J, Pommier, S, Beneteau, M, Mondragón, L, Meynet, O, Zunino, B, Mouchotte, A, Verhoeyen, E, Guyot, M, Pagès, G, Mounier, N, Imbert, V, Colosetti, P, Goncalvès, D, Marchetti, S, Brière, J, Carles, M, Thieblemont, C, Ricci, J-E. GAPDH enhances the aggressiveness and the vascularization of non-Hodgkin’s B lymphomas via NF-κB-dependent induction of HIF-1α. Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, vol.29, no.5, 1163-1176.

  27. Chirico, Nicola, Vianelli, Alberto, Belshaw, Robert. Why genes overlap in viruses. Proceedings, Biological sciences, vol.277, no.1701, 3809-3817.

  28. Choi, Eunhee, Kikuchi, Sotaro, Gao, Haishan, Brodzik, Karolina, Nassour, Ibrahim, Yopp, Adam, Singal, Amit G., Zhu, Hao, Yu, Hongtao. Mitotic regulators and the SHP2-MAPK pathway promote IR endocytosis and feedback regulation of insulin signaling. Nature communications, vol.10, no.1, 1473-.

  29. Choi, E., Zhang, X., Xing, C., Yu, H.. Mitotic Checkpoint Regulators Control Insulin Signaling and Metabolic Homeostasis. Cell, vol.166, no.3, 567-581.

  30. Microbiol Cianciotto NP. 331 291 2001 

  31. Clapier, Cedric R., Cairns, Bradley R.. The Biology of Chromatin Remodeling Complexes. Annual review of biochemistry, vol.78, 273-304.

  32. Clark, Alice R., Lubsen, Nicolette H., Slingsby, Christine. sHSP in the eye lens: Crystallin mutations, cataract and proteostasis. The international journal of biochemistry & cell biology, vol.44, no.10, 1687-1697.

  33. Coller, H.A.. Is Cancer a Metabolic Disease?. The American journal of pathology, vol.184, no.1, 4-17.

  34. Conant, Gavin C., Wolfe, Kenneth H.. Turning a hobby into a job: How duplicated genes find new functions. Nature reviews. Genetics, vol.9, no.12, 938-950.

  35. Copley, Shelley D.. An evolutionary perspective on protein moonlighting. Biochemical Society transactions, vol.42, no.6, 1684-1691.

  36. 10.1007/978-1-4419-6706-0_1 

  37. Dietrich, Fred S., Voegeli, Sylvia, Brachat, Sophie, Lerch, Anita, Gates, Krista, Steiner, Sabine, Mohr, Christine, Pöhlmann, Rainer, Luedi, Philippe, Choi, Sangdun, Wing, Rod A., Flavier, Albert, Gaffney, Thomas D., Philippsen, Peter. The Ashbya gossypii Genome as a Tool for Mapping the Ancient Saccharomyces cerevisiae Genome. Science, vol.304, no.5668, 304-307.

  38. Dubin, R A, Wawrousek, E F, Piatigorsky, J. Expression of the murine alpha B-crystallin gene is not restricted to the lens.. Molecular and cellular biology, vol.9, no.3, 1083-1091.

  39. Dujon, Bernard, Sherman, David, Fischer, Gilles, Durrens, Pascal, Casaregola, Serge, Lafontaine, Ingrid, de Montigny, Jacky, Marck, Christian, Neuvéglise, Cécile, Talla, Emmanuel, Goffard, Nicolas, Frangeul, Lionel, Aigle, Michel, Anthouard, Véronique, Babour, Anna, Barbe, Valérie, Barnay, Stéphanie, Blanchin, Sylvie, Beckerich, Jean-Marie, Beyne, Emmanuelle, Bleykasten, Claudine, Boisramé, Anita, Boyer, Jeanne, Cattolico, Laurence, Confanioleri, Fabrice, de Daruvar, Antoine, Despons, Laurence, Fabre, Emmanuelle, Fairhead, Cécile, Ferry-Dumazet, Hélène, Groppi, Alexis, Hantraye, Florence, Hennequin, Christophe, Jauniaux, Nicolas, Joyet, Philippe, Kachouri, Rym, Kerrest, Alix, Koszul, Romain, Lemaire, Marc, Lesur, Isabelle, Ma, Laurence, Muller, Héloïse, Nicaud, Jean-Marc, Nikolski, Macha, Oztas, Sophie, Ozier-Kalogeropoulos, Odile, Pellenz, Stefan, Potier, Serge, R. Genome evolution in yeasts. Nature, vol.430, no.6995, 35-44.

  40. Esgleas, Miriam, Li, Yuanyi, Hancock, Mark A., Harel, Josée, Dubreuil, J. Daniel, Gottschalk, Marcelo. Isolation and characterization of α-enolase, a novel fibronectin-binding protein from Streptococcus suis. Microbiology, vol.154, no.9, 2668-2679.

  41. Espinosa-Cantú, Adriana, Ascencio, Diana, Barona-Gómez, Francisco, DeLuna, Alexander. Gene duplication and the evolution of moonlighting proteins. Frontiers in genetics, vol.6, 227-.

  42. Espinosa-Cantú, Adriana, Ascencio, Diana, Herrera-Basurto, Selene, Xu, Jiewei, Roguev, Assen, Krogan, Nevan J, DeLuna, Alexander. Protein Moonlighting Revealed by Noncatalytic Phenotypes of Yeast Enzymes. Genetics, vol.208, no.1, 419-431.

  43. Fallini, C., Bassell, G.J., Rossoll, W.. Spinal muscular atrophy: The role of SMN in axonal mRNA regulation. Brain research, vol.1462, 81-92.

  44. Fares, Mario A.. The evolution of protein moonlighting: adaptive traps and promiscuity in the chaperonins. Biochemical Society transactions, vol.42, no.6, 1709-1714.

  45. Feng, Youjun, Pan, Xiuzhen, Sun, Wen, Wang, Changjun, Zhang, Huimin, Li, Xianfu, Ma, Ying, Shao, Zhuqing, Ge, Junchao, Zheng, Feng, Gao, George F, Tang, Jiaqi. Streptococcus suis enolase functions as a protective antigen displayed on the bacterial cell surface.. The Journal of infectious diseases : official publication of the Infectious Diseases Society of America, vol.200, no.10, 1583-1592.

  46. Franco-Serrano, Luis, Cedano, Juan, Perez-Pons, Josep Antoni, Mozo-Villarias, Angel, Piñol, Jaume, Amela, Isaac, Querol, Enrique. A hypothesis explaining why so many pathogen virulence proteins are moonlighting proteins. Pathogens and disease, vol.76, no.5, fty046-.

  47. Franco-Serrano, Luis, Huerta, Mario, Hernández, Sergio, Cedano, Juan, Perez-Pons, JosepAntoni, Piñol, Jaume, Mozo-Villarias, Angel, Amela, Isaac, Querol, Enrique. Multifunctional Proteins: Involvement in Human Diseases and Targets of Current Drugs. The Protein Journal, vol.37, no.5, 444-453.

  48. FRIEDLAND, J S, SHATTOCK, R, REMICK, D G, GRIFFIN, G E. Mycobacterial 65-kD heat shock protein induces release of proinflammatory cytokines from human monocytic cells. Clinical and experimental immunology : an official journal of the British Society for Immunology, vol.91, no.1, 58-62.

  49. Fulde, Marcus, Rohde, Manfred, Polok, Andy, Preissner, Klaus T., Chhatwal, Gursharan Singh, Bergmann, Simone. Cooperative Plasminogen Recruitment to the Surface of Streptococcus canis via M Protein and Enolase Enhances Bacterial Survival. mBio, vol.4, no.2, e00629-12-.

  50. Ganapathy-Kanniappan, Shanmugasundaram. Evolution of GAPDH as a druggable target of tumor glycolysis?. Expert opinion on therapeutic targets, vol.22, no.4, 295-298.

  51. Gao, X., Wang, H., Yang, Jenny J., Liu, X., Liu, Z.R.. Pyruvate Kinase M2 Regulates Gene Transcription by Acting as a Protein Kinase. Molecular cell, vol.45, no.5, 598-609.

  52. Ge, Jingping, Catt, Diana M., Gregory, Richard L.. Streptococcus mutans Surface α-Enolase Binds Salivary Mucin MG2 and Human Plasminogen. Infection and immunity, vol.72, no.11, 6748-6752.

  53. Gomis-Rüth, F.Xavier, Dessen, Andréa, Timmins, Joanna, Bracher, Andreas, Kolesnikowa, Larissa, Becker, Stephan, Klenk, Hans-Dieter, Weissenhorn, Winfried. The Matrix Protein VP40 from Ebola Virus Octamerizes into Pore-like Structures with Specific RNA Binding Properties. Structure, vol.11, no.4, 423-433.

  54. Green, Douglas R., Fitzgerald, Patrick. Just So Stories about the Evolution of Apoptosis. Current biology : CB, vol.26, no.13, R620-R627.

  55. Hannibal, Luciana, Collins, Daniel, Brassard, Julie, Chakravarti, Ritu, Vempati, Rajesh, Dorlet, Pierre, Santolini, Jérôme, Dawson, John H., Stuehr, Dennis J.. Heme Binding Properties of Glyceraldehyde-3-phosphate Dehydrogenase. Biochemistry, vol.51, no.43, 8514-8529.

  56. Hao, Zhenyue, Duncan, Gordon S., Chang, Chia-Che, Elia, Andrew, Fang, Min, Wakeham, Andrew, Okada, Hitoshi, Calzascia, Thomas, Jang, YingJu, You-Ten, Annick, Yeh, Wen-Chen, Ohashi, Pamela, Wang, Xiaodong, Mak, Tak W.. Specific Ablation of the Apoptotic Functions of Cytochrome c Reveals a Differential Requirement for Cytochrome c and Apaf-1 in Apoptosis. Cell, vol.121, no.4, 579-591.

  57. Hara, Makoto R., Agrawal, Nishant, Kim, Sangwon F., Cascio, Matthew B., Fujimuro, Masahiro, Ozeki, Yuji, Takahashi, Masaaki, Cheah, Jaime H., Tankou, Stephanie K., Hester, Lynda D., Ferris, Christopher D., Hayward, S. Diane, Snyder, Solomon H., Sawa, Akira. S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding. Nature cell biology, vol.7, no.7, 665-674.

  58. Henderson, Brian. An overview of protein moonlighting in bacterial infection. Biochemical Society transactions, vol.42, no.6, 1720-1727.

  59. Henderson, Brian, Martin, Andrew. Bacterial Virulence in the Moonlight: Multitasking Bacterial Moonlighting Proteins Are Virulence Determinants in Infectious Disease. Infection and immunity, vol.79, no.9, 3476-3491.

  60. Hickey, Tyler B. M., Thorson, Lisa M., Speert, David P., Daffé, Mamadou, Stokes, Richard W.. Mycobacterium tuberculosisCpn60.2 and DnaK Are Located on the Bacterial Surface, Where Cpn60.2 Facilitates Efficient Bacterial Association with Macrophages. Infection and immunity, vol.77, no.8, 3389-3401.

  61. Horwitz, J. Alpha-crystallin can function as a molecular chaperone.. Proceedings of the National Academy of Sciences of the United States of America, vol.89, no.21, 10449-10453.

  62. Huang, Qiaojia, Lan, Fenghua, Zheng, Zhiyong, Xie, Feilai, Han, Junyong, Dong, Lihong, Xie, Yanchuan, Zheng, Feng. Akt2 Kinase Suppresses Glyceraldehyde-3-phosphate Dehydrogenase (GAPDH)-mediated Apoptosis in Ovarian Cancer Cells via Phosphorylating GAPDH at Threonine 237 and Decreasing Its Nuclear Translocation. The Journal of biological chemistry, vol.286, no.49, 42211-42220.

  63. Ingolia, T D, Craig, E A. Four small Drosophila heat shock proteins are related to each other and to mammalian alpha-crystallin.. Proceedings of the National Academy of Sciences of the United States of America, vol.79, no.7, 2360-2364.

  64. Itakura, Masanori, Nakajima, Hidemitsu, Kubo, Takeya, Semi, Yuko, Kume, Satoshi, Higashida, Shusaku, Kaneshige, Akihiro, Kuwamura, Mitsuru, Harada, Naoki, Kita, Akinori, Azuma, Yasu-Taka, Yamaji, Ryoichi, Inui, Takashi, Takeuchi, Tadayoshi. Glyceraldehyde-3-phosphate Dehydrogenase Aggregates Accelerate Amyloid-β Amyloidogenesis in Alzheimer Disease. The Journal of biological chemistry, vol.290, no.43, 26072-26087.

  65. Iwaki, T., Kume-Iwaki, A., Liem, R.K.H., Goldman, J.E.. αB-crystallin is expressed in non-lenticular tissues and accumulates in Alexander's disease brain. Cell, vol.57, no.1, 71-78.

  66. Jacquin, M A, Chiche, J, Zunino, B, Bénéteau, M, Meynet, O, Pradelli, L A, Marchetti, S, Cornille, A, Carles, M, Ricci, J-E. GAPDH binds to active Akt, leading to Bcl-xL increase and escape from caspase-independent cell death. Cell death and differentiation, vol.20, no.8, 1043-1054.

  67. Jeffery, Constance J.. Moonlighting proteins. Trends in biochemical sciences, vol.24, no.1, 8-11.

  68. Jeffery, Constance J.. An introduction to protein moonlighting. Biochemical Society transactions, vol.42, no.6, 1679-1683.

  69. Jiang, Xuejun, Wang, Xiaodong. CYTOCHROME C-MEDIATED APOPTOSIS. Annual review of biochemistry, vol.73, 87-106.

  70. Jiang, Y., Li, X., Yang, W., Hawke, David H., Zheng, Y., Xia, Y., Aldape, K., Wei, C., Guo, F., Chen, Y., Lu, Z.. PKM2 Regulates Chromosome Segregation and Mitosis Progression of Tumor Cells. Molecular cell, vol.53, no.1, 75-87.

  71. Jiang, Yuhui, Wang, Yugang, Wang, Ting, Hawke, David H., Zheng, Yanhua, Li, Xinjian, Zhou, Qin, Majumder, Sadhan, Bi, Erfei, Liu, David X., Huang, Suyun, Lu, Zhimin. PKM2 phosphorylates MLC2 and regulates cytokinesis of tumor cells. Nature communications, vol.5, 5566-5566.

  72. Kellis, Manolis, Birren, Bruce W., Lander, Eric S.. Proof and evolutionary analysis of ancient genome duplication in the yeast Saccharomyces cerevisiae. Nature, vol.428, no.6983, 617-624.

  73. Kesimer, Mehmet, Kiliç, Nedret, Mehrotra, Ravi, Thornton, David J, Sheehan, John K. Identification of salivary mucin MUC7 binding proteins from Streptococcus gordonii. BMC microbiology, vol.9, 163-163.

  74. Khan, Ishita K, Bhuiyan, Mansurul, Kihara, Daisuke. DextMP: deep dive into text for predicting moonlighting proteins. Bioinformatics, vol.33, no.14, i83-i91.

  75. Kim, J.W., Kim, S.J., Han, S.M., Paik, S.Y., Hur, S.Y., Kim, Y.W., Lee, J.M., Namkoong, S.E.. Increased Glyceraldehyde-3-Phosphate Dehydrogenase Gene Expression in Human Cervical Cancers. Gynecologic oncology, vol.71, no.2, 266-269.

  76. Kim, Sol, Lee, Jungwoon, Kim, Jungho. Regulation of oncogenic transcription factor hTAFII68-TEC activity by human glyceraldehyde-3-phosphate dehydrogenase (GAPDH). The Biochemical journal, vol.404, no.2, 197-206.

  77. Kops, Geert JPL. The kinetochore and spindle checkpoint in mammals. Frontiers in bioscience, vol.13, no.10, 3606-.

  78. Kops, Geert J. P. L., Weaver, Beth A. A., Cleveland, Don W.. On the road to cancer: aneuploidy and the mitotic checkpoint. Nature reviews. Cancer, vol.5, no.10, 773-785.

  79. Kroemer, Guido. Mitochondrial implication in apoptosis. Towards an endosymbiont hypothesis of apoptosis evolution. Cell death and differentiation, vol.4, no.6, 443-456.

  80. Lamb, Christopher A, Nühlen, Stefanie, Judith, Delphine, Frith, David, Snijders, Ambrosius P, Behrends, Christian, Tooze, Sharon A. TBC 1D14 regulates autophagy via the TRAPP complex and ATG 9 traffic. The EMBO journal, vol.35, no.3, 281-301.

  81. Lara-Gonzalez, P., Westhorpe, Frederick G., Taylor, Stephen S.. The Spindle Assembly Checkpoint. Current biology : CB, vol.22, no.22, R966-R980.

  82. Li, Lily Y., Luo, Xu, Wang, Xiaodong. Endonuclease G is an apoptotic DNase when released from mitochondria. Nature, vol.412, no.6842, 95-99.

  83. Li, Xinjian, Jiang, Yuhui, Meisenhelder, Jill, Yang, Weiwei, Hawke, David H., Zheng, Yanhua, Xia, Yan, Aldape, Kenneth, He, Jie, Hunter, Tony, Wang, Liwei, Lu, Zhimin. Mitochondria-Translocated PGK1 Functions as a Protein Kinase to Coordinate Glycolysis and the TCA Cycle in Tumorigenesis. Molecular cell, vol.61, no.5, 705-719.

  84. Li, Yonghong, Nowotny, Petra, Holmans, Peter, Smemo, Scott, Kauwe, John S. K., Hinrichs, Anthony L., Tacey, Kristina, Doil, Lisa, van Luchene, Ryan, Garcia, Veronica, Rowland, Charles, Schrodi, Steve, Leong, Diane, Gogic, Goran, Chan, Joanne, Cravchik, Anibal, Ross, David, Lau, Kit, Kwok, Shirley, Chang, Sheng-Yung, Catanese, Joe, Sninsky, John, White, Thomas J., Hardy, John, Powell, John, Lovestone, Simon, Morris, John C., Thal, Leon, Owen, Michael, Williams, Julie, Goate, Alison, Grupe, Andrew. Association of late-onset Alzheimer's disease with genetic variation in multiple members of the GAPD gene family. Proceedings of the National Academy of Sciences of the United States of America, vol.101, no.44, 15688-15693.

  85. Liang, Ji, Cao, Ruixiu, Wang, Xiongjun, Zhang, Yajuan, Wang, Pan, Gao, Hong, Li, Chen, Yang, Fan, Zeng, Rong, Wei, Ping, Li, Dawei, Li, Wenfeng, Yang, Weiwei. Mitochondrial PKM2 regulates oxidative stress-induced apoptosis by stabilizing Bcl2. Cell research, vol.27, no.3, 329-351.

  86. Lin, S.-N.. Helicobacter pylori heat-shock protein 60 induces production of the pro-inflammatory cytokine IL8 in monocytic cells. Journal of medical microbiology, vol.54, no.3, 225-233.

  87. Liu, Kaiyan, Tang, Zhenjie, Huang, Amin, Chen, Ping, Liu, Panpan, Yang, Jing, Lu, Wenhua, Liao, Jianwei, Sun, Yicheng, Wen, Shijun, Hu, Yumin, Huang, Peng. Glyceraldehyde-3-phosphate dehydrogenase promotes cancer growth and metastasis through upregulation of SNAIL expression. International journal of oncology, vol.50, no.1, 252-262.

  88. Liu, Xuesong, Kim, Caryn Naekyung, Yang, Jie, Jemmerson, Ronald, Wang, Xiaodong. Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c. Cell, vol.86, no.1, 147-157.

  89. Lu, Yun, Rolland, Stéphane G., Conradt, Barbara. A molecular switch that governs mitochondrial fusion and fission mediated by the BCL2-like protein CED-9 of Caenorhabditis elegans. Proceedings of the National Academy of Sciences of the United States of America, vol.108, no.41,

  90. Lu, Zhimin, Hunter, Tony. Metabolic Kinases Moonlighting as Protein Kinases. Trends in biochemical sciences, vol.43, no.4, 301-310.

  91. Luo, Xuelian, Tang, Zhanyun, Rizo, Josep, Yu, Hongtao. The Mad2 Spindle Checkpoint Protein Undergoes Similar Major Conformational Changes Upon Binding to Either Mad1 or Cdc20. Molecular cell, vol.9, no.1, 59-71.

  92. Luo, Xuelian, Tang, Zhanyun, Xia, Guohong, Wassmann, Katja, Matsumoto, Tomohiro, Rizo, Josep, Yu, Hongtao. The Mad2 spindle checkpoint protein has two distinct natively folded states. Nature structural & molecular biology, vol.11, no.4, 338-345.

  93. Madureira, Pedro, Baptista, Marina, Vieira, Marta, Magalhães, Vanessa, Camelo, Ana, Oliveira, Liliana, Ribeiro, Adília, Tavares, Delfina, Trieu-Cuot, Patrick, Vilanova, Manuel, Ferreira, Paula. Streptococcus agalactiae GAPDH Is a Virulence-Associated Immunomodulatory Protein. The journal of immunology : official journal of the American Association of Immunologists, vol.178, no.3, 1379-1387.

  94. Marioni, Riccardo E., Harris, Sarah E., Zhang, Qian, McRae, Allan F., Hagenaars, Saskia P., Hill, W. David, Davies, Gail, Ritchie, Craig W., Gale, Catharine R., Starr, John M., Goate, Alison M., Porteous, David J., Yang, Jian, Evans, Kathryn L., Deary, Ian J., Wray, Naomi R., Visscher, Peter M.. GWAS on family history of Alzheimer’s disease. Translational psychiatry, vol.8, no.1, 99-.

  95. Martin, Andrew C.R.. Structural biology of moonlighting: lessons from antibodies. Biochemical Society transactions, vol.42, no.6, 1704-1708.

  96. Milev, Miroslav P., Hasaj, Benedeta, Saint-Dic, Djenann, Snounou, Sary, Zhao, Qingchuan, Sacher, Michael. TRAMM/TrappC12 plays a role in chromosome congression, kinetochore stability, and CENP-E recruitment. The Journal of cell biology, vol.209, no.2, 221-234.

  97. Milo, Ron. What is the total number of protein molecules per cell volume? A call to rethink some published values. BioEssays, vol.35, no.12, 1050-1055.

  98. Mori, Yuka, Yamaguchi, Masaya, Terao, Yutaka, Hamada, Shigeyuki, Ooshima, Takashi, Kawabata, Shigetada. α-Enolase of Streptococcus pneumoniae Induces Formation of Neutrophil Extracellular Traps. The Journal of biological chemistry, vol.287, no.13, 10472-10481.

  99. Moscona, A A, Fox, L, Smith, J, Degenstein, L. Antiserum to lens antigens immunostains Müller glia cells in the neural retina.. Proceedings of the National Academy of Sciences of the United States of America, vol.82, no.16, 5570-5573.

  100. Muchmore, Steven W., Sattler, Michael, Liang, Heng, Meadows, Robert P., Harlan, John E., Yoon, Ho Sup, Nettesheim, David, Chang, Brian S., Thompson, Craig B., Wong, Sui-Lam, Ng, Shi-Chung, Fesik, Stephen W.. X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death. Nature, vol.381, no.6580, 335-341.

  101. A major surface protein on group A streptococci is a glyceraldehyde-3- phosphate-dehydrogenase with multiple binding activity. The Journal of experimental medicine, vol.176, no.2, 415-426.

  102. Pancholi, V, Fischetti, V A. Glyceraldehyde-3-phosphate dehydrogenase on the surface of group A streptococci is also an ADP-ribosylating enzyme.. Proceedings of the National Academy of Sciences of the United States of America, vol.90, no.17, 8154-8158.

  103. Pancholi, Vijaykumar, Fischetti, Vincent A.. Regulation of the Phosphorylation of Human Pharyngeal Cell Proteins by Group A Streptococcal Surface Dehydrogenase: Signal Transduction between Streptococci and Pharyngeal Cells. The Journal of experimental medicine, vol.186, no.10, 1633-1643.

  104. Piatigorsky, J, O'Brien, W E, Norman, B L, Kalumuck, K, Wistow, G J, Borras, T, Nickerson, J M, Wawrousek, E F. Gene sharing by delta-crystallin and argininosuccinate lyase.. Proceedings of the National Academy of Sciences of the United States of America, vol.85, no.10, 3479-3483.

  105. Piatigorsky, J., Wistow, G.J.. Enzyme/crystallins: Gene sharing as an evolutionary strategy. Cell, vol.57, no.2, 197-199.

  106. Popgeorgiev, Nikolay, Bonneau, Benjamin, Ferri, Karine F., Prudent, Julien, Thibaut, Julien, Gillet, Germain. The Apoptotic Regulator Nrz Controls Cytoskeletal Dynamics via the Regulation of Ca2+ Trafficking in the Zebrafish Blastula. Developmental cell, vol.20, no.5, 663-676.

  107. Qian, Xu, Li, Xinjian, Lu, Zhimin. Protein kinase activity of the glycolytic enzyme PGK1 regulates autophagy to promote tumorigenesis. Autophagy, vol.13, no.7, 1246-1247.

  108. Quessy, Sylvain, Busque, Philippe, Higgins, Robert, Jacques, Mario, Dubreuil, J.Daniel. Description of an albumin binding activity for Streptococcus suis serotype 2. FEMS microbiology letters, vol.147, no.2, 245-250.

  109. Anticancer Res Ramos D 439 35 2015 

  110. Révillion, F, Pawlowski, V, Hornez, L, Peyrat, J.-P. Glyceraldehyde-3-phosphate dehydrogenase gene expression in human breast cancer. European journal of cancer, vol.36, no.8, 1038-1042.

  111. Rice, Alan M., McLysaght, Aoife. Dosage-sensitive genes in evolution and disease. BMC biology, vol.15, no.1, 78-.

  112. Rolland, Stéphane G., Lu, Yun, David, Charles N., Conradt, Barbara. The BCL-2–like protein CED-9 of C. elegans promotes FZO-1/Mfn1,2– and EAT-3/Opa1–dependent mitochondrial fusion. The Journal of cell biology, vol.186, no.4, 525-540.

  113. Rosenberg, Scott C., Corbett, Kevin D.. The multifaceted roles of the HORMA domain in cellular signaling. The Journal of cell biology, vol.211, no.4, 745-755.

  114. Royle, Stephen J.. Mitotic Moonlighting Functions for Membrane Trafficking Proteins. Traffic, vol.12, no.7, 791-798.

  115. Royle, Stephen J., Bright, Nicholas A., Lagnado, Leon. Clathrin is required for the function of the mitotic spindle. Nature, vol.434, no.7037, 1152-1157.

  116. Royle, Stephen J., Lagnado, Leon. Trimerisation is important for the function of clathrin at the mitotic spindle. Journal of cell science, vol.119, no.19, 4071-4078.

  117. Cancer Res Schek N 6354 48 1988 

  118. Scrivens, P. James, Noueihed, Baraa, Shahrzad, Nassim, Hul, Sokunthear, Brunet, Stephanie, Sacher, Michael. C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking. Molecular biology of the cell, vol.22, no.12, 2083-2093.

  119. Sen, Nilkantha, Hara, Makoto R., Kornberg, Michael D., Cascio, Matthew B., Bae, Byoung-Il, Shahani, Neelam, Thomas, Bobby, Dawson, Ted M., Dawson, Valina L., Snyder, Solomon H., Sawa, Akira. Nitric oxide-induced nuclear GAPDH activates p300/CBP and mediates apoptosis. Nature cell biology, vol.10, no.7, 866-873.

  120. Sigler, Paul B., Xu, Zhaohui, Rye, Hays S., Burston, Steven G., Fenton, Wayne A., Horwich, Arthur L.. STRUCTURE AND FUNCTION IN GroEL-MEDIATED PROTEIN FOLDING. Annual review of biochemistry, vol.67, 581-608.

  121. Sironi, Lucia, Mapelli, Marina, Knapp, Stefan, Antoni, Anna De, Jeang, Kuan‐Teh, Musacchio, Andrea. Crystal structure of the tetrameric Mad1–Mad2 core complex: implications of a ‘safety belt’ binding mechanism for the spindle checkpoint. The EMBO journal, vol.21, no.10, 2496-2506.

  122. Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH): The Quintessential Moonlighting Protein in Normal Cell Function and in Human Disease Sirover MA. 2017 

  123. Sirover, Michael A.. Pleiotropic effects of moonlighting glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in cancer progression, invasiveness, and metastases. Cancer and metastasis reviews, vol.37, no.4, 665-676.

  124. Sriram, G., Martinez, J.A., McCabe, E.R.B., Liao, J.C., Dipple, K.M.. Single-Gene Disorders: What Role Could Moonlighting Enzymes Play?. American journal of human genetics, vol.76, no.6, 911-924.

  125. Strich, Randy. Programmed Cell Death Initiation and Execution in Budding Yeast. Genetics, vol.200, no.4, 1003-1014.

  126. Comp. Biochem. Phys. D Stump AD 220 8 2013 

  127. Sunaga, Katsuyoshi, Takahashi, Hiroshi, Chuang, De-Maw, Ishitani, Ryoichi. Glyceraldehyde-3-phosphate dehydrogenase is over-expressed during apoptotic death of neuronal cultures and is recognized by a monoclonal antibody against amyloid plaques from Alzheimer's brain. Neuroscience letters, vol.200, no.2, 133-136.

  128. Suzuki, Yasuyuki, Imai, Yuzuru, Nakayama, Hiroshi, Takahashi, Kazuko, Takio, Koji, Takahashi, Ryosuke. A Serine Protease, HtrA2, Is Released from the Mitochondria and Interacts with XIAP, Inducing Cell Death. Molecular cell, vol.8, no.3, 613-621.

  129. Tait, Stephen W. G., Green, Douglas R.. Mitochondria and cell death: outer membrane permeabilization and beyond. Nature reviews. Molecular cell biology, vol.11, no.9, 621-632.

  130. Tamaoka, Akira, Endoh, Riuko, Shoji, Shin'ichi, Takahashi, Hiroshi, Hirokawa, Katsuiku, Teplow, David B., Selkoe, Dennis J., Mori, Hiroshi. Antibodies to amyloid β protein (Aβ) crossreact with glyceraldehyde-3-phosphate dehydrogenase (GAPDH). Neurobiology of aging, vol.17, no.3, 405-414.

  131. Tang, Zhenjie, Yuan, Shuqiang, Hu, Yumin, Zhang, Hui, Wu, Wenjing, Zeng, Zhaolei, Yang, Jing, Yun, Jingping, Xu, Ruihua, Huang, Peng. Over-expression of GAPDH in human colorectal carcinoma as a preferred target of 3-Bromopyruvate Propyl Ester. Journal of bioenergetics and biomembranes, vol.44, no.1, 117-125.

  132. Tarze, A, Deniaud, A, Le Bras, M, Maillier, E, Molle, D, Larochette, N, Zamzami, N, Jan, G, Kroemer, G, Brenner, C. GAPDH, a novel regulator of the pro-apoptotic mitochondrial membrane permeabilization. Oncogene, vol.26, no.18, 2606-2620.

  133. Teichner, Adar, Eytan, Esther, Sitry-Shevah, Danielle, Miniowitz-Shemtov, Shirly, Dumin, Elena, Gromis, Jonathan, Hershko, Avram. p31 comet promotes disassembly of the mitotic checkpoint complex in an ATP-dependent process. Proceedings of the National Academy of Sciences of the United States of America, vol.108, no.8, 3187-3192.

  134. Terao, Yutaka, Yamaguchi, Masaya, Hamada, Shigeyuki, Kawabata, Shigetada. Multifunctional Glyceraldehyde-3-phosphate Dehydrogenase of Streptococcus pyogenes Is Essential for Evasion from Neutrophils. The Journal of biological chemistry, vol.281, no.20, 14215-14223.

  135. Cancer Res Tokunaga K 5616 47 1987 

  136. 10.1002/1097-0142(20000701)89:1<152::AID-CNCR20>3.0.CO;2-T 

  137. Wan, Jun, Block, Samuel, Scribano, Christina M., Thiry, Rebecca, Esbona, Karla, Audhya, Anjon, Weaver, Beth A.. Mad1 destabilizes p53 by preventing PML from sequestering MDM2. Nature communications, vol.10, no.1, 1540-.

  138. Wan, J., Zhu, F., Zasadil, Lauren M., Yu, J., Wang, L., Johnson, A., Berthier, E., Beebe, David J., Audhya, A., Weaver, Beth A.. A Golgi-Localized Pool of the Mitotic Checkpoint Component Mad1 Controls Integrin Secretion and Cell Migration. Current biology : CB, vol.24, no.22, 2687-2692.

  139. Wang, Qin, Woltjer, Randall L., Cimino, P. J., Pan, Catherine, Montine, Kathleen S., Zhang, Jing, Montine, Thomas J.. Proteomic analysis of neurofibrillary tangles in Alzheimer disease identifies GAPDH as a detergent‐insoluble paired helical filament tau binding protein. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, vol.19, no.7, 1-12.

  140. Wang, Wangfei, Jeffery, Constance J.. An analysis of surface proteomics results reveals novel candidates for intracellular/surface moonlighting proteins in bacteria. Molecular bioSystems, vol.12, no.5, 1420-1431.

  141. Westhorpe, Frederick G., Tighe, Anthony, Lara-Gonzalez, Pablo, Taylor, Stephen S.. p31comet-mediated extraction of Mad2 from the MCC promotes efficient mitotic exit. Journal of cell science, vol.124, no.22, 3905-3916.

  142. Wistow, Graeme J., Mulders, John W. M., de Jong, Wilfried W.. The enzyme lactate dehydrogenase as a structural protein in avian and crocodilian lenses. Nature, vol.326, no.6113, 622-624.

  143. Wolfe, Kenneth H., Shields, Denis C.. Molecular evidence for an ancient duplication of the entire yeast genome. Nature, vol.387, no.6634, 708-713.

  144. Xia, Li, Qin, Kang, Wang, Xin-Ran, Wang, Xiao-Ling, Zhou, Ai-Wu, Chen, Guo-Qiang, Lu, Ying. Pyruvate kinase M2 phosphorylates H2AX and promotes genomic instability in human tumor cells. Oncotarget, vol.8, no.65, 109120-109134.

  145. Yang, Maojun, Li, Bing, Tomchick, Diana R., Machius, Mischa, Rizo, Josep, Yu, Hongtao, Luo, Xuelian. p31comet Blocks Mad2 Activation through Structural Mimicry. Cell, vol.131, no.4, 744-755.

  146. Yang, W., Xia, Y., Hawke, D., Li, X., Liang, J., Xing, D., Aldape, K., Hunter, T., Alfred Yung, W.K., Lu, Z.. PKM2 Phosphorylates Histone H3 and Promotes Gene Transcription and Tumorigenesis. Cell, vol.150, no.4, 685-696.

  147. Yokoyama, H., Nakos, K., Santarella-Mellwig, R., Rybina, S., Krijgsveld, J., Koffa, Maria D., Mattaj, Iain W.. CHD4 Is a RanGTP-Dependent MAP that Stabilizes Microtubules and Regulates Bipolar Spindle Formation. Current biology : CB, vol.23, no.24, 2443-2451.

  148. Yokoyama, Hideki, Rybina, Sofia, Santarella-Mellwig, Rachel, Mattaj, Iain W., Karsenti, Eric. ISWI is a RanGTP-dependent MAP required for chromosome segregation. The Journal of cell biology, vol.187, no.6, 813-829.

  149. Yoshida, Naofumi, Oeda, Kenji, Watanabe, Eijiro, Mikami, Toshiyuki, Fukita, Yoshikazu, Nishimura, Keiichiro, Komai, Koichiro, Matsuda, Kazuhiko. Chaperonin turned insect toxin. Nature, vol.411, no.6833, 44-44.

  150. Youle, Richard J., Strasser, Andreas. The BCL-2 protein family: opposing activities that mediate cell death. Nature reviews. Molecular cell biology, vol.9, no.1, 47-59.

  151. Zmasek, Christian M., Godzik, Adam. Evolution of the Animal Apoptosis Network. Cold Spring Harbor perspectives in biology, vol.5, no.3, a008649-a008649.

관련 콘텐츠

저작권 관리 안내
섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트

맨위로