[논문]Small Molecule Inhibitors of DYRK1A Identified by Computational and Experimental Approaches

Yoon, Hye Ree; Balupuri, Anand; Choi, Kwang-Eun; Kang, Nam Sook

doi:10.3390/ijms21186826

[해외논문] Small Molecule Inhibitors of DYRK1A Identified by Computational and Experimental Approaches 원문보기

International journal of molecular sciences, v.21 no.18, 2020년, pp.6826 -

Yoon, Hye Ree , Balupuri, Anand , Choi, Kwang-Eun , Kang, Nam Sook

Abstract ▼ AI-Helper

Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) is a protein kinase with diverse functions in cell regulation. Abnormal expression and activity of DYRK1A contribute to numerous human malignancies, Down syndrome, and Alzheimer’s disease. Notably, DYRK1A has been proposed as a potential therapeutic target for the treatment of diabetes because of its key role in pancreatic β-cell proliferation. Consequently, DYRK1A is an attractive drug target for a variety of diseases. Here, we report the identification of several DYRK1A inhibitors using our in-house topological water network-based approach. All inhibitors were further verified by in vitro assay.

Keyword

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