[논문]A Systems Biology Approach Identifies Hidden Regulatory Connections Between the Circadian and Cell-Cycle Checkpoints

Zou, Xianlin; Kim, Dae Wook; Gotoh, Tetsuya; Liu, Jingjing; Kim, Jae Kyoung; Finkielstein, Carla V.

doi:10.3389/fphys.2020.00327

[해외논문] A Systems Biology Approach Identifies Hidden Regulatory Connections Between the Circadian and Cell-Cycle Checkpoints 원문보기

Frontiers in physiology, v.11, 2020년, pp.327 -

Zou, Xianlin (Integrated Cellular Responses Laboratory, Department of Biological Sciences, Fralin Life Sciences Institute, Virginia Tech , Blacksburg, VA , United States) , Kim, Dae Wook (Department of Mathematical Sciences, Korea Advanced Institute of Science and Technology , Daejeon , South Korea) , Gotoh, Tetsuya (Integrated Cellular Responses Laboratory, Department of Biological Sciences, Fralin Life Sciences Institute, Virginia Tech , Blacksburg, VA , United States) , Liu, Jingjing (Integrated Cellular Responses Laboratory, Department of Biological Sciences, Fralin Life Sciences Institute, Virginia Tech , Blacksburg, VA , United States) , Kim, Jae Kyoung (Department of Mathematical Sciences, Korea Advanced Institute of Science and Technology , Daejeon , South Korea) , Finkielstein, Carla V. (Integrated Cellular Responses Laboratory, Department of Biological Sciences, Fralin Life Sciences Institute, Virginia Tech , Blacksb)

Abstract ▼ AI-Helper

Circadian rhythms form a self-sustaining, endogenous, time-keeping system that allows organisms to anticipate daily environmental changes. The core of the clock network consists of interlocking transcriptional-translational feedback loops that ensures that metabolic, behavioral, and physiological processes run on a 24 h timescale. The hierarchical nature of the clock manifests itself in multiple points of control on the daily cell division cycle, which relies on synthesis, degradation, and post-translational modification for progression. This relationship is particularly important for understanding the role of clock components in sensing stress conditions and triggering checkpoint signals that stop cell cycle progression. A case in point is the interplay among the circadian factor PERIOD2 (PER2), the tumor suppressor p53, and the oncogenic mouse double minute-2 homolog protein (MDM2), which is the p53’s negative regulator. Under unstressed conditions, PER2 and p53 form a stable complex in the cytosol and, along with MDM2, a trimeric complex in the nucleus. Association of PER2 to the C-terminus end of p53 prevents MDM2-mediated ubiquitylation and degradation of p53 as well as p53’s transcriptional activation. Remarkably, when not bound to p53, PER2 acts as substrate for the E3-ligase activity of MDM2; thus, PER2 is degraded in a phosphorylation-independent fashion. Unexpectedly, the phase relationship between PER2 and p53 are opposite; however, a systematic modeling approach, inferred from the oscillatory time course data of PER2 and p53, aided in identifying additional regulatory scenarios that explained, a priori, seemingly conflicting experimental data. Therefore, we advocate for a combined experimental/mathematical approach to elucidating multilevel regulatory cellular processes.

Keyword

참고문헌 (59)

Badura L. Swanson T. Adamowicz W. Adams J. Cianfrogna J. Fisher K. ( 2007 ). An inhibitor of casein kinase I epsilon induces phase delays in circadian rhythms under free-running and entrained conditions. J. Pharmacol. Exp. Ther. 322 730 ？ 738 . 10.1124/jpet.107.122846 17502429

상세보기
Bell-Pedersen D. Cassone V. M. Earnest D. J. Golden S. S. Hardin P. E. Thomas T. L. ( 2005 ). Circadian rhythms from multiple oscillators: lessons from diverse organisms. Nat. Rev. Genet. 6 544 ？ 556 . 10.1038/nrg1633 15951747

상세보기
Bjarnason G. A. Jordan R. C. Sothern R. B. ( 1999 ). Circadian variation in the expression of cell-cycle proteins in human oral epithelium. Am. J. Pathol. 154 613 ？ 622 . 10.1016/S0002-9440(10)65306-65300 10027418

상세보기
Bjarnason G. A. Jordan R. C. Wood P. A. Li Q. Lincoln D. W. Sothern R. B. ( 2001 ). Circadian expression of clock genes in human oral mucosa and skin: association with specific cell-cycle phases. Am. J. Pathol. 158 1793 ？ 1801 . 10.1016/S0002-9440(10)64135-64131 11337377

상세보기
Brown W. R. ( 1991 ). A review and mathematical analysis of circadian rhythms in cell proliferation in mouse, rat, and human epidermis. J. Invest. Dermatol. 97 273 ？ 280 . 10.1111/1523-1747.ep12480379 1830075

상세보기
Chen Z. Yoo S. H. Park Y. S. Kim K. H. Wei S. Buhr E. ( 2012 ). Identification of diverse modulators of central and peripheral circadian clocks by high-throughput chemical screening. Proc. Natl. Acad. Sci. U.S.A. 109 101 ？ 106 . 10.1073/pnas.1118034108 22184224

상세보기
Chiu J. C. Ko H. W. Edery I. ( 2011 ). NEMO/NLK phosphorylates PERIOD to initiate a time-delay phosphorylation circuit that sets circadian clock speed. Cell 145 357 ？ 370 . 10.1016/j.cell.2011.04.002 21514639

상세보기
D’Alessandro M. Beesley S. Kim J. K. Chen R. Abich E. Cheng W. ( 2015 ). A tunable artificial circadian clock in clock-defective mice. Nat. Commun. 6 : 8587 . 10.1038/ncomms9587 26617050

상세보기
D’Alessandro M. Beesley S. Kim J. K. Jones Z. Chen R. Wi J. ( 2017 ). Stability of wake-sleep cycles requires robust degradation of the PERIOD protein. Curr. Biol. 27 3454 ？ 3467.e8 . 10.1016/j.cub.2017.10.014 29103939

상세보기
Destici E. Oklejewicz M. Saito S. van der Horst G. T. ( 2011 ). Mammalian cryptochromes impinge on cell cycle progression in a circadian clock-independent manner. Cell Cycle 10 3788 ？ 3797 . 10.4161/cc.10.21.17974 22033214

상세보기
Eide E. J. Woolf M. F. Kang H. Woolf P. Hurst W. Camacho F. ( 2005 ). Control of mammalian circadian rhythm by CKIepsilon-regulated proteasome-mediated PER2 degradation. Mol. Cell Biol. 25 2795 ？ 2807 . 10.1128/MCB.25.7.2795-2807.2005 15767683

상세보기
Gallego M. Virshup D. M. ( 2007 ). Post-translational modifications regulate the ticking of the circadian clock. Nat. Rev. Mol. Cell Biol. 8 139 ？ 148 . 10.1038/nrm2106 17245414

상세보기
Gaucher J. Montellier E. Sassone-Corsi P. ( 2018 ). Molecular cogs: interplay between circadian clock and cell cycle. Trends Cell Biol. 28 368 ？ 379 . 10.1016/j.tcb.2018.01.006 29471986

상세보기
Gery S. Komatsu N. Baldjyan L. Yu A. Koo D. Koeffler H. P. ( 2006 ). The circadian gene per1 plays an important role in cell growth and DNA damage control in human cancer cells. Mol. Cell 22 375 ？ 382 . 10.1016/j.molcel.2006.03.038 16678109

상세보기
Gotoh T. Kim J. K. Liu J. Vila-Caballer M. Stauffer P. E. Tyson J. J. ( 2016 ). Model-driven experimental approach reveals the complex regulatory distribution of p53 by the circadian factor Period 2. Proc. Natl. Acad. Sci. U.S.A. 113 13516 ？ 13521 . 10.1073/pnas.1607984113 27834218

상세보기
Gotoh T. Vila-Caballer M. Liu J. Schiffhauer S. Finkielstein C. V. ( 2015 ). Association of the circadian factor Period 2 to p53 influences p53’s function in DNA-damage signaling. Mol. Biol. Cell 26 359 ？ 372 . 10.1091/mbc.E14-05-0994 25411341

상세보기
Gotoh T. Vila-Caballer M. Santos C. S. Liu J. Yang J. Finkielstein C. V. ( 2014 ). The circadian factor Period 2 modulates p53 stability and transcriptional activity in unstressed cells. Mol. Biol. Cell 25 3081 ？ 3093 . 10.1091/mbc.E14-05-0993 25103245

상세보기
Grechez-Cassiau A. Rayet B. Guillaumond F. Teboul M. Delaunay F. ( 2008 ). The circadian clock component BMAL1 is a critical regulator of p21WAF1/CIP1 expression and hepatocyte proliferation. J. Biol. Chem. 283 4535 ？ 4542 . 10.1074/jbc.M705576200 18086663

상세보기
Hirota T. Lewis W. G. Liu A. C. Lee J. W. Schultz P. G. Kay S. A. ( 2008 ). A chemical biology approach reveals period shortening of the mammalian circadian clock by specific inhibition of GSK-3beta. Proc. Natl. Acad. Sci. U.S.A. 105 20746 ？ 20751 . 10.1073/pnas.0811410106 19104043

상세보기
Hong C. I. Zamborszky J. Baek M. Labiscsak L. Ju K. Lee H. ( 2014 ). Circadian rhythms synchronize mitosis in Neurospora crassa . Proc. Natl. Acad. Sci. U.S.A. 111 1397 ？ 1402 . 10.1073/pnas.1319399111 24474764

상세보기
Huber A. L. Papp S. J. Chan A. B. Henriksson E. Jordan S. D. Kriebs A. ( 2016 ). CRY2 and FBXL3 cooperatively degrade c-MYC. Mol. Cell 64 774 ？ 789 . 10.1016/j.molcel.2016.10.012 27840026

상세보기
Iitaka C. Miyazaki K. Akaike T. Ishida N. ( 2005 ). A role for glycogen synthase kinase-3beta in the mammalian circadian clock. J. Biol. Chem. 280 29397 ？ 29402 . 10.1074/jbc.M503526200 15972822

상세보기
Kim D. W. Chang C. Chen X. Doran A. C. Gaudreault F. Wager T. ( 2019 ). Systems approach reveals photosensitivity and PER2 level as determinants of clock-modulator efficacy. Mol. Syst. Biol. 15 : e8838 . 10.15252/msb.20198838 31353796

상세보기
Kim J. K. ( 2016 ). Protein sequestration versus Hill-type repression in circadian clock models. IET Syst. Biol. 10 125 ？ 135 . 10.1049/iet-syb.2015.0090 27444022

상세보기
Kim J. K. Forger D. B. ( 2012 ). A mechanism for robust circadian timekeeping via stoichiometric balance. Mol. Syst. Biol. 8 : 630 . 10.1038/msb.2012.62 23212247

상세보기
Kim J. K. Forger D. B. Marconi M. Wood D. Doran A. Wager T. ( 2013 ). Modeling and validating chronic pharmacological manipulation of circadian rhythms. CPT Pharmacomet. Syst. Pharmacol. 2 : e57 . 10.1038/psp.2013.34 23863866

상세보기
Kim J. K. Josic K. Bennett M. R. ( 2014 ). The validity of quasi-steady-state approximations in discrete stochastic simulations. Biophys. J. 107 783 ？ 793 . 10.1016/j.bpj.2014.06.012 25099817

상세보기
Kloss B. Price J. L. Saez L. Blau J. Rothenfluh A. Wesley C. S. ( 1998 ). The Drosophila clock gene double-time encodes a protein closely related to human casein kinase Iepsilon. Cell 94 97 ？ 107 . 10.1016/s0092-8674(00)81225-81228 9674431
Koike N. Yoo S. H. Huang H. C. Kumar V. Lee C. Kim T. K. ( 2012 ). Transcriptional architecture and chromatin landscape of the core circadian clock in mammals. Science 338 349 ？ 354 . 10.1126/science.1226339 22936566

상세보기
Kowalska E. Ripperger J. A. Hoegger D. C. Bruegger P. Buch T. Birchler T. ( 2013 ). NONO couples the circadian clock to the cell cycle. Proc. Natl. Acad. Sci. U.S.A. 110 1592 ？ 1599 . 10.1073/pnas.1213317110 23267082

상세보기
Kruse J. P. Gu W. ( 2009 ). Modes of p53 regulation. Cell 137 609 ？ 622 . 10.1016/j.cell.2009.04.050 19450511

상세보기
Lee H. M. Chen R. Kim H. Etchegaray J. P. Weaver D. R. Lee C. ( 2011 ). The period of the circadian oscillator is primarily determined by the balance between casein kinase 1 and protein phosphatase 1. Proc. Natl. Acad. Sci. U.S.A. 108 16451 ？ 16456 . 10.1073/pnas.1107178108 21930935

상세보기
Liu J. Zou X. Gotoh T. Brown A. M. Jiang L. Wisdom E. L. ( 2018 ). Distinct control of PERIOD2 degradation and circadian rhythms by the oncoprotein and ubiquitin ligase MDM2. Sci. Signal. 11 : 556 10.1126/scisignal.aau0715

상세보기
Lowrey P. L. Shimomura K. Antoch M. P. Yamazaki S. Zemenides P. D. Ralph M. R. ( 2000 ). Positional syntenic c. Science l 483 ？ 492 .
Marchenko N. D. Hanel W. Li D. Becker K. Reich N. Moll U. M. ( 2010 ). Stress-mediated nuclear stabilization of p53 is regulated by ubiquitination and importin-alpha3 binding. Cell Death Differ. 17 255 ？ 267 . 10.1038/cdd.2009.173 19927155

상세보기
Matsuo T. Yamaguchi S. Mitsui S. Emi A. Shimoda F. Okamura H. ( 2003 ). Control mechanism of the circadian clock for timing of cell division in vivo. Science 302 255 ？ 259 . 10.1126/science.1086271 12934012

상세보기
Matsu-Ura T. Dovzhenok A. Aihara E. Rood J. Le H. Ren Y. ( 2016 ). Intercellular coupling of the cell cycle and circadian clock in adult stem cell culture. Mol. Cell 64 900 ？ 912 . 10.1016/j.molcel.2016.10.015 27867006

상세보기
Mazzoccoli G. Laukkanen M. O. Vinciguerra M. Colangelo T. Colantuoni V. ( 2016 ). A timeless link between circadian patterns and disease. Trends Mol. Med. 22 68 ？ 81 . 10.1016/j.molmed.2015.11.007 26691298

상세보기
Meng Q. J. Maywood E. S. Bechtold D. A. Lu W. Q. Li J. Gibbs J. E. ( 2010 ). Entrainment of disrupted circadian behavior through inhibition of casein kinase 1 (CK1) enzymes. Proc. Natl. Acad. Sci. U.S.A. 107 15240 ？ 15245 . 10.1073/pnas.1005101107 20696890

상세보기
Miki T. Matsumoto T. Zhao Z. Lee C. C. ( 2013 ). p53 regulates Period2 expression and the circadian clock. Nat. Commun. 4 : 2444 . 10.1038/ncomms3444 24051492

상세보기
Mori T. Binder B. Johnson C. H. ( 1996 ). Circadian gating of cell division in cyanobacteria growing with average doubling times of less than 24 hours. Proc. Natl. Acad. Sci. U.S.A. 93 10183 ？ 10188 . 10.1073/pnas.93.19.10183 8816773

상세보기
Nagoshi E. Saini C. Bauer C. Laroche T. Naef F. Schibler U. ( 2004 ). Circadian gene expression in individual fibroblasts: cell-autonomous and self-sustained oscillators pass time to daughter cells. Cell 119 693 ？ 705 . 10.1016/j.cell.2004.11.015 15550250

상세보기
Narasimamurthy R. Hunt S. R. Lu Y. Fustin J. M. Okamura H. Partch C. L. ( 2018 ). CK1delta/epsilon protein kinase primes the PER2 circadian phosphoswitch. Proc. Natl. Acad. Sci. U.S.A. 115 5986 ？ 5991 . 10.1073/pnas.1721076115 29784789

상세보기
O’Brate A. Giannakakou P. ( 2003 ). The importance of p53 location: nuclear or cytoplasmic zip code? Drug Resis.t Updat. 6 313 ？ 322 .
Ode K. L. Ueda H. R. ( 2018 ). Design principles of phosphorylation-dependent timekeeping in eukaryotic circadian clocks. Cold Spring Harb. Perspect. Biol. 10 : a028357 . 10.1101/cshperspect.a028357 29038116

상세보기
Ohsaki K. Oishi K. Kozono Y. Nakayama K. Nakayama K. I. Ishida N. ( 2008 ). The role of {beta}-TrCP1 and {beta}-TrCP2 in circadian rhythm generation by mediating degradation of clock protein PER2. J. Biochem. 144 609 ？ 618 . 10.1093/jb/mvn112 18782782

상세보기
Papp S. J. Huber A. L. Jordan S. D. Kriebs A. Nguyen M. Moresco J. J. ( 2015 ). DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization. eLife 4 : e04883 . 10.7554/eLife.04883 25756610

상세보기
Price J. L. Blau J. Rothenfluh A. Abodeely M. Kloss B. Young M. W. ( 1998 ). double-time is a novel Drosophila clock gene that regulates PERIOD protein accumulation. Cell 94 83 ？ 95 . 10.1016/s0092-8674(00)81224-81226 9674430

상세보기
Reischl S. Kramer A. ( 2011 ). Kinases and phosphatases in the mammalian circadian clock. FEBS Lett. 585 1393 ？ 1399 . 10.1016/j.febslet.2011.02.038 21376720

상세보기
Takahashi J. S. ( 2017 ). Transcriptional architecture of the mammalian circadian clock. Nat. Rev. Genet. 18 164 ？ 179 . 10.1038/nrg.2016.150 27990019

상세보기
Tamai T. K. Young L. C. Cox C. A. Whitmore D. ( 2012 ). Light acts on the zebrafish circadian clock to suppress rhythmic mitosis and cell proliferation. J. Biol. Rhythms 27 226 ？ 236 . 10.1177/0748730412440861 22653891

상세보기
Tsuchiya Y. Akashi M. Matsuda M. Goto K. Miyata Y. Node K. ( 2009 ). Involvement of the protein kinase CK2 in the regulation of mammalian circadian rhythms. Sci. Signal. 2 : ra26 . 10.1126/scisignal.2000305 19491384

상세보기
Unsal-Kacmaz K. Mullen T. E. Kaufmann W. K. Sancar A. ( 2005 ). Coupling of human circadian and cell cycles by the timeless protein. Mol. Cell. Biol. 25 3109 ？ 3116 . 10.1128/MCB.25.8.3109-3116.2005 15798197

상세보기
Vousden K. H. Prives C. ( 2009 ). Blinded by the light: the growing complexity of p53. Cell 137 413 ？ 431 . 10.1016/j.cell.2009.04.037 19410540

상세보기
Walton K. M. Fisher K. Rubitski D. Marconi M. Meng Q. J. Sladek M. ( 2009 ). Selective inhibition of casein kinase 1 epsilon minimally alters circadian clock period. J. Pharmacol. Exp. Ther. 330 430 ？ 439 . 10.1124/jpet.109.151415 19458106

상세보기
Xu Y. Padiath Q. S. Shapiro R. E. Jones C. R. Wu S. C. Saigoh N. ( 2005 ). Functional consequences of a CKIdelta mutation causing familial advanced sleep phase syndrome. Nature 434 640 ？ 644 . 10.1038/nature03453 15800623

상세보기
Yang Q. Pando B. F. Dong G. Golden S. S. van Oudenaarden A. ( 2010 ). Circadian gating of the cell cycle revealed in single cyanobacterial cells. Science 327 1522 ？ 1526 . 10.1126/science.1181759 20299597

상세보기
Zhang E. E. Liu A. C. Hirota T. Miraglia L. J. Welch G. Pongsawakul P. Y. ( 2009 ). A genome-wide RNAi screen for modifiers of the circadian clock in human cells. Cell 139 199 ？ 210 . 10.1016/j.cell.2009.08.031 19765810

상세보기
Zhou M. Kim J. K. Eng G. W. Forger D. B. Virshup D. M. ( 2015 ). A Period2 phosphoswitch regulates and temperature compensates circadian period. Mol. Cell 60 77 ？ 88 . 10.1016/j.molcel.2015.08.022 26431025

상세보기

LOADING...

활용도 분석정보

상세보기

다운로드

내보내기

활용도 Top5 논문

해당 논문의 주제분야에서 활용도가 높은 상위 5개 콘텐츠를 보여줍니다.
더보기 버튼을 클릭하시면 더 많은 관련자료를 살펴볼 수 있습니다.

표제어: PCR

동의어: Packet Collision Rate

용어 설명 출처 목록 (6)

용어 설명: PCR은 세균 특이성이 있는 primer를 이용하여 적은 수의 세균이 있을지라도 쉽게 검출할 수 있는 유용한 방법이며, 이를 이용하여 구강 내 치면세균막이나 타액에서 직접 세균을 검출할 수 있게 되었다[8].

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관 관리번호, 논문명, 대등논문명, 저자 , 저널/프로시딩명, 발행기관, 발행년, 발행언어, 권, 호, 시작페이지, 끝페이지, ISBN, ISSN, 주제분야, 키워드, 초록(한글), 초록(영문), 저자(소속기관)
저장형식	Text(ASCII format) Excel format RefWorks Direct Export RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증