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[해외논문] Multicopy Targeted Integration for Accelerated Development of High-Producing Chinese Hamster Ovary Cells 원문보기

ACS Synthetic biology, v.9 no.9, 2020년, pp.2546 - 2561  

Sergeeva, Daria (The Novo Nordisk Foundation Center for Biosustainability , Technical University of Denmark , Kgs. Lyngby 2800 , Denmark) ,  Lee, Gyun Min (The Novo Nordisk Foundation Center for Biosustainability , Technical University of Denmark , Kgs. Lyngby 2800 , Denmark) ,  Nielsen, Lars Keld (The Novo Nordisk Foundation Center for Biosustainability , Technical University of Denmark , Kgs. Lyngby 2800 , Denmark) ,  Grav, Lise Marie

Abstract AI-Helper 아이콘AI-Helper

The ever-growing biopharmaceutical industry relies on the production of recombinant therapeutic proteins in Chinese hamster ovary (CHO) cells. The traditional timelines of CHO cell line development can be significantly shortened by the use of targeted gene integration (TI). However, broad use of TI ...

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