[논문]Rapamycin increases the incidence of neuropsychiatric illness in kidney transplant patients through the suppression of neural stem cells

Kim, Yangsik; Lee, Jung Sun; Joo, Yeon Ho

doi:10.1038/s41398-020-0838-2

[해외논문] Rapamycin increases the incidence of neuropsychiatric illness in kidney transplant patients through the suppression of neural stem cells 원문보기

Translational psychiatry, v.10 no.1, 2020년, pp.156 -

Kim, Yangsik (Department of Psychiatry, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea) , Lee, Jung Sun (Department of Psychiatry, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea) , Joo, Yeon Ho (Department of Psychiatry, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea)

Abstract ▼ AI-Helper

Rapamycin inhibits protein translation in cells, including neural stem cells (NSCs), by suppressing the mechanistic target of rapamycin (mTOR). This drug has been widely used together with calcineurin inhibitors in transplantation patients to prevent graft rejection. Previous studies have reported an association between mTOR and depression, but few investigations of this have occurred in transplant recipients. We have here tested the psychiatric effects of rapamycin in mice. The animals treated with rapamycin showed decreased locomotion and sugar consumption. In these rapamycin-treated mice also, the granule cells in the dentate gyrus (DG), which actively differentiate and proliferate from NSC, showed decreases in both excitatory and inhibitory synaptic transmission. Furthermore, the SOX2/NeuN ratio in the DG was decreased in mice treated with rapamycin. We further show that kidney transplantation patients who are receiving rapamycin have more psychiatric disorder such as adjustment disorder. Clinical attention is thus needed when administering rapamycin to transplant recipients due to its behavioral effects and its impact on NSC.

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