[논문]Protein disulfide isomerase in cardiovascular disease

Xiong, Bei; Jha, Vishwanath; Min, Jeong-Ki; Cho, Jaehyung

doi:10.1038/s12276-020-0401-5

[국내논문] Protein disulfide isomerase in cardiovascular disease 원문보기

Experimental & molecular medicine : EMM, v.52 no.3, 2020년, pp.390 - 399

Xiong, Bei (Department of Pharmacology, University of Illinois-Chicago College of Medicine, Chicago, IL 60612 USA) , Jha, Vishwanath (Department of Pharmacology, University of Illinois-Chicago College of Medicine, Chicago, IL 60612 USA) , Min, Jeong-Ki (Biotherapeutics Translational Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea) , Cho, Jaehyung (Department of Pharmacology, University of Illinois-Chicago College of Medicine, Chicago, IL 60612 USA)

Abstract ▼ AI-Helper

Protein disulfide isomerase (PDI) participates in the pathogenesis of numerous diseases. Increasing evidence indicates that intravascular cell-derived PDI plays an important role in the initiation and progression of cardiovascular diseases, including thrombosis and vascular inflammation. Recent studies with PDI conditional knockout mice have advanced our understanding of the function of cell-specific PDI in disease processes. Furthermore, the identification and development of novel small-molecule PDI inhibitors has led into a new era of PDI research that transitioned from the bench to bedside. In this review, we will discuss recent findings on the regulatory role of PDI in cardiovascular disease.Exploring enzymes’ influence on cardiovascular diseaseEfforts to untangle the functions of a large family of enzymes could lead researchers to new therapies for diverse cardiovascular diseases. Members of the protein disulfide isomerase (PDI) family chemically modify other proteins in ways that can alter both their structure and biological activity. Jaehyung Cho of the University of Illinois at Chicago, USA and coworkers have reviewed numerous studies linking PDI with cardiovascular diseases, including thrombosis, heart attack, vascular inflammation, and stroke. The authors also report progress in developing small-molecule PDI inhibitors that could yield the treatment for these conditions.

참고문헌 (116)

1. Siddiqui TI Kumar KSA Dikshit DK Platelets and atherothrombosis: causes, targets and treatments for thrombosis Curr. Med. Chem. 2013 20 2779 2797 23590713

상세보기
2. Butera D Cook KM Chiu J Wong JW Hogg PJ Control of blood proteins by functional disulfide bonds Blood 2014 123 2000 2007 24523239

상세보기
3. Benham AM The protein disulfide isomerase family: key players in health and disease Antioxid. Redox Signal 2012 16 781 789 22142258

상세보기
4. Koivunen P ERp60 does not substitute for protein disulphide isomerase as the beta-subunit of prolyl 4-hydroxylase Biochem J. 1996 316 Pt 2 599 605 8687406
5. LaMantia M Glycosylation site binding protein and protein disulfide isomerase are identical and essential for cell viability in yeast Proc. Natl Acad. Sci. USA 1991 88 4453 4457 1840696

상세보기
6. Norgaard P Functional differences in yeast protein disulfide isomerases J. Cell Biol. 2001 152 553 562 11157982

상세보기
7. Cho J Protein disulfide isomerase in thrombosis and vascular inflammation J. Thromb. Haemost. 2013 11 2084 2091 24118938

상세보기
8. Puig A Gilbert HF Protein disulfide isomerase exhibits chaperone and anti-chaperone activity in the oxidative refolding of lysozyme J. Biol. Chem. 1994 269 7764 7771 7907332

상세보기
9. Bassuk JA Capodici C Berg RA Protein disulphide isomerase from human peripheral blood neutrophils J. Cell Physiol. 1990 144 280 286 1696272

상세보기
10. Kim K Platelet protein disulfide isomerase is required for thrombus formation but not essential for hemostasis in mice Blood 2013 122 1052 1061 23788140
11. Hahm E Extracellular protein disulfide isomerase regulates ligand-binding activity of alphaMbeta2 integrin and neutrophil recruitment during vascular inflammation Blood 2013 121 3789 3800 23460613
12. Zhou J The C-terminal CGHC motif of protein disulfide isomerase supports thrombosis J. Clin. Invest. 2015 125 4391 4406 26529254

상세보기
13. Bjelland S Tissue distribution and molecular heterogeneity of bovine thiol:protein-disulphide oxidoreductase (disulphide interchange enzyme) Comp. Biochem. Physiol. B 1987 87 907 914 3665436
14. Xu S Sankar S Neamati N Protein disulfide isomerase: a promising target for cancer therapy Drug Disco. Today 2014 19 222 240
15. Uehara T S-nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration Nature 2006 441 513 517 16724068

상세보기
16. Li J Platelet protein disulfide isomerase promotes glycoprotein Ibalpha-mediated platelet-neutrophil interactions under thromboinflammatory conditions Circulation 2019 139 1300 1319 30586735
17. Essex DW Wu Y Multiple protein disulfide isomerases support thrombosis Curr. Opin. Hematol. 2018 25 395 402 29994898

상세보기
18. Matsusaki, M. et al. The Protein Disulfide Isomerase Family: from proteostasis to pathogenesis. Biochim Biophys Acta Gen Subj 1864 , 10.1016/j.bbagen.2019.04.003 (2020).
19. Tian R The acidic C-terminal domain stabilizes the chaperone function of protein disulfide isomerase J. Biol. Chem. 2004 279 48830 48835 15358778

상세보기
20. Wang C Structural insights into the redox-regulated dynamic conformations of human protein disulfide isomerase Antioxid. Redox Signal 2013 19 36 45 22657537

상세보기
21. Nguyen VD Alternative conformations of the x region of human protein disulphide-isomerase modulate exposure of the substrate binding b’ domain J. Mol. Biol. 2008 383 1144 1155 18801374

상세보기
22. Wang C Plasticity of human protein disulfide isomerase: evidence for mobility around the X-linker region and its functional significance J. Biol. Chem. 2010 285 26788 26797 20516074

상세보기
23. Bekendam RH A substrate-driven allosteric switch that enhances PDI catalytic activity Nat. Commun. 2016 7 12579 27573496

상세보기
24. Brown DI Griendling KK Regulation of signal transduction by reactive oxygen species in the cardiovascular system Circ. Res. 2015 116 531 549 25634975

상세보기
25. Ali Khan H Mutus B Protein disulfide isomerase a multifunctional protein with multiple physiological roles Front Chem. 2014 2 70 25207270

상세보기
26. Trychta KA Back S Henderson MJ Harvey BK KDEL receptors are differentially regulated to maintain the ER proteome under calcium deficiency Cell Rep. 2018 25 1829 1840 30428351
27. Bartels AK KDEL receptor 1 contributes to cell surface association of protein disulfide isomerases Cell Physiol. Biochem 2019 52 850 868 30958660
28. Thon JN T granules in human platelets function in TLR9 organization and signaling J. Cell Biol. 2012 198 561 574 22908309

상세보기
29. Lominadze G Proteomic analysis of human neutrophil granules Mol. Cell Proteom. 2005 4 1503 1521
30. de APAM Protein disulfide isomerase redox-dependent association with p47(phox): evidence for an organizer role in leukocyte NADPH oxidase activation J. Leukoc. Biol. 2011 90 799 810 21791598

상세보기
31. Crescente M Intracellular trafficking, localization, and mobilization of platelet-borne thiol isomerases Arterioscler Thromb. Vasc. Biol. 2016 36 1164 1173 27079884

상세보기
32. Sharda A Defective PDI release from platelets and endothelial cells impairs thrombus formation in Hermansky-Pudlak syndrome Blood 2015 125 1633 1642 25593336

상세보기
33. Jasuja R Furie B Furie BC Endothelium-derived but not platelet-derived protein disulfide isomerase is required for thrombus formation in vivo Blood 2010 116 4665 4674 20668226

상세보기
34. Araujo TLS Protein disulfide isomerase externalization in endothelial cells follows classical and unconventional routes Free Radic. Biol. Med 2017 103 199 208 28034831

상세보기
35. Araujo TLS Fernandes CG Laurindo FRM Golgi-independent routes support protein disulfide isomerase externalization in vascular smooth muscle cells Redox Biol. 2017 12 1004 1010 28501017

상세보기
36. Chen IH Chang FR Wu YC Kung PH Wu CC 3,4-Methylenedioxy-beta-nitrostyrene inhibits adhesion and migration of human triple-negative breast cancer cells by suppressing beta1 integrin function and surface protein disulfide isomerase Biochimie 2015 110 81 92 25593085
37. Lahav J Sustained integrin ligation involves extracellular free sulfhydryls and enzymatically catalyzed disulfide exchange Blood 2002 100 2472 2478 12239158

상세보기
38. Lahav J Enzymatically catalyzed disulfide exchange is required for platelet adhesion to collagen via integrin alpha2beta1 Blood 2003 102 2085 2092 12791669
39. Khodier, C. et al. in Probe Reports from the NIH Molecular Libraries Program (2010).
40. Lin L Quercetin-3-rutinoside Inhibits Protein Disulfide Isomerase by Binding to Its b’x Domain J. Biol. Chem. 2015 290 23543 23552 26240139

상세보기
41. Zwicker, J. I. et al. Targeting protein disulfide isomerase with the flavonoid isoquercetin to improve hypercoagulability in advanced cancer. JCI Insight 4 (2019).
42. Karala AR Ruddock LW Bacitracin is not a specific inhibitor of protein disulfide isomerase FEBS J. 2010 277 2454 2462 20477872

상세보기
43. Chiu J Hogg PJ Allosteric disulfides: sophisticated molecular structures enabling flexible protein regulation J. Biol. Chem. 2019 294 2949 2960 30635401

상세보기
44. Hotchkiss KA Chesterman CN Hogg PJ Catalysis of disulfide isomerization in thrombospondin 1 by protein disulfide isomerase Biochemistry 1996 35 9761 9767 8703948
45. Bowley SR Fang C Merrill-Skoloff G Furie BC Furie B Protein disulfide isomerase secretion following vascular injury initiates a regulatory pathway for thrombus formation Nat. Commun. 2017 8 14151 28218242

상세보기
46. Cho J Protein disulfide isomerase capture during thrombus formation in vivo depends on the presence of beta3 integrins Blood 2012 120 647 655 22653978
47. Passam F Mechano-redox control of integrin de-adhesion Elife 2018 7 e34843 29932420

상세보기
48. Stopa JD Baker KM Grover SP Flaumenhaft R Furie B Kinetic-based trapping by intervening sequence variants of the active sites of protein-disulfide isomerase identifies platelet protein substrates J. Biol. Chem. 2017 292 9063 9074 28364042

상세보기
49. Wong JW Hogg PJ Analysis of disulfide bonds in protein structures J. Thromb. Haemost. 2010 8 2345

상세보기
50. Moldogazieva NT Lutsenko SV Terentiev AA Reactive oxygen and nitrogen species-induced protein modifications: implication in carcinogenesis and anticancer therapy Cancer Res. 2018 78 6040 6047 30327380

상세보기
51. Xiong Y Uys JD Tew KD Townsend DM S-glutathionylation: from molecular mechanisms to health outcomes Antioxid. Redox Signal 2011 15 233 270 21235352

상세보기
52. Townsend DM Nitrosative stress-induced s-glutathionylation of protein disulfide isomerase leads to activation of the unfolded protein response Cancer Res. 2009 69 7626 7634 19773442

상세보기
53. Makino K Correlation between attenuation of protein disulfide isomerase activity through S-mercuration and neurotoxicity induced by methylmercury Neurotox. Res. 2015 27 99 105 25288108

상세보기
54. Zai A Rudd MA Scribner AW Loscalzo J Cell-surface protein disulfide isomerase catalyzes transnitrosation and regulates intracellular transfer of nitric oxide J. Clin. Invest. 1999 103 393 399 9927500

상세보기
55. Kallakunta VM Slama-Schwok A Mutus B Protein disulfide isomerase may facilitate the efflux of nitrite derived S-nitrosothiols from red blood cells Redox Biol. 2013 1 373 380 24024174

상세보기
56. Bekendam RH Protein disulfide isomerase regulation by nitric oxide maintains vascular quiescence and controls thrombus formation J. Thromb. Haemost. 2018 16 2322 2335 30207066

상세보기
57. Meister A Glutathione metabolism and its selective modification J. Biol. Chem. 1988 263 17205 17208 3053703

상세보기
58. Michelet F Blood and plasma glutathione measured in healthy subjects by HPLC: relation to sex, aging, biological variables, and life habits Clin. Chem. 1995 41 1509 1517 7586526

상세보기
59. Mills BJ Weiss MM Lang CA Liu MC Ziegler C Blood glutathione and cysteine changes in cardiovascular disease J. Lab Clin. Med. 2000 135 396 401 10811054

상세보기
60. Uys JD Xiong Y Townsend DM Nitrosative stress-induced S-glutathionylation of protein disulfide isomerase Methods Enzymol. 2011 490 321 332 21266258
61. Ramming T Appenzeller-Herzog C The physiological functions of mammalian endoplasmic oxidoreductin 1: on disulfides and more Antioxid. Redox Signal 2012 16 1109 1118 22220984

상세보기
62. Appenzeller-Herzog C Riemer J Christensen B Sorensen ES Ellgaard L A novel disulphide switch mechanism in Ero1alpha balances ER oxidation in human cells EMBO J. 2008 27 2977 2987 18833192
63. Dias-Gunasekara S Tissue-specific expression and dimerization of the endoplasmic reticulum oxidoreductase Ero1beta J. Biol. Chem. 2005 280 33066 33075 16012172
64. Awazawa M Deregulation of pancreas-specific oxidoreductin ERO1beta in the pathogenesis of diabetes mellitus Mol. Cell Biol. 2014 34 1290 1299 24469402
65. Zito E Chin KT Blais J Harding HP Ron D ERO1-beta, a pancreas-specific disulfide oxidase, promotes insulin biogenesis and glucose homeostasis J. Cell Biol. 2010 188 821 832 20308425
66. Araki K Inaba K Structure, mechanism, and evolution of Ero1 family enzymes Antioxid. Redox Signal 2012 16 790 799 22145624

상세보기
67. Kakihana T Dynamic regulation of Ero1alpha and peroxiredoxin 4 localization in the secretory pathway J. Biol. Chem. 2013 288 29586 29594 23979138
68. Swiatkowska M Ero1alpha is expressed on blood platelets in association with protein-disulfide isomerase and contributes to redox-controlled remodeling of alphaIIbbeta3 J. Biol. Chem. 2010 285 29874 29883 20562109
69. Gimenez M Redox activation of Nox1 (NADPH Oxidase 1) involves an intermolecular disulfide bond between protein disulfide isomerase and p47(phox) in vascular smooth muscle cells Arterioscler Thromb. Vasc. Biol. 2019 39 224 236 30580571

상세보기
70. Jasuja R Protein disulfide isomerase inhibitors constitute a new class of antithrombotic agents J. Clin. Invest. 2012 122 2104 2113 22565308

상세보기
71. Swinney DC Biochemical mechanisms of drug action: what does it take for success? Nat. Rev. Drug Disco. 2004 3 801 808
72. Kaplan, A. et al. Small molecule-induced oxidation of protein disulfide isomerase is neuroprotective. Proc. Natl Acad. Sci. USA 112 , E2245？2252 (2015).
73. Zhou X Small molecule modulator of protein disulfide isomerase attenuates mutant huntingtin toxicity and inhibits endoplasmic reticulum stress in a mouse model of Huntington’s disease Hum. Mol. Genet. 2018 27 1545 1555 29462355

상세보기
74. Chlebowska-Tuz J Inhibition of protein disulfide isomerase induces differentiation of acute myeloid leukemia cells Haematologica 2018 103 1843 1852 30002127

상세보기
75. Xu S Discovery of an orally active small-molecule irreversible inhibitor of protein disulfide isomerase for ovarian cancer treatment Proc. Natl Acad. Sci. USA 2012 109 16348 16353 22988091

상세보기
76. Vatolin S Novel protein disulfide isomerase inhibitor with anticancer activity in multiple myeloma Cancer Res. 2016 76 3340 3350 27197150

상세보기
77. Khan MM Discovery of a small molecule PDI inhibitor that inhibits reduction of HIV-1 envelope glycoprotein gp120 ACS Chem. Biol. 2011 6 245 251 21121641
78. Ozcelik D Gene expression profiling of endoplasmic reticulum stress in Hepatitis C virus-containing cells treated with an inhibitor of protein disulfide isomerases ACS Omega 2018 3 17227 17235 30775641

상세보기
79. Hoffstrom BG Inhibitors of protein disulfide isomerase suppress apoptosis induced by misfolded proteins Nat. Chem. Biol. 2010 6 900 906 21079601

상세보기
80. Kaplan A Stockwell BR Structural Elucidation of a Small Molecule Inhibitor of Protein Disulfide Isomerase ACS Med. Chem. Lett. 2015 6 966 971 26500720
81. Ge J Small molecule probe suitable for in situ profiling and inhibition of protein disulfide isomerase ACS Chem. Biol. 2013 8 2577 2585 24070012
82. Kyani A Discovery and mechanistic elucidation of a class of protein disulfide isomerase inhibitors for the treatment of glioblastoma ChemMedChem 2018 13 164 177 29235250

상세보기
83. Chen K Detwiler TC Essex DW Characterization of protein disulphide isomerase released from activated platelets Br. J. Haematol. 1995 90 425 431 7794766

상세보기
84. Essex DW Chen K Swiatkowska M Localization of protein disulfide isomerase to the external surface of the platelet plasma membrane Blood 1995 86 2168 2173 7662965

상세보기
85. Essex DW Li M Protein disulphide isomerase mediates platelet aggregation and secretion Br. J. Haematol. 1999 104 448 454 10086777
86. Cho J Furie BC Coughlin SR Furie B A critical role for extracellular protein disulfide isomerase during thrombus formation in mice J. Clin. Invest 2008 118 1123 1131 18292814

상세보기
87. Qin RR Platelet activation in diabetic mice models: the role of vascular endothelial cell-derived protein disulfide isomerase-mediated GP IIb/IIIa receptor activation Aging (Albany NY) 2019 11 6358 6370 31437127
88. Zhou J May L Liao P Gross PL Weitz JI Inferior vena cava ligation rapidly induces tissue factor expression and venous thrombosis in rats Arterioscler Thromb. Vasc. Biol. 2009 29 863 869 19265029

상세보기
89. Subramaniam S Distinct contributions of complement factors to platelet activation and fibrin formation in venous thrombus development Blood 2017 129 2291 2302 28223279

상세보기
90. Muller-Calleja N Complement C5 but not C3 is expendable for tissue factor activation by cofactor-independent antiphospholipid antibodies Blood Adv. 2018 2 979 986 29716893

상세보기
91. Kothari H Nayak RC Rao LV Pendurthi UR Cystine 186-cystine 209 disulfide bond is not essential for the procoagulant activity of tissue factor or for its de-encryption Blood 2010 115 4273 4283 20237315

상세보기
92. Pendurthi UR Ghosh S Mandal SK Rao LV Tissue factor activation: is disulfide bond switching a regulatory mechanism? Blood 2007 110 3900 3908 17726162

상세보기
93. Bach RR Monroe D What is wrong with the allosteric disulfide bond hypothesis? Arterioscler Thromb. Vasc. Biol. 2009 29 1997 1998 19923558

상세보기
94. Zhou X Dai Q Huang X Neutrophils in acute lung injury Front Biosci. (Landmark Ed.) 2012 17 2278 2283 22652778
95. Erickson SE Recent trends in acute lung injury mortality: 1996-2005 Crit. Care Med. 2009 37 1574 1579 19325464

상세보기
96. Bennett TA Edwards BS Sklar LA Rogelj S Sulfhydryl regulation of L-selectin shedding: phenylarsine oxide promotes activation-independent L-selectin shedding from leukocytes J. Immunol. 2000 164 4120 4129 10754306

상세보기
97. Shimaoka M Reversibly locking a protein fold in an active conformation with a disulfide bond: integrin alphaL I domains with high affinity and antagonist activity in vivo Proc. Natl Acad. Sci. USA 2001 98 6009 6014 11353828
98. Shimaoka M Stabilizing the integrin alpha M inserted domain in alternative conformations with a range of engineered disulfide bonds Proc. Natl Acad. Sci. USA 2002 99 16737 16741 12466503
99. Li J Cho J Ser/Thr protein kinase Bbeta-NADPH oxidase 2 signaling in thromboinflammation Curr. Opin. Hematol. 2017 24 460 466 28650848
100. Li J Kim K Barazia A Tseng A Cho J Platelet-neutrophil interactions under thromboinflammatory conditions Cell Mol. Life Sci. 2015 72 2627 2643 25650236

상세보기
101. Thuerauf DJ Activation of the unfolded protein response in infarcted mouse heart and hypoxic cultured cardiac myocytes Circ. Res 2006 99 275 282 16794188

상세보기
102. Kiouptsi, K. et al. Hypoxia evokes increased PDI and PDIA6 expression in the infarcted myocardium of ex-germ-free and conventionally raised mice. Biol. Open 8 (2019).
103. Severino A Identification of protein disulfide isomerase as a cardiomyocyte survival factor in ischemic cardiomyopathy J. Am. Coll. Cardiol. 2007 50 1029 1037 17825711

상세보기
104. Toldo S Altered oxido-reductive state in the diabetic heart: loss of cardioprotection due to protein disulfide isomerase Mol. Med 2011 17 1012 1021 21637911

상세보기
105. Toldo S Severino A Abbate A Baldi A The role of PDI as a survival factor in cardiomyocyte ischemia Methods Enzymol. 2011 489 47 65 21266223
106. Tian F Protein disulfide isomerase increases in myocardial endothelial cells in mice exposed to chronic hypoxia: a stimulatory role in angiogenesis Am. J. Physiol. Heart Circ. Physiol. 2009 297 H1078 H1086 19617410

상세보기
107. Tanaka S Uehara T Nomura Y Up-regulation of protein-disulfide isomerase in response to hypoxia/brain ischemia and its protective effect against apoptotic cell death J. Biol. Chem. 2000 275 10388 10393 10744727

상세보기
108. Kam KY p-Hydroxybenzyl alcohol prevents brain injury and behavioral impairment by activating Nrf2, PDI, and neurotrophic factor genes in a rat model of brain ischemia Mol. Cells 2011 31 209 215 21347705

상세보기
109. Wen PY Tanshinone IIA increases levels of NeuN, protein disulfide isomerase, and Na+/K+-ATPase and decreases evidence of microglial activation after cerebral ischemic injury Neuroreport 2016 27 435 444 26966780

상세보기
110. Gele P Recovery of brain biomarkers following peroxisome proliferator-activated receptor agonist neuroprotective treatment before ischemic stroke Proteome Sci. 2014 12 24 24944524

상세보기
111. Libby P Ridker PM Maseri A Inflammation and atherosclerosis Circulation 2002 105 1135 1143 11877368

상세보기
112. Schwartz SM Perspectives series: cell adhesion in vascular biology. Smooth muscle migration in atherosclerosis and restenosis J. Clin. Invest 1997 99 2814 2816 9185501

상세보기
113. Pescatore LA Protein disulfide isomerase is required for platelet-derived growth factor-induced vascular smooth muscle cell migration, Nox1 NADPH oxidase expression, and RhoGTPase activation J. Biol. Chem. 2012 287 29290 29300 22773830

상세보기
114. Ping S Simultaneous increases in proliferation and apoptosis of vascular smooth muscle cells accelerate diabetic mouse venous atherosclerosis PLoS ONE 2015 10 e0141375 26488175

상세보기
115. Ping S Protein disulfide isomerase-mediated apoptosis and proliferation of vascular smooth muscle cells induced by mechanical stress and advanced glycosylation end products result in diabetic mouse vein graft atherosclerosis Cell Death Dis. 2017 8 e2818 28542133
116. Muller C Protein disulfide isomerase modification and inhibition contribute to ER stress and apoptosis induced by oxidized low density lipoproteins Antioxid. Redox Signal 2013 18 731 742 23083489

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