[논문]Emergence of Third-Generation Cephalosporin-Resistant Morganella morganii in a Captive Breeding Dolphin in South Korea

Park, Seon Young; Lee, Kyunglee; Cho, Yuna; Lim, Se Ra; Kwon, Hyemin; Han, Jee Eun; Kim, Ji Hyung

doi:10.3390/ani10112052

[해외논문] Emergence of Third-Generation Cephalosporin-Resistant Morganella morganii in a Captive Breeding Dolphin in South Korea 원문보기

Animals an open access journal from MDPI, v.10 no.11, 2020년, pp.2052 -

Park, Seon Young (Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Korea) , Lee, Kyunglee (lovesun139@kribb.re.kr (S.Y.P.)) , Cho, Yuna (dlatpfk13@kribb.re.kr (S.R.L.)) , Lim, Se Ra (hena0922@kribb.re.kr (H.K.)) , Kwon, Hyemin (Cetacean Research Institute, National Institute of Fisheries Science, Ulsan 44780, Korea) , Han, Jee Eun (moby19@korea.kr (K.L.)) , Kim, Ji Hyung (tnvlfldj@gmail.com (Y.C.))

Abstract ▼ AI-Helper

Simple SummaryThe emergence of antimicrobial resistance (AMR) has become an important consideration in animal health, including marine mammals, and several potential zoonotic AMR bacterial strains have been isolated from wild cetacean species. Although the emergence of AMR bacteria can be assumed to be much more plausible in captive than in free-ranging cetaceans owing to their frequent contact with humans and antibiotic treatments, the spread and its impacts of AMR bacteria in captive animals have not been adequately investigated yet. Here in this study, we present evidence on the presence of multidrug-resistant potential zoonotic bacteria which caused fatal infection in a captive dolphin bred at a dolphinarium in South Korea.AbstractThe emergence of antimicrobial resistant (AMR) strains of Morganella morganii is increasingly being recognized. Recently, we reported a fatal M. morganii infection in a captive bottlenose dolphin (Tursiops truncatus) bred at a dolphinarium in South Korea. According to our subsequent investigations, the isolated M. morganii strain KC-Tt-01 exhibited extensive resistance to third-generation cephalosporins which have not been reported in animals. Therefore, in the present study, the genome of strain KC-Tt-01 was sequenced, and putative virulence and AMR genes were investigated. The strain had virulence and AMR genes similar to those of other M. morganii strains, including a strain that causes human sepsis. An amino-acid substitution detected at the 86th residue (Arg to Cys) of the protein encoded by ampR might explain the extended resistance to third-generation cephalosporins. These results indicate that the AMR M. morganii strain isolated from the captive dolphin has the potential to cause fatal zoonotic infections with antibiotic treatment failure due to extended drug resistance, and therefore, the management of antibiotic use and monitoring of the emergence of AMR bacteria are urgently needed in captive cetaceans for their health and conservation.

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참고문헌 (18)

1. Berendonk T.U. Manaia C.M. Merlin C. Fatta-Kassinos D. Cytryn E. Walsh F. Burgmann H. Sørum H. Norstrom M. Pons M.N. Tackling antibiotic resistance: The environmental framework Nat. Rev. Microbiol. 2015 13 310 317 10.1038/nrmicro3439 25817583

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2. Dold C. Cetacea (Whales, Dolphins, Porpoises) Fowler’s Zoo and Wild Animal Medicine Volume 8-E-Book Elsevier Health Sciences St. Louis, MO, USA 2014 Volume 8 422
3. Schaefer A.M. Goldstein J.D. Reif J.S. Fair P.A. Bossart G.D. Antibiotic-resistant organisms cultured from Atlantic bottlenose dolphins ( Tursiops truncatus ) inhabiting estuarine waters of Charleston, SC and Indian River Lagoon, FL Ecohealth 2009 6 33 41 10.1007/s10393-009-0221-5 19415386

상세보기
4. Prichula J. Pereira R.I. Wachholz G.R. Cardoso L.A. Tolfo N.C.C. Santestevan N.A. Medeiros A.W. Tavares M. Frazzon J. D’Azevedo P.A. Resistance to antimicrobial agents among enterococci isolated from fecal samples of wild marine species in the southern coast of Brazil Mar. Pollut. Bull. 2016 105 51 57 10.1016/j.marpolbul.2016.02.071 26952995

상세보기
5. Wong S. Ocean sentinels: Marine mammals and antimicrobial resistance Proceedings of the 42nd Interscience Conference on Antimicrobial Agents and Chemotherapy San Diego, CA, USA 27？30 September 2002
6. Rozanova E.I. Alekseev A.Y. Abramov A.V. Rassadkin Y.N. Shestopalov A.M. Death of the killer whale Orsinus orca from bacterial pneumonia in 2003 Russ. J. Mar. Biol. 2007 33 321 323 10.1134/S1063074007050082

상세보기
7. Gili C. Biancani B. Gulland F. Mazzariol S. Meticillin-resistant Staphylococcus aureus (MRSA) associated dolphin mortality and the subsequent facility decolonisation protocol Vet. Rec. Case Rep. 2017 e000444 10.1136/vetreccr-2017-000444

상세보기
8. Mazzariol S. Corro M. Tonon E. Centelleghe C. Biancani B. Gili C. Death associated to methicillin resistant Staphylococcus aureus ST8 infection in two dolphins maintained under human care, Italy Front. Immunol. 2018 9 2726 10.3389/fimmu.2018.02726 30524446

상세보기
9. Liu H. Zhu J. Hu Q. Rao X. Morganella morganii , a non-negligent opportunistic pathogen Int. J. Infect Dis. 2016 50 10 17 10.1016/j.ijid.2016.07.006 27421818

상세보기
10. Hungerford J.M. Scombroid poisoning: A review Toxicon 2010 56 231 243 10.1016/j.toxicon.2010.02.006 20152850

상세보기
11. Elfadl A.K. Lee S.W. Kim J.H. Lee K.L. Ullah H.A. Chung M.J. Ghim S.G. Lee E.J. Kim Y.D. Kim S.M. Fatal fibrino-hemorrhagic bronchopneumonia associated with Morganella morganii in a bottlenose dolphin: A case report Dis. Aquat. Organ. 2017 127 41 47 10.3354/dao03184 29256426

상세보기
12. Clinical and Laboratory Standards Institute (CLSI) Performance Standards for Antimicrobial Susceptibility Testing: 24th Informational Supplement M100-S24 CLSI Wayne, PA, USA 2014
13. Holt J.G. Kreig N.R. Sneath P.H.A. Staley J.T. Williams S.T. Bergey’s Manual of Determinative Bacteriology 9th ed. Williams and Wilkins Co. Baltimore, MD, USA 1994
14. Stock I. Wiedemann B. Identification and natural antibiotic susceptibility of Morganella morganii Diagn. Microbiol. Infect. Dis. 1998 30 153 165 10.1016/S0732-8893(97)00243-5 9572021

상세보기
15. Chen Y.T. Peng H.L. Shia W.C. Hsu F.R. Ken C.F. Tsao Y.M. Chen C.H. Liu C.E. Hsieh M.F. Chen H.C. Whole-genome sequencing and identification of Morganella morganii KT pathogenicity-related genes BMC Genom. 2012 13 S4 10.1186/1471-2164-13-S7-S4 23282187

상세보기
16. Tessier F. Arpin C. Allery A. Quentin C. Molecular characterization of a TEM-21 β-lactamase in a clinical isolate of Morganella morganii Antimicrob. Agents Chemother. 1998 42 2125 2127 10.1128/AAC.42.8.2125 9687421

상세보기
17. Barroso H. Freitas-Vieira A. Duarte A. Molecular characterization of a ceftazidime-resistant Morganella morganii isolate producing a TEM-10 β-lactamase Antimicrob. Agents Chemother. 1999 43 434 435 10.1128/AAC.43.2.434 9989337

상세보기
18. Kuga A. Okamoto R. Inoue M. ampR gene mutations that greatly increase class C β-lactamase activity in Enterobacter cloacae Antimicrob. Agents Chemother. 2000 44 561 567 10.1128/AAC.44.3.561-567.2000 10681318

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