[논문]Astrocytes Control Sensory Acuity via Tonic Inhibition in the Thalamus

Kwak, Hankyul; Koh, Wuhyun; Kim, Sangwoo; Song, Kiyeong; Shin, Jeong-Im; Lee, Jung Moo; Lee, Elliot H.; Bae, Jin Young; Ha, Go Eun; Oh, Ju-Eun; Park, Yongmin Mason; Kim, Sunpil; Feng, Jiesi; Lee, Seung Eun; Choi, Ji Won; Kim, Ki Hun; Kim, Yoo Sung; Woo, Junsung; Lee, Dongsu; Son, Taehwang; Kwon, Soon Woo; Park, Ki Duk; Yoon, Bo-Eun; Lee, Jaeick; Li, Yulong; Lee, Hyunbeom; Bae, Yong Chul; Lee, C. Justin; Cheong, Eunji

doi:10.1016/j.neuron.2020.08.013

[해외논문] Astrocytes Control Sensory Acuity via Tonic Inhibition in the Thalamus 원문보기

Neuron, v.108 no.4, 2020년, pp.691 - 706.e10

Kwak, Hankyul (Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University) , Koh, Wuhyun (Division of Bio-Medical Science &Technology, KIST School, Korea University of Science and Technology) , Kim, Sangwoo (Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University) , Song, Kiyeong (Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University) , Shin, Jeong-Im (Division of Bio-Medical Science &Technology, KIST School, Korea University of Science and Technology) , Lee, Jung Moo (Center for Glia-Neuron Interaction, Korea Institute of Science and Technology) , Lee, Elliot H. (Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University) , Bae, Jin Young (Department of Anatomy and Neurobiology, School of Dentistry, Kyungpook National University) , Ha, Go Eun (Depar) , Oh, Ju-Eun , Park, Yongmin Mason , Kim, Sunpil , Feng, Jiesi , Lee, Seung Eun , Choi, Ji Won , Kim, Ki Hun , Kim, Yoo Sung , Woo, Junsung , Lee, Dongsu , Son, Taehwang , Kwon, Soon Woo , Park, Ki Duk , Yoon, Bo-Eun , Lee, Jaeick , Li, Yulong , Lee, Hyunbeom , Bae, Yong Chul , Lee, C. Justin , Cheong, Eunji

Abstract ▼ AI-Helper

Summary Sensory discrimination is essential for survival. However, how sensory information is finely controlled in the brain is not well defined. Here, we show that astrocytes control tactile acuity via tonic inhibition in the thalamus. Mechanistically, diamine oxidase (DAO) and the subsequent aldehyde dehydrogenase 1a1 (Aldh1a1) convert putrescine into GABA, which is released via Best1. The GABA from astrocytes inhibits synaptically evoked firing at the lemniscal synapses to fine-tune the dynamic range of the stimulation-response relationship, the precision of spike timing, and tactile discrimination. Our findings reveal a novel role of astrocytes in the control of sensory acuity through tonic GABA release. Highlights Thalamic astrocytes synthesize GABA via DAO and Aldh1a1 to mediate tonic inhibition Tonic GABA improves linearity and temporal fidelity of synaptically evoked TC firing Astrocytic tonic GABA improves tactile discrimination performance Graphical Abstract [DISPLAY OMISSION]

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