[논문]Efficacy and safety of CAEC (Canavalia gladiata arctium lappa extract complex) on immune function enhancement: An 8 week, randomised, double-blind, placebo-controlled clinical trial

Lyu, Yee Ran; Jung, Sol-ji; Lee, Su-Won; Yang, Won-Kyung; Kim, Seung-Hyung; Jung, In Chul; Kim, Kun-Hoae; Kim, Han-Young; Yang, Yun Jeong; Lee, Yunhee; Yoon, Suk Ran; Park, Yang-Chun

doi:10.1016/j.jff.2020.104259

[해외논문] Efficacy and safety of CAEC (Canavalia gladiata arctium lappa extract complex) on immune function enhancement: An 8 week, randomised, double-blind, placebo-controlled clinical trial 원문보기

Journal of functional foods : the official journal of the International Society for Nutraceuticals & Functional Foods, v.75, 2020년, pp.104259 -

Lyu, Yee Ran (Division of Respiratory Medicine, Dept. of Internal Medicine, College of Korean Medicine, Daejeon University) , Jung, Sol-ji (Immunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology) , Lee, Su-Won (Division of Respiratory Medicine, Dept. of Internal Medicine, College of Korean Medicine, Daejeon University) , Yang, Won-Kyung (Division of Respiratory Medicine, Dept. of Internal Medicine, College of Korean Medicine, Daejeon University) , Kim, Seung-Hyung (Institute of Traditional Medicine and Bioscience, Daejeon University) , Jung, In Chul (Department of Neuropsychiatry, College of Korean Medicine, Daejeon University) , Kim, Kun-Hoae (Central Research Laboratories of Aekyung Industrial Co. Ltd.) , Kim, Han-Young (Central Research Laboratories of Aekyung Industrial Co. Ltd.) , Yang, Yun Jeong (Immu) , Lee, Yunhee , Yoon, Suk Ran , Park, Yang-Chun

Abstract ▼ AI-Helper

Abstract The aim of this study was to evaluate the efficacy and safety of CAEC (Canavalia gladiata arctium lappa extract complex) in adults with white blood cells between 3 and 8 × 103 cells/µL by assessing natural killer (NK) cell activity and immune-related biomarkers. Overall, 100 participants (CAEC group = 50, placebo group = 50) were randomised, and administered CAEC or placebo once daily for 8 weeks, with an evaluation visit performed every 4 weeks. NK cell activity, the primary outcome, significantly increased in CAEC when compared with the placebo at effector-to-target (E:T) ratios of 25:1 and 50:1 after 8 weeks. Compared with the placebo group, IL-10 demonstrated significant differences at week 8 in the CAEC group. Our findings demonstrate that CAEC is safe and enhances immune function by stimulating NK cell activity through IL-10 expression. Hence, we anticipate that CAEC can be developed as a functional food for stimulating immunity. Highlights CAEC enhanced immune function by stimulating NK cell activity and IL-10 expression. CAEC significantly increased NK cell activity at E:T = 25:1 and 50:1 after 8 weeks. CAEC significantly increased the level of IL-10 after 8 weeks. CAEC will be able to serve as a functional food for stimulating immunity. Graphical abstract [DISPLAY OMISSION]

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