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[해외논문] Yeast Chd1p Unwraps the Exit Side DNA upon ATP Binding to Facilitate the Nucleosome Translocation Occurring upon ATP Hydrolysis

Biochemistry, v.59 no.47, 2020년, pp.4481 - 4487  

Kirk, Jaewon (Department of Physics and Astronomy, Institute of Applied Physics , Seoul National University , Seoul 08826 , Republic of Korea) ,  Lee, Ju Yeon (Department of Physics and Astronomy, Institute of Applied Physics , Seoul National University , Seoul 08826 , Republic of Korea) ,  Lee, Yejin (Department of Biological Sciences , Korea Advanced Institute of Science and Technology (KAIST) , Daejeon 34141 , Republic of Korea) ,  Kang, Chanshin (Department of Physics and Astronomy, Institute of Applied Physics , Seoul National University , Seoul 08826 , Republic of Korea) ,  Shin, Soochul (Department of Physics and Astronomy, Institute of Applied Physics , Seoul National University , Seoul 08826 , Republic of Korea) ,  Lee, Eunhye (Department of Biological Sciences , Korea Advanced Institute of Science and Technology (KAIST) , Daejeon 34141 , Republic of Korea Republic of Kore) ,  Song, Ji-Joon ,  Hohng, Sungchul

Abstract AI-Helper 아이콘AI-Helper

Chromodomain-helicase-DNA-binding protein 1 (CHD1) remodels chromatin by translocating nucleosomes along DNA, but its mechanism remains poorly understood. We use single-molecule fluorescence experiments to clarify the mechanism by which yeast CHD1 (Chd1p) remodels nucleosomes. We find that binding o...

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