[논문]Aralia continentalis kitagawa Extract Attenuates the Fatigue Induced by Exhaustive Exercise through Inhibition of Oxidative Stress

Yang, Dong Kwon; Lee, Sei-Jin; Adam, Gareeballah Osman; Kim, Shang-Jin

doi:10.3390/antiox9050379

[해외논문] Aralia continentalis kitagawa Extract Attenuates the Fatigue Induced by Exhaustive Exercise through Inhibition of Oxidative Stress 원문보기

Antioxidants, v.9 no.5, 2020년, pp.379 -

Yang, Dong Kwon (Department of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Jeonbuk National University, Iksan 54596, Korea) , Lee, Sei-Jin (dkyang0502@gmail.com (D.K.Y.)) , Adam, Gareeballah Osman (gorba000@gmail.com (G.O.A.)) , Kim, Shang-Jin (Korea Basic Science Institute Jeonju Center, Jeonju 54896, Korea)

Abstract ▼ AI-Helper

The present study aimed to evaluate the anti-fatigue effects of Aralia continentalis kitagawa (AC) extract during exhaustive exercise of rats by forced swimming. Rats were subjected to forced swimming until exhausted after pre-treatment with AC extract for 21 days. Exhaustion time significantly increased in rats treated with AC extract. AC treatment also preserved blood homeostasis during fatigue due to exhaustive exercise. For fatigue-related serum biomarkers, AC extract significantly fail to decrease glucose and triglyceride (TG), but ameliorated increased lactate levels compared with levels in control rats. Metabolic acidosis, a major cause of fatigue, was effectively attenuated by AC extract, according to metabolic acidosis-related blood parameters. AC extract suppressed muscle injury and attenuated gastrocnemius muscle apoptotic responses due to exhaustive exercise. To investigate the mechanisms behind the AC extract anti-fatigue effect, we evaluated its effect on oxidative stress-related fatigue. We showed that pro-oxidants were inhibited, while antioxidants were preserved by AC extract treatment. Therefore, the anti-fatigue effect of AC extract was mediated by suppression of oxidative stress. Overall, the study demonstrated that AC extract effectively attenuates fatigue from exhaustive exercise through oxidative stress inhibition. AC extract, as an antioxidant, could be utilized as a therapeutic or preventive strategy against exhaustive exercise fatigue.

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참고문헌 (54)

1. Ma J. Chen H. Liu X. Zhang L. Qiao D. Exercise-Induced Fatigue Impairs Bidirectional Corticostriatal Synaptic Plasticity Front. Cell. Neurosci. 2018 12 14 10.3389/fncel.2018.00014 29422839

상세보기
2. Hong R. Sur B. Yeom M. Lee B. Kim K.S. Rodriguez J.P. Lee S. Kang K.S. Huh C.K. Lee S.C. Anti-inflammatory and anti-arthritic effects of the ethanolic extract of Aralia continentalis Kitag. In IL-1β-stimulated human fibroblast-like synoviocytes and rodent models of polyarthritis and nociception Phytomedicine 2018 38 45 56 10.1016/j.phymed.2017.10.016 29425654

상세보기
3. Sandi C. Stress and cognition Wiley Interdiscip. Rev. Cogn. Sci. 2013 4 245 261 10.1002/wcs.1222 26304203

상세보기
4. Gonzalez J.T. Fuchs C.J. Betts J.A. Van Loon L.J.C. Liver glycogen metabolism during and after prolonged endurance-type exercise Am. J. Physiol. Endocrinol. Metab. 2016 311 E543 E553 10.1152/ajpendo.00232.2016 27436612

상세보기
5. Stolecka-Warzecha A. Kaczmarczyk T. ebrowska A. Assessment of anaerobic endurance based on selected biochemical parameters in 400 M/400 M hurdles male athletes Cent. Eur. J. Sport Sci. Med. 2016 14 101 110
6. Cairns S.P. Lactic acid and exercise performance: Culprit or friend? Sports Med. 2006 36 279 291 10.2165/00007256-200636040-00001 16573355

상세보기
7. Rahman M. Lee S.-J. Mun A.-R. Adam G.O. Park R.-M. Kim G.-B. Kang H.-S. Kim J.-S. Kim S.-J. Kim S.-Z. Relationships between blood Mg 2+ and energy metabolites/enzymes after acute exhaustive swimming exercise in rats Biol. Trace Elem. Res. 2014 161 85 90 10.1007/s12011-014-9983-x 25035192

상세보기
8. You L. Zhao M. Regenstein J.M. Ren J. In vitro antioxidant activity and in vivo anti-fatigue effect of loach (Misgurnus anguillicaudatus) peptides prepared by papain digestion Food Chem. 2011 124 188 194 10.1016/j.foodchem.2010.06.007

상세보기
9. Alessio H.M. Exercise-induced oxidative stress Med. Sci. Sports Exerc. 1993 25 218 224 10.1249/00005768-199302000-00010 8383786

상세보기
10. Simioni C. Zauli G. Martelli A.M. Vitale M. Sacchetti G. Gonelli A. Neri L.M. Oxidative stress: Role of physical exercise and antioxidant nutraceuticals in adulthood and aging Oncotarget 2018 9 17181 17198 10.18632/oncotarget.24729 29682215

상세보기
11. Kawamura T. Muraoka I. Exercise-Induced Oxidative Stress and the Effects of Antioxidant Intake from a Physiological Viewpoint Antioxidants 2018 7 119 10.3390/antiox7090119 30189660

상세보기
12. Jung K. Kim I.-H. Han D. Effect of medicinal plant extracts on forced swimming capacity in mice J. Ethnopharmacol. 2004 93 75 81 10.1016/j.jep.2004.03.022 15182908

상세보기
13. Zhou S.-S. Jiang J.-G. Anti-fatigue effects of active ingredients from traditional Chinese medicine: A review Curr. Med. Chem. 2019 26 1833 1848 10.2174/0929867324666170414164607 28413958

상세보기
14. Hwang Y.P. Choi J.H. Jeong H.G. Protective effect of the Aralia continentalis root extract against carbon tetrachloride-induced hepatotoxicity in mice Food Chem. Toxicol. 2009 47 75 81 10.1016/j.fct.2008.10.011 18984026

상세보기
15. Okuyama E. Nishimura S. Yamazaki M. Analgesic principles from Aralia cordata Thunb Chem. Pharm. Bull. 1991 39 405 407 10.1248/cpb.39.405 2054865

상세보기
16. Oh H.L. Lee D.-K. Lim H. Lee C.-H. HY253, a novel decahydrofluorene analog, from Aralia continentalis, induces cell cycle arrest at the G1 phase and cytochrome c-mediated apoptosis in human lung cancer A549 cells J. Ethnopharmacol. 2010 129 135 139 10.1016/j.jep.2010.02.010 20219657

상세보기
17. Lim H. Jung H.A. Choi J.S. Kim Y.S. Kang S.S. Kim H.P. Anti-inflammatory activity of the constituents of the roots of Aralia continentalis Arch. Pharmacal. Res. 2009 32 1237 1243 10.1007/s12272-009-1909-3

원문보기 상세보기
18. Chung C.-K. Jung M.-E. Ethanol fraction of Aralia elata Seemann enhances antioxidant activity and lowers serum lipids in rats when administered with benzo (α) pyrene Biol. Pharm. Bull. 2003 26 1502 1504 10.1248/bpb.26.1502 14519964

상세보기
19. Yoon Jeong H. Hyun Moh S. Yang Y. Yu T. Oh J. Jeong D. Hyo Yoon D. Myun Park K. Lee S. Woong Kim T. Src and Syk are targeted to an anti-inflammatory ethanol extract of Aralia continentalis J. Ethnopharmacol. 2012 143 746 753 10.1016/j.jep.2012.07.031 22885130

상세보기
20. Cardoso P.C.D.S. Rocha C. Leal M.F. Bahia M.D.O. Alcantara D.D.F.A. Dos Santos R.A. Goncalves N.D.S. Ambrosio S.R. Cavalcanti B.C. Moreira-Nunes C.A. Effect of diterpenoid kaurenoic acid on genotoxicity and cell cycle progression in gastric cancer cell lines Biomed. Pharmacother. 2017 89 772 780 10.1016/j.biopha.2017.02.085 28273639

상세보기
21. Song S.-J. Nakamura N. Ma C.-M. Hattori M. Xu S.-X. Five saponins from the root bark of Aralia elata Phytochemistry 2001 56 491 497 10.1016/S0031-9422(00)00379-4 11261582

상세보기
22. Yoshikawa M. Murakami T. Harada E. Murakami N. Yamahara J. Matsuda H. Bioactive saponins and glycosides. VI. Elatosides A and B, potent inhibitors of ethanol absorption, from the bark of Aralia elata SEEM. (Araliaceae): The structure-requirement in oleanolic acid glucuronide-saponins for the inhibitory activity Chem. Pharm. Bull. 1996 44 1915 1922 10.1248/cpb.44.1915 8904819

상세보기
23. Lee J.E. Sim S.J. Jeong W. Choi C.W. Kim N. Park Y. Kim M.J. Lee D. Hong S.S. Diterpenoids and phenolic analogues from the roots of Aralia continentalis J. Asian Nat. Prod. Res. 2020 1 8 10.1080/10286020.2020.1737859 32166984

상세보기
24. Hyun S.K. Jung H.A. Min B.S. Jung J.H. Choi J.S. Isolation of Phenolics, Nucleosides, Sacchardies and an Alkaloid from the root of Aralia cordata Netural. Product. Sci. 2010 16 20 25
25. Liu D. Wang H. Zhang Y. Zhang Z. Protective Effects of Chlorogenic Acid on Cerebral Ischemia/Reperfusion Injury Rats by Regulating Oxidative Stress-Related Nrf2 Pathway Drug Des. Dev. Ther. 2020 14 51 60 10.2147/DDDT.S228751 32021091

상세보기
26. Choi R.J. Shin E.M. Jung H.A. Choi J.S. Kim Y.S. Inhibitory effects of kaurenoic acid from Aralia continentalis on LPS-induced inflammatory response in RAW264.7 macrophages Phytomedicine 2011 18 677 682 10.1016/j.phymed.2010.11.010 21211951

상세보기
27. Park H.-J. Hong M.-S. Lee J.S. Leem K.-H. Kim C.-J. Kim J.-W. Lim S. Effects ofAralia continentalis on hyperalgesia with peripheral inflammation Phytother. Res. 2005 19 511 513 10.1002/ptr.1693 16114085

상세보기
28. Brancaccio P. Maffulli N. Limongelli F.M. Creatine kinase monitoring in sport medicine Br. Med. Bull. 2007 81？82 209 230 10.1093/bmb/ldm014

상세보기
29. Swain M.G. Fatigue in chronic disease Clin. Sci. Lond. 2000 99 1 8 10.1042/cs0990001 10887052

상세보기
30. Finsterer J. Biomarkers of peripheral muscle fatigue during exercise BMC Musculoskelet. Disord. 2012 13 218 10.1186/1471-2474-13-218 23136874

상세보기
31. Clarkson P.M. Hubal M.J. Exercise-induced muscle damage in humans Am. J. Phys. Med. Rehabil. 2002 81 S52 S69 10.1097/00002060-200211001-00007 12409811

상세보기
32. Baek Y.-H. Huh J.-E. Lee J.-D. Choi D.-Y. Park D.-S. Effect of Aralia cordata extracts on cartilage protection and apoptosis inhibition Biol. Pharm. Bull. 2006 29 1423 1430 10.1248/bpb.29.1423 16819182

상세보기
33. Tirapelli C.R. Ambrosio S.R. Coutinho S.T. de Oliveira D.C.R. da Costa F.B. de Oliveira A.M. Pharmacological comparison of the vasorelaxant action displayed by kaurenoic acid and pimaradienoic acid J. Pharm. Pharmacol. 2005 57 997 1004 10.1211/0022357056578 16102255

상세보기
34. Cheng W.-L. Lin T.-Y. Tseng Y.-H. Chu F.-H. Chueh P.J. Kuo Y.-H. Wang S.-Y. Inhibitory effect of human breast cancer cell proliferation via p21-mediated G1 cell cycle arrest by araliadiol isolated from Aralia cordata Thunb Planta. Med. 2011 77 164 168 10.1055/s-0030-1250177 20717878

상세보기
35. Bol’shakova I.V. Lozovskaia E.L. Sapezhinskii I.I. Antioxidant properties of a series of extracts from medicinal plants Biofizika 1997 42 480 483 9172694
36. Hwang Y.P. Choi J.H. Han E.H. Kim H.K. Kang S.K. Chung Y.C. Jeong H.G. Protective mechanisms of Aralia continentalis extract against tert-butyl hydroperoxide-induced hepatotoxicity: In vivo and in vitro studies Food Chem. Toxicol. 2008 46 3512 3521 10.1016/j.fct.2008.08.035 18824057

상세보기
37. Rahman M. Yang D.K. Kim G.-B. Lee S.-J. Kim S.-J. Nigella sativa seed extract attenuates the fatigue induced by exhaustive swimming in rats Biomed. Rep. 2017 6 468 474 10.3892/br.2017.866 28413647

상세보기
38. Ament W. Verkerke G.J. Exercise and fatigue Sports Med. 2009 39 389 422 10.2165/00007256-200939050-00005 19402743

상세보기
39. Hultman E. Greenhaff P.L. Skeletal muscle energy metabolism and fatigue during intense exercise in man Sci. Prog. 1991 75 361 370 1842855
40. Westerblad H. Bruton J.D. Katz A. Skeletal muscle: Energy metabolism, fiber types, fatigue and adaptability Exp. Cell Res. 2010 316 3093 3099 10.1016/j.yexcr.2010.05.019 20580710

상세보기
41. Lima F.D. Stamm D.N. Della-Pace I.D. Dobrachinski F. de Carvalho N.R. Royes L.F. Soares F.A. Rocha J.B. Gonzalez-Gallego J. Bresciani G. Swimming training induces liver mitochondrial adaptations to oxidative stress in rats submitted to repeated exhaustive swimming bouts PLoS ONE 2013 8 e55668 10.1371/journal.pone.0055668 23405192

상세보기
42. McKenna M.J. Harmer A.R. Fraser S.F. Li J.L. Effects of training on potassium, calcium and hydrogen ion regulation in skeletal muscle and blood during exercise Acta Physiol. Scand. 1996 156 335 346 10.1046/j.1365-201X.1996.199000.x 8729694

상세보기
43. Zhang Y. Xun P. Wang R. Mao L. He K. Can Magnesium Enhance Exercise Performance? Nutrients 2017 9 946 10.3390/nu9090946 28846654

상세보기
44. Nielsen F.H. Lukaski H.C. Update on the relationship between magnesium and exercise Magnes. Res. 2006 19 180 189 17172008
45. Karaki H. Urakawa N. Kutsky P. Potassium-induced contraction in smooth muscle J. Smooth Muscle Res. 1984 20 427 444 10.1540/jsmr1965.20.427

상세보기
46. McKenna M.J. Heigenhauser G.J.F. McKelvie R.S. MacDougall J.D. Jones N.L. Sprint training enhances ionic regulation during intense exercise in men J. Physiol. 1997 501 687 702 10.1111/j.1469-7793.1997.687bm.x 9218228

상세보기
47. Tang Y. Qi R. Wu H. Shi W. Xu Y. Li M. Reduction of hemoglobin, not iron, inhibited maturation of red blood cells in male rats exposed to high intensity endurance exercises J. Trace Elem. Med. Biol. 2019 52 263 269 10.1016/j.jtemb.2019.01.006 30732892

상세보기
48. Slattery K. Bentley D. Coutts A.J. The role of oxidative, inflammatory and neuroendocrinological systems during exercise stress in athletes: Implications of antioxidant supplementation on physiological adaptation during intensified physical training Sports Med. 2015 45 453 471 10.1007/s40279-014-0282-7 25398224

상세보기
49. Powers S.K. Jackson M.J. Exercise-induced oxidative stress: Cellular mechanisms and impact on muscle force production Physiol. Rev. 2008 88 1243 1276 10.1152/physrev.00031.2007 18923182

상세보기
50. Sun Y. Cui D. Zhang Z. Zhang T. Shi J. Jin H. Ge Z. Ji L. Attenuated oxidative stress following acute exhaustive swimming exercise was accompanied with modified gene expression profiles of apoptosis in the skeletal muscle of mice Oxi. Med. Cell. Longev. 2016 1 8 10.1155/2016/8381242

상세보기
51. Marfe G. Manzi V. Tafani M. Pucci B. Gambacurta A. Russo M.A. Sinibaldi-Salimei P. The modulation of sirtuins and apoptotic proteins in rats after exhaustive exercise Open J. Mol. Integr. Physiol. 2012 2 65 74 10.4236/ojmip.2012.23010

상세보기
52. Powers S.K. Hamilton K. Antioxidants and exercise Clin. Sports Med. 1999 18 525 536 10.1016/S0278-5919(05)70166-6 10410839

상세보기
53. Leeuwenburgh C. Ji L.L. Glutathione depletion in rested and exercised mice: Biochemical consequence and adaptation Arch. Biochem. Biophys. 1995 316 941 949 10.1006/abbi.1995.1125 7864653

상세보기
54. Li X.D. Sun G.F. Zhu W.B. Wang Y.H. Effects of high intensity exhaustive exercise on SOD, MDA, and NO levels in rats with knee osteoarthritis Genet. Mol. Res. 2015 14 12367 12376 10.4238/2015.October.16.3 26505386

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