[논문]General anesthesia activates the mitochondrial unfolded protein response and induces age-dependent, long-lasting changes in mitochondrial function in the developing brain

Lee, Yulim; Heo, Jun Young; Ju, Xianshu; Cui, Jianchen; Ryu, Min Jeong; Lee, Min Joung; Hong, Boohwi; Yoo, Sungho; Ahn, Jeonghoon; Kim, Yoon Hee; Ko, Youngkwon; Chung, Woosuk

doi:10.1016/j.neuro.2020.10.012

[해외논문] General anesthesia activates the mitochondrial unfolded protein response and induces age-dependent, long-lasting changes in mitochondrial function in the developing brain

Neurotoxicology, v.82, 2021년, pp.1 - 8

Lee, Yulim (Department of Biochemistry, Chungnam National University School of Medicine) , Heo, Jun Young (Department of Biochemistry, Chungnam National University School of Medicine) , Ju, Xianshu (Department of Biochemistry, Chungnam National University School of Medicine) , Cui, Jianchen (Department of Biochemistry, Chungnam National University School of Medicine) , Ryu, Min Jeong (Department of Biochemistry, Chungnam National University School of Medicine) , Lee, Min Joung (Department of Biochemistry, Chungnam National University School of Medicine) , Hong, Boohwi (Department of Anesthesia and Pain Medicine, Chungnam National University Hospital) , Yoo, Sungho (Department of Anesthesia and Pain Medicine, Chungnam National University Hospital) , Ahn, Jeonghoon (Department of Anesthesia and Pain Medicine, Chungnam National University Hospital) , Kim, Yoon Hee (D) , Ko, Youngkwon , Chung, Woosuk

Abstract ▼ AI-Helper

Abstract General anesthesia induces changes in dendritic spine number and synaptic transmission in developing mice. These changes are rather disturbing, as similar changes are seen in animal models of neurodevelopmental disorders. We previously suggested that mTor-dependent upregulation of mitochondrial function may be involved in such changes. To further understand the significance of mitochondrial changes after general anesthesia during neurodevelopment, we exposed young mice to 2.5 % sevoflurane for 2 h followed by injection of rotenone, a mitochondrial complex I inhibitor. In postnatal day 17 (PND17) mice, intraperitoneal injection of rotenone not only blocked sevoflurane-induced increases in mitochondrial function, it also prevented sevoflurane-induced changes in excitatory synaptic transmission. Interestingly, similar changes were not observed in younger, neonatal mice (PND7). We next assessed whether the mitochondrial unfolded protein response (UPRmt) acted as a link between anesthetic exposure and mitochondrial function. Expression of UPRmt proteins, which help maintain protein-folding homeostasis and increase mitochondrial function, was increased 6 h after sevoflurane exposure. Our results show that a single, brief sevoflurane exposure induces age-dependent changes in mitochondrial function that constitute an important mechanism for the increase in excitatory synaptic transmission in late postnatal mice, and also suggest mitochondria and UPRmt as potential targets for preventing anesthesia toxicity. Highlights A 2 -h sevoflurane exposure induces age-dependent mitochondrial changes in young mice. Blocking mitochondrial upregulation prevents sevoflurane-induced synaptic changes. Sevoflurane activates the mitochondrial unfolded protein response (UPRmt) in young mice. Mitochondria and UPRmt are potential targets for anesthesia-induced neurotoxicity.

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참고문헌 (45)

Metab. Brain Dis. Alimov 28 4 667 2013 10.1007/s11011-013-9430-2 Expression of autophagy and UPR genes in the developing brain during ethanol-sensitive and resistant periods

상세보기
Anesthesiology Amrock 122 1 87 2015 10.1097/ALN.0000000000000477 Long-term effects of single or multiple neonatal sevoflurane exposures on rat hippocampal ultrastructure

상세보기
Paediatr. Anaesth. Bartels 28 6 520 2018 10.1111/pan.13391 Estimating pediatric general anesthesia exposure: quantifying duration and risk

상세보기
Neurobiol. Dis. Boscolo 45 3 1031 2012 10.1016/j.nbd.2011.12.022 The abolishment of anesthesia-induced cognitive impairment by timely protection of mitochondria in the developing rat brain: the importance of free oxygen radicals and mitochondrial integrity

상세보기
Br. J. Anaesth. Boscolo 110 Suppl 1 i47 2013 10.1093/bja/aet073 Mitochondrial protectant pramipexole prevents sex-specific long-term cognitive impairment from early anaesthesia exposure in rats

상세보기
Anesthesiology Briner 112 3 546 2010 10.1097/ALN.0b013e3181cd7942 Volatile anesthetics rapidly increase dendritic spine density in the rat medial prefrontal cortex during synaptogenesis

상세보기
Br. J. Anaesth. Cabrera 124 3 e81 2020 10.1016/j.bja.2019.12.032 Sex differences in neurodevelopmental abnormalities caused by early-life anaesthesia exposure: a narrative review

상세보기
Anesthesiology Chung 126 2 288 2017 10.1097/ALN.0000000000001470 Sevoflurane exposure during the critical period affects synaptic transmission and mitochondrial respiration but not long-term behavior in mice

상세보기
Biochim. Biophys. Acta Coskun 1820 5 553 2012 10.1016/j.bbagen.2011.08.008 A mitochondrial etiology of Alzheimer and Parkinson disease

상세보기
Br. J. Anaesth. Deng 113 3 443 2014 10.1093/bja/aet469 Brain regional vulnerability to anaesthesia-induced neuroapoptosis shifts with age at exposure and extends into adulthood for some regions

상세보기
Annu. Rev. Biochem. Deshwal 89 501 2020 10.1146/annurev-biochem-062917-012739 Mitochondrial proteases: multifaceted regulators of mitochondrial plasticity

상세보기
Genetics Fox 192 4 1203 2012 10.1534/genetics.112.141267 Mitochondrial protein synthesis, import, and assembly

상세보기
Oxid. Med. Cell. Longev. Han 2019 2019 10.1155/2019/4174803 Chloramphenicol mitigates oxidative stress by inhibiting translation of mitochondrial complex I in dopaminergic neurons of toxin-induced parkinson’s disease model

상세보기
Aging Dis. Hu 7 1 14 2016 10.14336/AD.2015.0906 Mitochondrial impairment in cerebrovascular endothelial cells is involved in the correlation between body temperature and stroke severity

상세보기
PLoS One Johnson 14 3 2019 10.1371/journal.pone.0213543 Relevance of experimental paradigms of anesthesia induced neurotoxicity in the mouse

상세보기
Neurotoxicology Ju 70 146 2019 10.1016/j.neuro.2018.11.014 Anesthesia affects excitatory/inhibitory synapses during the critical synaptogenic period in the hippocampus of young mice: importance of sex as a biological variable

상세보기
Front. Cell. Neurosci. Ju 14 4 2020 The mTOR inhibitor rapamycin prevents general anesthesia-induced changes in synaptic transmission and mitochondrial respiration in late postnatal mice
Cell Metab. Khan 26 2 419 2017 10.1016/j.cmet.2017.07.007 mTORC1 regulates mitochondrial integrated stress response and mitochondrial myopathy progression

상세보기
Int. J. Mol. Sci. Kokubun 21 2 2020 10.3390/ijms21020450 Conflicting actions of inhalational anesthetics, neurotoxicity and neuroprotection, mediated by the unfolded protein response

상세보기
Korean J. Anesthesiol. Lee 71 4 255 2018 10.4097/kja.d.18.00165 Does pediatric anesthesia cause brain damage? - addressing parental and provider concerns in light of compelling animal studies and seemingly ambivalent human data

상세보기
Cell Li 119 6 873 2004 10.1016/j.cell.2004.11.003 The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses

상세보기
Pediatr. Res. Lingan 81 6 932 2017 10.1038/pr.2017.19 Preventing permeability transition pore opening increases mitochondrial maturation, myocyte differentiation and cardiac function in the neonatal mouse heart

상세보기
Neurotox. Res. Liu 31 2 218 2017 10.1007/s12640-016-9671-z Sevoflurane-induced endoplasmic reticulum stress contributes to neuroapoptosis and BACE-1 expression in the developing brain: the role of eIF2α

상세보기
Mol. Cell Mapa 38 1 89 2010 10.1016/j.molcel.2010.03.010 The conformational dynamics of the mitochondrial Hsp70 chaperone

상세보기
Cell Res. Melber 28 3 281 2018 10.1038/cr.2018.16 UPR(mt) regulation and output: a stress response mediated by mitochondrial-nuclear communication

상세보기
Neurosci. Biobehav. Rev. Meredith 50 180 2015 10.1016/j.neubiorev.2014.12.001 Sensitive and critical periods during neurotypical and aberrant neurodevelopment: a framework for neurodevelopmental disorders

상세보기
Mol. Neurobiol. Monzio Compagnoni 57 7 2959 2020 10.1007/s12035-020-01926-1 The role of mitochondria in neurodegenerative diseases: the lesson from Alzheimer’s disease and parkinson’s disease

상세보기
Mol. Cell Morita 67 6 922 2017 10.1016/j.molcel.2017.08.013 mTOR controls mitochondrial dynamics and cell survival via MTFP1

상세보기
Cold Spring Harb. Perspect. Biol. Naresh 11 6 2019 10.1101/cshperspect.a033944 Signaling and regulation of the mitochondrial unfolded protein response

상세보기
Trends Neurosci. Nelson 43 3 133 2020 10.1016/j.tins.2020.01.002 Early adversity and critical periods: neurodevelopmental consequences of violating the expectable environment

상세보기
Cell Death Dis. Ray 5 1 2014 10.1038/cddis.2013.513 Mitochondrial dysfunction, oxidative stress, and neurodegeneration elicited by a bacterial metabolite in a C. elegans Parkinson’s model

상세보기
Front. Mol. Biosci. Rodriguez 7 159 2020 Complex destabilization in the mitochondrial chaperonin Hsp60 leads to disease
Curr. Opin. Neurobiol. Rossi 57 149 2019 10.1016/j.conb.2019.02.001 Powerhouse of the mind: mitochondrial plasticity at the synapse

상세보기
PLoS Genet. Runkel 9 3 2013 10.1371/journal.pgen.1003346 Surveillance-activated defenses block the ROS-induced mitochondrial unfolded protein response

상세보기
Anesthesiology Sanchez 115 5 992 2011 10.1097/ALN.0b013e3182303a63 General anesthesia causes long-term impairment of mitochondrial morphogenesis and synaptic transmission in developing rat brain

상세보기
Neurotoxicol. Teratol. Walters 60 2 2017 10.1016/j.ntt.2016.11.005 Review of preclinical studies on pediatric general anesthesia-induced developmental neurotoxicity

상세보기
J. Neurosci. Workman 33 17 7368 2013 10.1523/JNEUROSCI.5746-12.2013 Modeling transformations of neurodevelopmental sequences across mammalian species

상세보기
PLoS One Wu 10 9 2015 10.1371/journal.pone.0138256 A mitochondrion-targeted antioxidant ameliorates isoflurane-induced cognitive deficits in aging mice

상세보기
Behav. Brain Res. Wu 305 115 2016 10.1016/j.bbr.2016.02.036 BDNF pathway is involved in the protective effects of SS-31 on isoflurane-induced cognitive deficits in aging mice

상세보기
J. Mol. Endocrinol. Xiao 64 2 67 2020 10.1530/JME-19-0207 Mitochondrial stress protein HSP60 regulates ER stress-induced hepatic lipogenesis

상세보기
Neurosci. Lett. Zhang 447 2-3 109 2008 10.1016/j.neulet.2008.09.083 Subclinical concentration of sevoflurane potentiates neuronal apoptosis in the developing C57BL/6 mouse brain

상세보기
PLoS One Zhang 11 4 2016 10.1371/journal.pone.0153505 Autophagy is involved in the sevoflurane anesthesia-induced cognitive dysfunction of aged rats

상세보기
Acta Anaesthesiol. Scand. Zheng 57 9 1167 2013 10.1111/aas.12163 Sevoflurane causes neuronal apoptosis and adaptability changes of neonatal rats

상세보기
J. Neurochem. Zhu 142 2 272 2017 10.1111/jnc.14057 Endoplasmic reticulum stress mediates distinct impacts of sevoflurane on different subfields of immature hippocampus

상세보기
Br. J. Anaesth. Zimin 120 5 1019 2018 10.1016/j.bja.2018.01.036 Isoflurane disrupts excitatory neurotransmitter dynamics via inhibition of mitochondrial complex I

상세보기

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