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Single-cell analysis of human B cell maturation predicts how antibody class switching shapes selection dynamics 원문보기

Science immunology, v.6 no.56, 2021년, pp.eabe6291 - eabe6291  

King, Hamish W. (Centre for Immunobiology, Blizard Institute, Queen Mary University of London, London E1 2AT, UK.) ,  Orban, Nara (Barts Health Ear, Nose and Throat Service, Royal London Hospital, London E1 1BB, UK.) ,  Riches, John C. (Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, UK.) ,  Clear, Andrew J. (Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, UK.) ,  Warnes, Gary (Flow Cytometry Core Facility, Blizard Institute, Queen Mary University of London, London E1 2AT, UK.) ,  Teichmann, Sarah A. (Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.) ,  James, Louisa K. (Centre for Immunobiology, Blizard Institute, Queen Mary University of London, London E1 2AT, UK.)

Abstract AI-Helper 아이콘AI-Helper

Protective humoral memory forms in secondary lymphoid organs where B cells undergo affinity maturation and differentiation into memory or plasma cells. Here, we provide a comprehensive roadmap of human B cell maturation with single-cell transcriptomics matched with bulk and single-cell antibody repe...

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