[논문]Pu'er tea water extract protects against cognitive impairment in a mouse model of lipopolysaccharide-induced neuroinflammation

Jeong, Yun Hee; Oh, You-Chang; Pak, Malk Eun; Li, Wei; Go, Younghoon; Lee, Jung-Jin

doi:10.1016/j.phymed.2020.153338

[해외논문] Pu'er tea water extract protects against cognitive impairment in a mouse model of lipopolysaccharide-induced neuroinflammation

Phytomedicine : international journal of phytotherapy and phytopharmacology, v.79, 2020년, pp.153338 -

Jeong, Yun Hee (Korean medicine (KM)-Application Center, Korea Institute of Oriental Medicine) , Oh, You-Chang (Korean medicine (KM)-Application Center, Korea Institute of Oriental Medicine) , Pak, Malk Eun (Korean medicine (KM)-Application Center, Korea Institute of Oriental Medicine) , Li, Wei (Korean medicine (KM)-Application Center, Korea Institute of Oriental Medicine) , Go, Younghoon (Korean medicine (KM)-Application Center, Korea Institute of Oriental Medicine) , Lee, Jung-Jin (Department of R&D Center, Myungmoon Bio Co.)

Abstract ▼ AI-Helper

Abstract Background Pu'er tea, a type of post-fermented tea made from Camellia sinensis leaves, has long been widely used in East Asian countries. It is mainly produced in southern China and is effective in preventing obesity due to its ability to break down fat. However, the effects of Pu'er tea on cognitive impairment or neuroinflammation by endotoxin have not yet been studied. Purpose Here, we assessed the inhibitory activity of Pu'er tea hot water extract (PTW) on neuroinflammation and cognitive impairment and explored its mechanism. Study design The ability of PTW to inhibit cognitive impairment was investigated in a mouse model of lipopolysaccharide (LPS)-induced neuroinflammation and murine microglia BV2 cells. Methods We examined whether oral administration of PTW prevented cognitive impairment and LPS-induced neuroinflammation using behavioral tests, Nissl staining, immunohistochemistry, western blotting, real-time reverse transcription-polymerase chain reaction (real-time RT-PCR), Griess assay, and enzyme-linked immunosorbent assay (ELISA). Results First, Morris water maze (MWM) and passive avoidance (PA) tests demonstrated that oral administration of PTW effectively attenuated LPS-induced spatial memory loss and inhibited neuronal damage of mouse brains. Histopathological analysis showed that PTW repressed LPS-induced expression of the activation markers ionized calcium-binding adaptor molecule-1 (Iba-1) and glial fibrillary acidic protein (GFAP). Furthermore, PTW inhibited the expression of amyloidogenesis proteins such as amyloid-β precursor protein (APP), C99, and β-secretase-1 (BACE-1); production of inflammatory proteins such as Iba-1, GFAP, inducible nitric oxide synthase (iNOS), and cyclooxygenase (COX)-2; activation of inflammatory pathways; and expression of inflammatory mediator mRNAs in hippocampal tissue. In cultured microglia, PTW treatment inhibited the generation of various inflammatory factors activated by LPS. Conclusion Our results in vivo and in vitro demonstrate that PTW effectively prevents cognitive impairment caused by neuroinflammation and is, therefore, a potential candidate for the development of a therapeutic agent for neurodegenerative diseases. Highlights PTW effectively prevents cognitive impairment in mice. PTW attenuated neuronal damage and histopathological changes in the mice brain. PTW suppressed the expression of activation markers in the mice brain. PTW inhibited the expression of neuroinflammatory mediators in vivo and in vitro. Graphical abstract [DISPLAY OMISSION]

Keyword

참고문헌 (30)

J. Neuroinflammation Allison 11 151 2014 10.1186/s12974-014-0151-1 The common inflammatory etiology of depression and cognitive impairment: a therapeutic target

상세보기
Mol. Immunol. Ashino 45 2106 2008 10.1016/j.molimm.2007.10.011 Negative feedback regulation of lipopolysaccharide-induced inducible nitric oxide synthase gene expression by heme oxygenase-1 induction in macrophages

상세보기
Anal. Biochem. Bradford 72 248 1976 10.1016/0003-2697(76)90527-3 A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

상세보기
Curr. Opin. Immunol. Beutler 12 20 2000 10.1016/S0952-7915(99)00046-1 TLR4: central component of the sole mammalian LPS sensor

상세보기
Mol. Nutr. Food Res. Chen 62 2 2018 Aromatic-Turmerone Attenuates LPS-Induced Neuroinflammation and Consequent Memory Impairment by Targeting TLR4-Dependent Signaling Pathway
Free Radic. Biol. Med. Cheng 92 15 2016 10.1016/j.freeradbiomed.2015.12.027 Cerebroprotection of Flavanol (−)-Epicatechin after Traumatic Brain Injury via Nrf2-dependent and -independent Pathways

상세보기
Cytotechnology Cheruku 70 245 2018 10.1007/s10616-017-0138-8 Catechin ameliorates doxorubicin-induced neuronal cytotoxicity in in vitro and episodic memory deficit in in vivo in Wistar rats

상세보기
Neurochem. Int. Choi 60 68 2012 10.1016/j.neuint.2011.11.005 Obovatol attenuates LPS-induced memory impairments in mice via inhibition of NF-κB signaling pathway

상세보기
Trends Cell Biol Cohen 7 353 1997 10.1016/S0962-8924(97)01105-7 The search for physiological substrates of MAP and SAP kinases in mammalian cells

상세보기
Nat. Rev. Neurosci. Eichenbaum 1 41 2000 10.1038/35036213 A cortical-hippocampal system for declarative memory

상세보기
Acta Neurobiol. Exp. Fan 74 298 2014 10.55782/ane-2014-1995 Systemic inflammation induces a profound long term brain cell injury in rats

상세보기
Cell Glass 140 918 2010 10.1016/j.cell.2010.02.016 Mechanisms underlying inflammation in neurodegeneration

상세보기
Neurobiol. Aging Grudzien 28 327 2007 10.1016/j.neurobiolaging.2006.02.007 Locus coeruleus neurofibrillary degeneration in aging, mild cognitive impairment and early Alzheimer's disease

상세보기
Glia Hartlage-Rubsamen 41 169 2003 10.1002/glia.10178 Astrocytic expression of the Alzheimer's disease beta-secretase (BACE1) is stimulus-dependent

상세보기
J. Food Drug Anal. Hsieh 24 722 2016 10.1016/j.jfda.2016.03.014 Antibacterial and laxative activities of strictinin isolated from Pu'er tea (Camellia sinensis)

상세보기
Am. J. Chin. Med. Jeong 45 1477 2017 10.1142/S0192415X1750080X Maydis Stigma Elicits Analgesia and Blocks Edema in Mice and Inhibits Inflammation in Macrophages

상세보기
PloS One Kim 8 e55792 2013 10.1371/journal.pone.0055792 Regulation of microglia activity by glaucocalyxin-A: attenuation of lipopolysaccharide-stimulated neuroinflammation through NF-κB and p38 MAPK signaling pathways

상세보기
J. Neurosci. Lehnardt 22 2478 2002 10.1523/JNEUROSCI.22-07-02478.2002 The toll-like receptor TLR4 is necessary for lipopolysaccharide-induced oligodendrocyte injury in the CNS

상세보기
Mol. Neurobiol. Liu 49 1350 2014 10.1007/s12035-013-8608-2 (‐)‐Epigallocatechin-3‐gallate ameliorates learning and memory deficits by adjusting the balance of TrkA/p75NTR signaling in APP/PS1 transgenic mice

상세보기
Neurology McGeer 38 1285 1988 10.1212/WNL.38.8.1285 Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains

상세보기
Brain Res. Bull. Mohamed 86 22 2011 10.1016/j.brainresbull.2011.07.001 Epicatechin attenuates doxorubicin-induced brain toxicity: Critical role of TNF-α, iNOS and NF-κB

상세보기
J. Neurosci. Methods Morris 11 47 1984 10.1016/0165-0270(84)90007-4 Developments of a water-maze procedure for studying spatial learning in the rat

상세보기
Nat. Rev. Neurosci Nguyen 3 216 2002 10.1038/nrn752 Innate immunity: The missing link in neuroprotection and neurodegeneration?

상세보기
Molecules Oh 24 20 2019 10.3390/molecules24203755 Angelicae Gigantis Radix Regulates LPS-Induced Neuroinflammation in BV2 Microglia by Inhibiting NF-κB and MAPK Activity and Inducing Nrf-2 Activity

상세보기
Evid. Based Complement. Alternat. Med Olajide 2012 2012 10.1155/2012/546873 Bridelia ferruginea Produces Antineuroinflammatory Activity through Inhibition of Nuclear Factor-kappa B and p38 MAPK Signalling

상세보기
J. Neuroinflammation Semmler 5 38 2008 10.1186/1742-2094-5-38 Sepsis causes neuroinflammation and concomitant decrease of cerebral metabolism

상세보기
J. Clin. Investig. Tak 107 7 2001 10.1172/JCI11830 NF-κB: A key role in inflammatory diseases

상세보기
J. Neuroinflammation Xuan 9 202 2012 10.1186/1742-2094-9-202 Hydrogen sulfide attenuates spatial memory impairment and hippocampal neuroinflammation in beta-amyloid rat model of Alzheimer's disease

상세보기
Nutr. Diabetes Yang 9 23 2019 10.1038/s41387-019-0092-y Inhibitory effects of pu-erh tea on alpha glucosidase and alpha amylase: a systemic review

상세보기
Int. Immunopharmacol. Zhang 65 438 2018 10.1016/j.intimp.2018.10.020 Vitamin C alleviates LPS-induced cognitive impairment in mice by suppressing neuroinflammation and oxidative stress

상세보기

LOADING...

활용도 분석정보

상세보기

다운로드

내보내기

활용도 Top5 논문

해당 논문의 주제분야에서 활용도가 높은 상위 5개 콘텐츠를 보여줍니다.
더보기 버튼을 클릭하시면 더 많은 관련자료를 살펴볼 수 있습니다.

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관 관리번호, 논문명, 대등논문명, 저자 , 저널/프로시딩명, 발행기관, 발행년, 발행언어, 권, 호, 시작페이지, 끝페이지, ISBN, ISSN, 주제분야, 키워드, 초록(한글), 초록(영문), 저자(소속기관)
저장형식	Text(ASCII format) Excel format RefWorks Direct Export RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증

[해외논문] Pu'er tea water extract protects against cognitive impairment in a mouse model of lipopolysaccharide-induced neuroinflammation

Abstract ▼ AI-Helper

Keyword

참고문헌 (30)

이 논문을 인용한 문헌

연구과제 타임라인

활용도 분석정보

활용도 Top5 논문

관련 콘텐츠

원문 URL 링크

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트

연합인증

[해외논문] Pu'er tea water extract protects against cognitive impairment in a mouse model of lipopolysaccharide-induced neuroinflammation

Abstract ▼ AI-Helper

Keyword

참고문헌 (30)

이 논문을 인용한 문헌

연구과제 타임라인

전체(0) 논문(0) 특허(0) 보고서(0)

전체(0) 논문(0) 특허(0) 보고서(0)

활용도 분석정보

활용도 Top5 논문 더보기

관련 콘텐츠

원문 URL 링크

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트

활용도 Top5 논문